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Nutrition: Antidoxidants
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Total 54788 results found since Jan 2013.
Txnrd3 knockout enhancement of lung injury induced by Ni exposure via the VEGF-VEGFR-2 axis and alleviation of this effect by melatonin
In conclusion, Ni causes lung injury by activating the VEGF-VEGFR-2 pathway and Txnrd3 knockout aggravates injury after Ni exposure.PMID:37716496 | DOI:10.1016/j.fct.2023.114032
Source: Food and Chemical Toxicology - September 16, 2023 Category: Food Science Authors: Pinnan Liu Yue Sun Senqiu Qiao Wenxue Ma Lihua Xu Yue Liu Xiaoxue Gai Qiaohan Liu Jingzeng Cai Ziwei Zhang Source Type: research
Multifunctional and theranostic hydrogels for wound healing acceleration: An emphasis on diabetic-related chronic wounds
Environ Res. 2023 Sep 14:117087. doi: 10.1016/j.envres.2023.117087. Online ahead of print.ABSTRACTHydrogels represent intricate three-dimensional polymeric structures, renowned for their compatibility with living systems and their ability to naturally degrade. These networks stand as promising and viable foundations for a range of biomedical uses. The practical feasibility of employing hydrogels in clinical trials has been well-demonstrated. Among the prevalent biomedical uses of hydrogels, a significant application arises in the context of wound healing. This intricate progression involves distinct phases of inflammation,...
Source: Environmental Research - September 16, 2023 Category: Environmental Health Authors: Pooya M Tehrany Parham Rahmanian Aryan Rezaee Golnaz Ranjbarpazuki Farima Sohrabi Fard Yasaman Asadollah Salmanpour Mohammad Arad Zandieh Ali Ranjbarpazuki Sajedeh Asghari Nazanin Javani Noushin Nabavi Amir Reza Aref Mehrdad Hashemi Mohsen Rashidi Afshin Source Type: research
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF- κB signaling
In this study, we aimed to determine the effects of lead acetate on reproductive function in male mice, identify the underlying mechanisms, and test counter measures to alleviate the toxic effects. Male mice were dosed with lead acetate (500 mg/L) in free drinking water for 12 weeks, and administered melatonin (5 mg/kg) or vitamin C (500 mg/kg) by intraperitoneal injection. Blood from the eyeball, testicles, and sperm from the caudal epididymis were collected after 12 weeks and analyzed. Pb exposure reduced sperm count and motility, increased sperm malformation (P < 0.01), disrupted testicular morphology and structure, ...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Ze-Min Zhao Su Mei Qi-Yue Zheng Jiao Wang Yi-Ru Yin Jiao-Jiao Zhang Xian-Zhong Wang Source Type: research
Curcumin protects against fenvalerate-induced neurotoxicity in zebrafish (Danio rerio) larvae through inhibition of oxidative stress
This study aimed to explore the mechanisms underlying FEN-induced neurotoxicity using the zebrafish (Danio rerio) model. We also investigated whether curcumin (CUR), a polyphenol antioxidant that exhibits neuroprotective properties, can prevent FEN-induced neurotoxicity. Here, zebrafish embryos were exposed to 0, 3.5, 7 and 14 μg/L of FEN from 4 to 96 h post fertilization (hpf) and neurotoxicity was assessed. Our results showed that FEN decreased the survival rate, heart rate, body length and spontaneous movement, and increased malformation rate. FEN caused neurobehavioral alterations, including decreased swimming distanc...
Source: Ecotoxicology and Environmental Safety - September 16, 2023 Category: Environmental Health Authors: Jiansheng Zhu Mingtao Huang Chunlan Liu Jingyu Wang Li Zou Fan Yang Renfei Zhu Source Type: research
< em > Alpinia nelumboides < /em > Nob.Tanaka, T.T.K.Van & amp; V.Hoang: phytochemical analysis and antioxidant activities of pseudo-stem and rhizome essential oils
Nat Prod Res. 2023 Sep 15:1-7. doi: 10.1080/14786419.2023.2256021. Online ahead of print.ABSTRACTAlpinia nelumboides Nob.Tanaka, T.T.K.Van & V.Hoang is the new Alpninia species discovered in Vietnam in 2023. Herein, we first hydrodistillated its pseudo-stems and rhizomes to obtain its essential oils, PS-EO and RH-EO. Their volatile compounds and total polyphenols were analysed by gas chromatography-mass spectrometry and the Folin-Ciocalteu method, respectively. Antioxidant activities were determined using four different approaches. The results showed that PS-EO and RH-EO contained 40 and 31 compounds, accounting for 99...
