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Nutrition: Antidoxidants
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Pathophysiology of diabetic hepatopathy and molecular mechanisms underlying the hepatoprotective effects of phytochemicals
Biomed Pharmacother. 2023 Sep 19;167:115502. doi: 10.1016/j.biopha.2023.115502. Online ahead of print.ABSTRACTPatients with diabetes are at risk for liver disorders including glycogen hepatopathy, non-alcoholic fatty liver disease, cirrhosis, and hepatic fibrosis. The pathophysiological mechanisms behind diabetic hepatopathy are complex, some of them include fatty acid accumulation, increased reactive oxygen species, increased advanced glycation end-products, hyperactivity of polyol pathways, increased apoptosis and necrosis, and promotion of fibrosis. A growing number of studies have shown that herbal extracts and their a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Leila Mobasheri Mitra Ahadi Ali Beheshti Namdar Mohaddeseh Sadat Alavi Abolfazl Bemidinezhad Seyed Mostafa Moshirian Farahi Mahdi Esmaeilizadeh Niloofar Nikpasand Elham Einafshar Ahmad Ghorbani Source Type: research
Neuroprotective Potential of Punicalagin, a Natural Component of Pomegranate Polyphenols: A Review
J Integr Neurosci. 2023 Aug 9;22(5):113. doi: 10.31083/j.jin2205113.ABSTRACTNeurodegenerative diseases (NDs), such as Alzheimer's disease (AD) and Parkinson's disease (PD), are major health problems worldwide. To date, available remedies against NDs are limited. In fact, current treatment options include drug intervention and nutritional therapy, which mainly focus on the repair of neuronal damage and functional monitoring. However, these treatments do not completely alleviate disease symptoms. Recently, eliminating harmful molecules, such as reactive oxygen species, and inhibiting neuroinflammation have become potential s...
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Peng Chen ZhiLei Guo Benhong Zhou Source Type: research
Natural deep eutectic solvent extraction of chlorogenic acid from Eucommia leaves: high extractability, stability, antibacterial, and antioxidant activity
New J. Chem., 2023, Advance Article DOI: 10.1039/D3NJ03313A, PaperYuan Zhu, Hang Li, Peng-Wei Xu, Xiao-Fan Yuan, Bing Zhao Chlorogenic acid (CGA) is a natural compound with potent antioxidant and antibacterial properties that can be extracted fromEucommia leaves (EL). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - September 20, 2023 Category: Chemistry Authors: Yuan Zhu Source Type: research
Oxidative stress in Arthrospira platensis by two organophosphate pesticides
In this study, various Chlorpyrifos (0-150 µg mL-1) and Dimethoate (0-250 µg mL-1) concentrations were added to the culture medium in laboratory to evaulate growth rate, chlorophyll-a content and antioxidant parameters of A. platensis. Optical Density (OD560) and chlorophyll-a decreased compared to the control for seven days in both pesticide applications. Superoxide dismutase (SOD) activity increased at 50 µg mL-1 Chlorpyrifos concentration but it decreased at all concentrations. Although Ascorbate peroxidase (APX) and glutathione reductase (GR) activities increased with Chlorpyrifos application, they did not change wi...
Source: An Acad Bras Cienc - September 20, 2023 Category: Science Authors: Hatice Tunca Ali Do ğru Feray K öçkar Hediye E Kili ç Tu ğba O Sevindik Source Type: research
Glutaredoxin proteins from E. coli isoforms were compared in terms of energy frustration
In this study, we have investigated the energy landscape and characterized the pattern of local frustration in different forms and states of the GRX protein ofE. coli.Analysis was done on the conformational alterations, significant changes in the frustration pattern, and different GRXs such as GRX-II, GRX-III, GRX-II-GSH, and GRX-III-GSH complex. We have found the practice of frustration, and structure was quite similar in the same isoform having different states of protein; however, a significant difference was observed between different isoforms. Moreover, oxidation of GRX-I introduced an extra α-helix increasing the de...
