Selective disruption of mTORC1 and mTORC2 in VTA astrocytes induces depression and anxiety-like behaviors in mice
Behav Brain Res. 2024 Feb 1;463:114888. doi: 10.1016/j.bbr.2024.114888. Online ahead of print.ABSTRACTDysfunction of the mechanistic target of rapamycin (mTOR) signaling pathway is implicated in neuropsychiatric disorders including depression and anxiety. Most studies have been focusing on neurons, and the function of mTOR signaling pathway in astrocytes is less investigated. mTOR forms two distinct complexes, mTORC1 and mTORC2, with key scaffolding protein Raptor and Rictor, respectively. The ventral tegmental area (VTA), a vital component of the brain reward system, is enrolled in regulating both depression and anxiety. ...
Source: Behavioural Brain Research - February 2, 2024 Category: Neurology Authors: Ziteng Zheng Han Zhou Lu Yang Lanlan Zhang Ming Guo Source Type: research
Mitophagy Activation by Rapamycin Enhances Mitochondrial Function and Cognition in 5 ×FAD Mice
This study reveals a novel mechanism involving mitophagy regulation underlying the therapeutic effect of rapamycin in AD. This study provides new insights and therapeutic targets for rapamycin in the treatment of AD. However, there are still some shortcomings in this topic; if we can further knock out the PINK1/Parkin gene in animals or use siRNA technology, we can further confirm the experimental results.PMID:38301932 | DOI:10.1016/j.bbr.2024.114889 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 1, 2024 Category: Neurology Authors: Wenrong Zheng Kualiang Li Meihua Zhong Kejun Wu Lele Zhou Jie Huang Libin Liu Zhou Chen Source Type: research
Olanzapine attenuates 5-HT2cR and GHSR1a interaction to increase orexigenic hypothalamic NPY: Implications for neuronal molecular mechanism of metabolic side effects of antipsychotics
Behav Brain Res. 2024 Feb 1;463:114885. doi: 10.1016/j.bbr.2024.114885. Online ahead of print.ABSTRACTThe main cause of second-generation antipsychotic (SGA)-induced obesity is considered due to the antagonism of serotonin 2c receptors (5-HT2cR) and activation of ghrelin receptor type 1a (GHSR1a) signalling. It is reported that 5-HT2cR interacted with GHSR1a, however it is unknown whether one of the SGA olanzapine alters the 5-HT2cR/GHSR1a interaction, affecting orexigenic neuropeptide signalling in the hypothalamus. We found that olanzapine treatment increased average energy intake and body weight gain in mice; olanzapine...
Source: Behavioural Brain Research - January 31, 2024 Category: Neurology Authors: Xiaoli Liu Xia Lan Xinyou Zhang Huaiyu Ye Lijun Shen Minmin Hu Xiaoqi Chen Mingxuan Zheng Katrina Weston-Green Tiantian Jin Xiaoying Cui Yi Zhou Xiangyu Lu Xu-Feng Huang Yinghua Yu Source Type: research
Cerebral, systemic physiological and behavioral responses to colored light exposure during a cognitive task: A SPA-fNIRS study
Behav Brain Res. 2024 Jan 29;462:114884. doi: 10.1016/j.bbr.2024.114884. Online ahead of print.ABSTRACTColored light has important implications for human health and well-being, as well as for the aesthetics and function of various environments. In addition to its effects on visual function, colored light has significant effects on cognitive performance, behavior and systemic physiology. The aim of the current study was to comprehensively investigate how colored light exposure (CLE) combined with a cognitive task (2-back) affects performance, cerebral hemodynamics, oxygenation, and systemic physiology as assessed by systemi...
Source: Behavioural Brain Research - January 31, 2024 Category: Neurology Authors: Hamoon Zohdi Josefa M ärki Felix Scholkmann Ursula Wolf Source Type: research
Contribution of the medial entorhinal cortex to performance on the Traveling Salesperson Problem in rats
Behav Brain Res. 2024 Jan 26;463:114883. doi: 10.1016/j.bbr.2024.114883. Online ahead of print.ABSTRACTIn order to successfully navigate through space, animals must rely on multiple cognitive processes, including orientation in space, memory of object locations, and navigational decisions based on that information. Although highly-controlled behavioral tasks are valuable for isolating and targeting specific processes, they risk producing a narrow understanding of complex behavior in natural contexts. The Traveling Salesperson Problem (TSP) is an optimization problem that can be used to study naturalistic foraging behaviors...
