Repeated bifenthrin exposure alters hippocampal Nurr-1/AChE and induces depression-like behavior in adult rats.
Abstract Exposure to insecticides has been associated with depression-like symptoms, especially among occupationally exposed populations, such as farmers. Although the neurotoxicity of pyrethroids such as bifenthrin (BF) is well established, it is still unclear whether exposure to BF may have deleterious effects on the hippocampus and thus behavior. We verified the hypothesis that repeated exposure to BF in a rat model elicits neurochemical and behavioral alterations, the latter of which reflects depression-related symptoms. Adult male Wistar rats (n = 12 per group) were orally administered with diff...
Source: Behavioural Brain Research - April 9, 2019 Category: Neurology Authors: Gargouri B, Bouchard M, Saliba SW, Fetoui H, Fiebich BL Tags: Behav Brain Res Source Type: research

Affective profiling for anxiety-like behavior in a rodent model of mTBI.
This study exposed rodents to repeated blast overpressure (BOP) and analyzed behavioral responses and molecular variables at 3 weeks and 6 months after exposure. We applied a modified version of a previously reported behavioral profiling approach that separates "affected" and "unaffected" rats based on the presence of anxiety-like behaviors (Ritov, 2016). We report that "affected" 3 week animals showed higher plasma corticosterone and amygdalar stathmin levels, while "affected" 6 month animals had lower prefrontal cortex stathmin. Higher corticosterone also paralleled anxiety behavio...
Source: Behavioural Brain Research - April 9, 2019 Category: Neurology Authors: Statz JK, Ciarlone SL, Goodrich JA, McCarron RM, Walker PB, Norris JN, Ahlers ST, Tschiffely AE Tags: Behav Brain Res Source Type: research

Effects of a methanol extract of Ficus platyphylla stem bark on a two-way active avoidance task and on body core temperature.
In this study, we examined the effects of the standardised methanol extract of F. platyphylla stem bark (FP) on two-way active avoidance learning and body core temperature to complement earlier studies on the neuroleptic potential of this medicinal plant, which is already in common use. The extract did not interfere with the acquisition and consolidation of the conditioned avoidance reaction (CAR), but did diminish the retrieval of CAR. The extract dose-dependently reduced body core temperature; this was significantly ameliorated by the use of amphetamine. The results confirmed the neuroleptic-like efficacy of FP, probably...
Source: Behavioural Brain Research - April 6, 2019 Category: Neurology Authors: Sutter J, Chindo BA, Becker A Tags: Behav Brain Res Source Type: research

Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion.
Abstract OBJECTIVES: Strong evidence has proven that cerebral hypoperfusion is closely related to Parkinson's disease (PD) with cognitive impairment. The aim of this study was to investigate the effect of chronic cerebral hypoperfusion (CCH) on cognitive dysfunction, structural abnormalities of the hippocampus and white matter (WM), and levels of inflammatory cytokines in control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse models. METHODS: In the present study, bilateral common carotid artery stenosis (BCCAS) was performed using microcoils, and the cognitive function and WM lesions ...
Source: Behavioural Brain Research - April 5, 2019 Category: Neurology Authors: Gao Y, Tang H, Nie K, Zhu R, Gao L, Feng S, Wang L, Zhao J, Huang Z, Zhang Y, Wang L Tags: Behav Brain Res Source Type: research

Gentle abdominal stroking ('belly rubbing') of pigs by a human reduces EEG total power and increases EEG frequencies.
Abstract The neurobiological response to gentle touch remains poorly understood, especially in the context of human-animal interaction. A novel approach allowed recording the pig electroencephalogram (EEG) cranially epidurally and wirelessly during positive interactions with a human. Stroking of the pig's abdomen ('belly rubbing'), applied opportunistically, elicited a distinct behavioral response characterized by lateral recumbency, limb stretching, frequent short-lasting grunts and eye closure. Pigs varied in their responsiveness to belly rubbing but all pigs showed it. Their EEG was compared to EEG during human...
Source: Behavioural Brain Research - April 5, 2019 Category: Neurology Authors: Rault JL, Truong S, Hemsworth L, Le Chevoir M, Bauquier S, Lai A Tags: Behav Brain Res Source Type: research

