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Drug allergy management in the elderly
Purpose of review Drug allergy management has previously not been emphasized in the elderly. However, the geriatric population poses several unique characteristics, challenges for drug allergy testing and considerations in the management. Especially in the era of COVID-19, the elderly population is a vulnerable cohort and reviewing the management during this unprecedented time is both timely and relevant. Recent findings In recent years, larger scale studies focusing on the epidemiology and prevalence trends of drug allergies among older adults has been summarized in this review. Emphasis on anaphylaxis in the o...
Source: Current Opinion in Allergy and Clinical Immunology - July 14, 2021 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Miguel Blanca and Paul Whitaker Source Type: research

Basophil activation test in food allergy: is it ready for real-time?
Purpose of review Utilization of basophil activation in the diagnosis and monitoring of food allergy has gained increasing recognition. An ex-vivo functional assay, basophil activation reflects clinical reactivity, thereby providing clinically relevant insights. Moreover, as a biomarker of reactivity and tolerance, basophil activation testing (BAT) may provide a useful tool for management of food allergies. Despite its utility, significant limitations of BAT have prevented widespread use. Addressing these limitations will increase the future application and adoption of BAT in food allergy. Recent findings A numb...
Source: Current Opinion in Allergy and Clinical Immunology - September 2, 2021 Category: Allergy & Immunology Tags: ANAPHYLAXIS AND INSECT ALLERGY: Edited by Gianenrico Senna and Mariana Castells Source Type: research

Chronic sinusitis pathophysiology: The role of allergy.
CONCLUSION: Treatments of this disease include agents directed at allergic mediators such as leukotriene modifiers and corticosteroids, although this doesnot necessarily signify that an IgE-dependent mechanism can be ascribed. However, more recently, omalizumab has shown promise, including in patientswithout obvious aeroallergen sensitization. Although many aspects of the role of allergy in CHES remain a mystery, the mechanisms that are being elucidatedallow for improved understanding of this disease, which ultimately will lead to better treatments for our patients who live daily with this disease. PMID: 23601202 [Pub...
Source: American Journal of Rhinology and Allergy - April 18, 2013 Category: ENT & OMF Authors: Kennedy JL, Borish L Tags: Am J Rhinol Allergy Source Type: research

Role of parental atopy in cow's milk allergy: a population-based study.
CONCLUSION: In families with children with persistent IgE-CMA, self-reporting of atopy by parents may be biased. Furthermore, the demonstration of IgE-mediated responses to allergens in parents is insufficient by itself, in a general population cohort, to predict which infants are at greatest risk of developing IgE-CMA. PMID: 23535093 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - April 1, 2013 Category: Allergy & Immunology Authors: Goldberg M, Eisenberg E, Elizur A, Rajuan N, Rachmiel M, Cohen A, Zadik-Mnuhin G, Katz Y Tags: Ann Allergy Asthma Immunol Source Type: research

Chapter 16: Determining the role of allergy in sinonasal disease.
Abstract The contributing role of specific IgE sensitization in the pathophysiology of sinonasal diseases including rhinitis, chronic rhinosinusitis (CRS), and nasal polyps is explored. Although it is estimated that sensitization to environmental allergens is present in 75% of patients with rhinitis, the role of allergy in CRS and nasal polyps is less certain. However, when atopy is present in the setting of nasal polyps, it is associated with worse quality of life and a higher incidence of asthma. Several theories have been put forth whereby inhalant aeroallergen exposure could drive the inflammatory response tha...
Source: American Journal of Rhinology and Allergy - May 1, 2013 Category: ENT & OMF Authors: Settipane RA, Borish L, Peters AT Tags: Am J Rhinol Allergy Source Type: research

The impact and treatment of allergic rhinitis in the Middle East: A comparison with the landmark allergy surveys from other worldwide regions.
CONCLUSION: There remains an unmet need in the treatment of nasal allergies worldwide. The allergy surveys highlight the key factors in choosing an INCS: fast, complete, and long-lasting symptom relief. There is opportunity for novel INCS treatments that address these needs while reducing troublesome side effects. Patient education must play a central role in treatment decision making, particularly in the Middle East, to achieve higher patient satisfaction. PMID: 24070203 [PubMed - as supplied by publisher]
Source: American Journal of Rhinology and Allergy - September 6, 2013 Category: ENT & OMF Tags: Am J Rhinol Allergy Source Type: research