Source: Natural Product Research - September 15, 2023 Category: Biochemistry Authors: Tuan Nguyen Hoang Hieu Tran-Trung Le Duc Giang Nguyen Thanh Triet Chen Tran Van Danh C Vu Anh Van Nguyen Nhi Nguyen Thanh To Khoa V A Nguyen Khoa Dang Nguyen Source Type: research
Diverse pharmacological potential of pyridazine analogs against various diseases
Med Chem. 2023 Sep 13. doi: 10.2174/1573406419666230913102835. Online ahead of print.ABSTRACTPyridazinone analogs possess diverse types of pharmacological activities, such as anticancer, antimicrobial, anticonvulsant, analgesic, anti-inflammatory, antioxidant, antihypertensive, antisecretory, antiulcer, and other useful pharmacological activities. They also possess cyclooxygenase (COX) inhibitors, dipeptidyl peptidase inhibitors, phosphodiesterase inhibitors, glutamate transporter activators, adenosine receptor antagonists, serotonin receptors antagonists, lipooxygenase, cholinesterase, vasodilator, and anesthetics. Pyrida...
Source: Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Mohammad Asif Mazen M Almehmadi Ahad Amer Alsaiari Source Type: research
Neuroprotective Potential of Tannic Acid Against Neurotoxic Outputs of Monosodium Glutamate in Rat Cerebral Cortex
This study was conducted to assess the neurotoxic and neuroprotective effects of these two dietary components in the rat cerebral cortex. Twenty-four Sprague Dawley rats were divided into 4 equal groups and were treated with MSG (2 g/kg) and TA (50 mg/kg) alone and in combination for 3 weeks. Alterations in oxidative stress indicators (MDA and GSH) were measured in the cortex tissues. In addition, changes in enzymatic activities and gene expression patterns of antioxidant system components (GST, GPx, CAT, and SOD) were investigated. Furthermore, mRNA expressions of FoxO transcription factors (Foxo1 and Foxo3) and apoptotic...
Source: Cell Research - September 15, 2023 Category: Cytology Authors: Medine Sibel Karagac Hamid Ceylan Source Type: research
Acetyl zingerone ameliorates osteoarthritis by inhibiting chondrocyte programmed cell death
Mol Med Rep. 2023 Nov;28(5):202. doi: 10.3892/mmr.2023.13089. Epub 2023 Sep 15.ABSTRACTOsteoarthritis (OA) is a degenerative disease that ultimately leads to joint deformity. The pathogenesis of OA is believed to involve abnormal chondrocyte death, with ferroptosis serving a key role in chondrocyte damage. The present study investigated whether acetyl zingerone (AZ), a newly identified antioxidant derived from curcumin, can alleviate the progression of OA. To investigate this, the present study performed various experiments, including crystal violet staining, flow cytometry, immunofluorescence and western blot analysis. In...
Source: Molecular Medicine - September 15, 2023 Category: Molecular Biology Authors: Xu Chen Jie Chen Chunbao Miao Guangrong Yin Zhuangzhuang Zhang Rongbin Sun Su Ni Source Type: research
Enhanced mechanical and functional properties of chitosan/polyvinyl alcohol/hydroxypropyl methylcellulose/alizarin composite film by incorporating cinnamon essential oil and tea polyphenols
In this study, cinnamon essential oil and tea polyphenols were added to chitosan/ polyvinyl alcohol/ hydroxypropyl methylcellulose/ alizarin composite films to enhance their mechanical and functional properties. Their addition to the composite films enhanced their antibacterial and antioxidant properties and significantly improved its elongation at break (p < 0.05). Cinnamon essential oil reduced the water vapor permeability, water content, and water solubility of composite films and improved their transparency. The composite films with additive exhibited excellent UV-barrier ability and pH responsivity. Fourier Transfo...
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Hongpeng Yu Qing Zhou Dong He JinJin Yang Kegang Wu Xianghua Chai Yujuan Xiang Xuejuan Duan Xiqin Wu Source Type: research
Cobalt oxide-chitosan based nanocomposites: Synthesis, characterization and their potential pharmaceutical applications
Int J Biol Macromol. 2023 Sep 13:126856. doi: 10.1016/j.ijbiomac.2023.126856. Online ahead of print.ABSTRACTThis research aimed to prepare, characterize, and investigate the biological efficacy of chitosan‑cobalt (II) oxide hybrid nanocomposites against a variety of micrograms. Analytical methods, FTIR, SEM, XRD, and EDX, were utilized to thoroughly characterize the produced CS-CoO nanocomposite. In FTIR spectra, the presence of the chitosan peaks in addition to that of CoO at 681 and 558 cm-1 confirmed that CoO molecules interact with the chitosan backbone. Moreover, in the XRD measurements, significantly less chitosan ...
