Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors.
Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors. Behav Brain Res. 2017 Jun 03;: Authors: Benham RS, Hewage NB, Suckow RF, Engin E, Rudolph U Abstract Deficits in neuronal inhibition via gamma-aminobutyric acid (GABA) type A receptors (GABAA-Rs) are implicated in the pathophysiology of major depressive disorder and the therapeutic effects of current antidepressant treatments, however, the relevant GABAA-R subtype as defined by its alpha subunit is still unknown. We previously re...
Source: Behavioural Brain Research - June 3, 2017 Category: Neurology Authors: Benham RS, Hewage NB, Suckow RF, Engin E, Rudolph U Tags: Behav Brain Res Source Type: research

Effects of chronic cocaine, morphine and methamphetamine on the mobility, immobility and stereotyped behaviors in crayfish.
Abstract The worth of crayfish as a model system for studies of addiction was not previously recognized because a drug-reward phenomenon had not been documented in this model system. In our previous experiments, we demonstrate that the crayfish natural reward pathways are sensitive to human drugs of abuse. This finding supports crayfish as a suitable model to characterize specific behaviors that are relevant in drug addiction research, and the current study builds on our previous findings. The aim of the present study was to investigate unconditioned neurobehavioral effects of repeated treatment regimens using coc...
Source: Behavioural Brain Research - June 2, 2017 Category: Neurology Authors: Imeh-Nathaniel A, Rincon N, Orfanakos VB, Brechtel L, Wormack L, Richardson E, Huber R, Nathaniel TI Tags: Behav Brain Res Source Type: research

Chronic corticosterone-induced impaired cognitive flexibility is not due to suppressed adult hippocampal neurogenesis.
Abstract Hippocampal neurogenesis has been implicated in the etiology of depression. Recent studies suggest new neurons add flexibility to hippocampal-dependent learning and memory. We hypothesized that suppressed hippocampal neurogenesis may contribute to impaired cognitive flexibility associated with depression. The chronic corticosterone (CORT)-induced animal model of depression was used. In Experiment 1, rats received either CORT (40mg/kg) or vehicle injections for 21days and were subjected to Water maze during the last six days of drug treatment. No group differences were found during the spatial learning pha...
Source: Behavioural Brain Research - June 1, 2017 Category: Neurology Authors: Lui E, Salim M, Chahal M, Puri N, Marandi E, Quadrilatero J, Satvat E Tags: Behav Brain Res Source Type: research

Chronic Cerebral Hypoperfusion Independently Exacerbate Cognitive Impairment Within the pathopoiesis of Parkinson's disease via Microvascular Pathology.
Abstract To date, the role of microvascular pathology and CHH in the development of PD-MCI is unclear. Here we investigated how cognitive impairment could be exacerbated in a mouse model of combined injury through the interaction of chronic cerebral hypoperfusion(CHH) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) toxicity damage. In the present study, C57BL/6 mouse underwent MPTP injection. Subjects were classified into PD with cognitive normal (PDCN) group and PD with mild cognitive impairment of (PD-MCI) group via Morris water maze test. Further, CHH was performed by stenosis of bilateral common carotid...
Source: Behavioural Brain Research - June 1, 2017 Category: Neurology Authors: Tang H, Gao Y, Zhang Q, Nie K, Zhu R, Gao L, Feng S, Wang L, Zhao J, Huang Z, Zhang Y, Wang L Tags: Behav Brain Res Source Type: research

The effect of hippocampal NMDA receptor blockade by MK-801 on cued fear extinction.
Abstract Extinction of conditioned fear has been suggested to be a new form of learning instead of erasure of what was originally learned, and the process is NMDA (N-methyl d-aspartate) receptor (NMDAR) dependent. Most of studies have so far revealed the important roles of NMDARs in the amygdala and medial prefrontal cortex (mPFC) in cued fear extinction. Although the ventral hippocampus has intimately reciprocal connections with the amygdala and mPFC, the role of its NMDARs in cued fear extinction remains unclear. The present experiment explored the issue by bilateral pre-extinction microinjection of the noncompe...
Source: Behavioural Brain Research - June 1, 2017 Category: Neurology Authors: Zhang B, Li CY, Wang XS Tags: Behav Brain Res Source Type: research

Immunization of Tg-APPswe/PSEN1dE9 mice with A β3-10-KLH vaccine prevents synaptic deficits of Alzheimer's disease.
Immunization of Tg-APPswe/PSEN1dE9 mice with Aβ3-10-KLH vaccine prevents synaptic deficits of Alzheimer's disease. Behav Brain Res. 2017 May 31;332:64-70 Authors: Meng Y, Ding L, Zhang H, Yin W, Yan Y, Cao Y Abstract The amyloid cascade hypothesis is widely accepted by researchers as the mechanism of Alzheimer's disease. Active immunization to eliminate Aβ depositions has been used in preclinical and clinical studies. Aβ3-10-KLH is a vaccine of the Aβ3-10 peptide combined with keyhole limpet hemocyanin (KLH). We immunized 2.5-month-old Tg-APPswe/PSEN1dE9 mice with Aβ3-10-KLH p...
Source: Behavioural Brain Research - May 31, 2017 Category: Neurology Authors: Meng Y, Ding L, Zhang H, Yin W, Yan Y, Cao Y Tags: Behav Brain Res Source Type: research

