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Nutrition: Antidoxidants
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BALB/c and C57BL/6 mice differ in oxidant and antioxidant responses in innate and adaptive immune cells in an asthma model induced by cockroach allergens
Int Immunopharmacol. 2023 Sep 15;124(Pt B):110892. doi: 10.1016/j.intimp.2023.110892. Online ahead of print.ABSTRACTAsthma is a complex and heterogenous disease affected by a multitude of factors. Several phenotypes of asthma exist which are influenced by various molecular mechanisms that include presence of antioxidant and oxidant enzymes in different immune cells such as dendritic cells (DCs), alveolar macrophages (AMs), neutrophils, and T cells. Close interaction between epithelial cells and dendritic cells initiates complex pathogenesis of asthma followed by involvement of other innate and adaptive immune cells. In chr...
Source: International Immunopharmacology - September 17, 2023 Category: Allergy & Immunology Authors: Layla A Al-Kharashi Saleh A Alqarni Sheikh F Ahmad Naif O Al-Harbi Sary Alsanea Khalid E Ibrahim Mohammad M Algahtani Khalid Alhazzani Gamal A Shazly Mohammad M Al-Harbi Ahmed Nadeem Source Type: research
Life-cycle exposure to tris (2-chloroethyl) phosphate (TCEP) causes alterations in antioxidative status, ion regulation and histology of zebrafish gills
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Sep 16;274:109746. doi: 10.1016/j.cbpc.2023.109746. Online ahead of print.ABSTRACTTris (2-chloroethyl) phosphate (TCEP) has been receiving great concerns owing to its ubiquitous occurrence in various environmental compartments and potential risks to wildlife and humans. Gill is structural basis for ion regulation and homeostasis in fish and susceptible to xenobiotics. However, current knowledge on the impacts of long-term exposure to TCEP on the structure and physiological function of fish gills are insufficient. In this work, zebrafish were exposed to environmental realistic ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 17, 2023 Category: Biochemistry Authors: Hangke Peng Hongkai Wang Wen Li Chen Jing Weiwei Zhang Haocheng Zhao Fengxiao Hu Source Type: research
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2023 Sep 15:S0891-5849(23)00636-6. doi: 10.1016/j.freeradbiomed.2023.09.012. Online ahead of print.ABSTRACTFerroptosis is a novel form of cell death that plays a critical role in the pathological and physiological processes of early brain injury following subarachnoid hemorrhage. Melatonin, as the most potent endogenous antioxidant, has shown strong protective effects against pathological changes following subarachnoid hemorrhage, but its impact on ferroptosis induced by subarachnoid hemorrhage remains unexplored. In our study, we established a subarachnoid hemorrhage model in male SD rats. We found th...
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Sheng-Ji Ma Chen Li Cong Yan Nan Liu Guang-You Jiang Hong-Rui Yang Hao-Chen Yan Ji-Yi Li Huai-Lei Liu Cheng Gao Source Type: research
Asiatic acid protects against pressure overload-induced heart failure in mice by inhibiting mitochondria-dependent apoptosis
CONCLUSIONS: Our findings suggest that AA effectively combats chronic TAC-induced and hydrogen peroxide-induced cardiomyocyte apoptosis through a mitochondria-dependent mechanism. AA reduces cellular levels of oxidative stress and inhibits the activation of the JNK pathway, highlighting its potential therapeutic value in the treatment of HF.PMID:37717794 | DOI:10.1016/j.freeradbiomed.2023.09.015
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Junjie Du Dongmin Yu Jinghang Li Linjie Si Dawei Zhu Ben Li Yizhou Gao Lifu Sun Xufeng Wang Xiaowei Wang Source Type: research
Life-cycle exposure to tris (2-chloroethyl) phosphate (TCEP) causes alterations in antioxidative status, ion regulation and histology of zebrafish gills
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Sep 15:109746. doi: 10.1016/j.cbpc.2023.109746. Online ahead of print.ABSTRACTTris (2-chloroethyl) phosphate (TCEP) has been receiving great concerns owing to its ubiquitous occurrence in various environmental compartments and potential risks to wildlife and humans. Gill is structural basis for ion regulation and homeostasis in fish and susceptible to xenobiotics. However, current knowledge on the impacts of long-term exposure to TCEP on the structure and physiological function of fish gills are insufficient. In this work, zebrafish were exposed to environmental realistic conc...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 17, 2023 Category: Biochemistry Authors: Hangke Peng Hongkai Wang Wen Li Chen Jing Weiwei Zhang Haocheng Zhao Fengxiao Hu Source Type: research
