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Nutrition: Antidoxidants
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Nrf2 and Ferroptosis: A New Research Direction for Ischemic Stroke
Cell Mol Neurobiol. 2023 Sep 20. doi: 10.1007/s10571-023-01411-y. Online ahead of print.ABSTRACTIschemic stroke (IS) is one of the leading causes of death and morbidity worldwide. As a novel form of cell death, ferroptosis is an important mechanism of ischemic stroke. Nuclear factor E2-related factor 2 (Nrf2) is the primary regulator of cellular antioxidant response. In addition to alleviating ischemic stroke nerve damage by reducing oxidative stress, Nrf2 regulates genes associated with ferroptosis, suggesting that Nrf2 may inhibit ferroptosis after ischemic stroke. However, the specific pathway of Nrf2 on ferroptosis in ...
Source: Cellular and Molecular Neurobiology - September 20, 2023 Category: Cytology Authors: Xiaoman Deng Wenming Chu Hanrui Zhang Yongjun Peng Source Type: research
Selenium in combination with a tomato lipid extract as a therapy for benign prostatic hyperplasia and its alterations in rats with induced BPH
J Cell Mol Med. 2023 Sep 19. doi: 10.1111/jcmm.17903. Online ahead of print.ABSTRACTBenign prostatic hyperplasia (BPH) is the most common adenoma in old men. Tomatoes are a rich source of bioactive compounds that, as well as selenium (Se), possess antioxidant and antiproliferative activity. The aim was to evaluate the therapeutic effect of Se in combination with a tomato extract in aged rats with BPH. Aged male Wistar rats were divided in the following groups (n = 10 rats/group): Control (C), BPH, BPH + Finasteride (BPH + F), BPH + Tomato Lipidic Extract (BPH + E), BPH + Selenium (BPH + S) and BPH plus E plus S (BPH + E + ...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: David Julian Arias-Ch ávez Patrick Mailloux-Salinas Jessica Ledesma Aparicio Elihu Campos-P érez Omar Noel Medina-Campos Jos é Pedraza-Chaverri Guadalupe Bravo Source Type: research
Quantification of Phytochemicals and Metal Ions as well as the Determination of Volatile Compounds, Antioxidant, Antimicrobial and Antacid Activities of the Mimosa pudica L. Leaf: Exploration of Neglected and Under-Utilized Part
Chem Biodivers. 2023 Sep 20:e202301049. doi: 10.1002/cbdv.202301049. Online ahead of print.ABSTRACTMimosa pudica L. (MP) is well-known plant in traditional medicinal system, especially in India. Unfortunately, leaves of MP are less explored. To determine the food and nutritional value of the neglected part of Mimosa pudica L. (MP), that is MP leaves, phytochemicals and metal ions of MP were quantified by newly developed HPLC and ICPOES-based methods. The content of phytochemicals observed using HPLC analysis for chlorogenic acid, catechin, and epicatechin was 141.823 (±8.171), 666.621 (±11.432), and 293.175 (±12.743) μ...
Source: Chemistry and Biodiversity - September 20, 2023 Category: Biochemistry Authors: Ms Yashika Gandhi Shyam Baboo Prasad Vijay Kumar Hemant Soni Hemant Rawat Sujeet K Mishra Jyotika Grewal Simranjeet Singh Vaibhav Charde Akhil Gupta Sudhanshu Kumar Jha Gagandeep Singh Smriti Tandon Akshada Mrkute Praveen C Ramamurthy Ch Venkata Narasimha Source Type: research
Tripartite motif containing 59 mediates protective anti-oxidative effects in intestinal injury through Nrf2 signaling
Int Immunopharmacol. 2023 Sep 18;124(Pt B):110896. doi: 10.1016/j.intimp.2023.110896. Online ahead of print.ABSTRACTElevated evidence has reported the important role of oxidative stress injury and inflammatory response in the progression of colitis. Tumor Suppressor TSBF1, TRIM59, is a ubiquitin E3 ligase and mediates immune response. However, the underlying molecular function of TRIM59 on regulation of colitis is still not understood. In the current study, we identify the TRIM59 as a critical and novel endogenous suppressor of kelch-like ECH-associated protein 1 (KEAP1), and we also determine that TRIM59 is a KEAP1-intera...
Source: International Immunopharmacology - September 20, 2023 Category: Allergy & Immunology Authors: Bing Liu Yongsheng Gao Xin Liu Qin Lian Yanliang Li Source Type: research
Vitamin E Treatment Improves the Antioxidant Capacity of Patients Receiving Dialysis: A Systematic Review and Meta ‐Analysis
ConclusionVitamin E therapy has a favorable effect on the retention of antioxidant compounds in patients undergoing dialysis.
