Intracerebral injection of R-(-)-Apomorphine into the nucleus accumbens decreased carbachol-induced 22-kHz ultrasonic vocalizations in rats.
Abstract Rats can produce ultrasonic vocalizations (USVs) in a variety of different contexts that signal their emotional state to conspecifics. Under distress, rats can emit 22-kHz USVs, while during positive pro-social interactions rats can emit frequency-modulated (FM) 50-kHz USVs. It has been previously reported that rats with increasing emission of FM 50-kHz USVs in anticipation of rewarding electrical stimulation or positive pro-social interaction decrease the number of emitted 22-kHz USVs. The purpose of the present investigation was to determine, in a pharmacological-behavioural experiment, if the positive ...
Source: Behavioural Brain Research - January 25, 2019 Category: Neurology Authors: Silkstone M, Brudzynski SM Tags: Behav Brain Res Source Type: research

Cannabidiol modulates phosphorylated rpS6 signalling in a zebrafish model of Tuberous Sclerosis Complex.
Abstract Tuberous sclerosis complex (TSC) is a rare disease caused by mutations in the TSC1 or TSC2 genes and is characterized by widespread tumour growth, intractable epilepsy, cognitive deficits and autistic behaviour. CBD has been reported to decrease seizures and inhibit tumour cell progression, therefore we sought to determine the influence of CBD on TSC pathology in zebrafish carrying a nonsense mutation in the tsc2 gene. CBD treatment from 6 to 7 days post-fertilization (dpf) induced significant anxiolytic actions without causing sedation. Furthermore, CBD treatment from 3 dpf had no impact on tsc2-/- larva...
Source: Behavioural Brain Research - January 23, 2019 Category: Neurology Authors: Serra I, Scheldeman C, Bazelot M, Whalley BJ, Dallas ML, de Witte PAM, Williams CM Tags: Behav Brain Res Source Type: research

Effects of chronic cocaine exposure on the circadian rhythmic expression of the clock genes in reward-related brain areas in rats.
Abstract Drug addiction is a widespread social problem, which not only brings adverse consequences to the human body, but also causes great burden to the society. However, it's still unclear how the long-term and sustained cocaine exposure will affect clock genes' expression in the reward related brain areas. We hypothesize that chronic cocaine exposure causes changes in the circadian rhythmic expression of clock genes in brain regions associated with reward, since previous studies have shown that cocaine use causes circadian disorders. Sprague-Dawley male rats were administrated with cocaine 20 mg/kg at ZT...
Source: Behavioural Brain Research - January 22, 2019 Category: Neurology Authors: Wang DQ, Wang XL, Wang CY, Wang Y, Li SX, Liu KZ Tags: Behav Brain Res Source Type: research

Abnormal empathy-like pro-social behaviour in the valproic acid model of autism spectrum disorder.
Abstract Impairments in social behaviour are a defining feature of autism spectrum disorder (ASD). Individuals with ASD also usually present some difficulty to recognise or understand another person's feelings. Therefore, it is possible that altered empathy processing could hinder typical social interaction in ASD. Recently, robust paradigms confirmed that rodents show primordial forms of empathy-like behaviour. Therefore, in this work, we used one of these new protocols to test pro-social behaviour in the rat model of autism induced by Valproic Acid (VPA). We also evaluated possible beneficial effects of Resverat...
Source: Behavioural Brain Research - January 22, 2019 Category: Neurology Authors: Fontes-Dutra M, Della-Flora Nunes G, Terra JS, Souza-Nunes W, Bauer-Negrini G, Hirsch MM, Green L, Riesgo R, Gottfried C, Bambini-Junior V Tags: Behav Brain Res Source Type: research

Emission of 22 kHz vocalizations in rats as an evolutionary equivalent of human crying: Relationship to depression.
Abstract There is no clear relationship between crying and depression based on human neuropsychiatric observations. This situation originates from lack of suitable animal models of human crying. In the present article, an attempt will be made to answer the question whether emission of rat aversive vocalizations (22 kHz calls) may be regarded as an evolutionary equivalent of adult human crying. Using this comparison, the symptom of crying in depressed human patients will be reanalyzed. Numerous features and characteristics of rat 22 kHz aversive vocalizations and human crying vocalizations are equival...
Source: Behavioural Brain Research - January 21, 2019 Category: Neurology Authors: Brudzynski SM Tags: Behav Brain Res Source Type: research

The effects of early exposure to MK-801 during environmental enrichment on spatial memory, methamphetamine self-administration and cue-induced renewal in rats.
CONCLUSION: Early cognitive alterations have a profound impact on spatial memory and METH dependence. PMID: 30677450 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 21, 2019 Category: Neurology Authors: Zhang P, Pan J, Mao Z, Xu X, Lin D, Wu B, Zhou W, Liu Y Tags: Behav Brain Res Source Type: research

