Exploring transgenerational inheritance in epigenotypes of DAT heterozygous rats: circadian anomalies and attentional vulnerability
Behav Brain Res. 2024 Feb 24:114921. doi: 10.1016/j.bbr.2024.114921. Online ahead of print.ABSTRACTDopamine (DA) is mainly involved in locomotor activity, reward processes and maternal behaviors. Rats with KO gene for dopamine transporter (DAT) coding for a truncated DAT protein are in hyperdopaminergic conditions and develop stereotyped behaviors and hyperactivity. Our aim was to test the prior transgenerational modulation of wild and truncated allele as expressed in heterozygous DAT rats: specifically we addressed the possible sequelae due to genotype and gender of the ancestors, with regard to behavioral differences in ...
Source: Behavioural Brain Research - February 26, 2024 Category: Neurology Authors: Concetto Puzzo Fabiana Festucci Giuseppe Curcio Antonella Gigantesco Walter Adriani Source Type: research
Effects of cortisol administration on heart rate variability and functional connectivity across women with different depression histories
Behav Brain Res. 2024 Feb 24:114923. doi: 10.1016/j.bbr.2024.114923. Online ahead of print.ABSTRACTAbnormalities within the hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system have been implicated in depression. Studies have reported glucocorticoid insensitivity and reduced heart rate variability (HRV) in depressive disorders. However, little is known about the effects of cortisol on HRV and resting-state functional connectivity (rsFC) of the central autonomic network (CAN) in depression. We collected resting-state fMRI and cardiac data for women with different depression histories (n = 61) after adminis...
Source: Behavioural Brain Research - February 26, 2024 Category: Neurology Authors: Carissa L Philippi Emily Weible Alissa Ehlers Erin C Walsh Roxanne M Hoks Rasmus M Birn Heather C Abercrombie Source Type: research
The 5-HT2A, 5-HT5A, and 5-HT6 Serotonergic Receptors in The Medial Prefrontal Cortex Behave Differently in Extinction Learning: Does Social Support play a role?
Behav Brain Res. 2024 Feb 24:114922. doi: 10.1016/j.bbr.2024.114922. Online ahead of print.ABSTRACTStudies on the social modulation of fear have revealed that in social species, individuals in a distressed state show better recovery from aversive experiences when accompanied - referred to as social buffering. However, the underlying mechanisms remain unknown, hindering the understanding of such an approach. Our previous data showed that the presence of a conspecific during the extinction task inhibited the retrieval of fear memory without affecting the extinction memory in the retention test. Here, we investigate the role ...
Source: Behavioural Brain Research - February 26, 2024 Category: Neurology Authors: Clarissa Penha Farias Ana Karla Oliveira Leite Bianca Estefani Schmidt Jociane de Carvalho Myskiw Angela T S Wyse Source Type: research
Age dependent path Integration deficit in 5xFAD mice
Behav Brain Res. 2024 Feb 24:114919. doi: 10.1016/j.bbr.2024.114919. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is a severe neurodegenerative disorder and the most common form of dementia in elderly individuals, characterized by memory deficits, cognitive decline, and neuropathology. The identification of preclinical markers for AD remains elusive. We employed an ultrasound-evoked spatial memory assay to investigate path integration (PI) in wild type C57BL/6J and 5xFAD mice. We observed significant recruitment of the mammillary bodies (MB) and subiculum (Sub) - core regions of the Papez circuit during PI, as in...
Source: Behavioural Brain Research - February 26, 2024 Category: Neurology Authors: Kendall D Mar CIhanbee So Yixin Hou Jun Chul Kim Source Type: research
Exploring transgenerational inheritance in epigenotypes of DAT heterozygous rats: circadian anomalies and attentional vulnerability
Behav Brain Res. 2024 Feb 24:114921. doi: 10.1016/j.bbr.2024.114921. Online ahead of print.ABSTRACTDopamine (DA) is mainly involved in locomotor activity, reward processes and maternal behaviors. Rats with KO gene for dopamine transporter (DAT) coding for a truncated DAT protein are in hyperdopaminergic conditions and develop stereotyped behaviors and hyperactivity. Our aim was to test the prior transgenerational modulation of wild and truncated allele as expressed in heterozygous DAT rats: specifically we addressed the possible sequelae due to genotype and gender of the ancestors, with regard to behavioral differences in ...
