Neuro-Restorative Effect of Sertoli Cell Transplants in a Rat Model of Amyloid Beta Toxicity.
Abstract Alzheimer's disease (AD) is a degenerative nerve disease which adversely affects memory and learning skills. Currently, there is no disease-modifying therapeutic approach for AD. However, a growing body of literature suggests cell based therapies as a promising remedy for neurological disorders. Among the potential cell sources, testis- derived Sertoli cells (SCs) appear to be an attractive choice due to their immune-privileged capacities. Herein, we investigated the neuro-restorative/protective effects of SC transplants in a rat model of amyloid beta toxicity. To this end, GATA-4 and vimentin positive SC...
Source: Behavioural Brain Research - March 21, 2019 Category: Neurology Authors: Aliaghaei A, Meymand AZ, Boroujeni ME, Khodagoli F, Meftahi GH, Hadipour MM, Abdollahifar MA, Mesgar S, Ahmadi H, Danyali S, Hasani S, Sadeghi Y Tags: Behav Brain Res Source Type: research

Stress-Induced Neural Activation is Altered During Early Withdrawal from Chronic Methamphetamine.
Abstract Chronic methamphetamine (MA) use can lead to increased symptoms of depression and anxiety during abstinence. Less is known about the specific brain regions that are altered following repeated MA that may be associated with these behavioral perturbations. Furthermore, MA has been reported to recruit and activate microglia in the brain, which may exacerbate stress-associated behavioral changes. In the present study, male and female mice were injected with MA (5 mg/kg) or saline once daily for 10 days, and during early withdrawal were assessed for alterations in immediate early gene (c-Fos) responses ...
Source: Behavioural Brain Research - March 19, 2019 Category: Neurology Authors: Jacobskind JS, Rosinger ZJ, Brooks ML, Zuloaga DG Tags: Behav Brain Res Source Type: research

Effects of Cacna1c Haploinsufficiency on Social Interaction Behavior and 50-kHz Ultrasonic Vocalizations in Adult Female Rats.
r M Abstract The risk gene CACNA1C is strongly implicated in the etiology of all major psychiatric disorders, such as depressive disorder, bipolar disorder, autism spectrum disorder, and schizophrenia. These disorders feature high levels of comorbidity and share an overlap of symptoms; in particular, deficits in social functioning are common. Intriguingly, sex-dependent effects of CACNA1C single nucleotide polymorphisms on prevalence, health outcomes, and psychological traits have been reported, typically suggesting that women are more affected by CACNA1C mutations than men. In rodents, genetic modifications speci...
Source: Behavioural Brain Research - March 19, 2019 Category: Neurology Authors: Redecker TM, Kisko TM, Schwarting RKW, Wöhr M Tags: Behav Brain Res Source Type: research

Contribution of cognitive functions to postural control in anticipating self-paced and externally-triggered lower-limb perturbations.
DISCUSSION: We confirm that the preparatory activity of premotor areas is associated with the intentional engagement of upcoming actions since it occurs only before self-paced perturbations. The PFC anticipating both perturbations can be interpreted as an unintentional top-down cognitive control required by the tasks, especially involving attention and inhibition. However, before externally-triggered perturbations also other cognitive resources are required. The EBA activity anticipating externally-triggered perturbation may represent a visual prediction of the desired posture. PMID: 30898679 [PubMed - as supplied by ...
Source: Behavioural Brain Research - March 18, 2019 Category: Neurology Authors: Quinzi F, Berchicci M, Perri RL, Bianco V, Labanca L, Macaluso A, Di Russo F Tags: Behav Brain Res Source Type: research

Enhanced Executive Attention Efficiency after Adaptive Force Control Training: Behavioural and Physiological Results.
In this study, fingertip-based adaptive force control tasks (AFCT) were explored for attention training, and the visual-channel task called an attention network test (ANT) was used to measure the level of attention before and after AFCT. The purposes of this study were to investigate whether AFCT can enhance the attention level on the ANT task and to elucidate the underlying electrophysiological mechanisms. The results showed that the efficiency of the executive control network during ANT was significantly improved by the AFCT training, indicating that the AFCT training may enhance the executive attention level during visu...
Source: Behavioural Brain Research - March 18, 2019 Category: Neurology Authors: Liu M, Zhang J, Jia W, Chang Q, Shan S, Hu Y, Wang D Tags: Behav Brain Res Source Type: research

Effects of a rat model of gestational hypothyroidism on forebrain dopaminergic, gabaergic, and serotonergic systems and related behaviors.
EFFECTS OF A RAT MODEL OF GESTATIONAL HYPOTHYROIDISM ON FOREBRAIN DOPAMINERGIC, GABAERGIC, AND SEROTONERGIC SYSTEMS AND RELATED BEHAVIORS. Behav Brain Res. 2019 Mar 18;: Authors: da Cunha Menezes E, Dos Santos PR, Costa Goes T, de Carvalho VCB, Teixeira-Silva F, Stevens HE, Badauê-Passos D Abstract We investigated the effects of maternal hypothyroidism on forebrain dopaminergic, GABAergic, and serotonergic systems and related behavior in adult rat offspring. Experimental gestational hypothyroidism (EGH) was induced by administering 0.02% methimazole (MMI) to pregnant rats from gestational day 9 ...
Source: Behavioural Brain Research - March 18, 2019 Category: Neurology Authors: da Cunha Menezes E, Dos Santos PR, Costa Goes T, de Carvalho VCB, Teixeira-Silva F, Stevens HE, Badauê-Passos D Tags: Behav Brain Res Source Type: research