Corrigendum to "Latency to startle is reduced in the 5xFAD mouse model of Alzheimer's disease" [Behav. Brain Res. 359 (2019) 823-827].
Corrigendum to "Latency to startle is reduced in the 5xFAD mouse model of Alzheimer's disease" [Behav. Brain Res. 359 (2019) 823-827]. Behav Brain Res. 2019 Jan 19;: Authors: Story D, Chan E, Munro N, Rossignol J, Dunbar GL PMID: 30670295 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 19, 2019 Category: Neurology Authors: Story D, Chan E, Munro N, Rossignol J, Dunbar GL Tags: Behav Brain Res Source Type: research

Individual differences in voluntary alcohol consumption are associated with conditioned fear in the fear incubation model.
Abstract Previous research in male Long Evans rats has shown a relationship between low voluntary alcohol consumption and high conditioned fear after a single training session. Here, we determined whether chronic intermittent access (CIA) to alcohol during adolescence/early adulthood or during adulthood would alter or be associated with auditory-cued conditioned fear levels using an extended training fear incubation procedure. This training procedure leads to low fear soon after training that grows over one month. Rats received 6 weeks of CIA to 20% alcohol or water from PND 26-66. Ten or eleven days later, the ra...
Source: Behavioural Brain Research - January 18, 2019 Category: Neurology Authors: Pajser A, Limoges A, Long C, Pickens CL Tags: Behav Brain Res Source Type: research

Effect of estrous cycle on schizophrenia-like behaviors in MAM exposed rats.
In this study, we characterize the behavioral, electrophysiological and molecular alterations induced by prenatal MAM administration in female rats while also examining the potential effects of the estrous cycle on schizophrenia-like behaviors. Specifically, MAM-treated female offspring demonstrated deficits in sensorimotor gating, latent inhibition, and social interaction, consistent with those observed in male animals. Interestingly, amphetamine-induced locomotor activity, latent inhibition, and social interaction were also affected by the estrous cycle. To examine the potential cellular mechanisms associated with these ...
Source: Behavioural Brain Research - January 17, 2019 Category: Neurology Authors: Perez SM, Donegan JJ, Lodge DJ Tags: Behav Brain Res Source Type: research

Age-related changes in social behaviours in the 5xFAD mouse model of Alzheimer's disease.
Abstract In addition to memory impairments, patients with Alzheimer's disease (AD) exhibit a number of behavioural and psychological symptoms that can affect social interactions over the course of the disease. While altered social interactions have been demonstrated in a number of mouse models of AD, many models only recapitulate the initial stages of the disease, and these behavioural changes have yet to be examined over the course of disease progression. By performing a longitudinal study using the 5xFAD mouse model, we have demonstrated that transgenic females exhibit progressive alterations in social investiga...
Source: Behavioural Brain Research - January 16, 2019 Category: Neurology Authors: Kosel F, Torres Munoz P, Yang JR, Wong AA, Franklin TB Tags: Behav Brain Res Source Type: research

Dopamine type 1- and 2-like signaling in the modulation of spatial reference learning and memory.
z V Abstract Spatial reference memory is known to be modulated by the dopaminergic system involving different brain regions. Here, we sought to identify the contribution of D1 (D1R) and D2 (D2R)-like dopamine receptor signaling on learning and memory in a food rewarded hole-board task by intracerebroventricular infusing D1R- and D2R- like receptor agonists (SKF-81297 and Sumanirole) and antagonists (SCH 23390 and Remoxipride) once 30 min prior to daily training sessions. D1R agonism induced persistent enhancement of performance, whereas D1R antagonism impaired reference memory formation. D2R agonist and ant...
Source: Behavioural Brain Research - January 16, 2019 Category: Neurology Authors: Daba Feyissa D, Sialana FJ, Keimpema E, Kalaba P, Paunkov A, Engidawork E, Höger H, Lubec G, Korz V Tags: Behav Brain Res Source Type: research

Psycho-emotional status but not cognition are changed under the combined effect of ionizing radiations at doses related to deep space missions.
Abstract Human spaceflight launch is the big challenge that the humanity work on. The astronauts' task performance vulnerability to ionizing radiations is one of the major factors limiting deep space missions. In this work, we study the effect of ionizing radiations (γ-quanta and 12C6+ in combination) on cognitive abilities and psycho-emotional status of Wistar rats. Irradiation led to the hyperlocomotion, increase of anxiety-like behavior, suppression of depressive-like behavior and enhancement of spatial learning. These data are consistent with the neurochemical/molecular analysis: enhanced monoaminergic i...
Source: Behavioural Brain Research - January 15, 2019 Category: Neurology Authors: Kokhan VS, Shakhbazian EV, Markova NA Tags: Behav Brain Res Source Type: research