Source: Behavioural Brain Research - February 26, 2024 Category: Neurology Authors: Concetto Puzzo Fabiana Festucci Giuseppe Curcio Antonella Gigantesco Walter Adriani Source Type: research
Effects of cortisol administration on heart rate variability and functional connectivity across women with different depression histories
Behav Brain Res. 2024 Feb 24:114923. doi: 10.1016/j.bbr.2024.114923. Online ahead of print.ABSTRACTAbnormalities within the hypothalamic-pituitary-adrenal (HPA) axis and autonomic nervous system have been implicated in depression. Studies have reported glucocorticoid insensitivity and reduced heart rate variability (HRV) in depressive disorders. However, little is known about the effects of cortisol on HRV and resting-state functional connectivity (rsFC) of the central autonomic network (CAN) in depression. We collected resting-state fMRI and cardiac data for women with different depression histories (n = 61) after adminis...
Source: Behavioural Brain Research - February 26, 2024 Category: Neurology Authors: Carissa L Philippi Emily Weible Alissa Ehlers Erin C Walsh Roxanne M Hoks Rasmus M Birn Heather C Abercrombie Source Type: research
The 5-HT2A, 5-HT5A, and 5-HT6 Serotonergic Receptors in The Medial Prefrontal Cortex Behave Differently in Extinction Learning: Does Social Support play a role?
Behav Brain Res. 2024 Feb 24:114922. doi: 10.1016/j.bbr.2024.114922. Online ahead of print.ABSTRACTStudies on the social modulation of fear have revealed that in social species, individuals in a distressed state show better recovery from aversive experiences when accompanied - referred to as social buffering. However, the underlying mechanisms remain unknown, hindering the understanding of such an approach. Our previous data showed that the presence of a conspecific during the extinction task inhibited the retrieval of fear memory without affecting the extinction memory in the retention test. Here, we investigate the role ...
Source: Behavioural Brain Research - February 26, 2024 Category: Neurology Authors: Clarissa Penha Farias Ana Karla Oliveira Leite Bianca Estefani Schmidt Jociane de Carvalho Myskiw Angela T S Wyse Source Type: research
Behavioral and neurotransmitter changes on antiepileptic drugs treatment in the zebrafish pentylenetetrazol-induced seizure model
In this study, we observed that 5-HT and DA levels in the brain increased immediately after PTZ-induced seizures. Behavioral tests clearly showed that all of these AEDs suppressed the PTZ-induced seizures. Upon treatment of PTZ-induced seizures with these AEDs, CBZ decreased the glutamic acid and FFR increased the GABA levels; however, no neurotransmitter changes were observed in the brain after LEV administration. Thus, we demonstrated a series of neurotransmitter changes linked to behavioral changes during PTZ-induced epileptic seizures when LEV, CBZ, or FFR were administered. These findings will lead to a more detailed ...
Source: Behavioural Brain Research - February 25, 2024 Category: Neurology Authors: Kazuo Okanari Hitoshi Teranishi Ryohei Umeda Kenshiro Shikano Masanori Inoue Toshikatsu Hanada Kenji Ihara Reiko Hanada Source Type: research
Influence of a placebo tDCS treatment on Cybersickness and EEG-Neurofeedback success
Behav Brain Res. 2024 Feb 22:114917. doi: 10.1016/j.bbr.2024.114917. Online ahead of print.ABSTRACTVirtual Reality (VR) serves as a modern and powerful tool within the domain of neurofeedback (NF). Users can learn how to alter their own brain activation with the help of NF, for example visual feedback. VR can help to make the training more engaging and motivating with its immersive nature. However, cybersickness (CS) poses a serious problem, as it negatively affects up to 80% of all VR users. Especially women seem to be affected. Some studies suggest positive effects of placebo interventions, so that less CS in the users c...