Sex effects on behavioral markers of emergence from propofol and isoflurane anesthesia in rats.
This study aimed to characterize the emergence pattern following two anesthesia regimens in both sexes of rats. We considered six different markers of emergence from anesthesia: sigh, eye blinking, forelimb movement, mastication, neck extension, and recovery of the righting reflex (RORR). Spontaneous motor activity 24 hours after the anesthesia induction was also examined. Our results showed that the rank order of the emergence latency after intraperitoneal propofol, PRO, exposure was forelimb movement 
Source: Behavioural Brain Research - March 18, 2019 Category: Neurology Authors: Mansouri MT, Fidler JA, Meng QC, Eckenhoff RG, García PS Tags: Behav Brain Res Source Type: research

Nitric oxide donor molsidomine promotes retrieval of object recognition memory in a model of cognitive deficit induced by 192 IgG-saporin.
doza A, Ríos C, Pérez-Severiano F Abstract Nitric oxide (NO) plays a leading role in learning and memory processes. Previously, we showed its ability to modify the deleterious effect of immunotoxin 192 IgG-saporin (192-IgG-SAP) in the cholinergic system. The aim of this study was to analyze the potential of a NO donor (molsidomine, MOLS) to prevent the recognition memory deficits resulting from the septal cholinergic denervation by 192 IgG-SAP in rats. Quantification of neuronal and endothelial nitric oxide synthase (nNOS and eNOS, respectively) expression was evaluated in striatum, prefrontal cortex...
Source: Behavioural Brain Research - March 18, 2019 Category: Neurology Authors: Hernández-Melesio MA, Alcaraz-Zubeldia M, Jiménez-Capdeville ME, Martínez-Lazcano JC, Santoyo-Pérez ME, Quevedo-Corona L, Gerónimo-Olvera C, Sánchez-Mendoza A, Ríos C, Pérez-Severiano F Tags: Behav Brain Res Source Type: research

MicroRNA-132 regulates total protein of Nav1.1 and Nav1.2 in the hippocampus and cortex of rat with chronic cerebral hypoperfusion.
In this study, the expression of miR-132 was decreased in both the hippocampus and cortex of ratsfollowing CCH generated by bilateral common carotid artery occlusion (2VO). Lentiviral-mediated overexpression of miR-132 ameliorated dementia vulnerability induced by 2VO. At the molecular level, miR-132 repressed the increased protein expression of Nav1.1 and Nav1.2in both the hippocampus and cortex induced by 2VO.MiR-132 suppressed, while AMO-miR-132 enhanced, the level of Nav1.1 and Nav1.2 in primary cultured neonatal rat neurons (NRNs) detected by both western blot analysis and immunofluorescence analysis.Results obtained ...
Source: Behavioural Brain Research - March 15, 2019 Category: Neurology Authors: Hu XL, Wang XX, Zhu YM, Xuan LN, Peng LW, Liu YQ, Yang H, Yang C, Jiao L, Hang PZ, Sun LH Tags: Behav Brain Res Source Type: research

A dyad shows mutual changes during social buffering of conditioned fear responses in male rats.
Abstract The presence of an affiliative conspecific reduces stress responses to a wide variety of stimuli. This phenomenon is termed "social buffering". We previously found that the presence of another naïve rat (associate) reduced conditioned fear responses to an auditory conditioned stimulus in a conditioned subject rat. Although we subsequently conducted a series of studies to examine behavioral, physiological, and neural changes during social buffering in the conditioned subject, the changes in the associate remained unclear. Therefore, in the present study, we investigated the behavioral and ne...
Source: Behavioural Brain Research - March 14, 2019 Category: Neurology Authors: Kiyokawa Y, Yasong L, Takeuchi Y Tags: Behav Brain Res Source Type: research

Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats.
In conclusion, social isolation at adulthood induced epigenetic alterations and exacerbated the effects of chronic stress on HDAC5. Notwithstanding, social support counteracted the adverse effects of stress on HDAC5 expression. PMID: 30880220 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 14, 2019 Category: Neurology Authors: Borges JV, de Freitas BS, Antoniazzi V, de Souza Dos Santos C, Vedovelli K, Pires VN, Paludo L, de Lima MNM, Bromberg E Tags: Behav Brain Res Source Type: research

The immediate and delayed effects of single tDCS session over posterior parietal cortex on face-word associative memory.
Abstract Associative memory (AM), an ability to form and retrieve associations between information units is crucial for everyday functioning and is affected by ageing as well as by different neurological conditions. It was shown that rTMS over posterior parietal cortex (PPC) can improve AM of face-word pairs. Therefore, we examined if tDCS will produce comparable effects and explore whether the effect would persist one and five days following the stimulation. Thirty-seven healthy participants took part in cross-over sham-controlled study in which they received 20 minutes of anodal (1.5 mA) or sham tD...
Source: Behavioural Brain Research - March 14, 2019 Category: Neurology Authors: Bjekić J, Vulić K, Živanović M, Vujičić J, Ljubisavljević M, Filipović SR Tags: Behav Brain Res Source Type: research

