Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

In this study, herpes virus serological status and T cell, B cell, NK cell and monocyte populations were investigated in 251 ME/CFS patients, including 54 who were severely affected, and compared with those from 107 healthy participants and with 46 patients with Multiple Sclerosis. There were no differences in seroprevalence for six human herpes viruses between ME/CFS and healthy controls, although seroprevalence for the Epstein-Barr virus was higher in multiple sclerosis patients. Contrary to previous reports, no significant differences were observed in NK cell numbers, subtype proportions or in vitro responsiveness between ME/CFS patients and healthy control participants. In contrast, the T cell compartment was altered in ME/CFS, with increased proportions of effector memory CD8+ T cells and decreased proportions of terminally differentiated effector CD8+ T cells. Conversely, there was a significantly increased proportion of mucosal associated invariant T cells (MAIT) cells, especially in severely affected ME/CFS patients. These abnormalities demonstrate that an altered immunological state does exist in ME/CFS, particularly in severely affected people. This may simply reflect ongoing or recent infection, or may indicate future increased susceptibility to infection. Longitudinal studies of ME/CFS patients are needed to help to determine cause and effect and thus any potential benefits of immuno-modulatory treatments for ME/CFS. Introduction Myalgic encephalomyelitis (o...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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This study aimed to assess the relative safety and short-term efficacy of drug-eluting bead transarterial chemoembolization (DEB-TACE) and conventional transarterial chemoembolization (c-TACE) for treating peculiar anatomical sites of gastric cancer liver metastasis. MATERIAL AND METHODS Of the 68 patients with gastric cancer liver metastases confirmed by imaging and pathology, 35 were treated with DEB-TACE and 33 with c-TACE. The DEB-TACE group comprised 26 males and 9 females aged 28-75 years (56.8±6.3), and the c-TACE group included 19 males and 14 females aged 33-77 (60.2±9.4) years. Liver functions of th...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
CONCLUSIONS The network pharmacology analysis reveals the molecular biological mechanism of Artemisia annua anti-NSCLC via multiple active components, multi-channels, and multi-targets. This suggests that Artemisia annua might be developed as a promising anti-NSCLC drug. PMID: 32474568 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Optical scanning holography (OSH) is an attractive technique since 3D information can be obtained with a single pixel detector. However, ...
Source: Optics Letters - Category: Physics Authors: Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ01814G, PaperGurpreet Kaur, Monika Chaudhary, Kailash C Jena, Narinder Singh Abstract Environmental contamination due to increase in drug level is touching its alarming stage. There is an array of drugs such as antibiotics, antidepressants, analgesics, cancer chemotherapy drugs etc which... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Dalton Trans., 2020, Accepted Manuscript DOI: 10.1039/D0DT01365J, PerspectiveLuiz Gonzaga Fran ça de França Lopes, Edinilton Muniz Carvalho, Eduardo Henrique Silva Sousa Medicinal inorganic chemists have provided many strategies to tackle a myriad of diseases, pushing forward the frontiers of pharmacology. As an example, the fight against tuberculosis (TB), an infectious bacterial... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
Analyst, 2020, Advance Article DOI: 10.1039/D0AN00627K, PaperJun Liu, Cheng Cao We propose a novel GSH-generating prodrug to be used with a sulfonamide-induced “integrative” platform for selective cancer therapy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
Dr Fauci says he hasn ’t spoken to Trump in two weeks; New Zealand to consider easing restrictions earlier than planned; Mexico deaths pass 10,000. Follow the latest updatesSingapore reopens schoolsUK: Critics round on No 10 over ‘ridiculous’ rules for 14-day quarantineAustralia coronavirus updates – liveCoronavirus latest: at a glanceSee all our coronavirus coverage6.46amBSTTheAssociated Pressis carrying a report that says Chinese officials sat on releasing the genetic map, or genome, of the coronavirus for over a week after multiple government labs had fully decoded it, not sharing details key to ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Infectious diseases Science Microbiology Medical research UK news US news Australia news Source Type: news
Publication date: Available online 31 May 2020Source: Environmental Toxicology and PharmacologyAuthor(s): Badmus O. Olufunto, Njan Anoka, Ologe M. Olufunmilayo, Olatunji A. Lawrence
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
His group will study how abnormal calcium signals may contribute to human diseases such as allergies and asthma. (read more)
Source: Environmental Factor - NIEHS Newsletter - Category: Environmental Health Source Type: news
Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Emmie de Wit Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature) Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv) Remdesivir for MERS-CoV infection in macaques (PNAS) ChAdOX1 vaccination for SARS-CoV-2 in macaques ...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
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