The MAM-E17 schizophrenia rat model: Comprehensive behavioral analysis of pre-pubertal, pubertal and adult rats.
állai J, Szabó I, Karádi Z, Lénárd L Abstract The MAM-E17 model is one of the most accepted schizophrenia rat models, which follows the neurodevelopmental theory of the disease. While symptoms of MAM-E17 rats were studied extensively, their examinations were usually restricted to adulthood and in a few cases to prepuberty. It is well known, however, that schizophrenia symptoms often start at puberty or early adulthood. Therefore the purpose of this study was to investigate the behavioral characteristics of MAM-E17 rats in various tests throughout three different age-periods, name...
Source: Behavioural Brain Research - May 31, 2017 Category: Neurology Authors: Kállai V, Tóth A, Gálosi R, Péczely L, Ollmann T, Petykó Z, László K, Kállai J, Szabó I, Karádi Z, Lénárd L Tags: Behav Brain Res Source Type: research

Parent-of-origin effects on schizophrenia-relevant behaviours of type III neuregulin 1 mutant mice.
Abstract A robust, disease-relevant phenotype is paramount to the validity of genetic mouse models, which are an important tool in understanding complex diseases. Recent evidence from genome-wide association studies suggests the genetic contribution of parents to offspring is not equivalent. Despite this, few studies to date have examined the potential impact of parent genotype (i.e. origin of mutation) on the offspring of disease-relevant genetic mouse models. To elucidate the potential impact of the sex of the mutant parent on offspring phenotype, we characterized male and female offspring of an established schi...
Source: Behavioural Brain Research - May 31, 2017 Category: Neurology Authors: Shang K, Talmage DA, Karl T Tags: Behav Brain Res Source Type: research

BNDF heterozygosity is associated with memory deficits and alterations in cortical and hippocampal EEG power.
In this study, we investigated the effect of globally reduced BDNF levels on learning behavior and EEG power via BDNF heterozygous (KO) rats. We employed several behavioral tests that are thought to depend on cortical and hippocampal plasticity to varying degrees: novel object recognition, a test that is reliant on a variety of cognitive systems; contextual fear, which is highly hippocampal-dependent; and cued fear, which has been shown to be amygdala-dependent. We also examined the effects of BDNF reduction on cortical and hippocampal EEG spectral power via chronically implanted electrodes in the motor cortex and dorsal h...
Source: Behavioural Brain Research - May 30, 2017 Category: Neurology Authors: Geist PA, Dulka BN, Barnes A, Totty M, Datta S Tags: Behav Brain Res Source Type: research

The Paracrine effect of Cobalt chloride on BMSCs during cognitive function rescue in the HIBD rat.
In conclusion, CoCl2 activates HIF-1α signals in BMSCs. CoCl2 preconditioned BMSC culture medium likely effects neuroprotection by inducing long-term potentiation (LTP), which could be associated with GluR2 expression. The paracrine effects of hypoxia preconditioning on BMSCs could have applications in novel cell-based therapeutic strategies for hypoxic and ischemic brain injury. PMID: 28576310 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - May 30, 2017 Category: Neurology Authors: Dai Y, Li W, Zhong M, Chen J, Cheng Q, Liu Y, Li T Tags: Behav Brain Res Source Type: research

Understanding the complexities of traumatic brain injury: A big data approach to a big disease.
PMID: 28576458 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - May 30, 2017 Category: Neurology Authors: Agoston DV Tags: Behav Brain Res Source Type: research

Corrigendum to "TRPC3 channels critically regulate hippocampal excitability and contextual fear memory" Behav. Brain Res. 281(March) 2015, 69-77.
Corrigendum to "TRPC3 channels critically regulate hippocampal excitability and contextual fear memory" Behav. Brain Res. 281(March) 2015, 69-77. Behav Brain Res. 2017 May 30;: Authors: Neuner SM, Wilmott LA, Hope KA, Hoffmann B, Chong JA, Abramowitz J, Birnbaumer L, O'Connell K, Tryba AK, Greene AS, Chan CS, Kaczorowski CC PMID: 28576459 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - May 30, 2017 Category: Neurology Authors: Neuner SM, Wilmott LA, Hope KA, Hoffmann B, Chong JA, Abramowitz J, Birnbaumer L, O'Connell K, Tryba AK, Greene AS, Chan CS, Kaczorowski CC Tags: Behav Brain Res Source Type: research