The Attention Set-Shifting Test is Sensitive for Revealing Sex-based Impairments in Executive Functions Following Developmental Lead Exposure in Rats.
This study examined the effects of perinatal (PERI) and early postnatal (EPN) developmental low-level Pb-exposures in rats on frontoexecutive functions, using the Attention Set-Shift Test (ASST). Control males and females performed the ASST similarly. Male EPN rats had difficulty with simple discrimination (SD) of odors and failed to complete the compound discrimination (CD) stage of the ASST. All other Pb-exposed rats completed the training and testing. Male PERI rats performed worse on the SD, intradimensional (ID), and intradimensional-reversal (ID-Rev) ASST stages when compared to male Control rats. Female EPN rats per...
Source: Behavioural Brain Research - March 13, 2019 Category: Neurology Authors: Neuwirth LS, Masood S, Anderson DW, Schneider JS Tags: Behav Brain Res Source Type: research

Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice.
Abstract Neuroinflammation is often associated with the development of major depressive disorder (MDD)-related symptoms. Previous studies have indicated that activation of glial cells, upregulation of proinflammatory cytokines and dysregulation of adrenergic system in the central nervous system (CNS) could be the key mediators to modulate depression-related behaviors after peripheral immune activation. Central α7 nicotinic acetylcholine receptor (α7 nAChR) has a role in the regulation of the cholinergic anti-inflammatory pathway. The present study determined the effects of PNU120596, α7 nAChR pos...
Source: Behavioural Brain Research - March 12, 2019 Category: Neurology Authors: Alzarea S, Rahman S Tags: Behav Brain Res Source Type: research

MMP-9-BDNF pathway is implicated in cognitive impairment of male individuals with methamphetamine addiction during early withdrawal.
Abstract Cognitive impairment is often concomitant with current and abstinent methamphetamine (METH) misuse. However, the mechanism underlying the pathogenesis of cognitive impairment induced by METH remains unclear. As evidence indicates that brain-derived neurotrophic factor (BDNF) is associated with METH addiction, the present study aimed to investigate whether BDNF and the proteins regulating the BDNF signaling pathway might be implicated in the cognitive impairment of the METH abusers during early withdrawal. A total of 171 male subjects were recruited, including 85 METH abstainers and 86 healthy controls. Co...
Source: Behavioural Brain Research - March 12, 2019 Category: Neurology Authors: Cheng M, Liu Q, Wang Y, Hao Y, Jing P, Jiao S, Ma L, Pan C, Wu Y Tags: Behav Brain Res Source Type: research

Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice.
CA, Savegnago L Abstract In the last decades, selenium-containing compounds have received increasing attention because of their various biological and pharmacological properties. In the present study, we investigated the effects of 3-[(4-methoxyphenyl) selanyl]-2-phenylimidazo[1,2-a] pyridine (MPI; 1, 10 or 50 mg/kg, i.g.) on the acute restraint stress (ARS)-induced depressive- and anxiety-like behaviors in mice and the underlying mechanism. We used open filed test, forced swimming test, and splash test to evaluate depressive-like behavior, and marble burying and elevated plus maze test to measure anxiety-l...
Source: Behavioural Brain Research - March 12, 2019 Category: Neurology Authors: Domingues M, Casaril AM, Birmann PT, Bampi SR, Lourenço DA, Vieira BM, Dapper LH, Lenardão EJ, Sonego M, Collares T, Seixas FK, Brüning CA, Savegnago L Tags: Behav Brain Res Source Type: research

Dysregulation of miR-142 results in anxiety-like behaviors following single prolonged stress.
Abstract Posttraumatic stress disorder (PTSD) is a prevalent mental disorder that is classified as a trauma- and stressor-related disorder. While numerous epigenetic factors are related to the risk for PTSD, the precise mechanisms underlying this disorder remain unclear. However, accumulating evidence has demonstrated that dysregulation of microRNAs is involved in stress-related psychiatric disorders, resulting in anxiety-like behavior, memory-related deficits and aberrant neuronal plasticity. Here, rats exposed to single prolonged stress showed increased microRNA-142-5p levels in the amygdala and a concurrent red...
Source: Behavioural Brain Research - March 8, 2019 Category: Neurology Authors: Ji LL, Ye Y, Nie PY, Peng JB, Fu CH, Wang ZY, Tong L Tags: Behav Brain Res Source Type: research

Role of dorsal raphe nucleus GHS-R1a receptors in the regulation of inhibitory avoidance and escape behaviors in rats.
Abstract Ghrelin is a recently discovered peptide, mainly produced in the stomach and involved in body's energy-maintenance processes. Ghrelin exerts its actions by activating the growth hormone secretagogue receptor (GHS-R). Recent analyses indicate that ghrelin targets the brain to regulate a wealth of functions, including behavioral responses that have been associated with stress and anxiety mechanisms. In this context, evidence shows the presence of GHS-R receptors in the dorsal raphe nucleus (DRN), the main source of serotonergic neurons that innervate encephalic structures involved in emotional control. Our ...
Source: Behavioural Brain Research - March 8, 2019 Category: Neurology Authors: Cavalcante DP, Turones LC, Camargo-Silva G, Santana JS, Colugnati DB, Pansani AP, Xavier CH, Henschel Pobbe RL Tags: Behav Brain Res Source Type: research