Source: Molecular Nutrition and Food Research - September 20, 2023 Category: Food Science Authors: Ce Ni,
Wenhua Zhou,
Mengyuan Yu,
Xinyang Li,
Jian Li,
Yingchun Cui,
Wenpeng Cui Tags: Research Article Source Type: research
Byrsonima sericea Ethanol Extract Protected PC12 Cells from the Oxidative Stress and Apoptosis Induced by 6-Hydroxydopamine
This study aimed to evaluate the cytoprotective activity of the B. sericea ethanolic extract (BSEE) against the cytotoxicity induced by 6-hydroxydopamine (6-OHDA) in PC12 cells, an in vitro model of parkinsonism. The identification of phenolic compounds in the extract by HPLC-DAD revealed the presence of geraniin, rutin, isoquercetin, kaempferol 3-O-β-rutinoside, and quercetin. The BSEE (75-300 µg/mL) protected PC12 cells from toxicity induced by 6-OHDA (25 µg/mL), protected cell membrane integrity and showed antioxidant activity. BSEE was able to decrease nitrite levels, glutathione depletion, and protect cells from 6-...
Source: Neurochemical Research - September 19, 2023 Category: Neuroscience Authors: Albert Layo Costa de Assis Patricia de Ara újo Rodrigues Selene Maia de Morais Ana Livya Moreira Rodrigues Jessica Maria Pessoa Gomes Tyciane de Souza Nascimento Alfaete Vieira Oliveira Mayara Sandrielly Soares de Aguiar Geanne Matos de Andrade Source Type: research
Physiological and metabolomic analyses reveal that Fe < sub > 3 < /sub > O < sub > 4 < /sub > nanoparticles ameliorate cadmium and arsenic toxicity in Panax notoginseng
This study provides insights into using nanoparticles to improve potential active ingredients of medicinal plants in metal (loid)-contaminated areas.PMID:37726032 | DOI:10.1016/j.envpol.2023.122578
Source: Environmental Pollution - September 19, 2023 Category: Environmental Health Authors: Tianquan Lu Xiaoning Wang Xianliang Cui Jifang Li Jin Xu Peng Xu Jinpeng Wan Source Type: research
Byrsonima sericea Ethanol Extract Protected PC12 Cells from the Oxidative Stress and Apoptosis Induced by 6-Hydroxydopamine
This study aimed to evaluate the cytoprotective activity of the B. sericea ethanolic extract (BSEE) against the cytotoxicity induced by 6-hydroxydopamine (6-OHDA) in PC12 cells, an in vitro model of parkinsonism. The identification of phenolic compounds in the extract by HPLC-DAD revealed the presence of geraniin, rutin, isoquercetin, kaempferol 3-O-β-rutinoside, and quercetin. The BSEE (75-300 µg/mL) protected PC12 cells from toxicity induced by 6-OHDA (25 µg/mL), protected cell membrane integrity and showed antioxidant activity. BSEE was able to decrease nitrite levels, glutathione depletion, and protect cells from 6-...
Source: Neurochemical Research - September 19, 2023 Category: Neuroscience Authors: Albert Layo Costa de Assis Patricia de Ara újo Rodrigues Selene Maia de Morais Ana Livya Moreira Rodrigues Jessica Maria Pessoa Gomes Tyciane de Souza Nascimento Alfaete Vieira Oliveira Mayara Sandrielly Soares de Aguiar Geanne Matos de Andrade Source Type: research
Renoprotective effects of ferulic acid mediated by AMPK α1 against lipopolysaccharide-induced damage
In conclusion, FA pretreatment can upregulate AMPKα1 expression and phosphorylation, inhibit inflammatory cytokine release and oxidative stress, improve mitochondrial function and energy supply, alleviate apoptosis, and ultimately protect renal tissue against LPS damage.PMID:37724953 | DOI:10.1016/j.intimp.2023.109703
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Li Niu Liang Wang Xinlan He Qigui Fan Maosi Chen Yang Qiao Huang Huang Songqing Lai Qing Wan Zeyu Zhang Ming He Huan He Source Type: research
Byrsonima sericea Ethanol Extract Protected PC12 Cells from the Oxidative Stress and Apoptosis Induced by 6-Hydroxydopamine
This study aimed to evaluate the cytoprotective activity of the B. sericea ethanolic extract (BSEE) against the cytotoxicity induced by 6-hydroxydopamine (6-OHDA) in PC12 cells, an in vitro model of parkinsonism. The identification of phenolic compounds in the extract by HPLC-DAD revealed the presence of geraniin, rutin, isoquercetin, kaempferol 3-O-β-rutinoside, and quercetin. The BSEE (75-300 µg/mL) protected PC12 cells from toxicity induced by 6-OHDA (25 µg/mL), protected cell membrane integrity and showed antioxidant activity. BSEE was able to decrease nitrite levels, glutathione depletion, and protect cells from 6-...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Albert Layo Costa de Assis Patricia de Ara újo Rodrigues Selene Maia de Morais Ana Livya Moreira Rodrigues Jessica Maria Pessoa Gomes Tyciane de Souza Nascimento Alfaete Vieira Oliveira Mayara Sandrielly Soares de Aguiar Geanne Matos de Andrade Source Type: research
Feasibility and acceptability of miracle fruit application prior to the consumption of sour-tasting foods as a weight-loss strategy in adults with diabetes or prediabetes: A randomized crossover trial
Appetite. 2023 Sep 17:107046. doi: 10.1016/j.appet.2023.107046. Online ahead of print.ABSTRACTMiracle fruit (MF) has emerged as a promising option for healthy noncaloric sweeteners due to its sour-to-sweet taste-modifying effects and high antioxidant activity. We aimed to examine the feasibility and acceptability of using MF as a weight-loss strategy for individuals with diabetes or prediabetes. Fifty Korean-American men and women (25 participants each) aged 45-75 years with diabetes or prediabetes were recruited in this study. They participated in a randomized placebo-controlled crossover trial where they took the assigne...