Source: Behavioural Brain Research - February 24, 2024 Category: Neurology Authors: Lisa Maria Berger Guilherme Wood Silvia Erika Kober Source Type: research
Analysis of visual discrimination in Japanese eel (Anguilla japonica)
Behav Brain Res. 2024 Feb 22:114916. doi: 10.1016/j.bbr.2024.114916. Online ahead of print.ABSTRACTJapanese eels were trained to discriminate between a checkerboard panel and a plain gray panel in a circular pool with three pipes. One of the pipes was open, whereas the others were closed. The correct choice of discriminative stimulus was reinforced by entering the pipe. When the panels were displayed vertically (on the wall), the eels successfully learned discrimination, but they were unable to acquire the task when the panels were presented horizontally (on the floor). Enucleation of the retina impaired discrimination, wh...
Source: Behavioural Brain Research - February 24, 2024 Category: Neurology Authors: Shigeru Watanabe Source Type: research
Influence of a placebo tDCS treatment on Cybersickness and EEG-Neurofeedback success
Behav Brain Res. 2024 Feb 22:114917. doi: 10.1016/j.bbr.2024.114917. Online ahead of print.ABSTRACTVirtual Reality (VR) serves as a modern and powerful tool within the domain of neurofeedback (NF). Users can learn how to alter their own brain activation with the help of NF, for example visual feedback. VR can help to make the training more engaging and motivating with its immersive nature. However, cybersickness (CS) poses a serious problem, as it negatively affects up to 80% of all VR users. Especially women seem to be affected. Some studies suggest positive effects of placebo interventions, so that less CS in the users c...
Source: Behavioural Brain Research - February 24, 2024 Category: Neurology Authors: Lisa Maria Berger Guilherme Wood Silvia Erika Kober Source Type: research
Analysis of visual discrimination in Japanese eel (Anguilla japonica)
Behav Brain Res. 2024 Feb 22:114916. doi: 10.1016/j.bbr.2024.114916. Online ahead of print.ABSTRACTJapanese eels were trained to discriminate between a checkerboard panel and a plain gray panel in a circular pool with three pipes. One of the pipes was open, whereas the others were closed. The correct choice of discriminative stimulus was reinforced by entering the pipe. When the panels were displayed vertically (on the wall), the eels successfully learned discrimination, but they were unable to acquire the task when the panels were presented horizontally (on the floor). Enucleation of the retina impaired discrimination, wh...
Source: Behavioural Brain Research - February 24, 2024 Category: Neurology Authors: Shigeru Watanabe Source Type: research
Sevoflurane exerts antidepressant-like effects via the BDNF-TrkB pathway
In conclusion, this study provides evidence supporting the notion that sevoflurane exerts its antidepressant-like effect via the BDNF-TrkB signaling pathway.PMID:38387696 | DOI:10.1016/j.bbr.2024.114918 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 22, 2024 Category: Neurology Authors: Shaohua You Yishuang Wu Yongxin Guo Meng Wu Mingzi Ran Fuyang Cao Xinyu Hao Lujia Yang Hong Zhang Weidong Mi Li Tong Source Type: research
Sevoflurane exerts antidepressant-like effects via the BDNF-TrkB pathway
In conclusion, this study provides evidence supporting the notion that sevoflurane exerts its antidepressant-like effect via the BDNF-TrkB signaling pathway.PMID:38387696 | DOI:10.1016/j.bbr.2024.114918 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 22, 2024 Category: Neurology Authors: Shaohua You Yishuang Wu Yongxin Guo Meng Wu Mingzi Ran Fuyang Cao Xinyu Hao Lujia Yang Hong Zhang Weidong Mi Li Tong Source Type: research
A Generative Adaptive Convolutional Neural Network with Attention Mechanism for Driver Fatigue Detection with Class-imbalanced and Insufficient Data
Behav Brain Res. 2024 Feb 19:114898. doi: 10.1016/j.bbr.2024.114898. Online ahead of print.ABSTRACTOver the past few years, fatigue driving has emerged as one of the main causes of traffic accidents, necessitating the development of driver fatigue detection systems. However, many existing methods involves tedious manual parameter tunings, a process that is both time-consuming and results in task-specific models. On the other hand, most of the researches on fatigue recognition are based on class-balanced and sufficient data, and effectively "mine" meaningful information from class-imbalanced and insufficient data for fatigu...
Source: Behavioural Brain Research - February 21, 2024 Category: Neurology Authors: Le He Li Zhang Qiang Sun XiangTian Lin Source Type: research