Perinatal nicotine exposure impairs learning of a skilled forelimb reaching task in male but not female adult mice.
Abstract Developmental tobacco or nicotine exposure is associated with various adverse outcomes in human and preclinical studies, respectively. For example, perinatal nicotine exposure in mice causes morphologic changes in neurons across sensory and motor cortices and results in impairments in sensory learning. However, the effects of developmental nicotine exposure on motor learning have not been reported. To determine whether nicotine-induced changes in behavior extend to motor tasks, we provided female C57Bl/6 dams with nicotine drinking water (200 μg/ml in 2% saccharin), or vehicle (2% saccharin), a standar...
Source: Behavioural Brain Research - April 5, 2019 Category: Neurology Authors: Lee AM, Picciotto MR Tags: Behav Brain Res Source Type: research

Comparison of the effects of nimodipine and deferoxamine on brain injury in rat with subarachnoid hemorrhage.
This study aimed to compare the efficacy of nimodipine and deferoxamine on these sequelae of SAH. A rat model of SAH was established by the double-hemorrhage method. These rats were injected with saline (intraperitoneal, IP), nimodipine (IP), or deferoxamine (IP and intranasal) every 12 h for 5 days after SAH. The MRI scanning, including magnetic resonance angiography, diffusion tensor imaging, T2-weighted imaging, was performed to detect the brain structure. The levels of iron metabolism-related proteins were examined by Western blot analysis. The Morris water maze (MWM) test was used to assess the cognitive functi...
Source: Behavioural Brain Research - April 3, 2019 Category: Neurology Authors: Qin Y, Li G, Sun Z, Xu X, Gu J, Gao F Tags: Behav Brain Res Source Type: research

Mesenchymal stem cell therapy improves spatial memory and hippocampal structure in aging rats.
MESENCHYMAL STEM CELL THERAPY IMPROVES SPATIAL MEMORY AND HIPPOCAMPAL STRUCTURE IN AGING RATS. Behav Brain Res. 2019 Apr 02;: Authors: Zappa Villar MF, Lehmann M, García MG, Mazzolini G, Morel GR, Cónsole GM, Podhajcer O, Reggiani PC, Goya RG Abstract There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine in the brain as they have shown neurogenic and immunomodulatory activities. We assessed the effect of intracerebroventricular (icv) administration of human bone marrow-derived MSCs (hBM-MSCs) on spatial memory and hippocampal...
Source: Behavioural Brain Research - April 2, 2019 Category: Neurology Authors: Zappa Villar MF, Lehmann M, García MG, Mazzolini G, Morel GR, Cónsole GM, Podhajcer O, Reggiani PC, Goya RG Tags: Behav Brain Res Source Type: research

Expression of aggressiveness modulates mesencephalic c-fos activation during a social interaction test in Japanese quail (Coturnix japonica).
Abstract It is well known that during a social conflict, interactions are dependent on the animal's propensity to behave aggressively as well as the behavior of the opponent. However, discriminating between these two confounding factors was difficult. Recently, a Social Interaction (SI) test using photocastrated males as non-aggressive stimuli was proposed as a useful tool to evaluate aggressiveness. The avian Intercollicular- Griseum centralis complex (comparable to mammalian periaqueductal gray) has been reported as a crucial node in the descending pathways that organize behavioral and autonomic aspects of defen...
Source: Behavioural Brain Research - April 2, 2019 Category: Neurology Authors: Caliva JM, Melleu FF, Marino-Neto J, Marin RH, Kembro JM Tags: Behav Brain Res Source Type: research

The Neural Systems of Emotion Regulation and Abnormalities in Major Depressive Disorder.
Abstract Major depressive disorder (MDD) is a mental disorder characterized by aberrant emotion regulation. The capacity for emotion regulation stems from diverse neural circuits including higher level cognitive structures involved in processing contextual information, and lower level limbic structures involved in triggering emotional expression. Cognitive theories of depression posit that the MDD-specific abnormalities in emotional control derive itself from dysfunctional cognitive processes including biased attention, rumination, and altered information processing and memory. The main objectives of the current n...
Source: Behavioural Brain Research - April 2, 2019 Category: Neurology Authors: Park C, Rosenblat JD, Lee Y, Pan Z, Cao B, Iacobucci M, McIntyre RS Tags: Behav Brain Res Source Type: research