Effects of exercise on depressive behavior and striatal levels of norepinephrine, serotonin and their metabolites in sleep-deprived mice.
The objective of this study is to evaluate the effects of exercise on anxiety and depressive behavior and striatal levels of norepinephrine (NE), serotonin and its metabolites in mice submitted to 6h of total sleep deprivation (6h-TSD) and 72h of Rapid Eye Movement (REM) sleep deprivation (72h-REMSD). Experimental groups were: (1) mice submitted to 6h-TSD by gentle handling; (2) mice submitted to 72h-REMSD by the flower pot method; (3) exercise (treadmill for 8 weeks); (4) exercise followed by 6h-TSD; (5) exercise followed by 72h-REMSD; (6) control (home cage). Behavioral tests included the Elevated Plus Maze and tail-susp...
Source: Behavioural Brain Research - May 29, 2017 Category: Neurology Authors: Daniele TMDC, de Bruin PFC, Rios ERV, de Bruin VMS Tags: Behav Brain Res Source Type: research

Transcranial direct current stimulation (tDCS) to improve naming ability in post-stroke aphasia: A critical review.
CONCLUSIONS: Several methodological issues have been identified in pre-efficacy studies that pose challenges in determining whether tDCS is a beneficial adjunct to behavioral aphasia therapy. Future studies need to improve the quality of the methods used to investigate the effect of tDCS for anomia. PMID: 28572057 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - May 29, 2017 Category: Neurology Authors: ALHarbi MF, Armijo-Olivo S, Kim ES Tags: Behav Brain Res Source Type: research

Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression.
Abstract The immuno-inflammatory activation triggered by various stresses play an important role in pathophysiology of depression. The immune responses display differential pathological characters in different stresses. However, comparative data and analysis on behavioural, inflammatory and neurochemical changes in different stress-induced depression is limited. To imitate different stressful situations, in this study, mice were subjected to a single injection of LPS (0.5mg/kg, i.p.) and UCMS (4 week period), respectively. LPS-stressed mice showed more immobility time in FST and TST, as well as more time in periph...
Source: Behavioural Brain Research - May 29, 2017 Category: Neurology Authors: Zhao X, Cao F, Liu Q, Li X, Xu G, Liu G, Zhang Y, Yang X, Yi S, Xu F, Fan K, Ma J Tags: Behav Brain Res Source Type: research

Opioid receptors mediate the acquisition, but not the expression of mitragynine-induced conditioned place preference in rats.
n Z Abstract Mitragynine is the main psychoactive ingredient of the herbal drug preparation Kratom (Ketum), derived from the plant Mitragyna speciosa. Kratom is a widely abused drug in Southeast Asian and has a psychostimulant profile at low-medium doses, while high doses have opioidergic effects. Mitragynine was shown to possess opiate receptor affinity. However, its role in the behavioural effects of mitragynine is unclear. Here we asked whether the reinforcing effects of mitragynine are mediated by opiate receptors using a conditioned place preference (CPP) paradigm in rats. In the first experiment we tested th...
Source: Behavioural Brain Research - May 27, 2017 Category: Neurology Authors: Yusoff NHM, Mansor SM, Müller CP, Hassan Z Tags: Behav Brain Res Source Type: research

Modulation of synaptic plasticity by short-term aerobic exercise in adult mice.
Abstract Physiological effects of different types, of continuous and interval aerobic training, have been largely described and studied in the adult man. It was previously indicated that interval training plays an important role in maximizing both peripheral muscle and central cardiorespiratory adaptations, permitting significant functional improvement even in healthy sedentary subjects. Since the outcome of different aerobic training trials on cognitive processes had never been evaluated, we compared, on an experimental mouse model, the effects of four training exercise protocols, named respectively C100, I 100, ...
Source: Behavioural Brain Research - May 27, 2017 Category: Neurology Authors: D'Arcangelo G, Triossi T, Buglione A, Melchiorri G, Tancredi V Tags: Behav Brain Res Source Type: research

Deletion of one allele of Mthfd1 (methylenetetrahydrofolate dehydrogenase 1) impairs learning in mice.
In this study, we evaluated cognitive function in Mthfd1(gt/+) male and female mice using a behavioral battery composed of eight different tests. We found that these mice display impaired cue-conditioned learning, while other behaviors remain intact. PMID: 28559181 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - May 27, 2017 Category: Neurology Authors: Pjetri E, Zeisel SH Tags: Behav Brain Res Source Type: research

Time dependent effect of chronic embryonic exposure to ethanol on zebrafish: Morphology, biochemical and anxiety alterations.
This study was conducted to assess the neurotoxic effects of chronic embryonic exposure to ethanol in the zebrafish, taking into consideration the time dependent effect. Two types of exposure regimen were applied in this study. Withdrawal exposure group received daily exposure starting from gastrulation until hatching, while continuous exposure group received daily exposure from gastrulation until behavioural assessment at 6dpf (days post fertilization). Chronic embryonic exposure to ethanol decreased spontaneous tail coiling at 24hpf (hour post fertilization), heart rate at 48hpf and increased mortality rate at 72hpf. The...
Source: Behavioural Brain Research - May 27, 2017 Category: Neurology Authors: Ramlan NF, Sata NSAM, Hassan SN, Bakar NA, Ahmad S, Zulkifli SZ, Abdullah CAC, Ibrahim WNW Tags: Behav Brain Res Source Type: research

