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Infectious Disease: Herpes

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Total 364 results found since Jan 2013.

Using the Self-Controlled Tree-Temporal Scan Statistic to Assess the Safety of Live Attenuated Herpes Zoster Vaccine.
Abstract The self-controlled tree-temporal scan statistic allows detection of potential vaccine- or drug-associated adverse events without pre-specifying the specific events or post-exposure risk intervals of concern. It thus opens a promising new avenue for safety studies. The method has been successfully used to evaluate the safety of two vaccines for adolescents and young adults, but its suitability to study vaccines for older adults had not been established. The current study applied the method to assess the safety of live attenuated herpes zoster vaccination during 2011-2017 in U.S. adults ≥ 60 years old, u...
Source: Am J Epidemiol - May 6, 2019 Category: Epidemiology Authors: Yih WK, Kulldorff M, Dashevsky I, Maro JC Tags: Am J Epidemiol Source Type: research

Editorial: Shaping of Human Immune System and Metabolic Processes by Viruses and Microorganisms
Conclusions In conclusion, articles in this Research Topic made a very significant contribution to our understanding of the role played by environmental factors, dysbiotic conditions, and infections in triggering diseases. Since this is a rapidly expanding area of research, many other factors contributing to the onset of these diseases are not covered here. We are confident, however, that further studies will expand the list as well as bring a better understanding of mechanisms involved in the onset of autoimmune and autoinflammatory diseases. Author Contributions All authors listed have made a substantial, direct and i...
Source: Frontiers in Microbiology - April 16, 2019 Category: Microbiology Source Type: research

Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
This study was carried out in accordance with the recommendations of The London School of Hygiene & Tropical Medicine (LSHTM) Research Ethics Committee (Ref. 6123) and the National Research Ethics Service (NRES) London-Bloomsbury Research Ethics Committee (REC ref. 11/10/1760, IRAS ID: 77765), with written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the LSHTM Research Ethics Committee and the NRES London-Bloomsbury Research Ethics Committee. Author Contributions JC, HD, LN, EL, and ER devised the study ...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

A Systematic Review on Predisposition to Lymphoid (B and T cell) Neoplasias in Patients With Primary Immunodeficiencies and Immune Dysregulatory Disorders (Inborn Errors of Immunity)
Conclusions Though this is not a comprehensive summary of malignancies in PIDDs, or even lymphoproliferative disease in this area, this review summarizes the Medline-indexed published reports of B and T lymphomas in patients with PIDDs. This report highlights the diversity of malignant lymphoproliferative disorders in setting of PIDDs, and its associated challenges of diagnosis and treatment. The pathological classification and nomenclature for the lymphoid malignancies with variably reported and postulated underlying mechanisms were inconsistent and inadequate for many of these published reports. A wide range of treatmen...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Case Study: Mechanism for Increased Follicular Helper T Cell Development in Activated PI3K Delta Syndrome
This study was carried out after written informed consent from all subjects. All subjects gave written informed consent in accordance with the Declaration of Helsinki. The protocol was approved by the Stanford University and UCLA Institutional Review Boards. Author Contributions MB provided patient care and obtained IRB approval. RO prepared histology images. MB, TT, and RB designed the research. TT and LP conducted experiments and analyzed data. MB made the molecular model. MB and TT wrote the manuscript. Funding Funding for this work came from the Jeffrey Modell Foundation and from the NIH/NIGMS (R01 GM110482 to MB)....
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Experimental Analysis of Viral –Host Interactions
Experimental Analysis of Viral–Host Interactions Joseph Gillen and Aleksandra Nita-Lazar* Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States Viral and pathogen protein complexity is often limited by their relatively small genomes, thus critical functions are often accomplished by complexes of host and pathogen proteins. This requirement makes the study of host–pathogen interactions critical for the understanding of pathogenicity and virology. This review article discusses proteomic methods that offer a...
Source: Frontiers in Physiology - April 10, 2019 Category: Physiology Source Type: research

The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells
This study was provided by the Canadian Institutes of Health Research and the Manitoba Health Research Council. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Sprent J, Kishimoto H. The thymus and central tolerance. Philos Trans R Soc Lond B Biol Sci. (2001) 356:609–16. doi: 10.1098/rstb.2001.0846 PubMed Abstract | CrossRef Full Text | Google Scholar 2. Sakaguchi S, Wing K, Miyara M. Regulatory T cells - a brief history and perspective...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Predictive factors for progression to chronicity or recurrence after the first attack of acute urticaria in preschool-age children.
CONCLUSIONS: Preschool-aged children with acute urticaria should be evaluated for infections at the time of admission. Patients with unknown etiology, negative Herpes virus serology, absence of atopic dermatitis, and long lasting urticaria should be followed up for chronicity and recurrence. PMID: 30904182 [PubMed - as supplied by publisher]
Source: Allergologia et Immunopathologia - March 19, 2019 Category: Allergy & Immunology Authors: Cetinkaya PG, Soyer O, Esenboga S, Sahiner UM, Teksam O, Sekerel BE Tags: Allergol Immunopathol (Madr) Source Type: research