The effects of glucocorticoids on depressive and anxiety-like behaviors, mineralocorticoid receptor-dependent cell proliferation regulates anxiety-like behaviors.
In conclusion, our results indicate that MR-dependent neurogenesis was closely related with anxiety-like behavior. PMID: 30654121 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 14, 2019 Category: Neurology Authors: Chen J, Wang ZZ, Zhang S, Chu SF, Mou Z, Chen NH Tags: Behav Brain Res Source Type: research

Technology or ecology? New tools to assess cognitive judgement bias in mice.
SH Abstract Cognitive judgement bias tests have become important new tools for the assessment of animal emotions. They allow for the inference of an animals' emotional state based on ambiguous cue interpretations. As mice are the predominantly used animal model for cognitive and behavioural neuroscience, research in this field would considerably benefit from the development of suitable judgement bias tests for this species. Against this background, we aimed to implement two different active choice cognitive judgement bias paradigms for mice in a methodological study. For this purpose, two experiments were conduct...
Source: Behavioural Brain Research - January 14, 2019 Category: Neurology Authors: Krakenberg V, Woigk I, Garcia Rodriguez L, Kästner N, Kaiser S, Sachser N, Richter SH Tags: Behav Brain Res Source Type: research

AMPA receptors are involved in prefrontal direct current stimulation effects on long-term working memory and GAP-43 expression.
This study investigated the influence of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) on prefrontal anodal DC-induced effects on spatial working memory and GAP-43 expression. Male Wistar rats well-trained in radial maze procedures received five sessions of anodal epidural DC stimulation (eDCS: 400 µA, 13 minutes, one daily session) over the left mPFC, or a respective sham procedure, and afterwards they received a single dose (1 mg/kg) of perampanel (PRP), an AMPARs antagonist, or vehicle 30 minutes before the performance of 4-h delayed task. The prefrontal ...
Source: Behavioural Brain Research - January 14, 2019 Category: Neurology Authors: Martins CW, de Melo Rodrigues LC, Nitsche MA, Nakamura-Palacios EM Tags: Behav Brain Res Source Type: research

Spatiotemporal Analysis of Category and Target-related Information Processing in the Brain during Object Detection.
Abstract To recognize a target object, the brain implements strategies which involve a combination of externally sensory-driven and internally task-driven mechanisms. While several studies have suggested a role for frontal brain areas in enhancing task-related representations in visual cortices, especially in the lateral-occipital cortex, they have remained silent about the type of information transferred to visual areas. However, the recently developed methods of representational connectivity analysis, allowed us to track the movement of different types of information in the brain. Accordingly, we designed an EEG...
Source: Behavioural Brain Research - January 14, 2019 Category: Neurology Authors: Karimi-Rouzbahani H, Vahab E, Ebrahimpour R, Menhaj MB Tags: Behav Brain Res Source Type: research

Special issue: serotonin.
SPECIAL ISSUE: SEROTONIN. Behav Brain Res. 2019 Jan 14;357-358:A1 Authors: Padovan CM PMID: 30526960 [PubMed - in process] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - December 13, 2018 Category: Neurology Authors: Padovan CM Tags: Behav Brain Res Source Type: research

Special Issue: Neural basis of motivation and cognitive control.
PMID: 30223945 [PubMed - in process] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - September 19, 2018 Category: Neurology Authors: O'Neill M, Brown V Tags: Behav Brain Res Source Type: research

Editorial to the Special Issue: Animal Model of the Year 2036: Novel Perspectives in Behavioral Neuroscience.
PMID: 30115300 [PubMed - in process] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - August 19, 2018 Category: Neurology Authors: Dere E, Jolkkonen J, Voikar V, Tanila H Tags: Behav Brain Res Source Type: research

Chronic corticosterone increases Δfosb and crfr1 immunoreactivity in brain regions that modulate aversive conditioning.
CHRONIC CORTICOSTERONE INCREASES ΔFOSB AND CRFR1 IMMUNOREACTIVITY IN BRAIN REGIONS THAT MODULATE AVERSIVE CONDITIONING. Behav Brain Res. 2018 Aug 14;: Authors: Scalize Hirata RY, Dos Santos TB, de Andrade JS, Le Sueur Maluf L, Antunes HKM, Britto LRG, Céspedes IC, de Barros Viana M Abstract Previous studies showed that chronic treatment with corticosterone facilitates elevated T-maze (ETM) inhibitory avoidance and a step-down avoidance task, responses that have been used to investigate aversive conditioning and memory processes. On the other hand, chronic corticosterone does not alter ETM...
Source: Behavioural Brain Research - August 14, 2018 Category: Neurology Authors: Scalize Hirata RY, Dos Santos TB, de Andrade JS, Le Sueur Maluf L, Antunes HKM, Britto LRG, Céspedes IC, de Barros Viana M Tags: Behav Brain Res Source Type: research