Spectral and temporal properties of calls reveal deficits in ultrasonic vocalizations of adult Fmr1 knockout mice.
Abstract The Fmr1 knockout (KO) mouse has commonly been used to investigate communication impairments, one of the key diagnostic symptoms, observed in Fragile X syndrome (FXS) and Autism spectrum disorder (ASD). Many studies have found alterations in ultrasonic vocalizations (USVs) in neonatal Fmr1 KO mice, however, there is limited research investigating whether these deficits continue into adulthood. In the present study, we examine differences in female urine-induced ultrasonic vocalizations, scent marking behavior, odor discrimination, and open field activity in adult male Fmr1 KO and WT mice. Overall, we foun...
Source: Behavioural Brain Research - May 25, 2017 Category: Neurology Authors: Hodges SL, Nolan SO, Reynolds CD, Lugo JN Tags: Behav Brain Res Source Type: research

Altered reward sensitivity in female offspring of cocaine-exposed fathers.
Abstract Recent rodent studies have demonstrated that parental cocaine exposure can influence offspring behavior, supporting the idea that environmental insults can impact subsequent generations. However, studies on the effects of paternal cocaine exposure are limited and multiple inconsistencies exist. In the current study, we behaviorally characterize the effects of paternal cocaine exposure in a C57BL/6J intergenerational mouse model. Male sires were administered cocaine hydrochloride (20mg/kg) or saline (0.01mL/g) once a day for 75 days, and bred with drug naïve females twenty-four hours after the final i...
Source: Behavioural Brain Research - May 25, 2017 Category: Neurology Authors: Fischer DK, Rice RC, Martinez-Rivera A, Donohoe M, Rajadhyaksha AM Tags: Behav Brain Res Source Type: research

Habenula and interpeduncular nucleus differentially modulate predator odor-induced innate fear behavior in rats.
Abstract Fear is an important behavioral system helping humans and animals to survive potentially dangerous situations. Fear can be innate or learned. Whereas the neural circuits underlying learned fear are already well investigated, the knowledge about the circuits mediating innate fear is still limited. We here used a novel, unbiased approach to image in vivo the spatial patterns of neural activity in odor-induced innate fear behavior in rats. We intravenously injected awake unrestrained rats with a 99m-technetium labeled blood flow tracer (99mTc-HMPAO) during ongoing exposure to fox urine or water as control, a...
Source: Behavioural Brain Research - May 25, 2017 Category: Neurology Authors: Vincenz D, Wernecke KEA, Fendt M, Goldschmidt J Tags: Behav Brain Res Source Type: research

Socially induced plasticity in sensorimotor gating in the African cichlid fish Astatotilapia burtoni.
Abstract Deficits in sensorimotor gating (PPI), social defeat and social withdrawal are hallmark features of several neurological and neuropsychiatric disorders. However, the link between social environment and PPI i.e., the possible role of social defeat in driving PPI plasticity, is far from clear. Here we explored these questions in the African cichlid fish Astatotilapia burtoni, where males exist as two distinct yet reversible phenotypes. In fish communities, DOMs exhibit frequent aggressive and territorial behaviors, threatening and attacking SUBs, which respond either by engaging in fights and fleeing, or by...
Source: Behavioural Brain Research - May 24, 2017 Category: Neurology Authors: Neumeister H, Adelman M, Gallagher W, Gou J, Merrins K, Perkowski M, Shih S, Terranova B, Preuss T Tags: Behav Brain Res Source Type: research

The neural correlates of reciprocity are sensitive to prior experience of reciprocity.
es GA Abstract Reciprocity is central to human relationships and is strongly influenced by multiple factors including the nature of social exchanges and their attendant emotional reactions. Despite recent advances in the field, the neural processes involved in this modulation of reciprocal behavior by ongoing social interaction are poorly understood. We hypothesized that activity within a discrete set of neural networks including a putative moral cognitive neural network is associated with reciprocity behavior. Nineteen healthy adults underwent functional magnetic resonance imaging scanning while playing the trust...
Source: Behavioural Brain Research - May 24, 2017 Category: Neurology Authors: Cáceda R, Prendes-Alvarez S, Hsu JJ, Tripathi SP, Kilts CD, James GA Tags: Behav Brain Res Source Type: research

Body Mass is Positively Associated with Neural Response to Sweet Taste, But Not Alcohol, Among Drinkers.
Abstract Obesity is a large and growing public health concern, presenting enormous economic and health costs to individuals and society. A burgeoning literature demonstrates that overweight and obese individuals display different neural processing of rewarding stimuli, including caloric substances, as compared to healthy weight individuals. However, much extant research on the neurobiology of obesity has focused on addiction models, without highlighting potentially separable neural underpinnings of caloric intake versus substance use. The present research explores these differences by examining neural response to ...
Source: Behavioural Brain Research - May 23, 2017 Category: Neurology Authors: Gardiner CK, YorkWilliams SL, Bryan AD, Hutchison KE Tags: Behav Brain Res Source Type: research