Sex and estrous cycle dependent changes in locomotor activity, anxiety and memory performance in aged mice after exposure of light at night.
Abstract Light-at-night (LAN) can affect mammalian behaviour. But, the effects of LAN on aged rodents remain undefined yet. In the present investigation, aged Swiss Albino mice, habituated in regular light-dark cycle, were exposed to bright-light-pulse (1-hr) at night on the day of study followed by experimentations for assessment of locomotor activities in the open field, anxiety in the elevated plus maze and short-term memory for novel object recognition (NOR) in the habituated field. Under without-bright-light exposure, (a) aged proestrous females showed greater locomotor activities and less anxiety than in age...
Source: Behavioural Brain Research - March 7, 2019 Category: Neurology Authors: Chakrabarti N Tags: Behav Brain Res Source Type: research

Effects of Orientation Change during Environmental Learning on Age-Related Difference in Spatial Memory.
Abstract It has been suggested that older adults suffer a greater degree of decline in environmental learning when navigating in an environment than when reading a map of the environment. However, the two types of spatial learning differ not only in perspectives (i.e., navigation is done with a ground-level perspective; a map is read from an aerial perspective) but also in orientations (i.e., orientations vary during navigation; spatial information is drawn from a single orientation in a map), making it unclear which factor critically affects older adults' spatial learning. The present study addressed this issue b...
Source: Behavioural Brain Research - March 6, 2019 Category: Neurology Authors: Yamamoto N, Fox MJ, Boys E, Ord J Tags: Behav Brain Res Source Type: research

Augmented Improvement of Cognition and Memory by Aripiprazole add-on for Cilostazol Treatment in the Chronic Cerebral Hypoperfusion Mouse model.
This study aimed to explore augmented improvement of cognition and memory by aripiprazole add-on for cilostazol treatment in vascular dementia model. Male C57BL/6 mice were subjected to BCAS, and spatial probe and memory retention were examined using the Morris water maze (MWM) test. In the present study, the escape latency on the first day after 3rd week was 21.4 ± 4.0 sec in sham-operated mice, and 76.3 ± 4.2 sec in the vehicle-treated BCAS mice. In the spatial probe tests in the 3rd week, aripiprazole (1 mg/kg/day) showed time-dependently amelioration in spa...
Source: Behavioural Brain Research - March 6, 2019 Category: Neurology Authors: Park SY, Kim HY, Lee YS, Heo HJ, Shin HK, Lee WS, Hong KW, Kim CD Tags: Behav Brain Res Source Type: research

Differential Effects of Transcranial Direct Current Stimulation on Antiphase and Inphase Motor Tasks: a Pilot Study.
Abstract Ageing is associated with a decline in motor function that critically interferes with activities of daily living involving manual dexterity. Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that has been shown to enhance manual dexterity in healthy aging adults. The supplementary motor area (SMA) is involved in motor preparation and bimanual control; therefore, bihemispheric tDCS incorporating the SMA may preferentially enhance bimanual motor movements in healthy older adults. The aim of the current study was to determine if tDCS incorporating SMA could improve ma...
Source: Behavioural Brain Research - March 6, 2019 Category: Neurology Authors: Ryan K, Schranz A, Duggal N, Bartha R Tags: Behav Brain Res Source Type: research

Effects of corticosterone on the expression of mature brain-derived neurotrophic factor (mBDNF) and proBDNF in the hippocampal dentate gyrus.
Abstract Chronic stressor induces the release of glucocorticoid from the adrenal glands, the subsequent decrease of hippocampal volume, and the development of depression. Brain-derived neurotrophic factor (BDNF), composed of mature BDNF (mBDNF) and proBDNF, plays opposite roles in the structural integrity of the brain. However, the underlying mechanism of glucocorticoid-induced hippocampal atrophy remains unclear. Using the open field test, sucrose preference test, elevated plus maze test, and forced swimming test, we observed that the chronic (3 w) administration of corticosterone (CORT) (50 μg/m...
Source: Behavioural Brain Research - March 6, 2019 Category: Neurology Authors: Li J, Chen J, Ma N, Yan D, Wang Y, Zhao X, Zhang Y, Zhang C Tags: Behav Brain Res Source Type: research

Adult social isolation leads to anxiety and spatial memory impairment: brain activity pattern of COx and c-Fos.
;ndez M, Arias JL Abstract Social isolation during adulthood is a frequent problem that leads to a large variety of adverse emotional and cognitive effects. However, most of the social isolation rodent procedures begin the separation early post-weaning. This work explores locomotor activity, anxiety-like behaviour, and spatial working memory after twelve weeks of adult social isolation. In order to study the functional contribution of selected brain areas following a working memory task, we assessed neuronal metabolic activity through quantitative cytochrome oxidase histochemistry and c-Fos immunohistochemistry. B...
Source: Behavioural Brain Research - March 6, 2019 Category: Neurology Authors: Zorzo C, Méndez-López M, Méndez M, Arias JL Tags: Behav Brain Res Source Type: research

