Effects of Paradoxical Sleep Deprivation on Oxidative Parameters in the Serum and Brain of Mice Submitted to the Animal Model of Hyperglycemia
Behav Brain Res. 2024 Apr 22:115008. doi: 10.1016/j.bbr.2024.115008. Online ahead of print.ABSTRACTThe present study aimed to investigate the effects of paradoxical sleep deprivation (PSD) on behavioral and oxidative stress parameters in the brain and serum of mice submitted to the animal model of hyperglycemia induced by alloxan, mimicking the main symptom of diabetes mellitus (DM). Adults C57BL/6 male and female mice received an injection of alloxan, and ten days later, the animals were submitted to the PSD for 36hr. The animals' behavioral parameters were evaluated in the open-field test. Oxidative stress parameters [Di...
Source: Behavioural Brain Research - April 24, 2024 Category: Neurology Authors: Julia Panato-Da Rosa Isadora Gava Sandrini Taise Possamai-Della Jorge M Aguiar-Geraldo Maria Lu ísa Machado-Laureano Alexandra I Zugno Jo ão Quevedo Samira S Valvassori Source Type: research
Reach-to-Grasp and tactile discrimination task: A new task for the study of sensory-motor learning
Behav Brain Res. 2024 Apr 20;466:115007. doi: 10.1016/j.bbr.2024.115007. Online ahead of print.ABSTRACTAlthough active touch in rodents arises from the forepaws as well as whiskers, most research on active touch only focuses on whiskers. This results in a paucity of tasks designed to assess the process of active touch with a forepaw. We develop a new experimental task, the Reach-to-Grasp and Tactile Discrimination task (RGTD task), to examine active touch with a forepaw in rodents, particularly changes in processes of active touch during motor skill learning. In the RGTD task, animals are required to (1) extend their forel...
Source: Behavioural Brain Research - April 22, 2024 Category: Neurology Authors: Yudai Yoshinaga Nobuya Sato Source Type: research
Reach-to-Grasp and tactile discrimination task: A new task for the study of sensory-motor learning
Behav Brain Res. 2024 Apr 20;466:115007. doi: 10.1016/j.bbr.2024.115007. Online ahead of print.ABSTRACTAlthough active touch in rodents arises from the forepaws as well as whiskers, most research on active touch only focuses on whiskers. This results in a paucity of tasks designed to assess the process of active touch with a forepaw. We develop a new experimental task, the Reach-to-Grasp and Tactile Discrimination task (RGTD task), to examine active touch with a forepaw in rodents, particularly changes in processes of active touch during motor skill learning. In the RGTD task, animals are required to (1) extend their forel...
Source: Behavioural Brain Research - April 22, 2024 Category: Neurology Authors: Yudai Yoshinaga Nobuya Sato Source Type: research
Sustained insulin treatment restoring metabolic status, body weight, and cognition in an anorexia nervosa-like animal model in mice
CONCLUSION: The PSA-RA-based insulin delivery system effectively restores metabolic balance, body weight, and cognitive function in the AN model. Its ability to steadily release insulin makes it a promising candidate for AN treatment."PMID:38642861 | DOI:10.1016/j.bbr.2024.115001 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 20, 2024 Category: Neurology Authors: Yosefa Avraham Tovi Shapira-Furman Ravi Saklani Bob Van Heukelom Moshe Carmel Lia Vorobiev Leah Lipsker Donna R Zwas Elliot M Berry Abraham J Domb Source Type: research
Alpha Event-Related Decreases During Encoding in Adults with ADHD - An Investigation of Sustained Attention and Working Memory Processes
CONCLUSIONS: Our results corroborate the robustness of alpha as a marker of visual attention and suggest that occipital alpha ERD normalizes in adulthood, but with unique contributions of centro-occipital alpha ERD, suggesting a secondary source. This implies that deviations in processes other than previously reported visuospatial cortex engagement account for the persistent symptoms and cognitive deficits in adults with a history of ADHD.PMID:38642862 | DOI:10.1016/j.bbr.2024.115003 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 20, 2024 Category: Neurology Authors: Ren é Freichel Nicolas Zink Fang Yu Chang Juan Diego Vera Holly Truong Giorgia Michelini Sandra K Loo Agatha Lenartowicz Source Type: research
Hand differences in aiming task: a complementary spatial approach and analysis ofdynamic brain networks with EEG
Behav Brain Res. 2024 Apr 17:114973. doi: 10.1016/j.bbr.2024.114973. Online ahead of print.ABSTRACTLeft and right-hand exhibit differences in the execution of movements. Particularly, it has been shown that manual goal-directed aiming is more accurate with the right hand than with the left, which has been explained through the shorter time spent by the right hand in the feedback phase (FB). This explanation makes sense for the temporal aspects of the task; however, there is a lack of explanations for the spatial aspects. The present study hypothesizes that the right hand is more associated with the FB, while the left hand ...
