Physical exercise mitigates behavioral impairments in a rat model of sporadic Alzheimer's Disease.
atilde;es J Abstract Physical exercise has proven to be beneficial to mitigate several deleterious effects associated with neurodegenerative diseases, including Alzheimer's Disease (AD). Here, we investigated the role of long-term exercise as a preventive and therapeutic tool against AD cognitive and behavioral impairments using a sporadic AD-like rat model, established through the administration of streptozotocin (STZ) inside both cerebral ventricles (icv). Six-weeks-old Wistar male rats (56) were divided into groups (either saline or STZ): sedentary (Sed), voluntary physical activity (VPA), VPA + e...
Source: Behavioural Brain Research - November 13, 2019 Category: Neurology Authors: Bernardo TC, Beleza J, Rizo-Roca D, Santos-Alves E, Leal C, Martins MJ, Ascensão A, Magalhães J Tags: Behav Brain Res Source Type: research

Cyclic changes and actions of progesterone and allopregnanolone on cognition and hippocampal basal (stratum oriens) dendritic spines of female rats.
A, Picazo O Abstract Ovarian steroids modulate the neuronal structure and function during the estrous cycle, contrasting peak effects during the proestrus cycle and low effects during the metestrus cycle. An ovariectomy (OVX) decreases gonadal hormones and tests the effects of substitutive therapies. We studied female rats with a normal estrous cycle and we also studied the effects of systemic progesterone (P4, 4.0 mg/kg) or its reduced metabolite allopregnanolone (ALLO, 4.0 mg/kg, both for 10 days) in females who had had an OVX 16.5 weeks prior to the study (long-term OVX) with the novel object reco...
Source: Behavioural Brain Research - November 12, 2019 Category: Neurology Authors: Barreto Cordero LM, Carrillo JR, Roldán-Roldán G, Rasia-Filho AA, Flores G, Bringas ME, Briones-Aranda A, Picazo O Tags: Behav Brain Res Source Type: research

Catecholaminergic hippocampal activation is necessary for object recognition memory persistence induced by one-single physical exercise session.
CATECHOLAMINERGIC HIPPOCAMPAL ACTIVATION IS NECESSARY FOR OBJECT RECOGNITION MEMORY PERSISTENCE INDUCED BY ONE-SINGLE PHYSICAL EXERCISE SESSION. Behav Brain Res. 2019 Nov 12;:112356 Authors: Vargas LS, Ramires Lima K, Piaia Ramborger B, Roehrs R, Izquierdo I, Mello-Carpes PB Abstract Previously we demonstrated that a single physical exercise session promotes the persistence of object recognition (OR) memory and this effect involves the activation of the noradrenergic system. Here, using adult male Wistar rats (3 months old) we confirm that an aerobic single physical exercise session (30 min of treadmi...
Source: Behavioural Brain Research - November 12, 2019 Category: Neurology Authors: Vargas LS, Ramires Lima K, Piaia Ramborger B, Roehrs R, Izquierdo I, Mello-Carpes PB Tags: Behav Brain Res Source Type: research

Dynamic task observation: A gaze-mediated complement to traditional action observation treatment?
Abstract Action observation elicits changes in primary motor cortex known as motor resonance, a phenomenon thought to underpin several functions, including our ability to understand and imitate others' actions. Motor resonance is modulated not only by the observer's motor expertise, but also their gaze behaviour. The aim of the present study was to investigate motor resonance and eye movements during observation of a dynamic goal-directed action, relative to an everyday one - a reach-grasp-lift (RGL) action, commonly used in action-observation-based neurorehabilitation protocols. Skilled and novice golfers watched...
Source: Behavioural Brain Research - November 11, 2019 Category: Neurology Authors: D'Innocenzo G, Nowicky AV, Bishop DT Tags: Behav Brain Res Source Type: research

A novel experimental paradigm with improved ecological validity reveals robust action-associated enhancement of the N1 visual event-related potential in healthy adults.
Csifcsák G Abstract The association between an action and its sensory consequence has been linked to our sense of agency (SoA). While ecological validity is crucial in investigating such a complex phenomenon, previous paradigms focusing on the cortical analysis of movement-related images used simplified experimental protocols. Here, we examined the influence of action-associated predictive processes on visual event-related potentials (ERPs) in a paradigm that models everyday actions more precisely, using a commercial gesture control device, ecological stimuli depicting a human hand and a behavioural trainin...
Source: Behavioural Brain Research - November 11, 2019 Category: Neurology Authors: Balla VR, Szalóki S, Kilencz T, Dalos VD, Németh R, Csifcsák G Tags: Behav Brain Res Source Type: research

Automated radial 8-arm maze: A voluntary and stress-free behavior test to assess spatial learning and memory in mice.
Abstract The radial arm maze (RAM) is a common behavioral test to assess spatial working and reference memory in mice. However, conventional RAM experiments require a substantial degree of manual handling and animals are usually subjected to prolonged periods of food or water deprivation to achieve sufficient learning motivation resulting in stress-induced confounding effects and unwanted intra- and inter-subject variation. In a proof-of-concept approach to improve reliability and repeatability of results by refining the conventional maze methodology, we developed a voluntary, fully automated 8-arm RAM and tested ...
Source: Behavioural Brain Research - November 10, 2019 Category: Neurology Authors: Mei J, Kohler J, Spies C, Endres M, Banneke S, Emmrich JV Tags: Behav Brain Res Source Type: research