The microbiome and allergic diseases
That microbial infections can influence the development and severity of allergic diseases is well established. Examples include Staphylococcus aureus or herpes simplex infection in atopic dermatitis (AD) and various respiratory viral infections in asthma. Adults with AD have been found to have increased cutaneous, multiorgan, and system infections associated with considerable cost burden from hospitalization.1 The strong association of S aureus infection in AD has resulted in the frequent use of antibiotics for exacerbation of AD, even in the absence of overt skin infection.
Source: Annals of Allergy, Asthma and Immunology - January 9, 2019 Category: Allergy & Immunology Authors: Donald Y.M. Leung Tags: Perspective Source Type: research

Clinical Spectrum of Patients with Pathogenic Variant of STAT3 conferring Gain-of-Function: A Mimic of Autoimmune Lymphoproliferative Syndrome
Autoimmune lymphoproliferative syndrome (ALPS) is a rare genetic disorder caused by defective fas-mediated apoptosis. Patients often present in childhood with lymphoproliferation, splenomegaly and multilineage cytopenias (Price et al. Natural history of autoimmune lymphoproliferative syndrome associated with FAS gene mutations. Blood 2014). Though mutations in the FAS gene account for the majority of cases, an estimated 20% of patients who have no defined genetic cause are classified as ALPS-U (Shah et al. Autoimmune lymphoproliferative syndrome: an update and review of the literature. Current allergy and asthma reports 20...
Source: Blood - November 21, 2018 Category: Hematology Authors: Constantine, G., Su, H., Folio, L., Milner, J., Rao, V. K. Tags: 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections: Poster III Source Type: research

Immunological features of active herpesviral infection in bronchial asthma
Viral infection is associated with the development of asthma. However, the role of Human Herpesviriuses (HHV) in chronic lung diseases remains obscure. In order to evaluate the patterns and immune response to HHV infection, we detected the levels of antiviral IgG and IgE-Abs to Herpes simplex virus type 1 (HSV1), Cytomegalovirus(CMV) and Epstein-Barr Virus(EBV) in patients with bronchial asthma(BA)of different severity using modified ELISA. For assessment the influence of HHV on autoreactivity, the levels of IgE and IgG4-Abs to a tissue Ags were estimated.Asthma patients have significantly enhanced frequency of seropositiv...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Konishcheva, A., Gervazieva, V. Tags: Allergy and immunology Source Type: research

Hypersensitivity syndrome development and human herpes virus 6 reactivation in patients with secondary vasculitis
This study assesses lymphocyte phenotypic characteristics and activation markers in patients with hypersensitivity syndrome and HHV6 reactivation due to secondary vasculitis.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: K. Lishchuk-Yakymovych, I. Voznyak, O. Syzon, R. Pukalyak, O. Synenkyy, L. DuBuske Tags: P259 Source Type: research

Fever and respiratory distress in an infant: mannose-binding lectin deficiency?
We present an infant with multiple infections who was diagnosed with MBL deficiency.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: K. Reddy, S. Alagheband, L. Schmidt, A. Yates Tags: M272 Source Type: research

Human TANK-binding kinase 1 is required for early autophagy induction upon herpes simplex virus 1 infection
Mutations disrupting the Toll-like receptor 3 (TLR3) –dependent–interferon pathway can underlie herpes simplex encephalitis (HSE) of childhood caused by herpes simplex virus 1 (HSV1) infection. These otherwise healthy patients with HSE carry germline mutations in the TLR3-interferon circuit, including TIR domain–containing adapter–inducing IFN -β (TRIF) and TANK-binding kinase 1 (TBK1).1,2 Their dermal fibroblasts show impaired interferon production after HSV1 infection and polyinosinic-polycytidylic acid (poly[I:C]) stimulation.
Source: Journal of Allergy and Clinical Immunology - October 5, 2018 Category: Allergy & Immunology Authors: Liyana Ahmad, Bayarchimeg Mashbat, Corwin Leung, Charlotte Brookes, Samar Hamad, Sina Krokowski, Avinash R. Shenoy, Lazaro Lorenzo, Michael Levin, Peter O'Hare, Shen-Ying Zhang, Jean-Laurent Casanova, Serge Mostowy, Vanessa Sancho-Shimizu Tags: Letter to the Editor Source Type: research

Exploration of (hetero)aryl derived thienylchalcones for antiviral and anticancer activities.
CONCLUSION: Compounds V and VI were demonstrated viral inhibition towards Human cytomegalovirus, whereas cyclopropylquinoline derivative IV towards Rift Valley fever virus and Tacaribe virus. Additionally, cyclopropylquinoline derivative IV has displayed very good cytotoxicity against colon, breast and leukemia cell lines in vitro. PMID: 29792154 [PubMed - as supplied by publisher]
Source: Medicinal Chemistry - May 23, 2018 Category: Chemistry Authors: Patil V, Patil SA, Patil R, Bugarin A, Beaman K, Patil SA Tags: Med Chem Source Type: research