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Infectious Disease: Herpes
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Total 364 results found since Jan 2013.
Neonatal Onset of Hemophagocytic Lymphohistiocytosis Due to Prenatal Varicella-Zoster Infection in a Neonate with Griscelli Syndrome Type 2
We described a type 2GS syndrome with neonatal-onset HLH triggered by a prenatal infection.PMID:36243938 | DOI:10.18502/ijaai.v21i4.10297
Source: Iranian Journal of Allergy, Asthma and Immunology - October 16, 2022 Category: Allergy & Immunology Authors: Hamideh Nodehi Mohammad Faranoush Saba Arshi Mohammad Nabavi Mohammad Hasan Bemanian Sima Shokri Mohammad Reza Saghafi Mohammad-Sadegh Fallah Morteza Fallahpour Source Type: research
Azathioprine therapy induces selective NK cell Depletion and IFN- γ Deficiency predisposing to herpes virus reactivation
CONCLUSION: Our study highlights the risk of developing adverse events during Azathioprine therapy and suggests that NK cell monitoring could be valuable in clinical practice.PMID:36122787 | DOI:10.1016/j.jaci.2022.09.010
Source: Herpes - September 19, 2022 Category: Infectious Diseases Authors: Florian Ingelfinger Colin Sparano David Bamert David Reyes-Leiva Aakriti Sethi Lukas Rindlisbacher Pascale Zwicky Stefanie Kreutmair Corinne C Widmer Sarah Mundt Elena Cort és-Vicente Sonia Tugues Burkhard Becher Bettina Schreiner Source Type: research
The Genetics of Eczema Herpeticum
Clin Rev Allergy Immunol. 2022 Sep 17. doi: 10.1007/s12016-022-08953-x. Online ahead of print.ABSTRACTEczema herpeticum (EH) is a viral skin infection caused by herpes simplex virus (HSV) superimposed on eczematous skin lesions in atopic dermatitis (AD). Though the pathogenesis of EH has yet to be fully elucidated, the fact that EH is relatively rare despite a majority of adults showing serologic evidence of HSV exposure points to a genetic component predisposing to the disease. A number of genetic variants have been isolated in EH which may help distinguish a subgroup of patients susceptible to developing the condition. T...
Source: Herpes - September 17, 2022 Category: Infectious Diseases Authors: Elisabeth Hodara Peck Y Ong Source Type: research
Azathioprine therapy induces selective NK cell Depletion and IFN- γ Deficiency predisposing to herpes virus reactivation
Azathioprine is a widely prescribed drug for patients with chronic inflammatory diseases such as Myasthenia gravis or organ transplant recipients. Azathioprine exerts immunosuppressive effects by inhibiting intracellular purine synthesis and reducing the numbers of circulating B and T lymphocytes. Case reports indicate increased risk for serious infections that can occur despite regular measurements of lymphocyte counts during Azathioprine therapy.
Source: Journal of Allergy and Clinical Immunology - September 16, 2022 Category: Allergy & Immunology Authors: Florian Ingelfinger, Colin Sparano, David Bamert, David Reyes-Leiva, Aakriti Sethi, Lukas Rindlisbacher, Pascale Zwicky, Stefanie Kreutmair, Corinne C. Widmer, Sarah Mundt, Elena Cort és-Vicente, Sonia Tugues, Burkhard Becher, Bettina Schreiner Source Type: research
Defects of the Innate Immune System and Related Immune Deficiencies
AbstractThe innate immune system is the host ’s first line of defense against pathogens. Toll-like receptors (TLRs) are pattern recognition receptors that mediate recognition of pathogen-associated molecular patterns. TLRs also activate signaling transduction pathways involved in host defense, inflammation, development, and the production of inflammatory cytokines. Innate immunodeficiencies associated with defective TLR signaling include mutations inNEMO,IKBA,MyD88, andIRAK4. Other innate immune defects have been associated with susceptibility to herpes simplex encephalitis, viral infections, and mycobacterial disease, a...
Source: Clinical Reviews in Allergy and Immunology - August 1, 2022 Category: Allergy & Immunology Source Type: research
Factors associated with severity of atopic dermatitis - a Finnish cross-sectional study
CONCLUSIONS: Severity determinants in Finnish patients seem to be early-onset, male sex, smoking, overweight, concomitant asthma, palmar hyperlinearity, hand dermatitis and high IgE-levels. A sub-typing of patients in relation to confirmed severity determinants may be useful for course prediction, prognosis, and targeted AD management.PMID:35766133 | DOI:10.1111/jdv.18378
Source: Herpes - June 29, 2022 Category: Infectious Diseases Authors: A Salava V Salo J Lepp änen A Lauerma A Remitz Source Type: research
Janssen Presents Study Results Showing Clinical Efficacy for TREMFYA ® (guselkumab) and Long-Term Safety Profile for STELARA® (ustekinumab) for Patients Living with Inflammatory Bowel Disease at Digestive Disease Week® 2022
SPRING HOUSE, PENNSYLVANIA, May 24, 2022 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new data from the Phase 2 GALAXI 1 clinical trial of TREMFYA® (guselkumab) in adult patients with moderately to severely active Crohn’s disease (CD), and from three separate long-term pooled analyses of adult patients with ulcerative colitis (UC) and CD treated with STELARA® (ustekinumab).1,2,3,4 These data are being presented as oral and poster presentations and are among 29 Janssen abstracts presented during the Digestive Disease Week® (DDW) meeting taking place in person and virtually in San Di...
Source: Johnson and Johnson - May 24, 2022 Category: Pharmaceuticals Source Type: news
Treatment with Intravenous Acyclovir Desensitization for Severe Acyclovir Allergy: A Case of Herpes Encephalitis
Mikrobiyol Bul. 2022 Apr;56(2):371-376. doi: 10.5578/mb.20229816.ABSTRACTHerpes simplex virus (HSV) is a sporadic viral encephalitis agent that causes high mortality and morbidity, accompanied by neurological dysfunction findings. Acyclovir is the only antiviral treatment option that should be initiated in all patients with suspected encephalitis as soon as possible. Acyclovir is rarely possible to cause allergic reactions. It may occur in a wide range from generalized cutaneous rash to Stevens-Johnson syndrome. A case of HSV-1 encephalitis who had no treatment option other than intravenous acyclovir and was successfully t...
Source: Mikrobiyoloji Bulteni - April 28, 2022 Category: Microbiology Authors: Tu ğba Arslan Gülen G üzin Özden Tuba Turan ç Source Type: research