Adult neurogenesis and the dentate gyrus: predicting function from form.
Abstract Hypotheses about the functional properties of the dentate gyrus and adult dentate neurogenesis have been shaped by early observations of the anatomy of this region, mostly in rodents. This has led to the development of a few core propositions that have guided research over the past several years, including the predicted role of this region in pattern separation and the local transformation of inputs from the entorhinal cortex. We now have the opportunity to review these predictions and update these anatomical observations based on recently developed techniques that reveal the complex structure, connectivi...
Source: Behavioural Brain Research - November 10, 2019 Category: Neurology Authors: Christian KM, Ming GL, Song H Tags: Behav Brain Res Source Type: research

Haloperidol-Induced Hypokinesia in Rats is Differentially Affected by the Light/Dark Phase, Age, and Melatonin.
Abstract It has been well established that the striatal dopaminergic system is compromised with aging, namely D2 receptor function. Also well documented is the age related decline of the neurohormone, melatonin, in both humans and nonhuman animals. What has not been well studied is the possible interaction between the D2 receptor system and the age related decline in melatonin with its unmistakable pattern of synthesis and release exclusively during the dark phase. We tested the effect of the D2 antagonist, haloperidol (1.0 mg/kg ip), in adolescent (2 mo old) and adult rats (10 mo old) in the light (ZT3) an...
Source: Behavioural Brain Research - November 9, 2019 Category: Neurology Authors: Hussain S, Villarreal S, Ramirez N, Hussain A, Sumaya IC Tags: Behav Brain Res Source Type: research

Vitamin C Attenuates Memory Loss Induced by Post-Traumatic Stress like Behavior in a Rat Model.
Abstract Oxidative stress is associated with neuronal damage in many brain regions including the hippocampus; an area in the brain responsible of memory processing. Oxidative stress is also linked with many psychiatric conditions including post-traumatic stress disorder (PTSD). PTSD is triggered by traumatic experience and many PTSD patients show signs of memory impairment. Vitamin C is a water-soluble vitamin with antioxidant properties. Herein, we hypothesized that memory impairment observed during PTSD could be a result of oxidative stress in hippocampal tissues and that prophylactic vitamin C administration ma...
Source: Behavioural Brain Research - November 8, 2019 Category: Neurology Authors: Alzoubi KH, Shatnawi AF, Al-Qudah MA, Alfaqih MA Tags: Behav Brain Res Source Type: research

Role of orexinergic receptors in the dentate gyrus of the hippocampus in the acquisition and expression of morphine-induced conditioned place preference in rats.
This study examined the effects of intra-DG orexin-1 (OX1) and orexin-2 (OX2) receptor antagonists on the acquisition and expression of CPP induced by morphine. Two separate cannulas were inserted bilaterally into the DG, and a CPP paradigm was performed. The CPP scores and locomotor activities were recorded using Ethovision software. The results showed that intra-DG microinjection of SB334867 as a selective OX1R antagonist (0.5, 2.5, 12.5 nM/0.5 µl DMSO) or TCSOX229 as a selective OX2R antagonist (0.5, 2.5, 12.5 nM/0.5 µl DMSO) before a morphine subcutaneous injection (5 mg/k...
Source: Behavioural Brain Research - November 8, 2019 Category: Neurology Authors: Shirazy M, RayatSanati K, Jamali S, Haghparast A Tags: Behav Brain Res Source Type: research

Medial preoptic estrogen receptor-beta blunts the estrogen receptor-alpha mediated increases in wheel-running behavior of female rats.
Abstract Estrogens are believed to enhance rodent voluntary wheel-running through medial preoptic (mPOA) estrogen receptor α (ERα) signaling, with little role attributed to estrogen receptor β (ERβ). Systemic ERβ activation has been shown to mitigate ERα driven increases in wheel-running. Therefore, the present goal was to determine whether ERβ signaling in the mPOA plays a similar modulatory role over ERα. We utilized outbred wild-type (WT) and rats selectively bred for low voluntary running (LVR) behavior to address whether mPOA ERβ signaling blunts ERα driv...
Source: Behavioural Brain Research - November 8, 2019 Category: Neurology Authors: Grigsby KB, Kovarik CM, Mao X, Booth FW Tags: Behav Brain Res Source Type: research

Novel object recognition memory in REM sleep-deprived rats: role of the cannabinoid CB1 receptor.
Abstract A survey of the literature indicates that both rapid eye movement sleep deprivation (RSD) and activation of cannabinoid CB1 receptor (CB1R) may impair novel object recognition (NOR) memory in rodents. To our knowledge, so far, no previous study has investigated the probable effects of RSD on the different phases of NOR memory. Moreover, far too little attention has been paid to the potential role of the CB1R in the effects of RSD on object memory. Therefore, the major objective of this study was to investigate the probable role of the CB1R in the acquisition, consolidation, retrieval, and reconsolidation ...
Source: Behavioural Brain Research - November 8, 2019 Category: Neurology Authors: Shahveisi K, Khodamoradi M Tags: Behav Brain Res Source Type: research