Increased central dopaminergic activity might be involved in the behavioral abnormality of cuprizone exposure mice.
Abstract The neurotoxican cuprizone (CPZ, a copper chelator) has been used extensively to create a mouse model of demyelination. However, the effects on behavior of CPZ treatment have not been reported in C57BL/6 mice given a diet containing 0.4% CPZ within 3weeks. Behavioral abnormalities were assessed using a range of test: Y-maze, spontaneous locomotor activity, rota-rod test, novel object recognition, climbing. Mice exposed to CPZ displayed more arm entrance, locomotor movements, and climbing behavior, suggesting an increase in central nervous system activity. However, no significant differences either in spon...
Source: Behavioural Brain Research - May 23, 2017 Category: Neurology Authors: Chang H, Liu J, Zhang Y, Wang F, Wu Y, Zhang L, Ai H, Chen G, Yin L Tags: Behav Brain Res Source Type: research

Pavlovian influences on learning differ between rats and mice in a counter-balanced Go/NoGo judgement bias task.
Abstract Judgement bias tests of animal affect and hence welfare assume that the animal's responses to ambiguous stimuli, which may herald positive or negative outcomes, are under instrumental control and reflect 'optimism' or 'pessimism' about what will happen. However, Pavlovian control favours responses (e.g. approach or withdrawal) according to the valence associated with a stimulus, rather than the anticipated response outcomes. Typically, positive contexts promote action and approach whilst negative contexts promote inhibition or withdrawal. The prevalence of Go-for-reward (Go-pos) and NoGo-to-avoid-punishme...
Source: Behavioural Brain Research - May 23, 2017 Category: Neurology Authors: Jones S, Paul ES, Dayan P, Robinson ESJ, Mendl M Tags: Behav Brain Res Source Type: research

Characterization of Long-term Gait Deficits in Mouse dMCAO, Using the CatWalk System.
Abstract Evaluation of functional outcome is widely used across species to assess the recovery process following various pathological conditions, including spinal cord injury, musculo-skeletal injury, mithochondrial disease, neuropathic cancer, Huntington's disease, chronic pain, cortical lesion, and olivocerebellar degeneration among others. The Stroke Therapy Academic Industry Roundtable (STAIR) recommends multiple endpoints for behavioral studies in pre-clinical stroke research, to demonstrate their clinical relevance. One of the more challenging tasks in experimental stroke research is measuring long-term func...
Source: Behavioural Brain Research - May 23, 2017 Category: Neurology Authors: Caballero-Garrido E, Pena-Philippides JC, Galochkina Z, Erhardt E, Roitbak T Tags: Behav Brain Res Source Type: research

Prolonged deficits of associative motor learning in cynomolgus monkeys after long-term administration of phencyclidine.
Abstract Phencyclidine (PCP) is a potent drug of abuse that induces sustained schizophrenia-like symptoms in humans by blocking neurotransmission at N-methyl-D-aspartate (NMDA)-type glutamate receptors. Alterations in NMDA receptor function have been linked to numerous behavioral deficits and cognitive dysfunction. Classical eye-blink conditioning (EBC), including delay (dEBC) and trace (tEBC) pafadigms, provides an effective means to study the neurobiology of associative motor learning in rodents, mammals and primates. To assess whether administration of low-dosage PCP for extended periods has prolonged effect to...
Source: Behavioural Brain Research - May 23, 2017 Category: Neurology Authors: Wu B, Zhao XD, Zhang HM, Li X, Wu GY, Yang YS, Tian CY, Sui JF Tags: Behav Brain Res Source Type: research

Effect of PICALM rs3851179 polymorphism on the default mode network function in mild cognitive impairment.
Abstract Alterations in default mode network (DMN) functional connectivity (FC) might accompany the dysfunction of Alzheimer's disease (AD). Indeed, episodic memory impairment is a hallmark of AD, and mild cognitive impairment (MCI) has been associated with a high risk for AD. Phosphatidylinositol-binding clathrin assembly protein (PICALM) (rs3851179) has been associated with AD; in particular, the A allele may serve a protective role, while the G allele serves as a strong genetic risk factor. Therefore, the identification of genetic polymorphisms associated with the DMN is required in MCI subjects. In all, 32 MCI...
Source: Behavioural Brain Research - May 23, 2017 Category: Neurology Authors: Sun DM, Chen HF, Zuo QL, Su F, Bai F, Liu CF Tags: Behav Brain Res Source Type: research

Enriched environment alters the behavioral profile of tenascin-C deficient mice.
This study expands the existing knowledge about the phenotype associated with TnC deficiency, and reveals that the effect of genetic background on the behavioral response could be altered by post-weaning housing in a highly stimulating environment. PMID: 28549651 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - May 23, 2017 Category: Neurology Authors: Stamenkovic V, Milenkovic I, Galjak N, Todorovic V, Andjus P Tags: Behav Brain Res Source Type: research