Source: Braz J Biol - September 20, 2023 Category: Biology Authors: A Patel K Tiwari P Asrani H Alothaid A F A Alahmari R Mirdad M R Ajmal M Tarique Source Type: research
Peroxiredoxins in erythrocytes: far beyond the antioxidant role
J Mol Med (Berl). 2023 Sep 20. doi: 10.1007/s00109-023-02368-7. Online ahead of print.ABSTRACTThe red blood cells (RBCs) are essential to transport oxygen (O2) and nutrients throughout the human body. Changes in the structure or functioning of the erythrocytes can lead to several deficiencies, such as hemolytic anemias, in which an increase in reactive oxidative species generation is involved in the pathophysiological process, playing a significant role in the severity of several clinical manifestations. There are important lines of defense against the damage caused by oxidizing molecules. Among the antioxidant molecules, ...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Carla Peres de Paula Jo ão Pedro Maia de Oliveira da Silva Karen Simone Romanello Victoria Sim ões Bernardo Flaviene Felix Torres Danilo Gr ünig Humberto da Silva Anderson Ferreira da Cunha Source Type: research
Selenium in combination with a tomato lipid extract as a therapy for benign prostatic hyperplasia and its alterations in rats with induced BPH
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17903. Online ahead of print.ABSTRACTBenign prostatic hyperplasia (BPH) is the most common adenoma in old men. Tomatoes are a rich source of bioactive compounds that, as well as selenium (Se), possess antioxidant and antiproliferative activity. The aim was to evaluate the therapeutic effect of Se in combination with a tomato extract in aged rats with BPH. Aged male Wistar rats were divided in the following groups (n = 10 rats/group): Control (C), BPH, BPH + Finasteride (BPH + F), BPH + Tomato Lipidic Extract (BPH + E), BPH + Selenium (BPH + S) and BPH plus E plus S (BPH + E + ...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: David Julian Arias-Ch ávez Patrick Mailloux-Salinas Jessica Ledesma Aparicio Elihu Campos-P érez Omar Noel Medina-Campos Jos é Pedraza-Chaverri Guadalupe Bravo Source Type: research
Effects of tetrahydroxy stilbene glycoside derivatives on free radical damage and apoptosis in APP695V717I transgenic mice
Redox Rep. 2023 Dec;28(1):2259246. doi: 10.1080/13510002.2023.2259246. Epub 2023 Sep 20.ABSTRACTMitochondrial dysfunction leading to overproduction of oxygen free radicals is an important event in the development of Alzheimer's disease. Tetrahydroxy stilbene glycoside (TSG) is one of the main effective components of Polygonum multiflorum and has a certain free radical scavenging effect. We synthesized tetrahydroxy stilbene glycoside derivatives (Mito-TSGs) that can cross the mitochondrial membrane and may provide effective protection against Alzheimer's disease. This experiment investigates the protective mechanism of tetr...
Source: Redox Report : communications in free radical research - September 20, 2023 Category: Biochemistry Authors: Jun Qian Yun Li Yanyun Wang Qunying Ye Hongbo Luo Source Type: research
Fraxin in Combination with Dexamethasone Attenuates LPS-Induced Liver and Heart Injury and Their Anticytokine Activity in Mice
CONCLUSIONS: All interventions used in this study significantly reduced interleukin-8 (IL-8) levels and reduced LPS-induced liver and cardiac damage. The combination (FD) did not result in an evident superiority of either agent. More research is required to identify the possible usefulness of these agents in treating hyperinflammatory diseases, such as cytokine storms, in future clinical practice.PMID:37727368 | PMC:PMC10506875 | DOI:10.1155/2023/5536933
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Nada Sahib Shaker Hayder Bahaa Sahib Source Type: research
Comprehensive profiling of the metabolome in corn silage inoculated with or without < em > Lactiplantibacillus plantarum < /em > using different untargeted metabolomics analyses
Arch Anim Nutr. 2023 Sep 19:1-19. doi: 10.1080/1745039X.2023.2247824. Online ahead of print.ABSTRACTSilage fermentation is a complicated biochemical process involving interactions between microbes and metabolites. However, the overall metabolome feature of ensiled forage and its response to lactic acid bacteria inoculation is poorly understood. Hence, in this study metabolome profiles of whole-plant corn silage inoculated with or without Lactiplantibacillus plantarum were characterised via solid-phase microextraction/gas chromatography/mass spectrometry (SPME-GC-MS), gas chromatography/time-of-flight mass spectrometry (GC-...
Source: Archives of Animal Nutrition - September 20, 2023 Category: Nutrition Authors: Rina Su Wencan Ke Jie Bai Musen Wang Samaila Usman Dongmei Xie Dongmei Xu Mengyan Chen Xusheng Guo Source Type: research
Selenium in combination with a tomato lipid extract as a therapy for benign prostatic hyperplasia and its alterations in rats with induced BPH
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17903. Online ahead of print.ABSTRACTBenign prostatic hyperplasia (BPH) is the most common adenoma in old men. Tomatoes are a rich source of bioactive compounds that, as well as selenium (Se), possess antioxidant and antiproliferative activity. The aim was to evaluate the therapeutic effect of Se in combination with a tomato extract in aged rats with BPH. Aged male Wistar rats were divided in the following groups (n = 10 rats/group): Control (C), BPH, BPH + Finasteride (BPH + F), BPH + Tomato Lipidic Extract (BPH + E), BPH + Selenium (BPH + S) and BPH plus E plus S (BPH + E + ...