Neuroprotective effects of bergenin in Alzheimer's disease: Investigation through molecular docking, in vitro and in vivo studies.
Abstract Alzheimer's disease (AD) is an enervating and chronic progressive neurodegenerative disorder, occurring frequently in the elderly and adversely affecting intellectual capabilities and the cognitive processes. Bergenin possesses efficacious antioxidant, antiulcerogenic, anti-HIV, hepatoprotective, neuroprotective, anti-inflammatory and immunomodulatory activity along with antinociceptive effect and wound healing properties. Previous studies have shown that bergenin has in vitro bovine adrenal tyrosine hydroxylase inhibitory activity, mushroom tyrosinase inhibitory activities, β-secretase (BACE-1) enzy...
Source: Behavioural Brain Research - August 14, 2018 Category: Neurology Authors: Barai P, Raval N, Acharya S, Borisa A, Bhatt H, Acharya N Tags: Behav Brain Res Source Type: research

Reversal elimination of morphine conditioned behavior by an anti-dopaminergic post-trial drug treatment during re-consolidation.
Abstract Morphine has potent pro-dopamine effects that can be manifested as hyper-locomotion and these behavioral effects can undergo conditioning and sensitization. The aim of the present study was to assess whether an inhibitory dopaminergic post-trial treatment (0.05 mg/kg apomorphine) given during re-consolidation could reduce morphine conditioning. To induce conditioned morphine hyperactivity and control for morphine exposure, a paired/unpaired Pavlovian conditioning protocol was used. The morphine paired groups received morphine in the open-field test arena and the unpaired groups received the same mo...
Source: Behavioural Brain Research - August 13, 2018 Category: Neurology Authors: Leite JB, de Mello Bastos JM, Samuels RI, Carey RJ, Carrera MP Tags: Behav Brain Res Source Type: research

Using the behavioral flexibility operant task to detect long-term deficits in rats following middle cerebral artery occlusion.
The objective of this study was to determine the sensitivity of certain behavioral tasks, up to seven weeks following occlusion of the middle cerebral artery (MCAo) in rats. A battery of behavioral tasks, including rotorod, cylinder, and limb-placement, was conducted weekly for seven weeks. Also, a behavioral flexibility operant task was introduced at the end of the study to measure cognitive deficits. All functional outcome measures showed significant differences between stroke and control groups, indicating that these tasks are sensitive enough to detect deficits in a long-term MCAo study in rats. This provides useful in...
Source: Behavioural Brain Research - August 11, 2018 Category: Neurology Authors: Andrews MMM, Peruzzaro S, Raupp S, Wilks J, Rossignol J, Dunbar GL Tags: Behav Brain Res Source Type: research

Social behavioral phenotyping of the zebrafish Casper mutant following embryonic alcohol exposure.
We report that exposure to 1% alcohol from either 6 to 24, or 24 to 26 hours postfertilization reduces the social behavior of adult casper zebrafish. Our findings set the stage for the use of this important zebrafish resource in studies of FASD. PMID: 30107225 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - August 11, 2018 Category: Neurology Authors: Fernandes Y, Rampersad M, Eberhart JK Tags: Behav Brain Res Source Type: research

Body composition, biochemical, behavioral and molecular alterations in overfed rats after chronic exposure to SSRI.
nha C Abstract Serotonin (5-HT) plays a regulatory role in coordinating the neural circuits regulating energy balance, with differences in both 5-HT availability at the synapse and the activity of 5-HT receptors mediating anorectic (via POMC/CART activation) and orexigenic (via NPY/AgRP activation) responses. In conditions of overweight and obesity the control of energy balance is clearly deregulated, and serotonergic modulation appears to make a significant contribution to weight gain. Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI) that increases 5-HT availability in the synaptic cleft may thus...
Source: Behavioural Brain Research - August 9, 2018 Category: Neurology Authors: da Silva AI, Braz GRF, de A Silva SC, da S Pedroza AA, de Lima-Júnior NC, de A Silva TL, Jacques Lagranha C Tags: Behav Brain Res Source Type: research

Neural correlates of liraglutide effects in persons at risk for Alzheimer's Disease.
Abstract Insulin resistance (IR) is a metabolic state preceding development of type 2 diabetes (DM2), cardiovascular disease, and neurodegenerative disorders, including Alzheimer's Disease (AD). Liraglutide, a glucagon-like peptide-1 (GLP) agonist, is an insulin-sensitizing agent with neuroprotective properties, as shown in animal studies. The purpose of this double-blinded, placebo-controlled study was to examine the neural effects of administration of liraglutide in cognitively normal late middle-aged individuals with subjective cognitive complaints (half of subjects had family history of AD). Seed-based resting...
Source: Behavioural Brain Research - August 9, 2018 Category: Neurology Authors: Watson KT, Wroolie TE, Tong G, Foland-Ross LC, Frangou S, Singh M, McIntyre R, Roat-Shumway S, Myoraku A, Reiss AL, Rasgon NL Tags: Behav Brain Res Source Type: research