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Ali H Bashal Khaled D Khalil Ahmed M Abu-Dief Mohamed A El-Atawy Source Type: research
The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways
Ageing Res Rev. 2023 Sep 13:102075. doi: 10.1016/j.arr.2023.102075. Online ahead of print.ABSTRACTParkinson disease (PD) is a progressive neurodegenerative disease (NDD) of the brain. It has been reported that prolactin (PRL) hormone plays a differential effect in PD, may be increasing, reduced or unaffected. PRL level is dysregulated in different neurodegenerative disorders including PD. Preclinical and clinical studies pointed out that PRL may has a neuroprotective against PD neuropathology . Though, the mechanistic role of PRL in PD is not fully elucidated. Therefore, the objective of the present review was to clarify t...
Source: Ageing Research Reviews - September 15, 2023 Category: Genetics & Stem Cells Authors: Haydar M Al-Kuraishy Majid S Jabir Ali I Al-Gareeb Ali K Albuhadily Source Type: research
Vitis Myb14 confer cold and drought tolerance by activating Lipid transfer protein genes expression and Reactive oxygen species scavenge
In this study, we investigate its role in abiotic stress tolerance. Significant differences in expression were observed between two grape varieties, Vitis amurensis (Cold-hardy) and V. vinifera (Cold-sentitive), under abiotic and hormone treatments. Both VvMyb14 and VaMyb14 demonstrated responsiveness to cold, drought and high salt treatment, but VaMyb14 exhibited a quicker and more pronounced response. To investigate further, we overexpressed VaMyb14 in A. thalina and found that VaMyb14 OE plants showed significantly enhanced cold and drought tolerance compared to wild-type plants. Additionally, the transgenic lines exhib...
Source: Gene - September 15, 2023 Category: Genetics & Stem Cells Authors: Linchuan Fang Zeming Wang Lingye Su Linzhong Gong Haiping Xin Source Type: research
The influence of atorvastatin, amlodipine and ethoxidol on ubiquinol and ubiquinone endogenous plasma concentrations in patients with chronic heart failure
CONCLUSION: Amlodipine is able to neutralize the negative effect of atorvastin on the redox balance of CoQ10 in patients with CHF. An additional prescription of the antioxidant ethoxidol to standard therapy for patients with CHF was substantiated. Determination of the redox state of CoQ10 in plasma can be used to diagnose and assess the degree of oxidative stress in patients with cardiovascular diseases, as well as to assess the efficacy and safety of ongoing pharmacotherapy.PMID:37711113 | DOI:10.2174/1389200224666230913133201
Source: Current Drug Metabolism - September 15, 2023 Category: Drugs & Pharmacology Authors: Vladlena I Zozina Svetlana N Kondratenko Evgenia V Shikh Liudmila M Krasnykh Evgeny S Melnikov Vladimir G Kukes Source Type: research
Ebselen: A Review on its Synthesis, Derivatives, Anticancer Efficacy and Utility in Combating SARS-COV-2
Mini Rev Med Chem. 2023 Sep 14. doi: 10.2174/1389557523666230914103339. Online ahead of print.ABSTRACTEbselen is a selenoorganic chiral compound with antioxidant properties comparable to glutathione peroxidase. It is also known as 2-phenyl-1,2-benzisoselenazol-3(2H)-one. In studies examining its numerous pharmacological activities, including antioxidant, anticancer, antiviral, and anti-Alzheimer's, ebselen has demonstrated promising results. This review's primary objective was to emphasize the numerous synthesis pathways of ebselen and their efficacy in fighting cancer. The data were collected from multiple sources, includ...
Source: Mini Reviews in Medicinal Chemistry - September 15, 2023 Category: Chemistry Authors: Farak Ali Shahnaz Alom Sheikh Rezzak Ali Biswanarayan Kondoli Prativa Sadhu Chinmoyee Borah Bibhuti Bushan Kakoti Surajit Kumar Ghosh Anshul Shakya Abdul Baquee Ahmed Udaya Pratap Singh Hans Raj Bhatt Source Type: research
Mentha pulegium: A Plant With Several Medicinal Properties
Endocr Metab Immune Disord Drug Targets. 2023 Sep 14. doi: 10.2174/1871530323666230914103731. Online ahead of print.ABSTRACTThe species Mentha pulegium L. (M. pulegium L.) belongs to the family Lamiaceae, native to Europe, North Africa, and the Middle East, and the genus Mentha. It has been traditionally used in food, cosmetics, and medicines. It is a perennial, fragrant, well-liked, herbaceous plant that can grow up to half a meter tall. It is extensively used as a food flavoring, particularly for Moroccan traditional drinks. Chewing mint and M. pulegium, a relaxing and refreshing plant, can be used to treat hiccups and a...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - September 15, 2023 Category: Endocrinology Authors: Smail Amtaghri Miloudia Slaoui Mohamed Eddouks Source Type: research