Testing cognitive functions in rodent disease models: present pitfalls and future perspectives.
Abstract Testing of cognitive functions in rodent disease models constitutes a substantial sector of behavioral neuroscience. It is most often needed in phenotyping genetically modified new rodent (usually mouse) lines or in preclinical testing of cognitive effects of new CNS drugs. This review concerns present pitfalls and future perspectives in this large field, with an emphasis on memory testing in CNS disease models and their preclinical drug testing. It is important to realize that no behavioral test is specific for a single cognitive domain. There are numerous noncognitive factors that may lead to impaired p...
Source: Behavioural Brain Research - May 17, 2017 Category: Neurology Authors: Tanila H Tags: Behav Brain Res Source Type: research

Food and water intake, body temperature and metabolic consequences of interleukin-1 β microinjection into the cingulate cortex of the rat.
Food and water intake, body temperature and metabolic consequences of interleukin-1β microinjection into the cingulate cortex of the rat. Behav Brain Res. 2017 May 17;: Authors: Csetényi B, Hormay E, Szabó I, Takács G, Nagy B, László K, Karádi Z Abstract In order to elucidate whether cytokine mechanisms of the cingulate cortex (cctx) are important in the central regulation of homeostasis, in the present study, feeding-metabolic effects of direct bilateral microinjection of interleukin-1β (IL-1β) into the cctx of the rat have been investigated. S...
Source: Behavioural Brain Research - May 17, 2017 Category: Neurology Authors: Csetényi B, Hormay E, Szabó I, Takács G, Nagy B, László K, Karádi Z Tags: Behav Brain Res Source Type: research

Regional differences in dopamine receptor blockade affect timing impulsivity that are altered by d-amphetamine on differential reinforcement of low-rate responding (DRL) behavior in rats.
Abstract The ability to control when to start an action and when to stop is crucial in human and animal behavior. A failure to suppress premature behavior or carry out an action in a timely manner is commonly seen in several neuropsychological disorders. Despite the phenomenon, the exact neural mechanisms underlying this timing impulsivity remain to be elucidated. Systemic injection of d-amphetamine (AMP) has been shown to disrupt rat's performance in the differential reinforcement of low-rate (DRL) task that requires both optimal timing and proper impulsive control as measured by peak time and non-reinforced resp...
Source: Behavioural Brain Research - May 17, 2017 Category: Neurology Authors: Cheng RK, Liao RM Tags: Behav Brain Res Source Type: research

Two-hit model of schizophrenia induced by neonatal immune activation and peripubertal stress in rats: study of sex differences and brain oxidative alterations.
do D Abstract Schizophrenia is considered to be a developmental disorder with distinctive sex differences. Aiming to simulate the vulnerability of the third trimester of human pregnancy to the developmental course of schizophrenia, an animal model was developed, using neonatal poly(I:C) as a first-hit, and peripubertal stress as a second-hit, i.e. a two-hit model. Since, to date, there have been no references to sex differences in the two-hit model, our study sought to determine sex influences on the development of behavior and brain oxidative change in adult rats submitted to neonatal exposure to poly(I:C) on pos...
Source: Behavioural Brain Research - May 17, 2017 Category: Neurology Authors: Monte AS, Mello BSF, Borella VCM, da Silva Araujo T, da Silva FER, Sousa FCF, de Oliveira ACP, Gama CS, Seeman MV, Vasconcelos SMM, Lucena DF, Macêdo D Tags: Behav Brain Res Source Type: research

Voluntary wheel running ameliorates depression-like behaviors and brain blood oxygen level-dependent signals in chronic unpredictable mild stress mice.
CONCLUSIONS: These results suggested that VWR exercise ameliorated depression-like behaviors and brain BOLD signals in CUMS induced depression mice. PMID: 28527694 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - May 17, 2017 Category: Neurology Authors: Huang P, Dong Z, Huang W, Zhou C, Zhong W, Hu P, Wen G, Sun X, Hua H, Cao H, Gao L, Lv Z Tags: Behav Brain Res Source Type: research

Levodopa has primarily negative influences on postural control in patients with Parkinson's disease.
Abstract Patients with Parkinson's disease have better functional status and motor performance under on-drug conditions. However, the administration of levodopa leads to greater postural sway. The present study's primary objective was to determine whether this on-drug problem may be related to a lack of adjustment in postural control mechanisms and body segment rotations. Fourteen patients with Parkinson's disease and 14 controls performed two gaze-shift tasks (40° to the left and 40° to the right, at 0.125 and 0.25Hz) and a stationary gaze task in two sessions (an off-drug session and an on-drug session f...
Source: Behavioural Brain Research - May 16, 2017 Category: Neurology Authors: Bonnet CT, Delval A, Szaffarczyk S, Defebvre L Tags: Behav Brain Res Source Type: research

Prenatal lipopolysaccharide induces hypothalamic dopaminergic hypoactivity and autistic-like behaviors: repetitive self-grooming and stereotypies.
Abstract Previous investigations by our group have shown that prenatal exposure to lipopolysaccharide (LPS), which mimics infection by gram-negative bacteria, induces social, cognitive, and communication deficits. For a complete screening of autistic-like behaviors, the objective of this study was to evaluate if our rat model also induces restricted and repetitive stereotyped behaviors. Thus, we studied the self-grooming microstructure. We also studied the neurochemistry of hypothalamus and frontal cortex, which are brain areas related to autism to better understand central mechanisms involved in our model. Prenat...
Source: Behavioural Brain Research - May 16, 2017 Category: Neurology Authors: Kirsten TB, Bernardi MM Tags: Behav Brain Res Source Type: research

