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Folate conjugated nanomedicines for selective inhibition of mTOR signaling in polycystic kidneys at clinically relevant doses
Biomaterials. 2023 Sep 13;302:122329. doi: 10.1016/j.biomaterials.2023.122329. Online ahead of print.ABSTRACTAlthough rapamycin is a very effective drug for rodents with polycystic kidney disease (PKD), it is not encouraging in the clinical trials due to the suboptimal dosages compelled by the off-target side effects. We here report the generation, characterization, specificity, functionality, pharmacokinetic, pharmacodynamic and toxicology profiles of novel polycystic kidney-specific-targeting nanoparticles (NPs). We formulated folate-conjugated PLGA-PEG NPs, which can be loaded with multiple drugs, including rapamycin (a...
Source: Biomaterials - September 18, 2023 Category: Materials Science Authors: Rajasekharreddy Pala Ayan K Barui Ashraf M Mohieldin Jing Zhou Surya M Nauli Source Type: research
Application of nanoparticles in Dentistry
Bioinformation. 2023 Jan 31;19(1):14-18. doi: 10.6026/97320630019014. eCollection 2023.ABSTRACTNanoparticles(NPs) are of particle sizes lesser than 100nm and are insoluble the field which deal with the handling of these particles is coined as "Nanotechnology" as their particle size is smaller, they can penetrate easily therefore they are applied in various medical fields, drug delivery and in dentistry as they have antimicrobial property, reduces friction, anti-inflammatory and antioxidant property. Many studies have been done to evaluate its application and its cytotoxicity by varying its concentration and various studies...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Sheloni Missier Mary Mahesh Ramakrishnan Saravana Dinesh Sudalaimani Paulpandian Shanmugam Rajeshkumar Jebilla Pringle Source Type: research
Dimethyl fumarate attenuates cholestatic liver injury by activating the NRF2 and FXR pathways and suppressing NLRP3/GSDMD signaling in mice
Exp Cell Res. 2023 Sep 16:113781. doi: 10.1016/j.yexcr.2023.113781. Online ahead of print.ABSTRACTThe progression of cholestasis is characterized by excessive accumulation of bile acids (BAs) in the liver, which leads to oxidative stress (OS), inflammation and liver injury. There are currently limited treatments for cholestasis. Therefore, appropriate drugs for cholestasis treatment need to be developed. Dimethyl fumarate (DMF) has been widely used in the treatment of various diseases and exerts antioxidant and anti-inflammatory effects, but its effect on cholestatic liver disease remains unclarified. We fed mice 3,5-dieth...
Source: Experimental Cell Research - September 18, 2023 Category: Cytology Authors: Ziqian Xu Wan Tang Qiaoling Xie Xinyu Cao Mengni Zhang Xiaoxun Zhang Jin Chai Source Type: research
Tert-Butyl Hydroperoxide induces Ferroptosis of Bone Mesenchymal Stem cells by repressing the Prominin2/BACH1/ROS axis
CONCLUSION: Our findings revealed a mechanism that the prominin2/BACH1/ROS axis participates in BMSCs ferroptosis and the strengthening of this axis is promising to subsist BMSCs after explantation.PMID:37721001 | DOI:10.1152/ajpcell.00224.2023
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Yuzhu Xu Pan Fan Xuanfei Xu Lei Liu Lele Zhang Xi Li Jiadong Wang Yuao Tao Xiaolong Li Dandan Xu Xiaohui Wang Yan Zhou Yuntao Wang Source Type: research
Structural variations of lignin and lignin-carbohydrate complexes from the fruit shells of Camellia oleifera during ripening
Int J Biol Macromol. 2023 Sep 16:126946. doi: 10.1016/j.ijbiomac.2023.126946. Online ahead of print.ABSTRACTCamellia oleifera fruit shell (CFS), a waste lignocellulosic biomass resulting from Camellia oleifera oil production industry, is abundantly available in Southern China. Herein, to understand the structural variations of CFS lignins and lignin-carbohydrate complexes (LCC) during ripening, the native lignin and LCC fractions from CFS (harvested every seven days from October 1 to 30, 2022) were isolated and characterized systematically. The molecular weights of both MWL and DEL fractions steadily increased during ripen...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xichuang Cheng Ruxia Ning Pengfei Li Fenglun Zhang Kun Wang Jianxin Jiang Source Type: research