Spatial information is preferentially processed by the distal part of CA3: Implication for memory retrieval.
Abstract For the past decades, CA3 was considered as a single functional entity. However, strong differences between the proximal (close to the dentate gyrus) and the distal (close to CA2) parts of CA3 in terms of connectivity patterns, gene expression and electrophysiological properties suggest that it is not the case. We recently showed that proximal CA3 (together with distal CA1) preferentially deals with non-spatial information [1]. In contrast to proximal CA3, distal CA3 mainly receives and predominantly projects to spatially tuned areas. Here, we tested if distal CA3 preferentially processes spatial informat...
Source: Behavioural Brain Research - August 8, 2018 Category: Neurology Authors: Flasbeck V, Atucha E, Nakamura NH, Yoshida M, Sauvage MM Tags: Behav Brain Res Source Type: research

Basolateral amygdala inactivation eliminates fear-induced underestimation of time in a temporal bisection task.
We examined interval timing-time perception in the seconds-to-minutes range-of the fear-inducing stimulus and the role of the amygdala in this phenomenon. Rats were initially trained to perform a temporal bisection task, in which their responses to levers A and B were reinforced following 2-s and 8-s tones, respectively. After acquisition, the rats were also presented with tones of intermediate durations and pressed one of the two levers to indicate whether the tone duration was closer to 2 or 8 s. Subsequently, the rats underwent differential fear conditioning, in which one frequency tone (conditioned stimulus; CS+...
Source: Behavioural Brain Research - August 8, 2018 Category: Neurology Authors: Kamada T, Hata T Tags: Behav Brain Res Source Type: research

Hippo/YAP signaling pathway mitigates blood-brain barrier disruption after cerebral ischemia/reperfusion injury.
In this study, we investigated whether the Hippo/YAP pathway plays a role in I/R injury in brain, especially in regard to I/R-induced BBB breakdown. The results of our study indicate that I/R injury led to an overall decrease in activity of the core proteins, YAP and TAZ, over a 24-h period. The most dramatic change was observed 1.5 h after reperfusion. In rats that underwent 1.5 h of reperfusion, intraperitoneal injection of YAP agonist dexamethasone activated YAP and TAZ and led to improved neurologic function, smaller brain infarct sizes, increased levels of tight junction proteins, decreased BBB permeabil...
Source: Behavioural Brain Research - August 6, 2018 Category: Neurology Authors: Gong P, Zhang Z, Zou C, Tian Q, Chen X, Hong M, Liu X, Chen Q, Xu Z, Li M, Wang J Tags: Behav Brain Res Source Type: research

Cerebral and behavioural response to human voices is mediated by sex and sexual orientation.
Abstract Several studies report sex differences in sensitivity to gendered stimuli. We assume many of these to reflect differences as to the sex to which one feels attracted rather than to biological sex per se. Investigating voice perception, a function of high social relevance, we show that the behavioural and neural (BOLD) responses to male and female voices are mediated by sex and sexual orientation. In heterosexual men and women, we found an opposite-sex effect, reflected in higher classification accuracy for and a response bias towards voices of the other sex, while the effect became apparent as same-sex eff...
Source: Behavioural Brain Research - August 3, 2018 Category: Neurology Authors: Smith E, Junger J, Pauly K, Kellermann T, Dernt B, Habel U Tags: Behav Brain Res Source Type: research

Thinking about the past to shape the present: Neural activation during the recall of relationship episodes.
chter A Abstract Reflecting on oneself and others in relationships is an ability that is central to our social existence. Specifically, considering formative autobiographical experiences in relationships may contribute to more flexibility in perceiving, as well as in shaping present relationships. Reflecting on such experiences mobilizes different social cognitive and affective processes. We aim to explore the neural basis of these processes. With a newly developed functional magnetic imaging (fMRI) task, we investigated brain activation in 35 healthy individuals during recall of relationship episodes involving th...
Source: Behavioural Brain Research - August 2, 2018 Category: Neurology Authors: Wade-Bohleber LM, Böker H, Ernst J, Grimm S, Brügger N, Berwian IM, Vetter J, Preller KH, Himmighoffen H, Kleim B, Seifritz E, Richter A Tags: Behav Brain Res Source Type: research

