Histamine and Receptors in Neuroinflammation: Their Roles on neurodegenerative diseases
Behav Brain Res. 2024 Mar 22:114964. doi: 10.1016/j.bbr.2024.114964. Online ahead of print.ABSTRACTHistamine, an auto-reactive substance and mediator of inflammation, is synthesized from histidine through the action of histidine decarboxylase (HDC). It primarily acts on histamine receptors in the central nervous system (CNS). Increasing evidence suggests that histamine and its receptors play a crucial role in neuroinflammation, thereby modulating the pathology of neurodegenerative diseases. Recent studies have demonstrated that histamine regulates the phenotypic switching of microglia and astrocytes, inhibits the productio...
Source: Behavioural Brain Research - March 24, 2024 Category: Neurology Authors: Zhenyu Zhou Qi An Wanying Zhang Yixin Li Qihang Zhang Haijing Yan Source Type: research
Gastrodin ameliorates depressive-like behaviors via modulating gut microbiota in CUMS-induced mice
CONCLUSION: Our results suggested that GAS improved depressive-like behaviors in mice and impacted the microbial composition of the gut. Our research indicated that dysbiosis of the gut microbiota may be affected by GAS treatment, which improved depressive-like behaviors in the CUMS-induced mouse model of depression.PMID:38521360 | DOI:10.1016/j.bbr.2024.114968 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 23, 2024 Category: Neurology Authors: Yanan Zhao Shaokun Qin Zixian Yang Ye Lu Zongmin Ma Xin Ping Guoqiang Sun Lin Pei Source Type: research
β-Asarone inhibitsAutophagy by activating the PI3K/Akt/mTOR Pathway in a Rat Model of Depression in Parkinson's Disease
CONCLUSIONS: We concluded that β-asarone might improve the behavior of DPD model rats by activating the PI3K/Akt/mTOR pathway, inhibiting autophagy and protecting neuron.PMID:38518853 | DOI:10.1016/j.bbr.2024.114966 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 22, 2024 Category: Neurology Authors: Zhifang Wang Ping-E Huang Nanbu Wang Qinxin Zhang Jian Kang Yongqi Fang Baile Ning Ling Li Source Type: research
β-Asarone inhibitsAutophagy by activating the PI3K/Akt/mTOR Pathway in a Rat Model of Depression in Parkinson's Disease
CONCLUSIONS: We concluded that β-asarone might improve the behavior of DPD model rats by activating the PI3K/Akt/mTOR pathway, inhibiting autophagy and protecting neuron.PMID:38518853 | DOI:10.1016/j.bbr.2024.114966 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 22, 2024 Category: Neurology Authors: Zhifang Wang Ping-E Huang Nanbu Wang Qinxin Zhang Jian Kang Yongqi Fang Baile Ning Ling Li Source Type: research
Cuscuta chinensis Lam. Flavonoids (CCLF) alleviate the symptoms of sepsis-associated encephalopathy via PI3K/Nrf2 pathway
Behav Brain Res. 2024 Mar 16:114887. doi: 10.1016/j.bbr.2024.114887. Online ahead of print.ABSTRACTSepsis-associated encephalopathy (SAE) frequently encounters patients who are in intensive care units and ~70% of patients with severe systemic infection. However, due to the unclear pathological mechanisms of SAE, the desease-modifying drug is still lack. Here, we aimed to explore whether the flavonoid components extracted from CCL (CCLF) seeds possess protective effects on SAE animals, and systematically evaluate the transcriptomic alteration (in the hippocampus) after CCLF treatment on SAE animals employing RNA sequencing....
