Litter reduction-induced obesity promotes early depressive-like behavior and elevated prefrontal cortex GFAP expression in male offspring
Behav Brain Res. 2023 Dec 26:114839. doi: 10.1016/j.bbr.2023.114839. Online ahead of print.ABSTRACTAIMS: The present study was developed to investigate how litter reduction-induced obesity promotes early depressive-related behaviors in rodent offspring.MAIN METHODS: We employed a standardized litter size reduction protocol, dividing litters into groups: normal litters (NL), consisting of six males and six females pups and small litters (SL), comprising two males and two females pups. Maternal behavior was monitored during the initial week of lactation. Subsequently, we assessed the pups for weight gain, locomotor activity,...
Source: Behavioural Brain Research - December 28, 2023 Category: Neurology Authors: D ébora Cristina da Cunha Nones C íntia Onofra Novais Viviana Carolina Trujillo Rojas Priscila de Paula Franco Elisa da Silva Estevam Mariana Santos Silva Alexandre Giusti-Paiva Tayllon Dos Anjos-Garcia Fabiana Cardoso Vilela Source Type: research
Litter reduction-induced obesity promotes early depressive-like behavior and elevated prefrontal cortex GFAP expression in male offspring
Behav Brain Res. 2023 Dec 26:114839. doi: 10.1016/j.bbr.2023.114839. Online ahead of print.ABSTRACTAIMS: The present study was developed to investigate how litter reduction-induced obesity promotes early depressive-related behaviors in rodent offspring.MAIN METHODS: We employed a standardized litter size reduction protocol, dividing litters into groups: normal litters (NL), consisting of six males and six females pups and small litters (SL), comprising two males and two females pups. Maternal behavior was monitored during the initial week of lactation. Subsequently, we assessed the pups for weight gain, locomotor activity,...
Source: Behavioural Brain Research - December 28, 2023 Category: Neurology Authors: D ébora Cristina da Cunha Nones C íntia Onofra Novais Viviana Carolina Trujillo Rojas Priscila de Paula Franco Elisa da Silva Estevam Mariana Santos Silva Alexandre Giusti-Paiva Tayllon Dos Anjos-Garcia Fabiana Cardoso Vilela Source Type: research
Litter reduction-induced obesity promotes early depressive-like behavior and elevated prefrontal cortex GFAP expression in male offspring
Behav Brain Res. 2023 Dec 26:114839. doi: 10.1016/j.bbr.2023.114839. Online ahead of print.ABSTRACTAIMS: The present study was developed to investigate how litter reduction-induced obesity promotes early depressive-related behaviors in rodent offspring.MAIN METHODS: We employed a standardized litter size reduction protocol, dividing litters into groups: normal litters (NL), consisting of six males and six females pups and small litters (SL), comprising two males and two females pups. Maternal behavior was monitored during the initial week of lactation. Subsequently, we assessed the pups for weight gain, locomotor activity,...
Source: Behavioural Brain Research - December 28, 2023 Category: Neurology Authors: D ébora Cristina da Cunha Nones C íntia Onofra Novais Viviana Carolina Trujillo Rojas Priscila de Paula Franco Elisa da Silva Estevam Mariana Santos Silva Alexandre Giusti-Paiva Tayllon Dos Anjos-Garcia Fabiana Cardoso Vilela Source Type: research
Differential expression of alpha-synuclein in the hippocampus of shr and sla16 isogenic rat strains
Behav Brain Res. 2023 Dec 25:114835. doi: 10.1016/j.bbr.2023.114835. Online ahead of print.ABSTRACTTwo inbred strains, Lewis (LEW) and Spontaneously Hypertensive Rats (SHR), are well-known for their contrasting behavior related to anxiety/emotionality. Studies with these two strains led to the discovery of the Quantitative Trait Loci (QTL) on chromosome 4 (Anxrr16). To better understand the influences of this genomic region, the congenic rat strain SLA16 (SHR.LEW-Anxrr16) was developed. SLA16 rats present higher hyperactivity/impulsivity, deficits in learning and memory, and lower basal blood pressure than the SHR strain, ...
Source: Behavioural Brain Research - December 27, 2023 Category: Neurology Authors: Rachel De Barros Oliveira Mayara Anselmi Renata Cristina Nunes Marchette Katiane Roversi Guilherme Pasetto Fadanni Luana Martins De Carvalho Samara Damasceno Isabella Aparecida Heinrich Rodrigo Bainy Leal Juliana Cavalli Renato Elias Moreira-J únior Ana Source Type: research
CX3CR1 mediates Motor Dysfunction in Mice through 5-HTR2a
Behav Brain Res. 2023 Dec 23:114837. doi: 10.1016/j.bbr.2023.114837. Online ahead of print.ABSTRACTCX3CR1 knockout could induce motor dysfunction in several neurological disease models mainly through regulating microglia's function. While CX3CR1 was expressed on neurons in a few reports, whether neuronal CX3CR1 could affect the function of neurons and mediate motor dysfunction under physiological conditions is unknown. To elucidate the roles of neuronal CX3CR1 on motor dysfunction, CX3CR1 knockout mice were created. Rotarod test and Open field test found that the CX3CR1-/- mice's motor capacity was reduced. Immunofluoresce...