Single prolonged stress decreases sign-tracking and cue-induced reinstatement of cocaine-seeking.
Abstract Exposure to prolonged, uncontrollable stress reduces reward-seeking behavior, resulting in anhedonia in neuropsychiatric disorders, such as posttraumatic stress disorder. However, it is unclear to what degree stressed subjects lose interest in rewards themselves or in reward-related cues that instigate reward-seeking behavior. In the present study, we investigated the effects of single prolonged stress (SPS) on cue-directed behavior in two different procedures: Pavlovian conditioned approach (PCA) and cue-induced reinstatement of cocaine-seeking. In Experiment 1, rats were exposed to SPS and tested for th...
Source: Behavioural Brain Research - August 2, 2018 Category: Neurology Authors: Fitzpatrick CJ, Jagannathan L, Lowenstein E, Robinson TE, Becker JB, Morrow JD Tags: Behav Brain Res Source Type: research

sucrose ingestion induces glutamate AMPA receptor phosphorylation in dorsal hippocampal neurons: Increased sucrose experience prevents this effect.
Abstract Evidence suggests that meal-related memory influences later eating behavior. Memory can serve as a powerful mechanism for controlling eating behavior because it provides a record of recent intake that likely outlasts most physiological signals generated by ingestion. Dorsal (dHC) and ventral hippocampal (vHC) neurons are critical for memory, and we demonstrated previously that they limit energy intake during the postprandial period. If dHC or vHC neurons control intake through a process that requires memory, then ingestion should increase events necessary for synaptic plasticity in dHC and vHC during the ...
Source: Behavioural Brain Research - August 1, 2018 Category: Neurology Authors: Ross A, Barnett N, Faulkner A, Hannapel R, Parent MB Tags: Behav Brain Res Source Type: research

Prenatal Ethanol Exposure Increases Risk of Psychostimulant Addiction.
Abstract Prenatal ethanol exposure (PE) causes many cognitive and behavioral deficits including increased drug addiction risk, demonstrated by enhanced ethanol intake and behavioral phenotypes associated with addiction risk. Additionally, preclinical studies show that PE persistently changes the function of dopaminergic neurons in the ventral tegmental area, a major neural substrate for addiction, and alters these neurons' responses to psychostimulants. Accordingly, PE could also lead to increased risk of addiction to drugs of abuse, other than ethanol. In the present study, addiction risk was examined utilizing p...
Source: Behavioural Brain Research - August 1, 2018 Category: Neurology Authors: Wang R, Shen YL, Hausknecht KA, Chang L, Haj-Dahmane S, Vezina P, Shen RY Tags: Behav Brain Res Source Type: research

Scopolamine increases perseveration in mice subjected to the detour test.
This study also shows that a mouse detour task is a suitable model for detecting the effect of anticholinergic drugs on perseveration in contrast to the previously applied tests. PMID: 30071270 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 30, 2018 Category: Neurology Authors: Juszczak GR, Stryjek R Tags: Behav Brain Res Source Type: research

Danger and safety signals independently influence persistent pathological avoidance in anxiety-vulnerable Wistar Kyoto rats: A role for impaired configural learning in anxiety vulnerability.
Abstract Pathological avoidance behavior in anxiety and anxiety-related disorders has a large role in the persistence and severity of disease. Individuals are cued to avoid potential aversive events by learned danger and safety signals in the environment. Individuals with anxiety demonstrate a bias to utilize danger signals more than safety signals, in contrast to those without these disorders. Therefore, the present study investigated if danger and safety signals differentially influenced persistent avoidance in an animal model of anxiety-vulnerability, the Wistar Kyoto (WKY) rat, relative to the outbred Sprague ...
Source: Behavioural Brain Research - July 28, 2018 Category: Neurology Authors: Spiegler KM, Smith IM, Pang KCH Tags: Behav Brain Res Source Type: research

Exploring the neuromechanism of chronic ephedrine addiction in rhesus monkeys: a behavioural and brain resting-state fMRI study.
Abstract Ephedrine is thought to exert behavioural effects primarily through actions on the central nervous system. However, the neuromechanism underlying the effects of ephedrine addiction still remains unclear. Our study aimed to establish chronic ephedrine addiction models in rhesus monkeys and to investigate the neuromechanism of chronic ephedrine addiction using the behavioural methods combined with resting-state blood oxygenation level dependent-functional magnetic resonance imaging (BOLD-fMRI). Monkeys in the ephedrine addiction group (n = 6) received intramuscular injections of ephedrine usin...
Source: Behavioural Brain Research - July 27, 2018 Category: Neurology Authors: Xie L, Ma Y, Huang J, Guo R, Wang J, Sun Z, Duan S, Wu B, Lin Z, Xiao Y, Ma S Tags: Behav Brain Res Source Type: research

Hyperbaric oxygen therapy restored traumatic stress-induced dysregulation of fear memory and related neurochemical abnormalities.
Abstract Individuals with posttraumatic stress disorder (PTSD) are characterized by fear memory problems and hypocortisolemia of which traumatic stress-induced monoaminergic disruption over infralimbic (IL) cortex is considered the key mechanism. Hyperbaric oxygen therapy (HBOT) has recently proven its utility in treating several mental disorders but remains unexplored for PTSD. The present study aimed to examine the effects of 5-day HBO paradigm on traumatic stress (single prolonged stress, SPS, an animal model of PTSD)-induced dysregulation of fear memory/anxiety profiles and related abnormalities in IL monoamin...
Source: Behavioural Brain Research - July 26, 2018 Category: Neurology Authors: Lin CC, Huang KL, Tung CS, Liu YP Tags: Behav Brain Res Source Type: research