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Qi Boxiang Sheng Liping Qian Tong Source Type: research
MKP1 may be involved in the occurrence of depression by regulating hippocampal autophagy in rats
CONCLUSION: Enhanced hippocampal autophagy via MKP1-mediated ERK dephosphorylation may contribute to the development of depression.PMID:38499157 | DOI:10.1016/j.bbr.2024.114962 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Laipeng Feng Huiying Wang Chen Chen Jiacheng Fu Liqin Zhao Xia Zhao Mengjun Geng Mengdi Ren Lidan Tong Yan Li Jingyang Gu Changhong Wang Source Type: research
Memory loss induced by lisdexamfetamine in the rat: A behavioral, electrophysiological, and histopathological Study
Behav Brain Res. 2024 Mar 16:114963. doi: 10.1016/j.bbr.2024.114963. Online ahead of print.ABSTRACTLisdexamfetamine (LDX) is one of the drugs commonly used to treat attention deficit hyperactivity disorder (ADHD). However, its neurological side effects, particularly on cognition, are not fully understood. The present study focused on memory in rats treated with four weeks of LDX injection. We compared LDX-treated rats with control ones, using several methods to evaluate the behavioral responses and electrophysiological, molecular, and histological properties in the hippocampus. Our findings demonstrated that subchronic adm...
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Seyedeh Naghmeh Nourirad Amhr-Hossein Bayat Moitaba Sani Amirreza Beirami Maral Hasanzadeh Susan Roustaee Mobina Fathi Kimia Vakili Siavash Parvardeh Gholam Hossein Meftahi Nahid Sarahian Fariba Khodagholi Abbas Aliaghaei Hojjat-Allah Abbaszadeh Meysam Ha Source Type: research
Cuscuta chinensis Lam. Flavonoids (CCLF) alleviate the symptoms of sepsis-associated encephalopathy via PI3K/Nrf2 pathway
Behav Brain Res. 2024 Mar 16:114887. doi: 10.1016/j.bbr.2024.114887. Online ahead of print.ABSTRACTSepsis-associated encephalopathy (SAE) frequently encounters patients who are in intensive care units and ~70% of patients with severe systemic infection. However, due to the unclear pathological mechanisms of SAE, the desease-modifying drug is still lack. Here, we aimed to explore whether the flavonoid components extracted from CCL (CCLF) seeds possess protective effects on SAE animals, and systematically evaluate the transcriptomic alteration (in the hippocampus) after CCLF treatment on SAE animals employing RNA sequencing....
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Qi Boxiang Sheng Liping Qian Tong Source Type: research
MKP1 may be involved in the occurrence of depression by regulating hippocampal autophagy in rats
CONCLUSION: Enhanced hippocampal autophagy via MKP1-mediated ERK dephosphorylation may contribute to the development of depression.PMID:38499157 | DOI:10.1016/j.bbr.2024.114962 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Laipeng Feng Huiying Wang Chen Chen Jiacheng Fu Liqin Zhao Xia Zhao Mengjun Geng Mengdi Ren Lidan Tong Yan Li Jingyang Gu Changhong Wang Source Type: research
Memory loss induced by lisdexamfetamine in the rat: A behavioral, electrophysiological, and histopathological Study
Behav Brain Res. 2024 Mar 16:114963. doi: 10.1016/j.bbr.2024.114963. Online ahead of print.ABSTRACTLisdexamfetamine (LDX) is one of the drugs commonly used to treat attention deficit hyperactivity disorder (ADHD). However, its neurological side effects, particularly on cognition, are not fully understood. The present study focused on memory in rats treated with four weeks of LDX injection. We compared LDX-treated rats with control ones, using several methods to evaluate the behavioral responses and electrophysiological, molecular, and histological properties in the hippocampus. Our findings demonstrated that subchronic adm...