Source: Behavioural Brain Research - April 19, 2024 Category: Neurology Authors: Lidiane Aparecida Fernandes T ércio Apolinário-Souza Gabriela Castellano Beatriz Couto Fortuna Guilherme Menezes Lage Source Type: research
Medicinal Cannabis oil improves anxiety-like and depressive-like behaviors in CCS mice via the BDNF/TRPC6 signaling pathway
CONCLUSIONS: We constructed a PTSD model with CCS and medicinal cannabis oil that significantly improved anxiety-like and depressive-like behaviors in CCS mice, which may play an anti-PTSD role by stimulating the BDNF/TRPC6 signaling pathway.PMID:38641178 | DOI:10.1016/j.bbr.2024.115005 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 19, 2024 Category: Neurology Authors: Baoying Shen Zhixing Wang Huijing Yu Xin Shen Lin Li Yi Ru Chunqi Yang Guangxu Du Chengcai Lai Yue Gao Source Type: research
Perturbations in Risk/Reward Decision Making and Frontal Cortical Catecholamine Regulation Induced by Mild Traumatic Brain Injury
Behav Brain Res. 2024 Apr 16:115002. doi: 10.1016/j.bbr.2024.115002. Online ahead of print.ABSTRACTMild traumatic brain injury (mTBI) disrupts cognitive processes that influence risk taking behavior. Little is known regarding the effects of repetitive mild injury (rmTBI) or whether these outcomes are sex specific. Risk/reward decision making is mediated by the prefrontal cortex (PFC), which is densely innervated by catecholaminergic fibers. Aberrant PFC catecholamine activity has been documented following TBI and may underlie TBI-induced risky behavior. The present study characterized the effects of rmTBI on risk/reward de...
Source: Behavioural Brain Research - April 18, 2024 Category: Neurology Authors: Christopher P Knapp Eleni Papadopoulos Jessica A Loweth Ramesh Raghupathi Stan B Floresco Barry D Waterhouse Rachel L Navarra Source Type: research
Alterations in the brain serotonin system and serotonin-regulated behavior during aging in zebrafish males and females
Behav Brain Res. 2024 Apr 15:115000. doi: 10.1016/j.bbr.2024.115000. Online ahead of print.ABSTRACTThe brain serotonin (5-HT) system performs a neurotrophic function and supports the plasticity of the nervous system, while its age-related changes can increase the risk of senile neurodegeneration. Zebrafish brain is highly resistant to damage and neurodegeneration due to its high regeneration potential and it is a promising model object in searching for molecular factors preventing age-related neurodegeneration. In the present study alterations in 5-HT-related behavior in the home tank and the novel tank diving test, as wel...
Source: Behavioural Brain Research - April 17, 2024 Category: Neurology Authors: Valentina S Evsiukova Ivan E Sorokin Peter A Kulikov Alexander V Kulikov Source Type: research
Neural responses to gaming content on social media in young adults
Behav Brain Res. 2024 Apr 15:115004. doi: 10.1016/j.bbr.2024.115004. Online ahead of print.ABSTRACTExcessive gaming can impair both mental and physical health, drawing widespread public and clinical attention, especially among young generations. People are now more exposed to gaming-related content on social media than before, and this exposure may have a significant impact on their behavior. However, the neural mechanisms underlying this effect remain unexplored. Using functional magnetic resonance imaging (fMRI), this study aimed to investigate the neural activity induced by gaming-related content on social media among y...