Restoring emotional stability: Cortisol effects on the neural network of cognitive emotion regulation.
Abstract Effective emotion regulation in stressful contexts is a key feature of mental health. Acute stress, however, impairs prefrontal top-down control, probably leading to a decline of emotion regulatory capacities. By contrast, the delayed cortisol increase in response to a stressor or after a pharmacological manipulation has been linked to mood-protecting effects and emotion regulation success. In this functional magnetic resonance imaging study, healthy men and women received either 30 mg cortisol or placebo 90 min before they were exposed to an emotion regulation paradigm involving neutral and...
Source: Behavioural Brain Research - April 1, 2019 Category: Neurology Authors: Jentsch VL, Merz CJ, Wolf OT Tags: Behav Brain Res Source Type: research

The role of anti-inflammatory cytokines in memory processing in a healthy brain.
THE ROLE OF ANTI-INFLAMMATORY CYTOKINES IN MEMORY PROCESSING IN A HEALTHY BRAIN. Behav Brain Res. 2019 Mar 31;: Authors: Arkhipov VI, Pershina EV, Levin SG Abstract The purpose of the work was to study the role of anti-inflammatory cytokines in memory processing in a healthy brain. Wistar rats were trained to perform a task with positive (food) reinforcement; and then the task performance was tested after intraventricular injection of IL-10 or TGF-β1. A microinjection into the brain of either of the two cytokines did not affect the performance of the task and did not have an anti-amnesic effect w...
Source: Behavioural Brain Research - March 31, 2019 Category: Neurology Authors: Arkhipov VI, Pershina EV, Levin SG Tags: Behav Brain Res Source Type: research

Theta and Alpha Band Oscillations During Value-Directed Strategic Processing.
This study examined theta and alpha band power differences linked to processing of high- versus low-value information. Thirty-three young adults (17 F; mean age: 21.2 ± 1.5 years) completed a value-directed word list learning task. The task consisted of five word lists that each contained a unique set of high- and low-value words that were visually presented one at a time and EEG corresponding to these words were examined. To encourage strategic processing, participants were informed that after each list they would be asked to recall as many words as possible with their goal being to maximize th...
Source: Behavioural Brain Research - March 31, 2019 Category: Neurology Authors: Nguyen LT, Marini F, Zacharczuk L, Llano DA, Mudar RA Tags: Behav Brain Res Source Type: research

Ventromedial prefrontal cortex is involved in preference and hedonic evaluation of tastes.
te;cz O, Kovács A, Karádi Z, Lénárd L Abstract The ventromedial prefrontal cortex (vmPFC) of rats has reciprocal connections with the gustatory and the hedonic impact coding structures. The main goal of the present study was to investigate the involvement of local neurons of vmPFC and their catecholaminergic innervations in taste preference and taste reactivity test. Therefore, kainate or 6-hydroxydopamine (6-OHDA) lesions were performed in the vmPFC by iontophoretic method. In the first experiment, taste preference was tested to 250 mM and 500 mM glucose solutions over wa...
Source: Behavioural Brain Research - March 30, 2019 Category: Neurology Authors: Berta B, Kertes E, Péczely L, Ollmann T, László K, Gálosi R, Kállai V, Petykó Z, Zagorácz O, Kovács A, Karádi Z, Lénárd L Tags: Behav Brain Res Source Type: research

Downregulation of sonic hedgehog signaling in the hippocampus leads to neuronal apoptosis in high-fat diet-fed mice.
CONCLUSION: Downregulation of hippocampal SHH signaling leads to neuronal apoptosis and cognitive deficits in HFD-fed mice. These findings provide useful information for the identification of potential targets for research and therapeutic interventions for cognitive impairment in obesity. PMID: 30940514 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 30, 2019 Category: Neurology Authors: Qin S, Sun D, Zhang C, Tang Y, Zhou F, Zheng K, Tang R, Zheng Y Tags: Behav Brain Res Source Type: research