Nanopeptide CI20 remarkably enhances growth performance and disease resistances by improving the mucosal structure, antioxidant capacity, and immunity in mandarin fish (Siniperca chuatsi)
In this study, the nanopeptide CI20, which was created by conjugating antimicrobial peptide gcIFN-20H and CMCS, were evaluated the feeding effect in mandarin fish (Siniperca chuatsi). Compared with the control group, 150 mg/kg C-I20-fed fish showed the second highest growth performance with no significant changes in body composition. C-I20-fed fish showed more goblet cells and thicker mucin after feeding. The 150 mg/kg CI20 diet boosted the antioxidant capacity, immunity, and digestive enzymes. After Aeromonas hydrophila and infection spleen and kidney necrosis virus infection, the survival rates in the 150 mg/kg CI20 grou...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xingchen Huo Jiao Chang Qiwei Zhang Weicheng Wang Pengxu Wang Fengxia Zhao Shan He Chunrong Yang Xiaoling Liu Xufang Liang Yongan Zhang Jianguo Su Source Type: research
Fabrication and characterization of new levan@CBD biocomposite sponges as potential materials in natural, non-toxic wound dressing applications
In this study, porous bacterial levan-based sponges containing cannabis oil (Lev@CBDs) were prepared and fully characterized. The sponges exhibited a suitable swelling ratio, proper water vapor transmission rate, sufficient thermal stability, desired mechanical properties, and good antioxidant and anti-inflammatory properties. The obtained Lev@CBD materials were evaluated in terms of their interaction with proteins, human serum albumin and fibrinogen, of which fibrinogen revealed the highest binding effect. Moreover, the obtained biomaterials exhibited antibacterial activity against Staphylococcus aureus and Pseudomonas ae...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Dorota Chelminiak-Dudkiewicz Miloslav Machacek Jolanta Dlugaszewska Magdalena Wujak Aleksander Smolarkiewicz-Wyczachowski Szymon Bocian Kinga Mylkie T Goslinski Michal P Marszall Marta Ziegler-Borowska Source Type: research
Evaluation of possible attenuative role of chrysoeriol against polyethylene microplastics instigated testicular damage: A biochemical, spermatogenic and histological study
Food Chem Toxicol. 2023 Sep 16:114043. doi: 10.1016/j.fct.2023.114043. Online ahead of print.ABSTRACTThe current study was designed to evaluate the protective role of chrysoeriol against polyethylene microplastics (PE-MP) induced testicular damage. Forty eight male rats were distributed into 4 equal groups: vehicle control, PE-MP administrated, PE-MP + chrysoeriol co-administrated and only chrysoeriol supplemented group. The administration of PE-MP significantly reduced the activities of anti-oxidant enzymes, i.e., glutathione peroxidase, catalase, glutathione reductase and superoxide dismutase, whereas the levels of react...
Source: Food and Chemical Toxicology - September 18, 2023 Category: Food Science Authors: Muhammad Umar Ijaz Faria Saher Nemra Aslam Ali Hamza Haseeb Anwar Saad Alkahtani Hammad Ahmad Khan Mian Nadeem Riaz Source Type: research
Correlation of Dietary Macro- and Micro-Mineral Intake with Seminal Plasma Quality/Quantity and Oxidant/Antioxidant Status in Infertile Compared to the Normal Men: a Case-Control Study
Biol Trace Elem Res. 2023 Sep 18. doi: 10.1007/s12011-023-03834-6. Online ahead of print.ABSTRACTMale infertility is a global public health issue, but studies on the correlation between the dietary components and sperm quality showed inconclusive results due to the heterogeneous population with different dietary habits and environmental stimuli. Herein, the correlation of dietary macro- and micro-mineral intake was evaluated with quality/quantity and oxidant/antioxidant status of seminal fluid in infertile compared to the healthy men. One hundred twenty men attending to the infertility clinic of Ayatollah Mousavi Hospital ...