Comparing the effect of temporal delay on the availability of egocentric and allocentric information in visual search.
Abstract Frames of reference play a central role in perceiving an object's location and reaching to pick that object up. It is thought that the ventral stream, believed to subserve vision for perception, utilises allocentric coding, while the dorsal stream, argued to be responsible for vision for action, primarily uses an egocentric reference frame. We have previously shown that egocentric representations can survive a delay; however, it is possible that in comparison to allocentric information, egocentric information decays more rapidly. Here we directly compare the effect of delay on the availability of egocentr...
Source: Behavioural Brain Research - May 16, 2017 Category: Neurology Authors: Ball K, Birch Y, Lane A, Ellison A, Schenk T Tags: Behav Brain Res Source Type: research

Neurochemical correlates of functional plasticity in the mature cortex of the brain of rodents.
Abstract It is commonly accepted that increase of input to sensory structures in mammals is known to produce marked changes in cortical recipient areas. This paper reviews the data concerning manifestations of changes in primary somatosensory cortex of adult animals caused by classical conditioning with reinforcement: aversive (whisker-shock) and appetitive (whisker-water) trainings. These include: anatomical, electrophysiological responses, receptor autoradiography, expression of GABA, GAD at mRNA and protein levels, expression of neuronal and astroglial GAT-1 puncta and inhibitory synaptogenesis in the hollows o...
Source: Behavioural Brain Research - May 15, 2017 Category: Neurology Authors: Siucinska E Tags: Behav Brain Res Source Type: research

Relationship between the changes in M1 excitability after motor learning and arousal state as assessed by short-latency afferent inhibition.
Abstract To examine the factors that influence the inter-individual differences in the changes in primary motor cortex (M1) excitability seen after motor learning, we investigated the relationship between the amplitude of transcranial magnetic stimulation-induced motor evoked potentials (MEP) and short-latency afferent inhibition (SAI) after motor learning, based on the working hypothesis that SAI can be used to evaluate cortical acetylcholine (ACh) activity. To confirm this working hypothesis, we manipulated the arousal state of the subjects using a vigilance task, the outcomes of which might be correlated with c...
Source: Behavioural Brain Research - May 15, 2017 Category: Neurology Authors: Koizume Y, Hirano M, Kubota S, Tanaka S, Funase K Tags: Behav Brain Res Source Type: research

Role of acetylcholine and serotonin in novelty processing using an oddball paradigm.
Abstract The processing of novel stimuli is known to take place in the hippocampus and frontal cortex, and is influenced by the cholinergic system. This ability is crucial to help detect changes in the environment and adapt behavior accordingly. Previous research has shown that acetylcholine (ACh) can interact with serotonin (5-HT) at the hippocampal level, which may have consequences for cognitive functioning. However, little is known about the exact nature of this ACh and 5-HT interaction as well their possible interactive effects on novelty processing. We investigated the interactive role of ACh and 5-HT in nov...
Source: Behavioural Brain Research - May 13, 2017 Category: Neurology Authors: Caldenhove S, Borghans LGJM, Blokland A, Sambeth A Tags: Behav Brain Res Source Type: research

Behavioural outcomes of adult female offspring following maternal stress and perinatal fluoxetine exposure.
Abstract Depression, anxiety, and stress are common in pregnant women. One of the primary pharmacological treatments for anxiety and depression is the antidepressant fluoxetine (Flx). Maternal stress, depression, and Flx exposure are known to effect neurodevelopment of the offspring, however, their combined effects have been scarcely studied, especially in female offspring. The present study investigated the combined effects of maternal stress during pregnancy and perinatal exposure to Flx on the behaviour of female mice as adults. METHODS: Mouse dams were exposed to either chronic unpredictable stress (embry...
Source: Behavioural Brain Research - May 13, 2017 Category: Neurology Authors: Kiryanova V, Meunier SJ, Dyck RH Tags: Behav Brain Res Source Type: research

Water and T-maze protocols are equally efficient methods to assess spatial memory in 3xTg Alzheimer's disease mice.
Abstract Rodent spatial memory is commonly tested using the water-maze; however, there is a potential confound of stress on learning in this behavioural paradigm. This is particularly relevant when testing spatial memory in models of neurodegeneration, such as the 3xTg mouse model for Alzheimer's disease. Here, we first confirmed that 3xTgAD mice express fear conditioning and then compared the performance of young and middle-aged mice on short-duration versions of the radial arm water-maze (RAWM) and the minimally stressful T-maze spontaneous alternation task. Our main questions were: (1) does the reliance on stre...
Source: Behavioural Brain Research - May 13, 2017 Category: Neurology Authors: Davis KE, Burnett K, Gigg J Tags: Behav Brain Res Source Type: research

