Spontaneous food allergy in Was ‐/‐ mice occurs independent of FcεRI‐mediated mast cell activation

ConclusionsWas‐/‐ mice provide a model of food allergy with the advantage of mimicking polysensitization and low food‐antigen IgE titers as observed in humans with clinical food allergy. This model will facilitate studies on aberrant immune responses during spontaneous disease development. Our results imply that therapeutic targeting of the IgE/FcεRI activation cascade will not affect sensitization to food.This article is protected by copyright. All rights reserved.

Source: Allergy - June 10, 2017 Category: Allergy & Immunology Authors: Willem S. Lexmond, Jeremy A. Goettel, Benjamin F. Sallis, Katelyn McCann, Edmond H. H. M. Rings, Erika Jensen ‐Jarolim, Samuel Nurko, Scott B. Snapper, Edda Fiebiger Tags: Original Article: Experimental Allergy and Immunology Source Type: research