Tetrahydrobiopterin administration facilitates amphetamine-induced dopamine release and motivation in mice.
sel S Abstract Dopamine (DA) is a critical neurotransmitter involved in motivational processes. Tetrahydrobiopterin (BH4) is an essential cofactor for tyrosine hydroxylase, the rate-limiting enzyme in DA synthesis. Decreases in BH4 levels are observed in several DA-related neuropsychiatric diseases involving impairment in motivation. Yet, whether BH4 could be used to treat motivational deficits has not been comprehensively investigated. To investigate the effects of exogenous BH4 administration on the dopaminergic system and related behaviors, we acutely injected mice with BH4 (50 mg/kg). Passage of BH4 thr...
Source: Behavioural Brain Research - November 8, 2019 Category: Neurology Authors: Fanet H, Ducrocq F, Tournissac M, Oummadi A, Lo A, Bourrassa P, De Smedt-Peyrusse V, Azzougen B, Capuron L, Layé S, Moussa F, Trifilieff P, Calon F, Vancassel S Tags: Behav Brain Res Source Type: research

The metaplastic effects of ketamine on sucrose renewal and contextual memory reconsolidation in rats.
In conclusion, the molecular analysis of ketamine metaplastic effects in key brain areas suggest a possible involvement of glutamatergic receptors in the inhibition of sucrose renewal but not of contextual memory reconsolidation. The inhibition of renewal could be correlated to hippocampal and accumbal decreased levels of GluA1 and mGluR5, whereas, the lack of effect on contextual memory reconsolidation could be correlated to decreased GluN2B expression in hippocampus, landmark of destabilization-insensitive state. PMID: 31706797 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - November 7, 2019 Category: Neurology Authors: Piva A, Caffino L, Padovani L, Pintori N, Mottarlini F, Sferrazza G, Paolone G, Fumagalli F, Chiamulera C Tags: Behav Brain Res Source Type: research

AMPK activation increases postoperative cognitive impairment in intermittent hypoxia rats via direct activating PAK2.
Abstract The pathogenesis of postoperative cognitive impairment of obstructive sleep apnea-hypopnea syndrome (OSAHS) individuals remains unclear. AMP activated protein kinase (AMPK) is a ubiquitous sensor/effector of cell stresses. Thus we detected the role and underlying mechanisms of AMPK in postoperative cognitive impairment of OSAHS individuals in intermittent hypoxia rats. Cognitive function was evaluated by novel object recognition test and Barnes maze during the first 4 days after laparotomy. We found that laparotomy induced postoperative cognitive impairment and AMPK activation in intermittent hypoxia rats...
Source: Behavioural Brain Research - November 7, 2019 Category: Neurology Authors: Mei X, Tan G, Qing W Tags: Behav Brain Res Source Type: research

Ketamine reverses the impaired fear memory extinction and accompanied depressive-like behaviors in adolescent mice.
In this study, to evaluate our hypothesis, we intraperitoneal (i.p.) injection of ketamine in adolescent mice and found that ketamine exhibited a rapid antidepressant effect and facilitated the fear memory extinction. Moreover, ketamine can also reverse the accompanied depressive-like behaviors and restore long-term potentiation (LTP) induction in extinction process, which involved the presynaptic mechanism. Our results suggest that ketamine exhibited an antidepressant effect in FST and facilitated the fear memory extinction via presynaptic-mediated synaptic plasticity, which may provide new strategy for treatment of PTSD....
Source: Behavioural Brain Research - November 6, 2019 Category: Neurology Authors: Wei MD, Wang YH, Lu K, Lv BJ, Wang Y, Chen WY Tags: Behav Brain Res Source Type: research

Cognitive performance of the MAM-E17 schizophrenia model rats in different age-periods.
acute;cs A, Zagoracz O, Berta B, Karádi Z, Ollmann T Abstract Cognitive disturbances are among the most important features of schizophrenia, and have a significant role in the outcome of the disease. However, the treatment of cognitive symptoms is poorly effective. In order to develop new therapeutic opportunities, the MAM-E17 rat model of schizophrenia can be an appropriate implement. In the present study we investigated several cognitive capabilities of MAM-treated rats using radial arm maze (RAM) task, which corresponds to the recent research directives. Because of the diachronic appearance of schizophre...
Source: Behavioural Brain Research - November 5, 2019 Category: Neurology Authors: Kállai V, Lénárd L, Péczely L, Gálosi R, Dusa D, Tóth A, László K, Kertes E, Kovács A, Zagoracz O, Berta B, Karádi Z, Ollmann T Tags: Behav Brain Res Source Type: research

Association of 11 β-Hydroxysteroid Dehydrogenase Type1 (HSD11b1) Gene Polymorphisms with Outcome of Antidepressant Therapy and Suicide Attempts.
This study aimed to assess whether HSD11B1 genotypes and haplotypes are associated with depression risk, severity of symptoms and suicidal attempts, considering early-life stress as an environmental factor. Here, 142 depressive patients and 103 healthy controls were included. Patients were enrolled from the Affective Disorders ambulatory and day hospital units, both within the University General Hospital of Ribeirao Preto. All subjects were clinically assessed applying the Mini-PLUS International Neuropsychiatric Interview, followed by the 21-item GRID-Hamilton Depression Scale, Childhood Trauma Questionnaire and Beck Scal...
Source: Behavioural Brain Research - November 5, 2019 Category: Neurology Authors: Figaro-Drumond FV, Pereira SC, Menezes IC, von Werne Baes C, Coeli-Lacchini FB, Oliveira-Paula GH, Cleare AJ, Young AH, Tanus-Santos JE, Juruena MF, Lacchini R Tags: Behav Brain Res Source Type: research