Latency to startle is reduced in the 5xFAD mouse model of Alzheimer's disease.
Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder that results in cognitive decline and a number of other neuropsychiatric symptoms. One area that is often affected by neuropsychiatric disease is the response to sudden, loud noises, as measured by the acoustic startle response (ASR), and prepulse inhibition (PPI), which indicates sensory-gating abilities. Evidence suggests AD patients, even early in the disease, show alteration in ASR. Studies have also shown changes in this measure in transgenic mouse models of AD. To assess the homology of 5xFAD mice to AD patients, the current study ...
Source: Behavioural Brain Research - July 25, 2018 Category: Neurology Authors: Story D, Chan E, Munro N, Rossignol J, Dunbar GL Tags: Behav Brain Res Source Type: research

Combined early life stressors: prenatal nicotine and maternal deprivation interact to influence behavioral phenotypes in rats.
We report here that multiple early stressors including prenatal nicotine and MD can modulate the neuroanatomy of the amygdala and VTA. These early life stressors can interact to influence the development of depressive-like and addictive behaviors. PMID: 30055209 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 25, 2018 Category: Neurology Authors: Bassey RB, Gondré-Lewis MC Tags: Behav Brain Res Source Type: research

Involvement of D1- and D2-like dopamine receptors in the dentate gyrus in the acquisition, expression, and extinction of the morphine-induced conditioned place preference in rats.
Abstract In the current study, we investigated the role of intra-dentate gyrus (DG) administration of D1 and/or D2 receptor antagonists on the expression, acquisition, and extinction of morphine-CPP. Cannulae were implanted bilaterally into the DG region in male Wistar rats and CPP was induced by the subcutaneous injection of morphine (5 mg/kg) during a 3-day conditioning phase. Three experimental designs were separately employed in the CPP paradigm during the acquisition, expression and extinction phases, and different doses (0.25, 1, or 4 μg/0.5 μl saline) of SCH23390, as a selective D...
Source: Behavioural Brain Research - July 24, 2018 Category: Neurology Authors: Katebi N, Farahimanesh S, Fatahi Z, Zarrabian S, Haghparast A Tags: Behav Brain Res Source Type: research

5-Methoxy- α-methyltryptamine (5-MeO-AMT), a tryptamine derivative, induces head-twitch responses in mice through the activation of serotonin receptor 2a in the prefrontal cortex.
This study shows that 5-MeO-AMT induces HTR through 5-HTR2a activation in the prefrontal cortex, and may have low potential for abuse. PMID: 30053461 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 24, 2018 Category: Neurology Authors: Abiero A, Botanas CJ, Val Sayson L, Custodio RJ, de la Peña JB, Kim M, Lee HJ, Seo JW, Ryu IS, Min Chang C, Yang JS, Sup Lee Y, Jang CG, Kim HJ, Cheong JH Tags: Behav Brain Res Source Type: research

Adolescent and adult nicotine exposure differentially impacts oral nicotine and oral saccharin self-administration in mice.
Abstract Smokers that begin during adolescence are more likely to develop nicotine dependence than those who begin as adults. However, the factors that contribute to this remain largely unknown. Here we utilized a novel operant oral nicotine self-administration procedure in mice to assess the consequences of adolescent nicotine exposure on nicotine and saccharin (non-drug) reinforcement in adults. Animals were given non-contingent exposure to either saline or nicotine using the osmotic minipumps during both adolescence and adulthood for 2 weeks. Reinforcing efficacy for oral nicotine and saccharin was assessed usi...
Source: Behavioural Brain Research - July 24, 2018 Category: Neurology Authors: Cole RD, Wolsh C, Zimmerman M, Harrington E, Gould TJ, Parikh V Tags: Behav Brain Res Source Type: research

G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats.
Abstract Postmenopausal depression has been shown to be related to the reduction of ovarian hormones produced as a woman transitions from a menopausal to a post-menopausal stage. What remains to be known is which type of estrogen receptor plays a key role in estrogen neuroprotection, a process that may be mediated by potentiating brain mitochondrial function and inhibiting mitochondria-associated apoptosis. In order to better imitate the condition of postmenopause, we conducted our research on aged female rats. Plasma estrogen levels declined significantly in ovariectomized rats and 16-month-old female rats, while...
Source: Behavioural Brain Research - July 21, 2018 Category: Neurology Authors: Wang J, Yu R, Han QQ, Huang HJ, Wang YL, Li HY, Wang HM, Chen XR, Ma SL, Yu J Tags: Behav Brain Res Source Type: research