Source: Behavioural Brain Research - December 25, 2023 Category: Neurology Authors: Jingchun Pei Yongwei Zou Cheng Wan Shuangshuang Liu Bin Hu Zhigao Li Zhiwei Tang Source Type: research
LPC20K modified from krill oil ameliorates the scopolamine-induced cognitive impairment
Behav Brain Res. 2023 Dec 23:114836. doi: 10.1016/j.bbr.2023.114836. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by cognitive impairment. It is common in the elderly. Etiologically, dysfunction of cholinergic neurotransmitter system is prominent in AD. However, disease modifying drug for AD is still unavailable. We hypothesized that krill oil and modified krill oil containing 20% lysophosphatidylcholine-docosahexaenoic acid (LPC-DHA, LPC20K) could play a crucial role in AD by improving cognitive functions measured by several behavioral tests. We found that LPC20K could ameliorate short-term, lon...
Source: Behavioural Brain Research - December 25, 2023 Category: Neurology Authors: Keontae Park Chang Hyeon Kong Woo Chang Kang Mijin Jeon Won Hyung Lee Juyeon Lee Sang Chul Kim Seo Yun Jung Jong Hoon Ryu Source Type: research
CX3CR1 mediates Motor Dysfunction in Mice through 5-HTR2a
Behav Brain Res. 2023 Dec 23:114837. doi: 10.1016/j.bbr.2023.114837. Online ahead of print.ABSTRACTCX3CR1 knockout could induce motor dysfunction in several neurological disease models mainly through regulating microglia's function. While CX3CR1 was expressed on neurons in a few reports, whether neuronal CX3CR1 could affect the function of neurons and mediate motor dysfunction under physiological conditions is unknown. To elucidate the roles of neuronal CX3CR1 on motor dysfunction, CX3CR1 knockout mice were created. Rotarod test and Open field test found that the CX3CR1-/- mice's motor capacity was reduced. Immunofluoresce...
Source: Behavioural Brain Research - December 25, 2023 Category: Neurology Authors: Jingchun Pei Yongwei Zou Cheng Wan Shuangshuang Liu Bin Hu Zhigao Li Zhiwei Tang Source Type: research
LPC20K modified from krill oil ameliorates the scopolamine-induced cognitive impairment
Behav Brain Res. 2023 Dec 23:114836. doi: 10.1016/j.bbr.2023.114836. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by cognitive impairment. It is common in the elderly. Etiologically, dysfunction of cholinergic neurotransmitter system is prominent in AD. However, disease modifying drug for AD is still unavailable. We hypothesized that krill oil and modified krill oil containing 20% lysophosphatidylcholine-docosahexaenoic acid (LPC-DHA, LPC20K) could play a crucial role in AD by improving cognitive functions measured by several behavioral tests. We found that LPC20K could ameliorate short-term, lon...
Source: Behavioural Brain Research - December 25, 2023 Category: Neurology Authors: Keontae Park Chang Hyeon Kong Woo Chang Kang Mijin Jeon Won Hyung Lee Juyeon Lee Sang Chul Kim Seo Yun Jung Jong Hoon Ryu Source Type: research
CX3CR1 mediates Motor Dysfunction in Mice through 5-HTR2a
Behav Brain Res. 2023 Dec 23:114837. doi: 10.1016/j.bbr.2023.114837. Online ahead of print.ABSTRACTCX3CR1 knockout could induce motor dysfunction in several neurological disease models mainly through regulating microglia's function. While CX3CR1 was expressed on neurons in a few reports, whether neuronal CX3CR1 could affect the function of neurons and mediate motor dysfunction under physiological conditions is unknown. To elucidate the roles of neuronal CX3CR1 on motor dysfunction, CX3CR1 knockout mice were created. Rotarod test and Open field test found that the CX3CR1-/- mice's motor capacity was reduced. Immunofluoresce...
Source: Behavioural Brain Research - December 25, 2023 Category: Neurology Authors: Jingchun Pei Yongwei Zou Cheng Wan Shuangshuang Liu Bin Hu Zhigao Li Zhiwei Tang Source Type: research
LPC20K modified from krill oil ameliorates the scopolamine-induced cognitive impairment
Behav Brain Res. 2023 Dec 23:114836. doi: 10.1016/j.bbr.2023.114836. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is characterized by cognitive impairment. It is common in the elderly. Etiologically, dysfunction of cholinergic neurotransmitter system is prominent in AD. However, disease modifying drug for AD is still unavailable. We hypothesized that krill oil and modified krill oil containing 20% lysophosphatidylcholine-docosahexaenoic acid (LPC-DHA, LPC20K) could play a crucial role in AD by improving cognitive functions measured by several behavioral tests. We found that LPC20K could ameliorate short-term, lon...