Source: Behavioural Brain Research - January 28, 2024 Category: Neurology Authors: Jena B Hales Larissa Olivas Daniela Abouchedid Rachel E Blaser Source Type: research
Sex-dependent regulation of social avoidance by oxytocin signaling in the ventral tegmental area
Behav Brain Res. 2024 Jan 24;462:114881. doi: 10.1016/j.bbr.2024.114881. Online ahead of print.ABSTRACTIt has been hypothesized that oxytocin increases the salience of social stimuli, whether the valence is positive or negative, through its interactions with the ventral tegmental area (VTA). Indeed, oxytocin neurons project to the VTA and activate dopamine neurons that are necessary for social experiences with positive valence. Surprisingly, though, there has not been an investigation of the role of oxytocin in the VTA in mediating social experiences with negative valence (e.g., social stress). Given that there are sex dif...
Source: Behavioural Brain Research - January 25, 2024 Category: Neurology Authors: Zachary A Grieb Susan Lee Maura C Stoehr Benjamin W Horne Alisa Norvelle Emma K Shaughnessy H Elliott Albers Kim L Huhman Source Type: research
Behavioral effects of 6-hydroxydopamine-induced damage to nigro-striatal pathway and Locus coeruleus as a rodent model of Parkinson's disease
Behav Brain Res. 2024 Jan 23;462:114873. doi: 10.1016/j.bbr.2024.114873. Online ahead of print.ABSTRACTParkinson's disease (PD) is a chronic and progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the Substantia nigra pars compacta (SNpc), which leads to motor and non-motor symptoms (NMS). NMS can appear many years before the classical motor symptoms and are associated with the neurodegeneration of several nuclei; in this work, we highlight the neurodegeneration of Locus coeruleus (LC) in PD. The aim was to investigate the effects of depleting SNpc and LC catecholaminergic neurons on...
Source: Behavioural Brain Research - January 24, 2024 Category: Neurology Authors: Isabella B Bustelli Luiz M Oliveira Nelson F Correa-Netto Roberta S Stilhano Ariadiny L Caetano Source Type: research
CircPTK2 may be associated with depressive-like behaviors by influencing miR-182-5p
CONCLUSION: Collectively, our findings suggest the participation of circPTK2 and its underlying mechanism in MDD, which might provide a potential target for MDD therapy.PMID:38266777 | DOI:10.1016/j.bbr.2024.114870 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 24, 2024 Category: Neurology Authors: Kunyu Wang Yu Yang Yiwen Wang Zhuoya Jiang Shaokuan Fang Source Type: research
Acupuncture activates IRE1/XBP1 endoplasmic reticulum stress pathway in Parkinson's disease model rats
Behav Brain Res. 2024 Jan 22;462:114871. doi: 10.1016/j.bbr.2024.114871. Online ahead of print.ABSTRACTAcupuncture has demonstrated its efficacy as a treatment for Parkinson's disease (PD). Thus, the objective of this study was to investigate the potential mechanisms underlying acupuncture's effects on PD treatment. Our approach involved several steps. Firstly, we assessed the behavioral changes in PD rats, the modulation of dopamine (DA) and 5-hydroxytryptamine (5-HT) levels in the striatum, as well as the alteration in α-synuclein (α-syn) levels in the midbrain, aiming to evaluate the efficacy of acupuncture in PD trea...
Source: Behavioural Brain Research - January 24, 2024 Category: Neurology Authors: Zhifang Wang Menglin Kou Qiyue Deng Haotian Yu Jilin Mei Jing Gao Wen Fu Baile Ning Source Type: research
Tonic noradrenergic input to neurons in the dorsal raphe nucleus mediates food intake in male mice
In this study we investigated the participation of norepinephrine (NE) signaling in the DRN in the satiety response. Intra-DRN administration of NE causes an increase in the 2-hour food intake of sated mice, an effect that was blocked by previous administration of yohimbine, an α2 antagonist. Similarly, Intra-DRN administration of clonidine, an α2 agonist, increases food intake in sated mice. This result indicates that in the satiated mice exogenous NE acts on α2 receptors to increase food intake. Furthermore, administration of phenylephrine, an α1 agonist, decreases food intake in fasted mice and prazosin, an α1 anta...
Source: Behavioural Brain Research - January 24, 2024 Category: Neurology Authors: Rafael Appel Flores Raoni C Dos-Santos Isabelle Rodrigues-Santos Aline Alves de Jesus Jos é Antunes-Rodrigues Lucila L K Elias Source Type: research
Some key parameters in contextual fear conditioning and extinction in adult rats
In this study we evaluated the effects of the number of sessions, the number of unconditioned stimuli per acquisition session and the distribution of extinction sessions to assess fear acquisition and extinction and determine under which conditions generalization occurred in adult, male rats. We observed that the organization and spacing of sessions were relevant factors in the acquisition and extinction of contextual fear memories. Extinction occurred with significantly greater robustness when sessions were spread over two days. Furthermore, results indicated that exposure to a single 0.3 mA, 0.5 s footshock in two differ...
