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Confirmation of efficacy, elucidation of mechanism, and new search for indications of radon therapy
J Clin Biochem Nutr. 2022 Mar;70(2):87-92. doi: 10.3164/jcbn.21-85. Epub 2021 Oct 2.ABSTRACTIndications of radon therapy include various diseases related to respiratory, painful, digestive, chronic degenerative, senile, etc. derived from reactive oxygen species, but most are based on empirical prescriptions. For this reason, we have evaluated the relation between the biological response caused by radon and the tissue/organ absorbed dose more quantitatively, and have promoted the elucidation of mechanisms related to the indication and searching newly. As a result, as a mechanism, a series of moderate physiological stimulati...
Source: Clinical Biochemistry - April 11, 2022 Category: Biochemistry Authors: Kiyonori Yamaoka Takahiro Kataoka Source Type: research

A Background Search on the Potential Role of < em > Scutellaria < /em > and Its Essential Oils
Biomed Res Int. 2022 Jul 27;2022:7265445. doi: 10.1155/2022/7265445. eCollection 2022.ABSTRACTScutellaria (Lamiaceae), which contains over 350 species, usually known as skullcaps, is found throughout Europe, the United States, and East Asia. In traditional Chinese medicine, several species are used to wipe out heat-evil and remove surface ills (TCM). The current study examines the ethnopharmacology, biological activity, and chemical substances associated with Scutellaria species. More than 295 chemicals, including flavonoids and diterpenes, have been identified. Scutellaria and its active principles have been shown in stud...
Source: Biomed Res - August 15, 2022 Category: Research Authors: Mehrukh Zehravi Chenmala Karthika Abul Kalam Azad Zubair Ahmad Farhat S Khan Md Sohanur Rahman Rokeya Akter Md Habibur Rahman Source Type: research

Synthesis and SPAR exploration of new semicarbazone-triazole hybrids in search of potent antioxidant, antibacterial and antifungal agents.
Abstract A new series of semicarbazone-triazole hybrid derivatives have been synthesized by condensation between heterocyclic aldehydes and the commercial semicarbazide hydrochloride. The in vitro antioxidant activity of these species was tested using 1,1-diphenyl-2-picrylhydrazyl radical, 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and Ferric reducing antioxidant power assays and their antimicrobial activity against different microbial strains was carried out. Furthermore, molecular properties prediction and drug likeness were also determinated using Molinspiration. Among such derivatives, compounds (E)...
Source: Molecular Biology Reports - December 3, 2018 Category: Molecular Biology Authors: Brahmi J, Bakari S, Nasri S, Nasri H, Kadri A, Aouadi K Tags: Mol Biol Rep Source Type: research

Nordihydroguaiaretic Acid in Therapeutics: Beneficial to Toxicity Profiles and the Search for its Analogs.
Abstract Nordihydroguaiaretic acid (NDGA) is a plant lignan obtained from creosote bush, Larrea tridentata and is known to possess antioxidant, anticancer activities and is used in traditional medicine in North America and Mexico. However, its prolonged consumption leads to liver damage and kidney dysfunction. Despite its toxicity and side effects, there is little awareness to forbid its consumption and its uses in treatment of medical ailments has continued over the years. Several reports discuss its therapeutic efficiency and its medical applications have tremendously been on the rise till date. There has been a...
Source: Current Cancer Drug Targets - October 21, 2019 Category: Cancer & Oncology Authors: Mala John GS, Takeuchi S, Venkatraman G, Rayala SK Tags: Curr Cancer Drug Targets Source Type: research

A comprehensive search of the primary and secondary metabolites and radical scavenging potential of Trillium govanianum Wall. ex D. Don
Chem Biodivers. 2021 Aug 10. doi: 10.1002/cbdv.202100300. Online ahead of print.ABSTRACTTrillium govanianum rhizomes are traditionally consumed as a raw powder and decoction for the treatment of health complications. Hence, the present study aimed to investigate whether aqueous and alcoholic extracts of T. govanianum rhizomes under hot and cold extraction conditions have similar or dissimilar chemical, nutrient, and antioxidant profiles. The total phenolics, flavonoids, carbohydrates, proteins, fats, and energy values were estimated in all the conditionally prepared samples. The total phenolics (21.23 ± 1.4 mg GAE/g extra...
Source: Chemistry and Biodiversity - August 10, 2021 Category: Biochemistry Authors: Dinesh Kumar Aakriti Sharma Robin Joshi Gireesh Nadda Dinesh Kumar Source Type: research

In vivo and in vitro anti-schistosomiasis effect of garlic (Allium sativum): a systematic review
CONCLUSION: Effective anti-schistosomal responses of garlic in studies show that the active compounds of garlic can be used as a complement with chemical drugs or as an alternative for them, and this is needed to optimize the consumption of these active compounds for medicinal uses.PMID:35227185 | DOI:10.2174/1570163819666220228154752
Source: Current Drug Discovery Technologies - March 1, 2022 Category: Drugs & Pharmacology Authors: Pegah Shakib Hamed Kalani Ali Safar Maken Ali Mustafa Zebardastpour Kobra Moradpour Jeffery Ho Vahideh Heydari Nazarabad Kourosh Cheraghipour Source Type: research