Preventive effects of Capparis Spinose extract on experimental periodontitis in rats: a histopathological and biochemical study
This study aimed to assess the effectiveness of Capparis Spinose (CS) in preventing the initiation and progression of experimental periodontitis and to evaluate the effect of its on systemic oxidative stress in rats by experimental periodontitis model. Twenty-four male rats were equally divided into; Ligatured (L), non-ligatured (NL), and Ligatured with CS (11 days/day per 20 mg/kg) (LC) groups. Experimental periodontitis was induced with the silk suture technic. Alveolar bone loss was examined, and total antioxidant capacity(TAOC), total oxidant status(TOS), and oxidative stress index(OSI) were analyzed in rat serum. Alth...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Hasan G ündoğar Hakan Özdemir Zeynep Deniz Şahin İnan Source Type: research
Characterization and biological evaluation of a novel flavonoid-collagen antioxidant hydrogel with cytoprotective properties
J Biomed Mater Res B Appl Biomater. 2023 Sep 16. doi: 10.1002/jbm.b.35321. Online ahead of print.ABSTRACTReactive oxygen species (ROS) play a critical and important role during wound healing but excess ROS at the wound site can lead to cellular damage and sub-optimal healing. Minimizing oxidative damage to the wound site and any supplemental therapeutic cells can be achieved by delivering exogenous antioxidants. Collagen hydrogels are ideal wound care materials due to their biocompatibility, high water content, and porous, three-dimensional architecture. Yet, they lack the inherent antioxidant activity that could help miti...
Source: Biomed Res - September 16, 2023 Category: Research Authors: Danielle M Nalband Prottasha Sarker Saad A Khan Donald O Freytes Source Type: research
Chrysin attenuates paclitaxel-induced hepatorenal toxicity in rats by suppressing oxidative damage, inflammation, and apoptosis
Life Sci. 2023 Sep 14:122096. doi: 10.1016/j.lfs.2023.122096. Online ahead of print.ABSTRACTAIMS: Paclitaxel (Pax) is a chemotherapeutic drug from the taxane family that is used in the treatment of human cancer, including ovarian, breast, and non-small cell lung carcinoma. Chrysin (CR) has antioxidant, anti-inflammatory, anti-apoptotic, anti-diabetic, and anti-carcinogenic properties, as well as hepatoprotective and renoprotective activities. In the present study, we evaluated the protective effect of CR against Pax-induced hepatorenal toxicity on inflammation, apoptosis, antioxidant levels, oxidative DNA damage, and histo...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Selim Çomaklı Sel çuk Özdemir Meryem G üloğlu Source Type: research
Multifunctional and theranostic hydrogels for wound healing acceleration: An emphasis on diabetic-related chronic wounds
Environ Res. 2023 Sep 14:117087. doi: 10.1016/j.envres.2023.117087. Online ahead of print.ABSTRACTHydrogels represent intricate three-dimensional polymeric structures, renowned for their compatibility with living systems and their ability to naturally degrade. These networks stand as promising and viable foundations for a range of biomedical uses. The practical feasibility of employing hydrogels in clinical trials has been well-demonstrated. Among the prevalent biomedical uses of hydrogels, a significant application arises in the context of wound healing. This intricate progression involves distinct phases of inflammation,...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Pooya M Tehrany Parham Rahmanian Aryan Rezaee Golnaz Ranjbarpazuki Farima Sohrabi Fard Yasaman Asadollah Salmanpour Mohammad Arad Zandieh Ali Ranjbarpazuki Sajedeh Asghari Nazanin Javani Noushin Nabavi Amir Reza Aref Mehrdad Hashemi Mohsen Rashidi Afshin Source Type: research
Two-month period of 500 mg lecithin-based delivery form of quercetin daily dietary supplementation counterbalances chronic fatigue symptoms: A double-blind placebo controlled clinical trial
CONCLUSION: The quercetin supplementation counterbalances CF symptoms.PMID:37716119 | DOI:10.1016/j.biopha.2023.115453
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Mariangela Rondanelli Antonella Riva Giovanna Petrangolini Clara Gasparri Simone Perna Source Type: research
