Sex differences in the anticompulsive-like effect of memantine: involvement of nitric oxide pathway but not AMPA receptors
Behav Brain Res. 2023 Dec 22:114834. doi: 10.1016/j.bbr.2023.114834. Online ahead of print.ABSTRACTMemantine, an N-Methyl-D-Aspartate (NMDA) antagonist, has been examined as a potential treatment for Obsessive-Compulsive Disorder (OCD). Yet, there is limited knowledge regarding how it works to reduce compulsive behaviour and whether it has different effects on individuals based on their sex. Herein, we investigated if there are sex differences in the anticompulsive-like effect of memantine in adult Swiss mice. Additionally, we explored whether the nitric oxide (NO) pathway and α-amino-3-hydroxy-5-methyl-4-isoazolepropioni...
Source: Behavioural Brain Research - December 24, 2023 Category: Neurology Authors: Breno Lopes Macedo Mariana Friedrich Veloso Isabella Braun Dias J úlia Grigorini Mori Ayub Vanessa Beijamini Source Type: research
Copaifera langsdorffii Desf. tree oleoresin-induced antinociception recruits µ < sub > 1 < /sub > - and κ -opioid receptors in the ventrolateral columns of the periaqueductal grey matter
Behav Brain Res. 2023 Dec 22:114832. doi: 10.1016/j.bbr.2023.114832. Online ahead of print.ABSTRACTPopular medicine has been using oleoresin from several species of copaiba tree for the treatment of various diseases and its clinical administration potentially causes antinociception. Electrical stimulation of ventrolateral (vlPAG) and dorsolateral (dlPAG) columns of the periaqueductal gray matter also causes antinociception. The aim this study was to verify the antinociceptive effect of oleoresin extracted from Copaifera langsdorffii tree and to test the hypothesis that oleoresin-induced antinociception is mediated by µ1- ...
Source: Behavioural Brain Research - December 24, 2023 Category: Neurology Authors: Vanessa Cristina Santana Bruna Magda Marmentini Ge órgia Guedes Cruz Leila Camila de Jesus Luana Walicheski F ábio Henrique Beffa Talles Henrique Pichinelli Maffei Rafaela Vieira Streg Valdir Flor êncio Veiga-Júnior Carla Regina Andrighetti Milena Cam Source Type: research
Long-term Impacts of Prenatal Maternal Immune Activation and Postnatal Maternal Separation on Maternal behavior in Adult Female Rats: Relevance to Postpartum Mental Disorders
Behav Brain Res. 2023 Dec 22:114831. doi: 10.1016/j.bbr.2023.114831. Online ahead of print.ABSTRACTEarly life adversities are known to exert long-term negative impacts on psychological and brain functions in adulthood. The present work examined how a prenatal brain insult and a postnatal stressor independently or interactively influence the quality of maternal care of postpartum female rats and their cognitive and emotional functions, as a way to identify the behavioral dysfunctions underlying childhood trauma-induced postpartum mental disorders (as indexed by impaired maternal care). Sprague-Dawley female offspring born f...
Source: Behavioural Brain Research - December 24, 2023 Category: Neurology Authors: Shinnyi Chou Ruiyong Wu Ming Li Source Type: research
The role of serotonin in modulating social competence in a cooperatively breeding fish
Behav Brain Res. 2023 Dec 21:114819. doi: 10.1016/j.bbr.2023.114819. Online ahead of print.ABSTRACTBehavioural interactions between conspecifics rely on the appreciation of social cues, which is achieved through biochemical switching of pre-existing neurophysiological pathways. Serotonin is one of the major neurotransmitters in the central nervous system responsible for the modulation of physiological and behavioural traits, in particular social behaviour. The relative importance of serotonin in modulating optimal social responses to the available social information (i.e., social competence) is yet unknown. Here we investi...
Source: Behavioural Brain Research - December 23, 2023 Category: Neurology Authors: Diogo F Antunes Pia R Stettler Taborsky Barbara Source Type: research
Differential effect of chronic mild stress on anxiety and depressive-like behaviors in three strains of male and female laboratory mice
Behav Brain Res. 2023 Dec 21:114829. doi: 10.1016/j.bbr.2023.114829. Online ahead of print.ABSTRACTMajor depressive disorder is the most common psychiatric disorder worldwide. To understand mechanisms and search for new approaches to treating depression, animal models are crucial. Chronic mild stress (CMS) is the most used animal model of depression. Although CMS is considered a robust model of depression, conflicting results have been reported for emotion-related behaviors, which the intrinsic characteristics of each rodent strain could explain. To further shed light on the impact of genetic background on the relevant par...