Sex, diurnal variation and retention interval differently affect performance of marmoset monkeys in a recognition memory task for object location.
Abstract In the spontaneous object-location (SOL) task, the ability to recognize where stimuli were located in a past encounter is assessed. Even if widely used in rodents, several aspects can affect task performance. It is thus important to assess potentially intervening variables in the new monkey SOL task. Here we assessed whether sex (male vs. females), circadian time (morning vs. afternoon) and retention interval (24 vs. 48 h) affect the performance of adult marmosets in this task. Two identical stimuli were initially explored on a 10-min sample trial. Thereafter, preferential exploration of the displa...
Source: Behavioural Brain Research - November 4, 2019 Category: Neurology Authors: Vannuchi CRS, Costa CS, de Jesus FM, Maior RS, Barros M Tags: Behav Brain Res Source Type: research

Association of decrease in insula fMRI activation with changes in trait anxiety in patients with craniomandibular disorder (CMD).
Abstract Patients with chronic pain and especially with craniomandibular disorder (CMD) show specific psychopathology in trait anxiety. In a previous longitudinal functional imaging study on CMD we found that the anterior insula was modulated by successful therapy intervention and pain relief. We here intended to investigate possible associations between anterior insula fMRI-activation during occlusal movements and trait anxiety over a splint therapy approach in patients with CMD. Three fMRI-investigations of a craniomandibular occlusion task were performed together with pain score evaluations and scoring of trait...
Source: Behavioural Brain Research - November 4, 2019 Category: Neurology Authors: Dammann J, Klepzig K, Schenkenberger E, Kordass B, Lotze M Tags: Behav Brain Res Source Type: research

The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice.
Abstract L-3,4-dihydroxyphenylalanine (L-DOPA) is currently the main drug used to treat Parkinson's disease (PD). However, long-term use of L-DOPA causes substantial side effects, and we hope to find a biological active ingredient that synergizes with a low-dose of L-DOPA to achieve the same therapeutic effect as that of a high-dose of L-DOPA. The natural product parthenolide (PTL) is the active ingredient in the medicinal plant feverfew (Tanacetum parthenium) and has antioxidant and anti-inflammatory properties. ACT001, a fumarate salt form of dimethylaminomicheliolide (DMAMCL), is a derivative of parthenolide an...
Source: Behavioural Brain Research - November 4, 2019 Category: Neurology Authors: Liu Q, Zhang S, Zhu D, Tang X, Che Y, Feng X Tags: Behav Brain Res Source Type: research

Rewarding effects of M4 but not M3 muscarinic cholinergic receptor antagonism in the rostromedial tegmental nucleus.
Abstract The rostromedial tegmental nucleus (RMTg) receives inputs from the laterodorsal tegmental and pedunculopontine tegmental nuclei, the two principle brainstem cholinergic nuclei. We tested the effects of RMTg M3 and M4 muscarinic cholinergic receptor antagonism in a conditioned place preference (CPP) paradigm in mice. RMTg infusions of the M3 muscarinic cholinergic receptor antagonist 1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide (4-DAMP) do not result in the acquisition of CPP but increase locomotor activation. By contrast, RMTg infusions of the M4 muscarinic cholinergic receptor antagonist Tropicamide...
Source: Behavioural Brain Research - November 4, 2019 Category: Neurology Authors: Buie N, Sodha D, Scheinman SB, Steidl S Tags: Behav Brain Res Source Type: research

Anabolic-androgenic steroid abuse and cognitive impairment: Testosterone IMPAIRS biconditional task performance in male rats.
Abstract Our goal is to understand the consequences of anabolic-androgenic steroid (AAS) abuse on cognitive function, using rats as a model. There is relatively little research on how AAS abuse impacts cognition. In the present study, rats were tested for their ability to use contextual information to guide decision-making in biconditional discrimination. The Stroop task is a classic human test for contextual decision-making. In rodents, biconditional discrimination challenges subjects to use contextual cues in the operant chamber to resolve the correct lever response when auditory and visual cues are incongruent....
Source: Behavioural Brain Research - November 4, 2019 Category: Neurology Authors: Wood RI, Serpa RO Tags: Behav Brain Res Source Type: research

Static and Dynamic Functional Connectivity of the Prefrontal Cortex during Resting-State Predicts Self-serving Bias in Depression.
Abstract Major depression disorder (MDD) is characterized by the lack of self-serving bias, which may inherently underlie the onset and maintenance of depression. Emerging neuroimaging evidences have indicated that the altered self-processing in MDD may be germane to the dysfunctional static resting-state functional connectivity (RSFC) of the prefrontal cortex (PFC). Although static RSFC studies provide tremendous amounts of evidences on functional changes in depression, explorations of dynamic RSFC among the PFC and other brain regions may elucidate the temporal changes of neural activities associated with depres...
Source: Behavioural Brain Research - November 4, 2019 Category: Neurology Authors: Cui G, Wang Y, Wang X, Zheng L, Li L, Li P, Zhang L, Guo Y, Chen Y, Sun Z, Meng X Tags: Behav Brain Res Source Type: research

Title: Blockade of muscarinic acetylcholine receptor by scopolamine impairs the memory formation of filial imprinting in domestic chicks (Gallus gallus domesticus).
In this study, we examined whether the imprinting acquisition in chick can be impaired by injecting muscarinic acetylcholine receptor (mAChR) antagonist scopolamine into the bilateral IMM. We show that the injection of scopolamine decreased the preference for the imprinting object in the test, but did not affect the number of approaches to the imprinting object during training. Immunoblotting and immunohistochemistry revealed that M3 receptors were expressed in the IMM. Our data suggest that acetylcholine is involved in the memory formation of imprinting through M3 receptors in the IMM. The scopolamine-injected chicks may ...
Source: Behavioural Brain Research - November 2, 2019 Category: Neurology Authors: Aoki N, Fujita T, Mori C, Fujita E, Yamaguchi S, Matsushima T, Homma KJ Tags: Behav Brain Res Source Type: research