Source: Behavioural Brain Research - December 25, 2023 Category: Neurology Authors: Keontae Park Chang Hyeon Kong Woo Chang Kang Mijin Jeon Won Hyung Lee Juyeon Lee Sang Chul Kim Seo Yun Jung Jong Hoon Ryu Source Type: research
Sex differences in the anticompulsive-like effect of memantine: involvement of nitric oxide pathway but not AMPA receptors
Behav Brain Res. 2023 Dec 22:114834. doi: 10.1016/j.bbr.2023.114834. Online ahead of print.ABSTRACTMemantine, an N-Methyl-D-Aspartate (NMDA) antagonist, has been examined as a potential treatment for Obsessive-Compulsive Disorder (OCD). Yet, there is limited knowledge regarding how it works to reduce compulsive behaviour and whether it has different effects on individuals based on their sex. Herein, we investigated if there are sex differences in the anticompulsive-like effect of memantine in adult Swiss mice. Additionally, we explored whether the nitric oxide (NO) pathway and α-amino-3-hydroxy-5-methyl-4-isoazolepropioni...
Source: Behavioural Brain Research - December 24, 2023 Category: Neurology Authors: Breno Lopes Macedo Mariana Friedrich Veloso Isabella Braun Dias J úlia Grigorini Mori Ayub Vanessa Beijamini Source Type: research
Copaifera langsdorffii Desf. tree oleoresin-induced antinociception recruits µ < sub > 1 < /sub > - and κ -opioid receptors in the ventrolateral columns of the periaqueductal grey matter
Behav Brain Res. 2023 Dec 22:114832. doi: 10.1016/j.bbr.2023.114832. Online ahead of print.ABSTRACTPopular medicine has been using oleoresin from several species of copaiba tree for the treatment of various diseases and its clinical administration potentially causes antinociception. Electrical stimulation of ventrolateral (vlPAG) and dorsolateral (dlPAG) columns of the periaqueductal gray matter also causes antinociception. The aim this study was to verify the antinociceptive effect of oleoresin extracted from Copaifera langsdorffii tree and to test the hypothesis that oleoresin-induced antinociception is mediated by µ1- ...
Source: Behavioural Brain Research - December 24, 2023 Category: Neurology Authors: Vanessa Cristina Santana Bruna Magda Marmentini Ge órgia Guedes Cruz Leila Camila de Jesus Luana Walicheski F ábio Henrique Beffa Talles Henrique Pichinelli Maffei Rafaela Vieira Streg Valdir Flor êncio Veiga-Júnior Carla Regina Andrighetti Milena Cam Source Type: research
Long-term Impacts of Prenatal Maternal Immune Activation and Postnatal Maternal Separation on Maternal behavior in Adult Female Rats: Relevance to Postpartum Mental Disorders
Behav Brain Res. 2023 Dec 22:114831. doi: 10.1016/j.bbr.2023.114831. Online ahead of print.ABSTRACTEarly life adversities are known to exert long-term negative impacts on psychological and brain functions in adulthood. The present work examined how a prenatal brain insult and a postnatal stressor independently or interactively influence the quality of maternal care of postpartum female rats and their cognitive and emotional functions, as a way to identify the behavioral dysfunctions underlying childhood trauma-induced postpartum mental disorders (as indexed by impaired maternal care). Sprague-Dawley female offspring born f...
Source: Behavioural Brain Research - December 24, 2023 Category: Neurology Authors: Shinnyi Chou Ruiyong Wu Ming Li Source Type: research
The role of serotonin in modulating social competence in a cooperatively breeding fish
Behav Brain Res. 2023 Dec 21:114819. doi: 10.1016/j.bbr.2023.114819. Online ahead of print.ABSTRACTBehavioural interactions between conspecifics rely on the appreciation of social cues, which is achieved through biochemical switching of pre-existing neurophysiological pathways. Serotonin is one of the major neurotransmitters in the central nervous system responsible for the modulation of physiological and behavioural traits, in particular social behaviour. The relative importance of serotonin in modulating optimal social responses to the available social information (i.e., social competence) is yet unknown. Here we investi...
Source: Behavioural Brain Research - December 23, 2023 Category: Neurology Authors: Diogo F Antunes Pia R Stettler Taborsky Barbara Source Type: research
Differential effect of chronic mild stress on anxiety and depressive-like behaviors in three strains of male and female laboratory mice
Behav Brain Res. 2023 Dec 21:114829. doi: 10.1016/j.bbr.2023.114829. Online ahead of print.ABSTRACTMajor depressive disorder is the most common psychiatric disorder worldwide. To understand mechanisms and search for new approaches to treating depression, animal models are crucial. Chronic mild stress (CMS) is the most used animal model of depression. Although CMS is considered a robust model of depression, conflicting results have been reported for emotion-related behaviors, which the intrinsic characteristics of each rodent strain could explain. To further shed light on the impact of genetic background on the relevant par...
Source: Behavioural Brain Research - December 23, 2023 Category: Neurology Authors: Carlos Medina-Saldivar Sergio Cruz-Visalaya Anzu Zevallos-Arias Grace V E Pardo Luis F Pacheco-Ot álora Source Type: research