Source: Behavioural Brain Research - December 23, 2023 Category: Neurology Authors: Carlos Medina-Saldivar Sergio Cruz-Visalaya Anzu Zevallos-Arias Grace V E Pardo Luis F Pacheco-Ot álora Source Type: research
Empagliflozin alleviates diabetes-induced cognitive impairments by lowering nicotinamide adenine dinucleotide phosphate oxidase-4 expression and potentiating the antioxidant defense system in brain tissue of diabetic rats
CONCLUSION: Uncontrolled diabetes negatively impacts mental function and impairs learning and cognitive performance via oxidative stress induction, the Nox-4 enzyme playing a central role. Empagliflozin reverses these effects, improving cognitive ability via promoting the anti-oxidative system and damping Nox-4 free radical generator enzyme expression. Therefore, empagliflozin is a promising treatment, providing both antidiabetic and extra-glycemic benefits for improving brain function in the diabetic milieu.PMID:38141785 | DOI:10.1016/j.bbr.2023.114830 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - December 23, 2023 Category: Neurology Authors: Habib Yaribeygi Mohammad Amin Hemmati Fatemeh Nasimi Roghayeh Pakdel Tannaz Jamialahmadi Amirhossein Sahebkar Source Type: research
The role of serotonin in modulating social competence in a cooperatively breeding fish
Behav Brain Res. 2023 Dec 21:114819. doi: 10.1016/j.bbr.2023.114819. Online ahead of print.ABSTRACTBehavioural interactions between conspecifics rely on the appreciation of social cues, which is achieved through biochemical switching of pre-existing neurophysiological pathways. Serotonin is one of the major neurotransmitters in the central nervous system responsible for the modulation of physiological and behavioural traits, in particular social behaviour. The relative importance of serotonin in modulating optimal social responses to the available social information (i.e., social competence) is yet unknown. Here we investi...
Source: Behavioural Brain Research - December 23, 2023 Category: Neurology Authors: Diogo F Antunes Pia R Stettler Taborsky Barbara Source Type: research
Differential effect of chronic mild stress on anxiety and depressive-like behaviors in three strains of male and female laboratory mice
Behav Brain Res. 2023 Dec 21:114829. doi: 10.1016/j.bbr.2023.114829. Online ahead of print.ABSTRACTMajor depressive disorder is the most common psychiatric disorder worldwide. To understand mechanisms and search for new approaches to treating depression, animal models are crucial. Chronic mild stress (CMS) is the most used animal model of depression. Although CMS is considered a robust model of depression, conflicting results have been reported for emotion-related behaviors, which the intrinsic characteristics of each rodent strain could explain. To further shed light on the impact of genetic background on the relevant par...
Source: Behavioural Brain Research - December 23, 2023 Category: Neurology Authors: Carlos Medina-Saldivar Sergio Cruz-Visalaya Anzu Zevallos-Arias Grace V E Pardo Luis F Pacheco-Ot álora Source Type: research
Empagliflozin Alleviates Diabetes-Induced Cognitive Impairments by Lowering Nicotinamide Adenine Dinucleotide Phosphate Oxidase-4 Expression and Potentiating the Antioxidant Defense System in Brain Tissue of Diabetic Rats
CONCLUSION: Uncontrolled diabetes negatively impacts mental function and impairs learning and cognitive performance via oxidative stress induction, the Nox-4 enzyme playing a central role. Empagliflozin reverses these effects, improving cognitive ability via promoting the anti-oxidative system and damping Nox-4 free radical generator enzyme expression. Therefore, empagliflozin is a promising treatment, providing both antidiabetic and extra-glycemic benefits for improving brain function in the diabetic milieu.PMID:38141785 | DOI:10.1016/j.bbr.2023.114830 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - December 23, 2023 Category: Neurology Authors: Habib Yaribeygi Mohammad Amin Hemmati Fatemeh Nasimi Roghayeh Pakdel Tannaz Jamialahmadi Amirhossein Sahebkar Source Type: research
Extraction of brain function pattern with visual-capture-task fMRI using dynamic time-window method in ADHD children
Behav Brain Res. 2023 Dec 20:114828. doi: 10.1016/j.bbr.2023.114828. Online ahead of print.ABSTRACTAttention deficit/Hyperactivity disorder (ADHD) has a great impact on children's development. This paper uses a novel adaptive brain state extraction algorithm to construct a dynamic time-window brain network, which captures the brain function pattern characteristics of ADHD children with higher temporal resolution. The test data were acquired by functional magnetic resonance imaging (fMRI) obtained from 23 children with ADHD during the visual-capture-task [age: (8.27 ± 2.77)]. A spatial standard deviation method is used aft...