Effects of enriched housing on the neuronal morphology of mice that lack zinc transporter 3 (ZnT3) and vesicular zinc.
ck RH Abstract In the central nervous system, certain neurons store zinc within the synaptic vesicles of their axon terminals. This vesicular zinc can then be released in an activity-dependent fashion as an intercellular signal. The functions of vesicular zinc are not entirely understood, but evidence suggests that it is important for some forms of experience-dependent plasticity in the brain. The ability of neurons to store and release vesicular zinc is dependent on expression of the vesicular zinc transporter, ZnT3. Here, we examined the neuronal morphology of mice that lack ZnT3. Brains were collected from mice...
Source: Behavioural Brain Research - November 2, 2019 Category: Neurology Authors: McAllister BB, Thackray SE, de la Orta BKG, Gosse E, Tak P, Chipak C, Rehal S, Valverde Rascón A, Dyck RH Tags: Behav Brain Res Source Type: research

The hippocampus, prefrontal cortex, and perirhinal cortex are critical to incidental order memory.
Abstract Considerable research in rodents and humans indicates the hippocampus and prefrontal cortex are essential for remembering temporal relationships among stimuli, and accumulating evidence suggests the perirhinal cortex may also be involved. However, experimental parameters differ substantially across studies, which limits our ability to fully understand the fundamental contributions of these structures. In fact, previous studies vary in the type of temporal memory they emphasize (e.g., order, sequence, or separation in time), the stimuli and responses they use (e.g., trial-unique or repeated sequences, and ...
Source: Behavioural Brain Research - November 1, 2019 Category: Neurology Authors: Allen LM, Lesyshyn RA, O'Dell SJ, Allen TA, Fortin NJ Tags: Behav Brain Res Source Type: research

Reward and Immune Responses in adolescent Females Following Experimental Traumatic Brain Injury.
Abstract The pathology of traumatic brain injury (TBI) adversely affects many brain regions, often resulting in the development of comorbid psychiatric disorders including substance use disorders (SUD). Although traditionally thought to be an epidemic that predominantly affects males, recent clinical studies report females have higher rates of concussions and longer recovery times than males. Yet, how neurotrauma, particularly deep within the brain, between the sexes is differentially manifested remains largely unknown. The risk of TBI peaks during adolescence when neuronal networks that regulate reward behaviors ...
Source: Behavioural Brain Research - November 1, 2019 Category: Neurology Authors: Cannella LA, Andrews A, Razmpour R, McGary H, Corbett C, Kahn J, Ramirez SH Tags: Behav Brain Res Source Type: research

Environmental Determinants of Behavioural Responses to Short-Term Stress in Rats: Evidence for Inhibitory Effect of Ambient Landmarks.
Abstract Behavioural responses to stress occur in an environment-dependent manner. Complex environments require flexible behavioural coping strategies and chronic stress usually generates psychomotor inhibition. Here, we examine if short-term stress also exerts an inhibitory effect on novelty-seeking, exploratory behaviours. Rats underwent acute restraint stress or were left undisturbed, and their neuroendocrine and behavioural responses were assessed at short- and long-term time points. Animals were individually tested in the open field task (OFT) and the corridor field task (CFT) with and without a central objec...
Source: Behavioural Brain Research - October 31, 2019 Category: Neurology Authors: Faraji J, Singh S, Soltanpour N, Sutherland RJ, Metz GAS Tags: Behav Brain Res Source Type: research

Prefrontal Working Memory Activity Predicts Episodic Memory Performance: A Neuroimaging Study.
Abstract Working memory (WM) and long term memory (LTM) are different neuropsychological processes, although distinction between these domains is an area of debate. LTM is thought to rely on hippocampal circuitry. Cognitive neuroscience models imply that WM processing may at least partially support LTM within regions of the prefrontal cortex (PFC). We sought to determine the association between PFC based WM processing and LTM in the visuospatial domain. In contrast to prior work, we aimed to query if WM was involved in learning and free recall trials as measured by standard neuropsychological tests of LTM. Forty-t...
Source: Behavioural Brain Research - October 30, 2019 Category: Neurology Authors: Melrose RJ, Zahniser E, Wilkins SS, Veliz J, Hasratian AS, Sultzer DL, Jimenez AM Tags: Behav Brain Res Source Type: research

Cortical Endogenous Opioids and Their Role in Facilitating Repetitive Behaviors in Deer Mice.
In this study, we pursue the mechanism of repetitive behaviors by performing stereological analyses and liquid chromatography/ mass spectrometry (LC-MS/MS) measurements of glutamate (Glut), GABA, 3,4-dihydroxyphenylacetic acid (DOPAC), dopamine (DA), leu-enkephalin (leu-enk), and dynorphin-A (dyn-A) in frontal cortex (FC), prefrontal cortex (PFC), and basal ganglia. The only significant stereological alteration was a negative correlation between repetitive behaviors and the cell count in the ventromedial striatum (VMS). Neurochemical analyses demonstrated a significant negative correlation between repetitive behaviors and ...
Source: Behavioural Brain Research - October 29, 2019 Category: Neurology Authors: Augustine F, Rajendran S, Singer HS Tags: Behav Brain Res Source Type: research

