A Systematic Review on Predisposition to Lymphoid (B and T cell) Neoplasias in Patients With Primary Immunodeficiencies and Immune Dysregulatory Disorders (Inborn Errors of Immunity)

Discussion In this section, we discuss the mechanisms responsible for lymphomagenesis in the various inborn errors of immunity and provide an overview of the treatment. Defects in Immune Responses That Predispose to Lymphomagenesis in PIDDs The complex immune mechanisms and their interplay that predisposes to neoplastic transformation of B or T cells and development of lymphomas in PIDD patients has not been fully elucidated. However, it is expected that the etiology in most cases is multifactorial and related to a dynamic regulation of immune response and environmental triggers (Figure 3). An underlying intrinsic susceptibility to DNA damage in some of these PIDDs, may provide a substrate for uncontrolled cell growth, impaired apoptosis of damaged cells, premature cellular senescence, all of which may be compounded by increased antigenic stimulation of adaptive lymphocytes by viruses, such as EBV (112). This uncontrolled stimulation in the setting of altered immune checkpoints and immune dysregulation characterized by T cell exhaustion, defective anti-tumor immune surveillance and overproduction of inflammatory cytokines provides a fertile setting for neoplastic transformation and lymphoproliferation (Figure 3). FIGURE 3 Figure 3. Illustration of potential interplay of mechanisms implicated in pathogenesis of malignancies in PIDs. Defective DNA Repair DNA integrity is constantly challenged at various levels as part of physiological processes. In lymphocyte...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

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Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Surendra Gulla, Dakshayani Lomada, Vadali V.S.S. Srikanth, Muthukonda Venkatakrishnan Shankar, Kakarla Raghava Reddy, Sarvesh Soni, Madhava C. ReddyAbstractNanoparticles' based cancer therapeutics are greatly dependent on the development of science and engineering of nanoparticles. In this article, important strategies based on nanoparticles used for cancer treatment are discussed. The inspiration to write this article is not only to review the existing strategies based on nanoparticles but also to highlight the pertinent and possible solutions ther...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Aaron Elbourne, Vi Khanh Truong, Samuel Cheeseman, Piumie Rajapaksha, Sheeana Gangadoo, James Chapman, Russell J. CrawfordAbstractAntimicrobial resistance (AMR) has been identified as one of the greatest threats to human health (Boucher et al., 2009, Bush et al., 2011, Centers for Disease Control and Prevention, 2013, Neu, 1992, Spellberg et al., 2008). Unfortunately, the current rise in AMR has made biofilm-related infections a primary health-care concern, since these biofilms can no longer be effectively treated using conventional antibiotic metho...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
ConclusionNo significant difference was found in the clinical manifestations, mortality, and complication between children and adults but children tended to have lesser chance of using alternative antibiotics, methylprednisolone and inhaled NO. The chance of associated cytomegalovirus (CMV) disease was also significantly lower in children.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
This study's main objectives were: (i) to carry out a comparative examination of the error estimates in both techniques and (ii) to generalize location assessment of the permanent low-density regional network in Central Alborz. The regional network operates under Iranian Seismological Center and its seismic data are massively applied. To reach the research goals, the dataset–method correlation matrix and the location variables were statistically processed. It was shown that the estimated earthquake epicenters by the linear and nonlinear methods are approximately similar for well-located events in each network. For de...
Source: Physics of the Earth and Planetary Interiors - Category: Physics Source Type: research
Publication date: Available online 21 May 2019Source: Comptes Rendus PhysiqueAuthor(s): Guy LavalAbstractAt their very beginning, the researches on the magnetic confinement fusion had to face up plasma instabilities. Macroscopic plasma instabilities were the first ones to be identified and they were found to be very harmful for plasma confinement. During the first years after the Atoms for Peace Meeting in 1958, the main goals of experimental and theoretical researches dealt with their suppression or control. During this period, two special types of instabilities, the localized interchange modes and the tearing modes, were...
Source: Comptes Rendus Physique - Category: Physics Source Type: research
In this work, the four optimum azimuthal angles are determined for a full-Stokes scanning polarimeter comprising a rectangular prism, quarter-wave plate, and four linear polarizers. The determinant and condition numbers of the measurement matrix are used as objective functions in an optimization ...
Source: Applied Optics - Category: Physics Authors: Source Type: research
Publication date: Available online 21 May 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Lamia Abou El-Kassem, Usama W. Hawas, Sahar El-Souda, Eman F. Ahmed, Wail El-Khateeb, Walid FayadAbstractForty-eight endophytic fungal strains were isolated and purified from ten Egyptian medicinal plants and their culture broth extracts were explored for HCV protease inhibitory activity and cytotoxicity. The ethyl acetate extracts of Alternaria alternata PGL-3, Cochlibolus lunatus PML-17, Nigrospora sphaerica EPS-38, followed by Emerecilla nidulans RPL-21 showed the most potent inhibition of HCV NS3/4A protease with...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
PMID: 31109506 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
PMID: 31109503 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
PMID: 31109502 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
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