The Pivotal Role of Regulatory T Cells in the Regulation of Innate Immune Cells

This study was provided by the Canadian Institutes of Health Research and the Manitoba Health Research Council. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. References 1. Sprent J, Kishimoto H. The thymus and central tolerance. Philos Trans R Soc Lond B Biol Sci. (2001) 356:609–16. doi: 10.1098/rstb.2001.0846 PubMed Abstract | CrossRef Full Text | Google Scholar 2. Sakaguchi S, Wing K, Miyara M. Regulatory T cells - a brief history and perspective. Eur J Immunol. (2007) 37(Suppl. 1):S116–23. doi: 10.1002/eji.200737593 PubMed Abstract | CrossRef Full Text | Google Scholar 3. Sakaguchi S, Miyara M, Costantino CM, Hafler DA. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol. (2010) 10:490–500. doi: 10.1038/nri2785 PubMed Abstract | CrossRef Full Text | Google Scholar 4. Weber SE, Harbertson J, Godebu E, Mros GA, Padrick RC, Carson BD, et al. Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo. J Immunol. (2006) 176:4730–9. doi: 10.4049/jimmunol.176.8.4730 PubMed Abstract | CrossRef Full Text | Google Scholar 5. Strauss L, Bergmann C, Whiteside TL. Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated ap...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

Rallis Viral skin infections often affect the sports community. The aim of this study was to assess the rates, location sites, and seasons of appearance of common viral cutaneous diseases in beach volleyball athletes in Greece. Five hundred and forty-nine beach volleyball athletes participated in this study. The average age was 28.4 years. The viral infections were herpes simplex (type 1), molluscum contagiosum and warts. The measured parameters included: gender, age, the season when athletes may be more susceptible to infections and the location of infection in the body. Practicing information such as the number of t...
Source: Viruses - Category: Virology Authors: Tags: Communication Source Type: research
Long-term use of enzyme-inducing antiseizure medications may increase incident cardiovascular disease risk in patients with epilepsy, prompting calls by some neurologists to retire the drugs.Medscape Medical News
Source: Medscape Internal Medicine Headlines - Category: Internal Medicine Tags: Neurology & Neurosurgery News Source Type: news
Abe Oudshoorn, Tanya Benjamin, Tracy A. Smith-Carrier, Sarah Benbow, Carrie Anne Marshall, Riley Kennedy, Jodi Hall, C. Susana Caxaj, Helene Berman, Deanna Befus Housing, Care and Support, Vol. ahead-of-print, No. ahead-of-print, pp.- People experiencing homelessness are uniquely vulnerable to the impacts of a pandemic, such as COVID-19. Therefore, governments across Canada have been implementing a patchwork of responses to address the needs of those who are homeless at this time. The purpose of this study is to both compile and assess the varying responses by exploring the breadth of actions presented i...
Source: Housing, Care and Support - Category: International Medicine & Public Health Authors: Source Type: research
ConclusionThere is no association between early initiation of adjuvant chemotherapy and post-operative complications including wound healing. Early initiation of chemotherapy ( ≤ 7 days) is feasible in unilateral WT or high-risk neuroblastoma patients who are otherwise doing well without resulting in a preponderance of wound healing complications.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
Two thirds of patients with diabetes achieve a good visual outcome of 20/40 or better after cataract surgery, according to one of the largest studies to assess visual acuity in people with diabetes undergoing cataract surgery.Reuters Health Information
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Ophthalmology News Source Type: news
DEMENTIA is a general term for symptoms associated with progressive brain decline, such as memory loss. Alzheimer's disease is the most common cause of dementia. According to the Physicians Committee for Responsible Medicine , you should "avoid" a particular vitamin supplement because it can contribute to your risk of the progressive brain decline.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
We present a case of an otherwise healthy 34-year-old male who developed end-stage pulmonary fibrosis following COVID-19 infection. He achieved haemodynamic stability with mechanical ventilation and extracorporeal membrane oxygenation (ECMO) but did not show any sign of weaning off ECMO; however, he successfully underwent bilateral lung transplantation.
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: CASE REPORT Source Type: research
DIABETES is a lifelong condition that can cause serious health woes for those affected by it - here are the 10 hidden symptoms to look out for.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Background: Recurrent acute otitis media in the first years of life can be explained by immune dysfunction. Consequently, it would be expected that otitis-prone (OP) children would be more susceptible to other infectious diseases, especially respiratory infections, since a component of the immune problem involves nasopharyngeal innate immunity. Design: Cohort study with prospective identification of all physician-diagnosed, medically attended respiratory illness visits in children 6 months to 5 years of age to determine the incidence of pneumonia, acute sinusitis, influenza and other bacterial and viral infectio...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
This study assessed whether disparities in MIS-C in the United States by race and ethnicity exceed known disparities in coronavirus disease 2019 (COVID-19) incidence. Methods: We compared the distribution of race and ethnicity among patients with MIS-C (
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
More News: Allergy | Allergy & Immunology | Arthritis | Asthma | Autoimmune Disease | Biology | Canada Health | Cancer | Cancer & Oncology | Clinical Trials | Cold Sores | Colon Cancer | Colorectal Cancer | Crohn's Disease | Dermatitis | Dermatology | Diabetes | Diabetes Type 1 | Endocrinology | Environmental Health | Epilepsy | Epithelial Cancer | Funding | Gastroenteritis | Gastroenterology | Genetics | Herpes | Inflammatory Bowel Disease | Influenza | Intensive Care | Laboratory Medicine | Legislation | Lung Transplant | Lupus | Molecular Biology | Multiple Sclerosis | Oral Cancer | Pancreas | Pancreatic Cancer | Parasitology | Pathology | Pediatrics | Respiratory Medicine | Rheumatoid Arthritis | Rheumatology | Science | Septic Shock | Skin | Skin Graft | Stem Cell Therapy | Stem Cells | Study | Tonsillitis | Transplant Surgery | Transplants | Tuberculosis | USA Health | Vasculitis | Vitamin A | Vitamins