Methamphetamine administration impairs behavior, memory and underlying signaling pathways in the hippocampus.
Abstract Methamphetamine (METH) is a strong psychostimulant drug which can essentially affect different brain regions. Hippocampus as one of main components of limbic system plays key roles in processing of short term, long term and spatial memory. Herein, we explored the changes in behavior, synaptic transmission and hippocampal volume along with gliosis following METH treatment. Besides, using genome-wide expression profiling, we applied a pathway-based approach to detect significantly dysregulated signaling pathways. In this regard, we found that METH administration interrupts spatial memory and long term poten...
Source: Behavioural Brain Research - October 25, 2019 Category: Neurology Authors: Golsorkhdan SA, Boroujeni ME, Aliaghaei A, Abdollahifar MA, Ramezanpour A, Nejatbakhsh R, Anarkooli IJ, Barfi E, Fridoni MJ Tags: Behav Brain Res Source Type: research

Rapid anti-PTSD-like activity of the TSPO agonist YL-IPA08: emphasis on brain GABA, neurosteroids and HPA axis function.
Abstract There is a serious need for fast-acting drugs to treat post-traumatic stress disorder (PTSD). Our previous studies revealed that YL-IPA08, a novel small-molecule TSPO agonist, exerted significant anti-PTSD effects in various animal models. However, the onset time of YL-IPA08 and its underlying mechanisms remain unclear. In the present study, we first investigated the time course of YL-IPA08 compared to selective serotonin reuptake inhibitors (SSRIs) in the well-known time-dependent sensitization model of PTSD. YL-IPA08 required only 2-4 days of treatment to take effect in behavioural models of PTSD, where...
Source: Behavioural Brain Research - October 24, 2019 Category: Neurology Authors: Shang C, Guo Y, Yao JQ, Fang XX, Sun LJ, Jiang XY, Ding ZC, Ran YH, Wang HL, Zhang LM, Li YF Tags: Behav Brain Res Source Type: research

Cornel Iridoid Glycoside Improves Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion via Activating PI3K/Akt/GSK-3 β/CREB Pathway in Rats.
Cornel Iridoid Glycoside Improves Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion via Activating PI3K/Akt/GSK-3β/CREB Pathway in Rats. Behav Brain Res. 2019 Oct 24;:112319 Authors: Wang MY, Meng M, Yang CC, Zhang L, Li YL, Zhang L, Li L Abstract Chronic cerebral hypoperfusion is an important risk factor for vascular dementia (VaD) and other brain dysfunctions, for which there are currently no effective medications available. In the present study, we investigated the potential therapeutic effects of cornel iridoid glycoside (CIG) on VaD in rats modeled by permanent bilateral common ...
Source: Behavioural Brain Research - October 24, 2019 Category: Neurology Authors: Wang MY, Meng M, Yang CC, Zhang L, Li YL, Zhang L, Li L Tags: Behav Brain Res Source Type: research

Effects of dopamine and serotonin synthesis inhibitors on the ketamine-, d-amphetamine-, and cocaine-induced locomotor activity of preweanling and adolescent rats: sex differences.
Abstract The pattern of ketamine-induced locomotor activity varies substantially across ontogeny and according to sex. Although ketamine is classified as an NMDA channel blocker, it appears to stimulate the locomotor activity of both male and female rats via a monoaminergic mechanism. To more precisely determine the neural mechanisms underlying ketamine's actions, male and female preweanling and adolescent rats were pretreated with vehicle, the dopamine (DA) synthesis inhibitor ∝-methyl-DL-p-tyrosine (AMPT), or the serotonin (5-HT) synthesis inhibitor 4-chloro-DL-phenylalanine methyl ester hydrochloride (PCPA...
Source: Behavioural Brain Research - October 23, 2019 Category: Neurology Authors: McDougall SA, Rios JW, Apodaca MG, Park GI, Montejano NR, Taylor JA, Moran AE, Robinson JAM, Baum TJ, Teran A, Crawford CA Tags: Behav Brain Res Source Type: research

A Time-Based Intervention to Treat Impulsivity in Male and Female Rats.
Abstract Time-based interventions have emerged as promising treatments for disorders associated with impulsivity. These interventions can be implemented to test their efficacy in preventing or treating impulsive choice in animal models of diseases related to impulsivity such as drug abuse. Impulsive choice is typically defined as choosing a smaller-sooner (SS) reward over a larger-later (LL) reward when the LL is relatively more optimal. Previous research has shown that these interventions promote LL choices in males and females, but sex differences have not been assessed. Because sex differences can complicate th...
Source: Behavioural Brain Research - October 23, 2019 Category: Neurology Authors: Panfil K, Bailey C, Davis I, Mains A, Kirkpatrick K Tags: Behav Brain Res Source Type: research

The Temporal Choreography of the Yo-Yo Movement of Getting Spaghetti into the Mouth by the Head-Fixed Mouse.
PMID: 31655097 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - October 23, 2019 Category: Neurology Authors: Whishaw IQ, Ghasroddashti A, Agha BM, Mohajerani MH Tags: Behav Brain Res Source Type: research