Source: Behavioural Brain Research - April 17, 2024 Category: Neurology Authors: Yuka Fujimoto Junya Fujino Daisuke Matsuyoshi Daisuke Jitoku Nanase Kobayashi Chenyu Qian Shoko Okuzumi Shisei Tei Takehiro Tamura Takefumi Ueno Makiko Yamada Hidehiko Takahashi Source Type: research
Alterations in the brain serotonin system and serotonin-regulated behavior during aging in zebrafish males and females
Behav Brain Res. 2024 Apr 15:115000. doi: 10.1016/j.bbr.2024.115000. Online ahead of print.ABSTRACTThe brain serotonin (5-HT) system performs a neurotrophic function and supports the plasticity of the nervous system, while its age-related changes can increase the risk of senile neurodegeneration. Zebrafish brain is highly resistant to damage and neurodegeneration due to its high regeneration potential and it is a promising model object in searching for molecular factors preventing age-related neurodegeneration. In the present study alterations in 5-HT-related behavior in the home tank and the novel tank diving test, as wel...
Source: Behavioural Brain Research - April 17, 2024 Category: Neurology Authors: Valentina S Evsiukova Ivan E Sorokin Peter A Kulikov Alexander V Kulikov Source Type: research
Neural responses to gaming content on social media in young adults
Behav Brain Res. 2024 Apr 15:115004. doi: 10.1016/j.bbr.2024.115004. Online ahead of print.ABSTRACTExcessive gaming can impair both mental and physical health, drawing widespread public and clinical attention, especially among young generations. People are now more exposed to gaming-related content on social media than before, and this exposure may have a significant impact on their behavior. However, the neural mechanisms underlying this effect remain unexplored. Using functional magnetic resonance imaging (fMRI), this study aimed to investigate the neural activity induced by gaming-related content on social media among y...
Source: Behavioural Brain Research - April 17, 2024 Category: Neurology Authors: Yuka Fujimoto Junya Fujino Daisuke Matsuyoshi Daisuke Jitoku Nanase Kobayashi Chenyu Qian Shoko Okuzumi Shisei Tei Takehiro Tamura Takefumi Ueno Makiko Yamada Hidehiko Takahashi Source Type: research
EEG complexity in emotion conflict task in individuals with psychiatric disorders
This study highlights the significance of investigating EEG complexity and its potential applications in the transdiagnostic exploration of impulsivity in psychiatric disorders.PMID:38621461 | DOI:10.1016/j.bbr.2024.114997 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 15, 2024 Category: Neurology Authors: Chao Gu Tina Chou Alik S Widge Darin D Dougherty Source Type: research
EEG complexity in emotion conflict task in individuals with psychiatric disorders
This study highlights the significance of investigating EEG complexity and its potential applications in the transdiagnostic exploration of impulsivity in psychiatric disorders.PMID:38621461 | DOI:10.1016/j.bbr.2024.114997 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 15, 2024 Category: Neurology Authors: Chao Gu Tina Chou Alik S Widge Darin D Dougherty Source Type: research
Prelimbic Cortex-Nucleus Accumbens Core Projection Positively Regulates Itch and Itch-Related Aversion
In this study, rat models of acute neck and cheek itch were established by subcutaneous injection of 5-HT, compound 48/80, or chloroquine. Immunofluorescence experiments determined that the number of c-Fos-immunopositive neurons in the Prl increased during acute itch. Chemogenetic inhibition of Prl glutamatergic neurons or Prl-NAcC glutamatergic projections can inhibit both histaminergic and nonhistaminergic itch-scratching behaviors and rectify the itch-related conditioned place aversion (CPA) behavior associated with nonhistaminergic itch. The Prl-NAcC projection may play an important role in the positive regulation of i...
Source: Behavioural Brain Research - April 14, 2024 Category: Neurology Authors: Jun-Hui Long Pu-Jun Wang Li Xuan Yao Juan Guang-Yan Wu Jun-Fei Teng Jian-Feng Sui Ya-Min Li Liu Yang Hong-Li Li Shu-Lei Liu Source Type: research