Source: Behavioural Brain Research - January 24, 2024 Category: Neurology Authors: M ónica Navarro-Sánchez Isis Gil-Miravet Daniel Montero-Caballero Esther Castillo-G ómez Andrew L Gundlach Francisco E Olucha-Bordonau Source Type: research
Neonatal treatment with para-chlorophenylalanine (pCPA) induces adolescent hyperactivity associated with changes in the paraventricular nucleus Crh and Trh expressions
Behav Brain Res. 2024 Jan 19;462:114867. doi: 10.1016/j.bbr.2024.114867. Online ahead of print.ABSTRACTDisruption of the brain serotoninergic (5-HT) system during development induces long-lasting changes in molecular profile, cytoarchitecture, and function of neurons, impacting behavioral regulation throughout life. In male and female rats, we investigate the effect of neonatal tryptophan hydroxylase (TPH) inhibition by using para-chlorophenylalanine (pCPA) on the expression of 5-HTergic system components and neuropeptides related to adolescent social play behavior regulation. We observed sex-dependent 5-HT levels decrease...
Source: Behavioural Brain Research - January 21, 2024 Category: Neurology Authors: Ver ónica Trujillo Tays Ara újo Camilo Evandro Valentim-Lima Qu ézia S R Carbalan Raoni C Dos-Santos Viviane Felintro Lu ís C Reis Danilo Lustrino Rodrigo Rorato Andr é S Mecawi Source Type: research
The molecular fingerprint of neuroinflammation in COVID-19: A comprehensive discussion on molecular mechanisms of neuroinflammation due to SARS-COV2 antigens
CONCLUSION: The neurological aspect of Coronavirus disease 2019 should be highlighted. Neurological, psychological, and behavioral aspects of Coronavirus disease 2019, prolonged Coronavirus disease 2019, and Coronavirus disease 2019 vaccines can be the upcoming issues. We need a global awareness where this aspect of the disease should be more considered in health research.PMID:38246395 | DOI:10.1016/j.bbr.2024.114868 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 21, 2024 Category: Neurology Authors: Zeinab Deris Zayeri Mehdi Torabizadeh Masoud Kargar Hashem Kazemi Source Type: research
Influence of maternal high-fat diet on offspring's locomotor activity during anxiety-related behavioral tests: A systematic review
Behav Brain Res. 2024 Jan 19;462:114869. doi: 10.1016/j.bbr.2024.114869. Online ahead of print.ABSTRACTThe aim of this review was to summarize and discuss the impact of a maternal high-fat diet on the locomotor activity of offspring during anxiety-related behavioral tests. A search was performed in the LILACS, Web of Science, SCOPUS and PUMBED databases, using the following inclusion criteria: studies in which rodent dams were submitted to a high-fat diet during gestation and/or lactation and in which the locomotor activity parameters of offspring were evaluated during an anxiety-related test. Twenty-three articles met the...
Source: Behavioural Brain Research - January 21, 2024 Category: Neurology Authors: Carolina Cadete Lucena Cavalcanti Raul Manh ães-de-Castro Wenicios Ferreira Chaves Erika Vanesa Cadena-Burbano Jos é Antonio-Santos Raquel da Silva Arag ão Source Type: research
Analysis of the cognitive and functional behavior of female rats in the periestropause after hormone therapy with estrogen
Behav Brain Res. 2024 Jan 15;462:114866. doi: 10.1016/j.bbr.2024.114866. Online ahead of print.ABSTRACTPerimenopause is a critical period, with severe cycle irregularity and lower estrogen secretion altering redox state biomarkers, leading to behavioral changes. The estrogen hormonal therapy (EHT) being commonly used to alleviate climacteric effects. Therefore, the aim of this study was to analyze anxiolytic profile, recognition memory (short and long term), ambulation, redox status, cell synaptic activity in locus coeruleus and hippocampus of Wistar rats in the periestropause after EHT. Forty rats participated in the stud...
Source: Behavioural Brain Research - January 17, 2024 Category: Neurology Authors: Thain á Daguane Esperança Beatriz Proc ópio Stringhetta-Villar D ébora Prazias Cavalcante Luana Galante Douradinho Gabriela Alice Fiais Rafael Pereira Antonio Hernandes Chaves-Neto Fernanda Barbosa Lima Rita C ássia Menegati Dornelles Source Type: research