Tactile stimulation of adult rats modulates hormonal responses, depression-like behaviors, and memory impairment induced by chronic mild stress: role of angiotensin II.
Abstract Physical touch can help to decrease the effects of stress. The aim of this study was to evaluate the influence of tactile stimulation on the hormonal and behavioral responses of young adult rats submitted to chronic mild unpredictable stress (CMS), considering the role of angiotensin II (Ang II). In Experiment 1, male rats were divided into 4 groups: control, stress, tactile stimulation (TS), and stress + TS. CMS was applied for three weeks. Tactile stimulation was applied for seven weeks, five days a week. After the CMS protocol, depression-like behaviors were evaluated by forced swimming a...
Source: Behavioural Brain Research - October 22, 2019 Category: Neurology Authors: Costa R, Leite Tamascia M, Sanches A, Peres Moreira R, Sousa Cunha T, Doki Nogueira M, Casarini DE, Klein Marcondes F Tags: Behav Brain Res Source Type: research

ASP2905, a specific inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3 gene, is psychoactive in mice and rats.
In this study, we used animal models of behavior to evaluate the antipsychotic activity of ASP2905, a potent and selective inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. ASP2905 inhibited hyperlocomotion induced by methamphetamine and by phencyclidine. In contrast, ASP2905 did not affect spontaneous locomotion, suggesting that ASP2905 selectively inhibits abnormal behaviors induced by stimulants. Chronic infusion of ASP2905 significantly ameliorated phencyclidine-induced prolongation of immobility time in mice subjected to the forced swimming test. These findings suggest that ASP2905 potentially ...
Source: Behavioural Brain Research - October 22, 2019 Category: Neurology Authors: Takahashi S, Okamura A, Yamazaki M, Ni K Tags: Behav Brain Res Source Type: research

Deferiprone ameliorates memory impairment in Scopolamine-treated rats: the impact of its iron-chelating effect on β-amyloid disposition.
This study investigated the potential neuroprotective and memory enhancing effects of the iron chelating drug, Deferiprone. Three doses (5, 10, and 20 mg/kg) were administered to rats treated with SCOP (1.14 mg/kg/day). Systemic administration of SCOP for seven days caused memory impairment which manifested as decreased time spent in platform quadrant in Morris water maze test, decreased retention latencies in passive avoidance test, and increased acetylcholinesterase (AChE) activity, Aβ, and free iron deposition. It was observed that pretreatment with Deferiprone increased platform quadrant time in Morr...
Source: Behavioural Brain Research - October 20, 2019 Category: Neurology Authors: Fawzi SF, Menze ET, Tadros MG Tags: Behav Brain Res Source Type: research

The Effects of Age on Cerebral Responses to Self-Initiated Actions during Social Interactions: An Exploratory Study.
Abstract Self-initiated action is critical to social interaction and individuals with social anxiety find it particularly difficult to initiate social interactions. We showed earlier that social exclusion encumbered self-initiated actions in the Cyberball task in young adults. Here, we examined whether behavioral performance and regional responses during self-initiated actions vary with age in 53 participants (21-74 years; 27 men). Behaviorally, participants were slower in tossing the ball during exclusion (EX) than during fair game (FG) sessions in both men and women. In women but not in men the reaction time (RT...
Source: Behavioural Brain Research - October 20, 2019 Category: Neurology Authors: Wang W, Zhornitsky S, Chao HH, Levy I, Joormann J, Li CR Tags: Behav Brain Res Source Type: research

Rosuvastatin improves olanzapine's effects on behavioral impairment and hippocampal, hepatic and metabolic damages in isolated reared male rats.
CONCLUSION: post-weaning IR as a model has behavioral, hippocampal, hepatic and marked metabolic changes more relevant to schizophrenia than drug-induced models. These effects were ameliorated by RSU and/or OLZ that are explained by their antioxidant, anti-inflammatory, anti-stress and anti-hyperlipidemic properties. Interestingly, co-treatment with both drugs showed a better effect. PMID: 31634496 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - October 18, 2019 Category: Neurology Authors: Mohammed A, El-Bakly WM, Ali A, El-Demerdash E Tags: Behav Brain Res Source Type: research

Enhanced methamphetamine-induced conditioned place preference in risk-taking rats.
In this study, we assessed individual differences in risk-taking behaviors using a rat gambling task (GT) and investigated the relationship between risk-taking behaviors and vulnerability to drug dependence using methamphetamine (METH)-induced conditioned place preference (CPP). In the GT using a radial arm maze, male Long-Evans rats were trained to choose one of three choice arms (a low-risk/low reward (L-L), a high-risk/high reward (H-H), and an empty arm) in 16 trials per day for 14 days. METH-induced CPP consisted of 6 sessions: habituation, conditioning, preference test (Test I), extinction, extinction test (Test II),...
Source: Behavioural Brain Research - October 18, 2019 Category: Neurology Authors: Takahashi K, Yamada K, Ichitani Y Tags: Behav Brain Res Source Type: research

Dissociation of wanting and liking in the sucrose preference test in dopamine transporter overexpressing rats.
Abstract The predominant theory of mesolimbic dopamine function in recent years has been the incentive salience hypothesis, which describes the role of midbrain dopaminergic circuits as encoding 'wanting', but not 'liking' of rewards, resulting in a dissociation of the two functions. However, until now, this dissociation was only established in separate behavioural assays. Here, we propose that the Sucrose Preference Test (SPT), which has previously been used to measure 'liking', can actually be interpreted in terms of both 'wanting' and 'liking': while relative preference is a proxy for 'liking', we argue that ab...
Source: Behavioural Brain Research - October 17, 2019 Category: Neurology Authors: Meyerolbersleben L, Winter C, Bernhardt N Tags: Behav Brain Res Source Type: research