Reduced expression of Kalirin-7 contributes to working memory deficit during chronic hypobaric hypoxia exposure.
In conclusion, it can be said therefore, that change in Kalirin-7 expression in the hippocampus is associated with HH induced working memory deficit. PMID: 30851319 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 6, 2019 Category: Neurology Authors: Alam S, Ray K, Jain V, Wadhwa M, Kumari P, Roy K, Chauhan G, Kishore K, Panjawani U, Singh SB Tags: Behav Brain Res Source Type: research

Repeated fluoxetine treatment induces long-lasting neurotrophic changes in the medial prefrontal cortex of adult rats.
In conclusion, repeated Flx treatment, with the paradigm used, induces long-lasting neuroplastic changes in the mPFC of normal adult rats, and such changes and related behavioral manifestations may persist up to 20 days after the last dose. PMID: 30849415 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 5, 2019 Category: Neurology Authors: Song T, Wu H, Li R, Xu H, Rao X, Gao L, Zou Y, Lei H Tags: Behav Brain Res Source Type: research

Physical and cognitive training are able to prevent recognition memory deficits related to amyloid beta neurotoxicity.
PHYSICAL AND COGNITIVE TRAINING ARE ABLE TO PREVENT RECOGNITION MEMORY DEFICITS RELATED TO AMYLOID BETA NEUROTOXICITY. Behav Brain Res. 2019 Mar 04;: Authors: Rossi Dare L, Garcia A, Alves N, Ventura Dias D, de Souza MA, Mello-Carpes PB Abstract Alzheimer's disease (AD) is characterized by the presence of amyloid-β (Aβ), oxidative damage and neuronal degeneration, which, together with other pathological events, promote progressive memory loss and cognitive decline. Non-pharmacological strategies have been study to provide some protection against the development of AD. Considering that physic...
Source: Behavioural Brain Research - March 4, 2019 Category: Neurology Authors: Rossi Dare L, Garcia A, Alves N, Ventura Dias D, de Souza MA, Mello-Carpes PB Tags: Behav Brain Res Source Type: research

Conditional approach as cooperation in predator inspection: a role for serotonin?
Abstract In guppies (Poecilia reticulata), a small number of individuals break away from a shoal and approach a potential predator, a behavior termed "predator inspection". These animals often employ a "conditional approach" strategy, in which an individual approaches the predator in the first move and subsequently approaches it only if a second individual swims even with it during inspection. This strategy is analogous to the "tit-for-tat" strategy of the Prisoner's Dilemma, suggesting that it could be used to study cooperation. Serotonin is thought to mediate cooperative behavior in...
Source: Behavioural Brain Research - March 2, 2019 Category: Neurology Authors: Pimentel AFN, Carvalho TDS, Lima F, Lima-Maximino M, Soares MC, Maximino C Tags: Behav Brain Res Source Type: research

Developmental outcomes after gestational antidepressant treatment with sertraline and its discontinuation in an animal model of maternal depression.
This study utilized a translational animal model of maternal depression (based on giving high levels of corticosterone (CORT, 40mg/kg, s.c.) or vehicle (Oil) for 21 days prior to conception) to investigate the effects of sertraline (a frequently prescribed SSRI; 20mg/kg p.o., treatment started ∼7 days prior to conception) and its discontinuation during pregnancy (on gestational day 16) compared to vehicle (water) treatment on the development of the offspring. Our results revealed that both corticosterone exposure prior to pregnancy and sertraline administration and its discontinuation during gestation had sex-specific ...
Source: Behavioural Brain Research - March 2, 2019 Category: Neurology Authors: Kott JM, Mooney-Leber SM, Brummelte S Tags: Behav Brain Res Source Type: research

Repeated Finasteride Administration Induces Depression-Like Behavior in Adult Male Rats.
This study provides the evidence that an animal model of finasteride-induced depression is feasible to investigate the cellular and molecular mechanisms, and the pharmacology underlying the neuropsychiatric effects of finasteride. Further, these results provide insights into the potential involvement of neurosteroids in depression and will lead to the development of novel therapeutics for its treatment. PMID: 30836157 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 2, 2019 Category: Neurology Authors: Sasibhushana RB, Shankaranarayana Rao BS, Srikumar BN Tags: Behav Brain Res Source Type: research

A novel joint HCPMMP method for automatically classifying Alzheimer's and different stage MCI patients.
Abstract A 360-area surface-based cortical parcellation was recently generated using multimodal data in a group average of 210 healthy young adults from the Human Connectome Project (HCP). In order to automatically and accurately identify mild cognitive impairment (MCI) at its two levels (early MCI and late MCI), Alzheimer's disease (AD) and healthy control (HC), a novel joint HCP MMP method was first proposed to delineate the cortical architecture and function connectivity in a group of non healthy adults. The proposed method was applied to register a dataset of 96 resting-state functional connectomes from the Al...
Source: Behavioural Brain Research - March 2, 2019 Category: Neurology Authors: Sheng J, Wang B, Zhang Q, Liu Q, Ma Y, Liu W, Shao M, Chen B Tags: Behav Brain Res Source Type: research