Source: Behavioural Brain Research - December 22, 2023 Category: Neurology Authors: Zhiwei Song Zhihao Zhu Han Zhang Suhong Wang Ling Zou Source Type: research
Are blind individuals immune to bodily illusions? Somatic rubber hand illusion in the blind revisited
Behav Brain Res. 2023 Dec 20:114818. doi: 10.1016/j.bbr.2023.114818. Online ahead of print.ABSTRACTMultisensory awareness of one's own body relies on the integration of signals from various sensory modalities such as vision, touch, and proprioception. But how do blind individuals perceive their bodies without visual cues, and does the brain of a blind person integrate bodily senses differently from a sighted person? To address this question, we aimed to replicate the only two previous studies on this topic, which claimed that blind individuals do not experience the somatic rubber hand illusion, a bodily illusion triggered ...
Source: Behavioural Brain Research - December 22, 2023 Category: Neurology Authors: Dominika Radziun Maksymilian Korczyk Marcin Szwed H Henrik Ehrsson Source Type: research
Evaluation of a headphones-fitted EEG system for the recording of auditory evoked potentials and mental workload assessment
In this study, we evaluated the relevance of a headphone- mounted electroencephalogram (EEG) system for monitoring mental workload. The participants (N=12) were instructed to pay attention to auditory alarms presented sporadically while performing the Multi-Attribute Task Battery (MATB) whose difficulty was staged across three conditions to manipulate mental workload. The P300 Event-Related Potentials (ERP) elicited by the presentation of auditory alarms were used as probes of attentional resources available. The amplitude and latency of P300 ERPs were compared across experimental conditions. Our findings indicate that the...
Source: Behavioural Brain Research - December 21, 2023 Category: Neurology Authors: Simon Ladouce Max Pietzker Dietrich Manzey Frederic Dehais Source Type: research
Bifidobacterium breve M-16V regulates the autonomic nervous system via the intestinal environment: A double-blind, placebo-controlled study
Behav Brain Res. 2023 Dec 19:114820. doi: 10.1016/j.bbr.2023.114820. Online ahead of print.ABSTRACTWe conducted a randomized controlled trial to investigate the potential of Bifidobacterium breve M-16V to improve mood in humans. In this evaluation, we incorporated the use of near-infrared spectroscopy (NIRS), which has been used to evaluate mood states in studies with small sample sizes. Participants were given B. breve M-16V (20 billion cells/day) for 6 weeks, and their mood state was assessed before and after ingestion. NIRS data were collected at rest and during a mental arithmetic task (under stress). Intake of B. brev...
Source: Behavioural Brain Research - December 21, 2023 Category: Neurology Authors: Natsumi Mutoh Masamichi Moriya Chendong Xu Kumiko Kato Satoshi Arai Noriyuki Iwabuchi Miyuki Tanaka Yin Jinghua Ronko Itamura Kaoru Sakatani Shinichi Warisawa Source Type: research
Evaluation of a headphones-fitted EEG system for the recording of auditory evoked potentials and mental workload assessment
In this study, we evaluated the relevance of a headphone- mounted electroencephalogram (EEG) system for monitoring mental workload. The participants (N=12) were instructed to pay attention to auditory alarms presented sporadically while performing the Multi-Attribute Task Battery (MATB) whose difficulty was staged across three conditions to manipulate mental workload. The P300 Event-Related Potentials (ERP) elicited by the presentation of auditory alarms were used as probes of attentional resources available. The amplitude and latency of P300 ERPs were compared across experimental conditions. Our findings indicate that the...
Source: Behavioural Brain Research - December 21, 2023 Category: Neurology Authors: Simon Ladouce Max Pietzker Dietrich Manzey Frederic Dehais Source Type: research
Bifidobacterium breve M-16V regulates the autonomic nervous system via the intestinal environment: A double-blind, placebo-controlled study
Behav Brain Res. 2023 Dec 19:114820. doi: 10.1016/j.bbr.2023.114820. Online ahead of print.ABSTRACTWe conducted a randomized controlled trial to investigate the potential of Bifidobacterium breve M-16V to improve mood in humans. In this evaluation, we incorporated the use of near-infrared spectroscopy (NIRS), which has been used to evaluate mood states in studies with small sample sizes. Participants were given B. breve M-16V (20 billion cells/day) for 6 weeks, and their mood state was assessed before and after ingestion. NIRS data were collected at rest and during a mental arithmetic task (under stress). Intake of B. brev...
Source: Behavioural Brain Research - December 21, 2023 Category: Neurology Authors: Natsumi Mutoh Masamichi Moriya Chendong Xu Kumiko Kato Satoshi Arai Noriyuki Iwabuchi Miyuki Tanaka Yin Jinghua Ronko Itamura Kaoru Sakatani Shinichi Warisawa Source Type: research