Altered neural responsivity to food cues in relation to food preferences, but not appetite-related hormone concentrations after RYGB-surgery.
CONCLUSIONS: RYGB leads to changed responsivity of the frontoparietal control network that orchestrates top-down control to high-energy food compared to low-energy food and non-food cues, rather than in reward related brain regions, in a satiated state. Together with correlations with the shift in food preference from high- to low-energy foods this indicates a possible role in new food preference formation. PMID: 30041007 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 21, 2018 Category: Neurology Authors: Zoon HFA, de Bruijn SEM, Smeets PAM, de Graaf C, Janssen IMC, Schijns W, Aarts EO, Jager G, Boesveldt S Tags: Behav Brain Res Source Type: research

Single Session, High-Intensity Aerobic Exercise Fails to Affect Plasticity-Related Protein Expression in the Rat Sensorimotor Cortex.
We examined immediate responses in animals following either a GXT, or two resting conditions: non-exercising treadmill controls (TC), and acclimatization controls (AC). Young, male Sprague-Dawley rats (n = 20) on a reverse light cycle (12 h/12 h) were exposed to a treadmill acclimatization procedure consisting of 8 days of increasing exercise intensity (10 m/min up to 25 m/min) for 10 minutes at the same time each day. The acclimatization was followed by 2 days of rest to reduce any carryover effects. On testing day, rats performed either a GXT, or rested (TC and AC), were then sacrificed and sensorimotor cor...
Source: Behavioural Brain Research - July 21, 2018 Category: Neurology Authors: Thacker JS, Yeung D, Chambers PJ, Tupling AR, Staines WR, Mielke JG Tags: Behav Brain Res Source Type: research

Chronic forced exercise inhibits stress-induced reinstatement of cocaine conditioned place preference.
Abstract Stress increases the likelihood of cocaine relapse in humans and animals, even following a prolonged extinction/abstinence period. Exercise has previously been shown to reduce stress and decrease the likelihood of drug dependence, while also reducing cravings in humans and inhibiting relapse behaviors due to other risk factors in rodents. The present study evaluated the efficacy of exercise to reduce stress-induced relapse to cocaine in a rodent model. Young adult female Sprague Dawley rats were tested for cocaine conditioned place preference (CPP), then split into sedentary or exercise (six weeks of one-...
Source: Behavioural Brain Research - July 20, 2018 Category: Neurology Authors: Robison LS, Alessi L, Thanos PK Tags: Behav Brain Res Source Type: research

High nursing demand reduces depression-like behavior despite increasing glucocorticoid concentrations and reducing hippocampal neurogenesis in late postpartum rats.
Abstract Approximately 15% of women who give birth develop postpartum depression (PPD) and the risk is greater in women who do not breastfeed or who cease breastfeeding early. In some women, early cessation or absence of breastfeeding precedes PPD, but the neuroendocrine mechanisms of this relationship are unknown. We tested whether nursing demand would alter behavioral and endocrine endpoints relevant for depression in postpartum rats. Adult female Sprague-Dawley rats underwent thelectomy (thel; removal of teats), sham surgery (sham), or no surgery (control). Litters were rotated between thel and sham rats every ...
Source: Behavioural Brain Research - July 19, 2018 Category: Neurology Authors: De Guzman RM, Saulsbery AI, Workman JL Tags: Behav Brain Res Source Type: research

The α5-GABAAR inverse agonist MRK-016 upregulates hippocampal BDNF expression and prevents cognitive deficits in LPS-treated mice, despite elevations in hippocampal Aβ.
The α5-GABAAR inverse agonist MRK-016 upregulates hippocampal BDNF expression and prevents cognitive deficits in LPS-treated mice, despite elevations in hippocampal Aβ. Behav Brain Res. 2018 Jul 19;: Authors: Eimerbrink MJ, Pendry RJ, Hodges SL, Wiles JD, Peterman JL, White JD, Hayes HB, Chumley MJ, Boehm GW Abstract Alzheimer's disease is marked by the presence of amyloid-beta (Aβ) plaques, elevated central cytokine levels, dysregulation of BDNF-related gene expression, and cognitive decline. Previously, our laboratory has demonstrated that repeated administration of peripheral LPS is...
Source: Behavioural Brain Research - July 19, 2018 Category: Neurology Authors: Eimerbrink MJ, Pendry RJ, Hodges SL, Wiles JD, Peterman JL, White JD, Hayes HB, Chumley MJ, Boehm GW Tags: Behav Brain Res Source Type: research

Predicting Antidepressant Response Using Early Changes in Cognition: A Systematic Review.
CONCLUSION: The identification of reliable early treatment predictors of antidepressant response would be clinically significant, enabling clinicians to more accurately evaluate the efficacy of selected treatment avenues. PMID: 30031025 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 18, 2018 Category: Neurology Authors: Park C, Pan Z, Brietzke E, Subramaniapillai M, Rosenblat JD, Zuckerman H, Lee Y, Fus D, McIntyre RS Tags: Behav Brain Res Source Type: research