Source: Appetite - September 19, 2023 Category: Nutrition Authors: Sung Eun Choi Taehwan Park Source Type: research
Impact of noscapine on halting the progression of pentylenetetrazole induced kindling epilepsy in mice
Clin Exp Pharmacol Physiol. 2023 Sep 19. doi: 10.1111/1440-1681.13825. Online ahead of print.ABSTRACTEpilepsy is caused by an excessive recurrent excitatory neuronal firing, characterized by motor, psychomotor, and sensory impairments. Current therapies fail to produce 100% outcomes because of the complexity of the disease, poor diagnosis, and upsurge to drug-resistant epilepsy. The study repurposed the drug 'noscapine' mainly known for its anti-tussive properties. For the management of epilepsy and its associated secondary complications. To confirm the effect of noscapine, adult mice were injected with pentylenetetrazole ...
Source: Clinical and Experimental Pharmacology and Physiology - September 19, 2023 Category: Drugs & Pharmacology Authors: Rishav Gupta Divya Soni Shubham Upadhayay Maanvi Dhureja Puneet Kumar Source Type: research
Renoprotective effects of ferulic acid mediated by AMPK α1 against lipopolysaccharide-induced damage
In conclusion, FA pretreatment can upregulate AMPKα1 expression and phosphorylation, inhibit inflammatory cytokine release and oxidative stress, improve mitochondrial function and energy supply, alleviate apoptosis, and ultimately protect renal tissue against LPS damage.PMID:37724953 | DOI:10.1016/j.intimp.2023.109703
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Li Niu Liang Wang Xinlan He Qigui Fan Maosi Chen Yang Qiao Huang Huang Songqing Lai Qing Wan Zeyu Zhang Ming He Huan He Source Type: research
Gelatin Sponges with a Uniform Interoperable Pore Structure and Biodegradability for Liver Injury Hemostasis and Tissue Regeneration
Biomacromolecules. 2023 Sep 19. doi: 10.1021/acs.biomac.3c00803. Online ahead of print.ABSTRACTDeveloping a hemostatic sponge that can effectively control bleeding from visceral injuries while guiding in situ tissue regeneration in incompressible wounds remains a challenge. Most of the existing hemostatic sponges degrade slowly, are relatively single-functioning, and cannot cope with complex environments. Herein, a biodegradable rapidly hemostatic sponge (GPZ) was created by dual-dynamic-bond cross-linking among Zn2+, protocatechualdehyde (PA)-containing catechol and aldehyde groups, and gelatin. GPZ had a uniformly distri...
Source: Biomacromolecules - September 19, 2023 Category: Biochemistry Authors: Yangrui Du Yangjing Bai Shiying Lang Dandan Xing Li Ma Kaijun Li Jinyu Peng Xinyun Li Gongyan Liu Source Type: research
Acetate Abates Arsenic-Induced Male Reproductive Toxicity by Suppressing HDAC and Uric Acid-Driven Oxido-inflammatory NFkB/iNOS/NO Response in Rats
This study investigated the impact of acetate on arsenic-induced male reproductive toxicity. Forty eight adult male Wistar rats were allotted into any of these four groups (n = 12 rats per group): vehicle-treated, sodium acetate-treated, arsenic-exposed, and arsenic-exposed + sodium acetate-treated. The results revealed that arsenic exposure prolonged the latencies of mount, intromission, and ejaculation and reduced the frequencies of mount, intromission, and ejaculation, as well as mating and fertility indices, litter size and weight, anogenital distance, anogenital index, and survival rate in male F1 offspring at weaning...
Source: Biological Trace Element Research - September 19, 2023 Category: Biology Authors: E E Besong T M Akhigbe J N Obimma O O Obembe R E Akhigbe Source Type: research