No evidence that wheel-running exercise impacts cocaine conditioned place preference in male C57BL/6J mice.
Abstract Wheel-running in rodents can mitigate addiction-related effects of drugs of abuse like cocaine. However, conditioned place preference (CPP) experiments have reported conflicting results, a situation warranting further studies. Our purpose was to test whether wheel-running exercise during adolescence could impact the formation and long-term retention of CPP to cocaine in mice. Male C57BL/6 J mice were individually housed either with (n = 32) or without (n = 32) a running wheel from the age of 35 days. Behavioral testing began 3 weeks after such housing, mice underwent a b...
Source: Behavioural Brain Research - March 2, 2019 Category: Neurology Authors: Lespine LF, Tirelli E Tags: Behav Brain Res Source Type: research

Group I metabotropic glutamate receptor antagonists impair discriminability of reinforcer magnitude, but not risky choice, in a probability-discounting task.
Abstract The glutamatergic system has been identified as an important mediator of risky choice. However, previous studies have focused primarily on ionotropic glutamate receptors (e.g., NMDA receptors). Little research has examined the contribution of metabotropic glutamate receptors (mGluRs) on risky choice. The goal of the current experiment was to determine the effects of mGluR1 and mGluR5 antagonism on risky choice as assessed in probability discounting (PD). Male Sprague Dawley rats (n = 24) were trained in PD, in which consistently choosing a large, probabilistic reward (LR) reflects risky choi...
Source: Behavioural Brain Research - March 1, 2019 Category: Neurology Authors: Yates JR, Chitwood MR, Evans KE, Kappesser JL, Murray CP, Paradella-Bradley TA, Torline BT Tags: Behav Brain Res Source Type: research

Neuroprotective effect of tanshinone IIA-incubated mesenchymal stem cells on A β25-35-induced neuroinflammation.
Neuroprotective effect of tanshinone IIA-incubated mesenchymal stem cells on Aβ25-35-induced neuroinflammation. Behav Brain Res. 2019 Mar 01;: Authors: Huang N, Li Y, Zhou Y, Zhou Y, Feng F, Shi S, Ba Z, Luo Y Abstract Mesenchymal stem cell transplantation can regulate neuroinflammation and treat Alzheimer's disease (AD), but its effect is attenuated by in vitro expansion. To solve this problem, we used tanshinone IIA (TIIA)-incubated mesenchymal stem cells (MSCs) to treat neuroinflammation caused by amyloid β-protein (Aβ). Here, we demonstrated that behavioral performance was rescued i...
Source: Behavioural Brain Research - March 1, 2019 Category: Neurology Authors: Huang N, Li Y, Zhou Y, Zhou Y, Feng F, Shi S, Ba Z, Luo Y Tags: Behav Brain Res Source Type: research

Neuregulin1 attenuates cognitive deficits and hippocampal CA1 neuronal apoptosis partly via ErbB4 receptor in a rat model of chronic cerebral hypoperfusion.
Abstract Neuregulin1 (NRG1) is an effective neuroprotectant. Previously we demonstrated that the expression of hippocampal NRG1/ErbB4 gradually decreased and correlates with neuronal apoptosis during chronic cerebral hypoperfusion (CCH). Here we aimed to further investigate the protective role of NRG1 in CCH. AG1478, an ErbB4 inhibitor, was used to explore the involvement of ErbB4 receptors in NRG1's action. Permanent bilateral common carotid artery occlusion (2VO) or sham operation was performed in Sprague-Dawley rats. NRG1 (100 μM) and AG1478 (50 mM) was administered intraventricularly. Eight we...
Source: Behavioural Brain Research - February 28, 2019 Category: Neurology Authors: Hei Y, Chen R, Mao X, Wang J, Long Q, Liu W Tags: Behav Brain Res Source Type: research

Cognitive and neuropsychiatric impairments vary as a function of injury severity at 12 months post-experimental diffuse traumatic brain injury: Implications for dementia development.
Abstract Traumatic brain injury (TBI) is a common risk factor for later neurodegeneration, which can manifest as dementia. Despite this, little is known about the time-course of development of functional deficits, particularly cognitive and neuropsychiatric impairments, and whether these differ depending on the nature of the initiating insult. Therefore, this study investigated long term functional impairment at 12 months post-injury following diffuse TBI of different severities. Male Sprague-Dawley rats (420-480 g; 10-12 weeks) were either given a sham surgery (n = 14) or subjected to Marmaro...
Source: Behavioural Brain Research - February 28, 2019 Category: Neurology Authors: Arulsamy A, Corrigan F, Collins-Praino LE Tags: Behav Brain Res Source Type: research

Effects of chronic mild stress induced depression on synaptic plasticity in mouse hippocampus.
This study investigated the effect of CMS on synaptic plasticity in hippocampus. Our results showed that CMS impaired spatial memory and exploring ability, disturbed the release of neurotransmitters including 5-hydroxytryptamine (5-HT) and dopamine (DA), reduced the density of synaptic vesicle in inner molecular layer, increased the number of thin spines in inner and outer molecular layer, whereas did not affect the density of spine apparatus, the above mentioned were probably related to the reduction of astrocytes and activation of microglial cells. PMID: 30825464 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 27, 2019 Category: Neurology Authors: Hei M, Chen P, Wang S, Li X, Xu M, Zhu X, Wang Y, Duan J, Huang Y, Zhao S Tags: Behav Brain Res Source Type: research