Multifunctional and theranostic hydrogels for wound healing acceleration: An emphasis on diabetic-related chronic wounds
Environ Res. 2023 Sep 14:117087. doi: 10.1016/j.envres.2023.117087. Online ahead of print.ABSTRACTHydrogels represent intricate three-dimensional polymeric structures, renowned for their compatibility with living systems and their ability to naturally degrade. These networks stand as promising and viable foundations for a range of biomedical uses. The practical feasibility of employing hydrogels in clinical trials has been well-demonstrated. Among the prevalent biomedical uses of hydrogels, a significant application arises in the context of wound healing. This intricate progression involves distinct phases of inflammation,...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Pooya M Tehrany Parham Rahmanian Aryan Rezaee Golnaz Ranjbarpazuki Farima Sohrabi Fard Yasaman Asadollah Salmanpour Mohammad Arad Zandieh Ali Ranjbarpazuki Sajedeh Asghari Nazanin Javani Noushin Nabavi Amir Reza Aref Mehrdad Hashemi Mohsen Rashidi Afshin Source Type: research
Characterization and biological evaluation of a novel flavonoid-collagen antioxidant hydrogel with cytoprotective properties
J Biomed Mater Res B Appl Biomater. 2023 Sep 16. doi: 10.1002/jbm.b.35321. Online ahead of print.ABSTRACTReactive oxygen species (ROS) play a critical and important role during wound healing but excess ROS at the wound site can lead to cellular damage and sub-optimal healing. Minimizing oxidative damage to the wound site and any supplemental therapeutic cells can be achieved by delivering exogenous antioxidants. Collagen hydrogels are ideal wound care materials due to their biocompatibility, high water content, and porous, three-dimensional architecture. Yet, they lack the inherent antioxidant activity that could help miti...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Danielle M Nalband Prottasha Sarker Saad A Khan Donald O Freytes Source Type: research
Anti-oxidant, diabetic and inflammatory activities of alpinia calcarata roscoe extract
CONCLUSION: Our findings demonstrated that leaf oil was slightly more promising results than rhizome oil of AC extract,which was ultimately showed medicinal potential of secondary metabolites with antioxidant, diabetic/inflammatory activities. Further, Eoils of AC have a wide range of pharmacological potential and promising anti-diabetic effects.PMID:37715949 | DOI:10.1002/cbdv.202300970
Source: Chemistry and Biodiversity - September 16, 2023 Category: Biochemistry Authors: Naorem Manglembi Devi Sankaranarayanan Nagarajan Chingakham Brajakishor Singh Mohammad Mujahid Ali Khan Anish Khan Nisha Khan Mohamed H Mahmoud Hassan Fouad AbuZar Ansari Source Type: research
Mikania micrantha Kunth: An Ethnopharmacological Treasure Trove of Therapeutic Potential
This study aimed at summarizing the traditional uses, phytochemical profile, and biological activities of M. micrantha based on obtainable information screened from different databases. The results suggest that fresh leaves and whole plant are frequently used in folk medicine. The plant contains more than 150 different phytochemicals under the following groups: essential oils, phenolics and flavonoids, terpenes, terpene lactones, glycosides, and sulfated flavonoids. It contains carbohydrates and micronutrients including vitamins and major and trace minerals. M. micrantha possesses antioxidant, anti-inflammatory, anti-micro...
Source: Chemistry and Biodiversity - September 16, 2023 Category: Biochemistry Authors: Muahmmad Ali Khan Dina M El-Kersh Md Shafiqul Islam Shams Ara Khan Hossam Kamli Chandan Sarkar Md Shimul Bhuia Tawhida Islam Manik Chandra Shill Glenda C Gobe Eda S önmez Gürer William N Setzer Javad Sharifi-Rad Muhammad Torequl Islam Source Type: research
Resveratrol alleviates MSU-induced gouty arthritis in rats through inhibition of HIF-1 α- and NLRP3-derived IL-1β secretion in macrophages
This study demonstrated that resveratrol significantly improved the symptoms of acute gouty arthritis and its potential mechanism may be IL-1β reduction via HIF-1α modulation and inhibition of NLRP3 inflammasome activation. Our study might offer a novel sight for the treatment of gouty arthritis.PMID:37715438 | DOI:10.14715/cmb/2023.69.7.5
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Yamen Wang Wei Li Tianhan Zhang Runmei Wang Tao Wang Qingyun Xie Meng Wei Source Type: research