The effects of early life stress on the excitatory/inhibitory balance of the medial prefrontal cortex.
Abstract Aversive environmental conditions during early life are known to cause long-lasting social deficits, similar to those observed in patients with neurodevelopmental disorders. However, the mechanism of how early life stress can cause social deficits is not well understood. To clarify how being in an aversive environment during development affects sociability, we conducted various analyses focusing on the excitatory and inhibitory (E/I) balance in the medial prefrontal cortex (mPFC) and how it is related to social deficits, with young adult male rats that had been exposed to maternal separation (MS). In our ...
Source: Behavioural Brain Research - October 17, 2019 Category: Neurology Authors: Ohta KI, Suzuki S, Warita K, Sumitani K, Tenkumo C, Ozawa T, Ujihara H, Kusaka T, Miki T Tags: Behav Brain Res Source Type: research

Effects of dietary 5-methoxyindole-2-carboxylic acid on brain functional recovery after ischemic stroke.
Abstract Stroke leads to devastating outcomes including impairments of sensorimotor and cognitive function that may be long lasting. New intervention strategies are needed to overcome the long-lasting effects of ischemic injury. Previous studies determined that treatment with 5-methoxyindole-2-carboxylic acid (MICA) conferred chemical preconditioning and neuroprotection against stroke. The purpose of the current study was to determine whether the preconditioning can lead to functional improvements after stroke (done by transient middle cerebral artery occlusion). After 4 weeks of MICA feeding, half the rats underw...
Source: Behavioural Brain Research - October 17, 2019 Category: Neurology Authors: Sumien N, Huang R, Chen Z, Vann PH, Wong JM, Li W, Yang S, Forster M, Yan LJ Tags: Behav Brain Res Source Type: research

Rewarding deep brain stimulation at the medial forebrain bundle favours avoidance conditioned response in a remote memory test, hinders extinction and increases neurogenesis.
, Segura-Torres P Abstract Intracranial Self-Stimulation (ICSS) at the medial forebrain bundle consistently facilitates learning and memory in rats when administered post-training or when administered non-concurrent to training, but its scope regarding remote memory has not yet been studied. The present work aims to test whether the combination of these two forms of ICSS administration can cause a greater persistence of the facilitating effect on remote retention and affect neurogenesis in the dentate gyrus (DG) of the hippocampus. Rats were trained in active avoidance conditioning and tested in two retention sess...
Source: Behavioural Brain Research - October 16, 2019 Category: Neurology Authors: Huguet G, Kádár E, Serrano N, Tapias-Espinosa C, García-Brito S, Morgado I, Aldavert-Vera L, Segura-Torres P Tags: Behav Brain Res Source Type: research

Potential causes of cognitive alterations in temporal lobe epilepsy.
Abstract Spatial and non-spatial memories are key processes whereby we process our environment on a daily basis, coding space, time and items to form unique memories. Both types of memory involve distributed and complex temporal lobe (TL) networks. In this review, we will discuss potential causes of spatial and non-spatial memory deficits, taking the example of temporal lobe epilepsy (TLE), a widespread neurological disorder characterized by cognitive comorbidities, in both animal models and TLE patients. We will start by briefly introducing TLE, then highlight by which underlying mechanisms TLE impairs TL-depende...
Source: Behavioural Brain Research - October 16, 2019 Category: Neurology Authors: Laetitia C Tags: Behav Brain Res Source Type: research

Inhibition of the left medial prefrontal cortex (mPFC) prolongs the social defeat-induced anxiogenesis in mice: Attenuation by NMDA receptor blockade in the right mPFC.
Abstract Chemical inhibition and nitrergic stimulation of the left and right medial prefrontal cortex (L and RmPFC), respectively, provoke anxiety in mice. Moreover, LmPFC inhibition immediately followed by a single social defeat stress (SDS) led to anxiogenesis in mice exposed to the elevated plus maze (EPM) 24 hours later. Given that glutamate NMDA (N-methyl-D-aspartate) receptors are densely present in the mPFC, we investigated (i) the time course of LmPFC inhibition + SDS-induced anxiogenesis and (ii) the effects of intra-RmPFC injection of AP-7 (a NMDA receptor antagonist) on this long-la...
Source: Behavioural Brain Research - October 16, 2019 Category: Neurology Authors: Victoriano G, Costa NS, Mascarenhas DC, Nunes-de-Souza RL Tags: Behav Brain Res Source Type: research

Enriched Environment Exposure Accelerates Rodent Driving Skills.
Abstract Although rarely used, long-term behavioral training protocols provide opportunities to shape complex skills in rodent laboratory investigations that incorporate cognitive, motor, visuospatial and temporal functions to achieve desired goals. In the current study, following preliminary research establishing that rats could be taught to drive a rodent operated vehicle (ROV) in a forward direction, as well as steer in more complex navigational patterns, male rats housed in an enriched environment were exposed to the rodent driving regime. Compared to standard-housed rats, enriched-housed rats demonstrated mor...
Source: Behavioural Brain Research - October 16, 2019 Category: Neurology Authors: Crawford LE, Knouse LE, Kent M, Vavra D, Harding O, LeServe D, Fox N, Hu X, Li P, Glory C, Lambert KG Tags: Behav Brain Res Source Type: research