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Seyedeh Naghmeh Nourirad Amhr-Hossein Bayat Moitaba Sani Amirreza Beirami Maral Hasanzadeh Susan Roustaee Mobina Fathi Kimia Vakili Siavash Parvardeh Gholam Hossein Meftahi Nahid Sarahian Fariba Khodagholi Abbas Aliaghaei Hojjat-Allah Abbaszadeh Meysam Ha Source Type: research
Cuscuta chinensis Lam. Flavonoids (CCLF) alleviate the symptoms of sepsis-associated encephalopathy via PI3K/Nrf2 pathway
Behav Brain Res. 2024 Mar 16:114887. doi: 10.1016/j.bbr.2024.114887. Online ahead of print.ABSTRACTSepsis-associated encephalopathy (SAE) frequently encounters patients who are in intensive care units and ~70% of patients with severe systemic infection. However, due to the unclear pathological mechanisms of SAE, the desease-modifying drug is still lack. Here, we aimed to explore whether the flavonoid components extracted from CCL (CCLF) seeds possess protective effects on SAE animals, and systematically evaluate the transcriptomic alteration (in the hippocampus) after CCLF treatment on SAE animals employing RNA sequencing....
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Qi Boxiang Sheng Liping Qian Tong Source Type: research
MKP1 may be involved in the occurrence of depression by regulating hippocampal autophagy in rats
CONCLUSION: Enhanced hippocampal autophagy via MKP1-mediated ERK dephosphorylation may contribute to the development of depression.PMID:38499157 | DOI:10.1016/j.bbr.2024.114962 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Laipeng Feng Huiying Wang Chen Chen Jiacheng Fu Liqin Zhao Xia Zhao Mengjun Geng Mengdi Ren Lidan Tong Yan Li Jingyang Gu Changhong Wang Source Type: research
Memory loss induced by lisdexamfetamine in the rat: A behavioral, electrophysiological, and histopathological Study
Behav Brain Res. 2024 Mar 16:114963. doi: 10.1016/j.bbr.2024.114963. Online ahead of print.ABSTRACTLisdexamfetamine (LDX) is one of the drugs commonly used to treat attention deficit hyperactivity disorder (ADHD). However, its neurological side effects, particularly on cognition, are not fully understood. The present study focused on memory in rats treated with four weeks of LDX injection. We compared LDX-treated rats with control ones, using several methods to evaluate the behavioral responses and electrophysiological, molecular, and histological properties in the hippocampus. Our findings demonstrated that subchronic adm...
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Seyedeh Naghmeh Nourirad Amhr-Hossein Bayat Moitaba Sani Amirreza Beirami Maral Hasanzadeh Susan Roustaee Mobina Fathi Kimia Vakili Siavash Parvardeh Gholam Hossein Meftahi Nahid Sarahian Fariba Khodagholi Abbas Aliaghaei Hojjat-Allah Abbaszadeh Meysam Ha Source Type: research
Cuscuta chinensis Lam. Flavonoids (CCLF) alleviate the symptoms of sepsis-associated encephalopathy via PI3K/Nrf2 pathway
Behav Brain Res. 2024 Mar 16:114887. doi: 10.1016/j.bbr.2024.114887. Online ahead of print.ABSTRACTSepsis-associated encephalopathy (SAE) frequently encounters patients who are in intensive care units and ~70% of patients with severe systemic infection. However, due to the unclear pathological mechanisms of SAE, the desease-modifying drug is still lack. Here, we aimed to explore whether the flavonoid components extracted from CCL (CCLF) seeds possess protective effects on SAE animals, and systematically evaluate the transcriptomic alteration (in the hippocampus) after CCLF treatment on SAE animals employing RNA sequencing....
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Qi Boxiang Sheng Liping Qian Tong Source Type: research
MKP1 may be involved in the occurrence of depression by regulating hippocampal autophagy in rats
CONCLUSION: Enhanced hippocampal autophagy via MKP1-mediated ERK dephosphorylation may contribute to the development of depression.PMID:38499157 | DOI:10.1016/j.bbr.2024.114962 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 18, 2024 Category: Neurology Authors: Laipeng Feng Huiying Wang Chen Chen Jiacheng Fu Liqin Zhao Xia Zhao Mengjun Geng Mengdi Ren Lidan Tong Yan Li Jingyang Gu Chonghong Wang Source Type: research