Hypersynchronicity in the default mode-like network in a neurodevelopmental animal model with relevance for schizophrenia.
CONCLUSIONS: MIA offspring displayed a differential pathophysiology depending on the maternal response to immune challenge. While Poly I:C WL offspring displayed hypersynchronicity in the DMN, altered NMDAR antagonist response was most pronounced in Poly I:C WG offspring. PMID: 30807809 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 23, 2019 Category: Neurology Authors: Missault S, Anckaerts C, Ahmadoun S, Blockx I, Barbier M, Bielen K, Shah D, Kumar-Singh S, De Vos WH, Van der Linden A, Dedeurwaerdere S, Verhoye M Tags: Behav Brain Res Source Type: research

Influence of the fat/carbohydrate component of snack food on energy intake pattern and reinforcing properties in rodents.
CP Abstract Hedonic intake of strongly rewarding foods is independent from biological needs and, thus, a common cause of obesity. The effect of potato chips on energy intake in a snacking model could be explained by their fat/carbohydrate content (FCHc). The present study investigated if the FCHc shapes energy intake patterns and reward processing of satiated rodents. Modulation of energy intake patterns was studied in an established snacking model offering FCHc rich food for 3 × 10 min/day to satiated rats. Reward processing was analyzed by a previously established conditioned place pr...
Source: Behavioural Brain Research - February 23, 2019 Category: Neurology Authors: Hess A, Kress S, Rakete S, Muench G, Kornhuber J, Pischetsrieder M, Müller CP Tags: Behav Brain Res Source Type: research

High-fructose diet initiated during adolescence does not affect basolateral amygdala excitability or affective-like behavior in Sprague Dawley rats.
Abstract Patients with type-2 diabetes, obesity, and metabolic syndrome have a significantly increased risk of developing depression. Dysregulated metabolism may contribute to the etiology of depression by affecting neuronal activity in key limbic areas. The basolateral amygdala (BLA) acts as a critical emotional valence detector in the brain's limbic circuit, and shows hyperactivity and abnormal glucose metabolism in depressed patients. Furthermore, administering a periadolescent high-fructose diet (HFrD; a model of metabolic syndrome) to male Wistar rats increases anxiety- and depressive-like behavior. Repeated ...
Source: Behavioural Brain Research - February 23, 2019 Category: Neurology Authors: O'Flaherty B, Neigh GN, Rainnie D Tags: Behav Brain Res Source Type: research

CAENORHABDITIS ELEGANS AS A MODEL SYSTEM TO IDENTIFY THERAPEUTICS FOR Alcohol USE DISORDERS.
Abstract Alcohol use disorders (AUDs) cause serious problems in society and few effective treatments are available. Caenorhabditis elegans (C. elegans) is an excellent invertebrate model to study the neurobiological basis of human behavior with a conserved, fully tractable genome, and a short generation time for fast generation of data at a fraction of the cost of other organisms. C. elegans demonstrate movement toward, and concentration-dependent self-exposure to various psychoactive drugs. The discovery of opioid receptors in C. elegans provided the impetus to test the hypothesis that C. elegans may be used as a...
Source: Behavioural Brain Research - February 22, 2019 Category: Neurology Authors: Katner SN, Bredhold KE, Steagall KB, Bell RL, Neal-Beliveau BS, Cheong MC, Engleman EA Tags: Behav Brain Res Source Type: research

Diagnostic Utility of Gut α-Synuclein in Parkinson's Disease: A Systematic Review and Meta-Analysis.
CONCLUSION: Heterogeneity was high in most of the studies. This systematic review and meta-analysis confirmed a high degree of association between gut α-synuclein and PD, which suggested that gut α-synuclein is a potential therapeutic intervention. The measurement of gut α-synuclein alone could lead to the underdiagnosis of PD. Future research combining gut α-synuclein with other biochemical markers could improve the standardization of current assays. PMID: 30802532 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 22, 2019 Category: Neurology Authors: Bu J, Liu J, Liu K, Wang Z Tags: Behav Brain Res Source Type: research

Alteration in oxytocin levels induced by early social environment affects maternal behavior and estrogen receptor alpha in mandarin voles (Microtus mandarinus).
Abstract Many studies have shown that the early social environment exerts long-term effects on the brain and also the parental behavior of adults. Oxytocin (OXT) is one of the most important neurotransmitters that regulate social behavior; howerve, whether the early social environment affects parental behavior via OXT remains unclear. Using socially monogamous adult mandarin voles (Microtus mandarinus), the present study found that 1) both paternal deprivation and early social deprivation significantly decreased OXT expression in both the paraventricular hypothalamic nucleus (PVN) and the supraoptic nucleus (SON) ...
Source: Behavioural Brain Research - February 22, 2019 Category: Neurology Authors: Feng T, An S, Kinden R, Zhang X, Jia R, Tai F Tags: Behav Brain Res Source Type: research