Reward loss and the basolateral amygdala: A function in reward comparisons.
ni MR Abstract The neural circuitry underlying behavior in reward loss situations is poorly understood. We considered two such situations: reward devaluation (from large to small rewards) and reward omission (from large rewards to no rewards). There is evidence that the central nucleus of the amygdala (CeA) plays a role in the negative emotion accompanying reward loss. However, little is known about the function of the basolateral nucleus (BLA) in reward loss. Two hypotheses of BLA function in reward loss, negative emotion and reward comparisons, were tested in an experiment involving pretraining excitotoxic BLA l...
Source: Behavioural Brain Research - May 13, 2017 Category: Neurology Authors: Kawasaki K, Annicchiarico I, Glueck AC, Morón I, Papini MR Tags: Behav Brain Res Source Type: research

Role of Cholinergic Receptors in Memory Retrieval Depends on Gender and Age of Memory.
In this study we evaluated the gender specific role of cholinergic receptors, i.e. muscarinic and nicotinic receptors, in memory retrieval in young Balb/c mice. Acute (only one injection, 30minutes before test) and sub-chronic (five days) muscarinic blockade (using scopolamine=1mg/kg) before test impaired retrieval of contextual fear memory in male (31.45±5.39% and 33.36±3.78% respectively) and female mice (22.88±5.73%; P 0.05). Only sub-chronic nicotinic receptor antagonism (using methyllycaconitine MLA=87.5μg/kg and dihydro β erythroidine DHβE=1mg/kg) in female showed significantly highe...
Source: Behavioural Brain Research - May 13, 2017 Category: Neurology Authors: Habiba R, Aamra M, Touqeer A Tags: Behav Brain Res Source Type: research

Characteristic and intermingled neocortical circuits encode different visual object discriminations.
Abstract Synaptic plasticity and neural network theories hypothesize that the essential information for advanced cognitive tasks is encoded in specific circuits and neurons within distributed neocortical networks. However, these circuits are incompletely characterized, and we do not know if a specific discrimination is encoded in characteristic circuits among multiple animals. Here, we determined the spatial distribution of active neurons for a circuit that encodes some of the essential information for a cognitive task. We genetically activated protein kinase C pathways in several hundred spatially-grouped glutama...
Source: Behavioural Brain Research - May 13, 2017 Category: Neurology Authors: Zhang GR, Zhao H, Cook N, Svestka M, Choi EM, Jan M, Cook RG, Geller AI Tags: Behav Brain Res Source Type: research

The PTZ kindling mouse model of epilepsy exhibits exploratory drive deficits and aberrant VTA dopamine neuron activity in both familiar and novel space.
Abstract Recurrent seizures that define epilepsy are often accompanied by psychosocial problems and cognitive deficits with incompletely understood aetiology. We therefore used the pentylenetetrazol (PTZ) kindling model of epilepsy in mice to examine potential seizure-associated neuropathologies, focusing on motivation, memory and novel-environment-induced activation of midbrain dopaminergic neurons. In addition to recurrent seizures, we found that PTZ kindling led to a strong suppression of novelty-driven exploration while largely sparing fear-driven exploration. The deficits in exploratory drive may be relevant ...
Source: Behavioural Brain Research - May 12, 2017 Category: Neurology Authors: Ahmadi M, Dufour JP, Seifritz E, Mirnajafi-Zadeh J, Saab BJ Tags: Behav Brain Res Source Type: research

Long-term reliability of the visual EEG Poffenberger paradigm.
uml;n O, Genc E Abstract The Poffenberger paradigm is a simple perception task that is used to estimate the speed of information transfer between the two hemispheres, the so-called interhemispheric transfer time (IHTT). Although the original paradigm is a behavioral task, it can be combined with electroencephalography (EEG) to assess the underlying neurophysiological processes during task execution. While older studies have supported the validity of both paradigms for investigating interhemispheric interactions, their long-term reliability has not been assessed systematically before. The present study aims to fill...
Source: Behavioural Brain Research - May 12, 2017 Category: Neurology Authors: Friedrich P, Ocklenburg S, Mochalski L, Schlüter C, Güntürkün O, Genc E Tags: Behav Brain Res Source Type: research

Bombesin administration impairs memory and does not reverse memory deficit caused by sleep deprivation.
Abstract Sleep deprivation impairs performance in emotional memory tasks, however this effect on memory is not completely understood. Possible mechanisms may involve an alteration in neurotransmission systems, as shown by the fact that many drugs that modulate neural pathways can prevent memory impairment by sleep loss. Gastrin releasing peptide (GRP) is a neuropeptide that emerged as a regulatory molecule of emotional memory through the modulation of other neurotransmission systems. Thus, the present study addressed the effect of intraperitoneal (IP) administration of bombesin (BB) (2.5, 5.0 and 10.0μg/kg), a ...
Source: Behavioural Brain Research - May 12, 2017 Category: Neurology Authors: Ferreira LBT, Oliveira SLB, Raya J, Esumi LA, Hipolide DC Tags: Behav Brain Res Source Type: research