Source: Biological Trace Element Research - September 18, 2023 Category: Biology Authors: Hossein Chiti Elham Hosseini Vahid Ebrahimi Seyedeh Neda Mousavi Source Type: research
Tert-Butyl Hydroperoxide induces Ferroptosis of Bone Mesenchymal Stem cells by repressing the Prominin2/BACH1/ROS axis
CONCLUSION: Our findings revealed a mechanism that the prominin2/BACH1/ROS axis participates in BMSCs ferroptosis and the strengthening of this axis is promising to subsist BMSCs after explantation.PMID:37721001 | DOI:10.1152/ajpcell.00224.2023
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Yuzhu Xu Pan Fan Xuanfei Xu Lei Liu Lele Zhang Xi Li Jiadong Wang Yuao Tao Xiaolong Li Dandan Xu Xiaohui Wang Yan Zhou Yuntao Wang Source Type: research
Performance evaluation, enzymatic activity change and metagenomic analysis of sequencing batch reactor under divalent zinc stress
This study can provide the insights into the influencing mechanism of Zn2+ on the biological nitrogen removal process.PMID:37722545 | DOI:10.1016/j.biortech.2023.129774
Source: Bioresource Technology - September 18, 2023 Category: Biotechnology Authors: Yuqiao Zhang Weiyi Qi Guangyu Chu Qianzhi Wang Chang Gao Wenzheng Chen Jiateng Liu Mengchun Gao Source Type: research
Exploring the Synthetic and Antioxidant Potential of 1,2-Disubstituted Benzimidazoles using Et3NHHSO4 Ionic Liquid Catalyst
Chem Biodivers. 2023 Sep 17:e202301159. doi: 10.1002/cbdv.202301159. Online ahead of print.ABSTRACTAn [Et3NH][HSO4] ionic-liquid catalyzed, intermolecular C-N bond formation for 1,2-disubstituted benzimidazole synthesis was achieved by the reaction of OPD and substituted aldehydes at ambient reaction conditions. Operational simplicity, use of easily available substrate and reagents, good yield in short reaction time, simple work-up, and column chromatographic free synthesis are remarkable features of this new protocol. The applicability of [Et3NH][HSO4] ionic-liquid as a green and inexpensive catalyst with good recyclabili...
Source: Chemistry and Biodiversity - September 18, 2023 Category: Biochemistry Authors: Nusrat Sahiba Pankaj Teli Priyadarshi Meena Shikha Agarwal Source Type: research
NECAB2 is an endosomal protein important for striatal function
Free Radic Biol Med. 2023 Sep 16:S0891-5849(23)00615-9. doi: 10.1016/j.freeradbiomed.2023.09.003. Online ahead of print.ABSTRACTSynaptic signaling depends on ATP generated by mitochondria. Dysfunctional mitochondria shift the redox balance towards a more oxidative environment. Due to extensive connectivity, the striatum is especially vulnerable to mitochondrial dysfunction. We found that neuronal calcium-binding protein 2 (NECAB2) plays a role in striatal function and mitochondrial homeostasis. NECAB2 is a predominantly endosomal striatal protein which partially colocalizes with mitochondria. This colocalization is enhance...
Source: Free Radical Biology and Medicine - September 18, 2023 Category: Biology Authors: Diones Bueno Partha Narayan Dey Teresa Schacht Christina Wolf Verena W üllner Elena Morpurgo Liliana Rojas-Charry Lena Sessinghaus Petra Leukel Clemens Sommer Konstantin Radyushkin Luise Florin Jan Baumgart Paul Stamm Andreas Daiber Guilherme Horta Leona Source Type: research
Ligustilide-loaded liposome ameliorates mitochondrial impairments and improves cognitive function via the PKA/AKAP1 signaling pathway in a mouse model of Alzheimer's disease
CONCLUSION: Liposome packaging for LIG is relatively biosafe and can overcome the instability of LIG. LIG alleviates mitochondrial dysfunctions and cognitive impairment via the PKA/AKAP1 signaling pathway. Our results provide experimental evidence that LIG-LPs may be a promising agent for AD therapy.PMID:37718506 | DOI:10.1111/cns.14460
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Qi Zhang Xiangxiang Zhang Bing Yang Yan Li Xue-Heng Sun Xiang Li Ping Sui Yi-Bin Wang Shu-Yu Tian Chun-Yan Wang Source Type: research
Biomonitoring of manganese metal pollution in water and its impacts on biological activities of Biomphalaria alexandrina snail and larvicidal potencies
Environ Sci Pollut Res Int. 2023 Sep 18. doi: 10.1007/s11356-023-29786-x. Online ahead of print.ABSTRACTMetal pollution has many dangerous environmental and human health consequences due to the bioaccumulation in the tissues. The present study aims to measure the bioaccumulation factor of the manganese (Mn) heavy metal in Biomphalaria alexandrina snails' tissues and water samples. The current results showed the concentration of Mn heavy metal in water (87.5 mg/l) and its bioaccumulation factor in Helisoma duryi tissue was higher than that in tissues of Physa acuta and B. alexandrina snails. Results showed that 87.5 mg/l Mn...
Source: Environmental Science and Pollution Research International - September 18, 2023 Category: Environmental Health Authors: Amina Mohamed Ibrahim Ahmed Abdel-Salam Abdel-Haleem Rania Gamal Taha Source Type: research