Plasticity of paternity: effects of fatherhood on synaptic, intrinsic and morphological characteristics of neurons in the medial preoptic area of male California mice.
Abstract Parental care by fathers enhances offspring survival and development in numerous species. In the biparental California mouse, Peromyscus californicus, behavioral plasticity is seen during the transition into fatherhood: adult virgin males often exhibit aggressive or indifferent responses to pups, whereas fathers engage in extensive paternal care. In this species and other biparental mammals, the onset of paternal behavior is associated with increased neural responsiveness to pups in specific brain regions, including the medial preoptic area of the hypothalamus (MPOA), a region strongly implicated in both ...
Source: Behavioural Brain Research - February 22, 2019 Category: Neurology Authors: Horrell ND, Saltzman W, Hickmott PW Tags: Behav Brain Res Source Type: research

Anxiolytic and antidepressant effects of ACPA and harmaline co-treatment.
Abstract Depression and anxiety disorders are among the most common illnesses and a close relationship between them has been found. Because the psychotropic effects and abuse liability of cannabis prevent its therapeutic application in depression and anxiety states, we decided to investigate the effects of the combination of ineffective doses of cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) and β-carbolines on anxiety- and depression-related behaviors in male NMRI mice. Anxiety- and depression-related behaviors were assesses using elevated plus maze (EPM) and forced swim test (FST), resp...
Source: Behavioural Brain Research - February 21, 2019 Category: Neurology Authors: Ebrahimi-Ghiri M, Nasehi M, Zarrindast MR Tags: Behav Brain Res Source Type: research

Increased Metabolic Activity and Hysteretic Enhanced GABAA Receptor Binding in A Rat Model of Salicylate-induced Tinnitus.
In this study, we applied a rat model of tinnitus via long-term salicylate administration. The combination of the gap pre-pulse inhibition of acoustic startle (GPIAS) and pre-pulse inhibition (PPI) tests were used to detect tinnitus-like behavior, and rats receiving 7 or 14 consecutive days of salicylate administration showed evidence of tinnitus. After positron emission tomography (PET) scan, we found that the metabolic activity was increased after salicylate treatment followed by enhanced GABAA receptor binding with cessation of salicylate administration in the auditory cortex (AC), medial prefrontal cortex (mPFC), hippo...
Source: Behavioural Brain Research - February 21, 2019 Category: Neurology Authors: Wu C, Bao W, Yi B, Wang Q, Wu X, Qian M, Zuo C, Huang Z Tags: Behav Brain Res Source Type: research

Hydroxychloroquine antiparkinsonian potential: Nurr1 modulation versus autophagy inhibition.
In conclusion, hydroxychloroquine successfully ameliorated PD motor dysfunction in spite of the fact that both autophagy and apoptosis were deregulated through Nurr1 modulation. PMID: 30797853 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 21, 2019 Category: Neurology Authors: Hedya SA, Safar MM, Bahgat AK Tags: Behav Brain Res Source Type: research

Restraint stress exacerbates cell degeneration induced by acute binge ethanol in the adolescent, but not in the adult or middle-aged, brain.
si RM Abstract Restraint stress (RS) induces neurotoxicity in the hippocampus, yet most of the studies have employed protracted RS (i.e., ≈ 21 days). Binge ethanol can induce brain toxicity, an effect affected by age. It could be postulated that RS may facilitate ethanol-induced neurotoxicity, perhaps to a greater extent in adolescent vs. older subjects. We analyzed whether adolescent, adult or middle-aged male rats exposed to five episodes of RS followed, 72h later, by binge ethanol (i.e., two administrations of 2.5 g/kg ethanol) exhibited hippocampal neurotoxicity. Adolescents, but not adult or middle-aged...
Source: Behavioural Brain Research - February 21, 2019 Category: Neurology Authors: Fernández MS, de Olmos S, Nizhnikov ME, Pautassi RM Tags: Behav Brain Res Source Type: research

Dopamine D4 receptor gene expression plays important role in extinction and reinstatement of cocaine-seeking behavior in mice.
Abstract Dopamine D4 receptor (DRD4) dysregulation is associated with a variety of behaviors including novelty-seeking, approach avoidance, and ADHD. DRD4 has also been shown to interact with the environment to produce changes in behavior and longevity. The present study sought to examine the role of DRD4 on cocaine-seeking behavior in the conditioned place preference (CPP) test and determine its effects on extinction and reinstatement in adult wild-type (WT), heterozygous (HT), and knockout (KO) mice. Results revealed that all mice, regardless of sex or genotype, developed a similar acquisition for a cocaine plac...
Source: Behavioural Brain Research - February 21, 2019 Category: Neurology Authors: Ananth M, Hetelekides EM, Hamilton J, Thanos PK Tags: Behav Brain Res Source Type: research

Incidental learning of allocentric and egocentric strategies by both men and women in a dual-strategy virtual Morris Water Maze.
Abstract In studies of human navigation, an underlying assumption is that, by nature, navigators are proficient with and strongly biased toward using only one strategy, either allocentric (cognitive mapping) or egocentric (stimulus-response based). Further, research often suggests that males are allocentric navigators whereas females are egocentric navigators. We tested these binary assumptions using two versions of a virtual Morris water maze (MWM). The Dual-strategy maze could be solved using either an allocentric or an egocentric strategy. Preferred strategy was tested by alternating test and probe trials. Two ...
Source: Behavioural Brain Research - February 19, 2019 Category: Neurology Authors: Ferguson TD, Livingstone-Lee SA, Skelton RW Tags: Behav Brain Res Source Type: research