Allergy training and immunotherapy in Latin America: results of a regional overview.
CONCLUSION: The present analysis helps to identify gaps in the field of allergologic training and SIT in Latin America, many of them amendable. PMID: 24125151 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - October 18, 2013 Category: Allergy & Immunology Authors: Baena-Cagnani CE, Larenas Linnemann D, Gómez M, Díaz SG, Solé D, Borges MS, Bousquet J, Sisul JC, Canonica GW, Gereda J, Passalacqua G, SLAAI Immunotherapy Working Group Tags: Ann Allergy Asthma Immunol Source Type: research

Can True Tolerance Be Produced in Food Allergy Patients?Can True Tolerance Be Produced in Food Allergy Patients?
This review looks at whether true immunologic tolerance is possible in food allergy patients. Medscape Allergy & Immunology
Source: Medscape Allergy Headlines - January 15, 2014 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology Expert Column Source Type: news

Esomeprazole: a safe alternative to lansoprazole allergy?
Abstract Proton pump inhibitors (PPIs) are widely prescribed drugs in daily practice. Allergic reactions, even small number of anaphylactic reactions to PPIs have been reported. Omeprazole, lansoprazole, pantoprazole, rapeprazol and esomeprazole are classified in the same group. Despite the similarity of biochemical structures among these drugs, presence of cross-reactivity between PPIs is controversial.1,2 In this letter, we present 3 lansoprazole allergy cases, who were prescribed and took esomeprazole safely after allergic reactions to lansoprazole. PMID: 24659167 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Kara M, Tanoglu A, Kutlu A, Sirkeci O, Kekilli M Tags: Iran J Allergy Asthma Immunol Source Type: research

The effects of alcohol consumption and smoking on allergy risk in Korean adults.
CONCLUSION: These findings suggest that history of smoking and frequent alcohol consumption are significantly associated with increased prevalence of sensitization to D. farinae. In addition, frequency of alcohol drinking was also related to a moderate increase in TIgE levels in Korean adults. PMID: 24717878 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - January 1, 2014 Category: ENT & OMF Authors: Kang JW, Baek SH, Rha MS, Kim JH Tags: Am J Rhinol Allergy Source Type: research

Prevalence of immediate-type food allergy in early childhood in seoul.
CONCLUSIONS: The prevalence of immediate-type FA in early childhood is 3.7%, and is higher in younger children. The most common offending foods differed with age. PMID: 24587949 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 16, 2014 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Can Fecal Calprotectin Level Be Used as a Markers of Inflammation in the Diagnosis and Follow-Up of Cow's Milk Protein Allergy?
CONCLUSIONS: FC levels may be a useful marker for follow-up treatment and recurrence determination in CMPA. PMID: 24404391 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 16, 2014 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Histamine-releasing factor and immunoglobulins in asthma and allergy.
Authors: Kawakami T, Kashiwakura J, Kawakami Y Abstract Factors that can induce the release of histamine from basophils have been studied for more than 30 years. A protein termed histamine-releasing factor (HRF) was purified and molecularly cloned in 1995. HRF can stimulate histamine release and IL-4 and IL-13 production from IgE-sensitized basophils and mast cells. HRF-like activities were found in bodily fluids during the late phase of allergic reactions, implicating HRF in allergic diseases. However, definitive evidence for the role of HRF in allergic diseases has remained elusive. On the other hand, we found ef...
Source: Allergy, Asthma and Immunology Research - November 16, 2014 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Allergy and the eye.
Authors: Bonini S Abstract This review of the major milestones in the history of ocular allergy and immunology shows how significantly this subdiscipline has contributed to the tremendous progress in the understanding of mechanisms of allergic and immunologic diseases, as well as in their better management. It also indicates unmet needs and priority areas for future research. PMID: 24925390 [PubMed - in process]
Source: Chemical Immunology and Allergy - December 2, 2014 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Landmarks in Allergy during the 19th Century.
Authors: Kay AB Abstract There were remarkable achievements in the 19th century in our understanding of the cells of the allergic response, the clear descriptions of hay fever and asthma, as well as the role of pollen in seasonal rhinitis. Although allergy as a concept was not developed until well into the 20th century, the foundations of our present understanding of these diseases were laid in the 1800s. The outstanding physicians and scientists of this time included Paul Ehrlich (who described mast cells, eosinophils and basophils), John Bostock (who provided the first detailed account of hay fever), Charles Blac...
Source: Chemical Immunology and Allergy - December 2, 2014 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research