Source: J Cell Mol Med - September 20, 2023 Category: Molecular Biology Authors: David Julian Arias-Ch ávez Patrick Mailloux-Salinas Jessica Ledesma Aparicio Elihu Campos-P érez Omar Noel Medina-Campos Jos é Pedraza-Chaverri Guadalupe Bravo Source Type: research
Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model
Biosci Rep. 2023 Sep 20:BSR20230128. doi: 10.1042/BSR20230128. Online ahead of print.ABSTRACTFerroptosis is a non-conventional cellular death caused by lipid peroxide induced iron deposition. Intracellular lipid accumulation followed by generation of lipid peroxides is an Hallmark of Non Alcoholic Fatty Liver Disease (NAFLD). Melatonin (MLT) is an important pineal hormone with tremendous antioxidant and anti-inflammatory properties. Various studies targeted ferroptosis in different diseases using melatonin. However, none of them focused the intrinsic mechanism of MLT's action to counteract ferroptosis in NAFLD. Hence, the ...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Moumita Saha Sanjib Das Krishnendu Manna Krishna Das Saha Source Type: research
Mineral elements and adiposity-related consequences in adolescents with intellectual disabilities
CONCLUSION: The intellectual disability of moderate type (MID) was associated with abnormal changes in the levels of essential mineral elements and adipokines and increased levels of cellular oxidative stress. Thus, evaluating plasma mineral elements and adipokines levels could be a potential diagnostic parameter for diagnosing MID.PMID:37730529 | DOI:10.1186/s12860-023-00490-5
Source: Mol Biol Cell - September 20, 2023 Category: Molecular Biology Authors: Ahmad H Alghadir Sami A Gabr Amir Iqbal Source Type: research
Quantification of Phytochemicals and Metal Ions as well as the Determination of Volatile Compounds, Antioxidant, Antimicrobial and Antacid Activities of the Mimosa pudica L. Leaf: Exploration of Neglected and Under-Utilized Part
Chem Biodivers. 2023 Sep 20:e202301049. doi: 10.1002/cbdv.202301049. Online ahead of print.ABSTRACTMimosa pudica L. (MP) is well-known plant in traditional medicinal system, especially in India. Unfortunately, leaves of MP are less explored. To determine the food and nutritional value of the neglected part of Mimosa pudica L. (MP), that is MP leaves, phytochemicals and metal ions of MP were quantified by newly developed HPLC and ICPOES-based methods. The content of phytochemicals observed using HPLC analysis for chlorogenic acid, catechin, and epicatechin was 141.823 (±8.171), 666.621 (±11.432), and 293.175 (±12.743) μ...
Source: Chemistry and Biodiversity - September 20, 2023 Category: Biochemistry Authors: Ms Yashika Gandhi Shyam Baboo Prasad Vijay Kumar Hemant Soni Hemant Rawat Sujeet K Mishra Jyotika Grewal Simranjeet Singh Vaibhav Charde Akhil Gupta Sudhanshu Kumar Jha Gagandeep Singh Smriti Tandon Akshada Mrkute Praveen C Ramamurthy Ch Venkata Narasimha Source Type: research
Evaluation the effect of dietary vitamin E, sesamin and thymoquinone bioactive compounds on immunological response, intestinal traits and MUC-2 gene expression in broiler Japanese quails ( < em > Coturnix japonica < /em > )
Anim Biotechnol. 2023 Sep 20:1-11. doi: 10.1080/10495398.2023.2259437. Online ahead of print.ABSTRACTThe current study was performed to determine the effect of dietary vitamin E, sesamin and thymoquinone bioactive lignans derived from sesame and black seed on immunological response, intestinal traits and Mucin2 gene expression in broiler quails. Three hundred and fifty (one days-old) quails were allotted to seven dietary treatments with five replicates as an experimental randomized design study. Treatments were basal diet as a control, control +100 and +200 mg of vitamin E, sesamin and thymoquinone per each kg of diet resp...
Source: Animal Biotechnology - September 20, 2023 Category: Biotechnology Authors: Yaser Rahimian Farshid Kheiri Mostafa Faghani Source Type: research