The Adapted Autobiographical Interview: A Systematic Review and Proposal for Conduct and Reporting.
ía A Abstract The adapted Autobiographical Interview (AI) is one of the most commonly used and widely cited measures of prospection in adult humans. The use of this instrument requires investigators to make many decisions that can influence the outcomes of studies. Here, we performed a systematic review of studies utilizing the adapted AI. We assessed and characterized the studies on various aspects of methodological quality and reporting. We then investigated and reported on several properties of adapted AI scores that have implications for their interpretation. We conclude by proposing Conduct and Reporti...
Source: Behavioural Brain Research - March 29, 2019 Category: Neurology Authors: Miloyan B, McFarlane K, Vásquez Echeverría A Tags: Behav Brain Res Source Type: research

Enriched experience during pregnancy and lactation protects against motor impairments induced by neonatal hypoxia-ischemia.
to CA Abstract Neonatal hypoxia-ischemia (HI) is responsible for movement disorders in preterm infants. Non-pharmacological strategies, such as environmental enrichment (EE) during adulthood, have shown positive effects on promoting sensorimotor recovery after HI. However, little is known about the effects of perinatal EE on sensorimotor function following HI. In present study we investigated the hypothesis that enriched experiences during pregnancy and lactation would reduce motor impairments caused by a model of neonatal HI in rats. At postnatal day (PND) 3, Wistar pups of both sexes were subject to the modified...
Source: Behavioural Brain Research - March 28, 2019 Category: Neurology Authors: Durán-Carabali LE, Sanches EF, Reichert L, Netto CA Tags: Behav Brain Res Source Type: research

Repeated treatments with the D1 dopamine receptor agonist SKF-38393 modulate cell viability via sustained ERK-Bad-Bax activation in dopaminergic neuronal cells.
This study investigated the effects of SKF-38393 on dopaminergic neuronal cell death in a 6-hydroxydopamine-lesioned rat model of Parkinson's disease (PD) and PC12 cells. In the PD model, SKF-38393 administration (3 and 10 mg/kg per day, s.c.) for 8 weeks significantly increased the number of tyrosine hydroxylase-immunopositive neuronal cells in nigrostriatal regions. SKF-38393 administration for 8 weeks induced phosphorylation of sustained ERK1/2 and Bad (Bcl-2-associated death promoter) at Ser155 (BadSer155), and augmented Bax (Bcl-2-associated X protein) expression. However, SKF-38393 only increased Bad phosphory...
Source: Behavioural Brain Research - March 28, 2019 Category: Neurology Authors: Park HJ, Zhao TT, Park KH, Lee MK Tags: Behav Brain Res Source Type: research

Kinetic deterioration of short memory in rat with acute hepatic encephalopathy: involvement of astroglial and neuronal dysfunctions.
Abstract Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome resulting from acute or chronic hepatic impairments. The clinical features of HE include attention as well as a mild cognitive deficits associated with impaired attentional and executive networks in patients as well as in animal models of HE. The underlining pathomechanism of memory impairment in HE patients is still not fully understood; however, it may involve a possible gliopathy as well as neuropathy. The aim of the present investigation is to assess progression of short working memory deterioration in acute HE and to delineate the gli...
Source: Behavioural Brain Research - March 27, 2019 Category: Neurology Authors: Khiat AE, Tamegart L, Draoui A, Fari RE, Sellami S, Rais H, Hiba OE, Gamrani H Tags: Behav Brain Res Source Type: research

Effect of acute exposure to hypobaric hypoxia on learning and memory in adult sprague-dawley rats.
Abstract The present study aimed to observe the effects of acute exposure to hypobaric hypoxia on learning and memory in adult Sprague-Dawley (SD) rats as well as the changes in N-methyl-D-aspartate receptor (NMDAR) subunits. Learning and memory abilities were evaluated with Morris water maze following simulated hypoxia at 5000 m or 7000 m for 2, 4 or 6 days. The number of red blood cells, the level of hemoglobin, oxidative stress markers, the extent of neuronal damage in the hippocampal CA1, and the expression of NMDAR subunits were all measured. In place navigation test, the escape latency signific...
Source: Behavioural Brain Research - March 27, 2019 Category: Neurology Authors: Zhu M, Xu M, Zhang K, Li J, Ma H, Xia G, Li X, Zhang B, Shi H Tags: Behav Brain Res Source Type: research

Estrogen receptors α and β in the central amygdala and the ventromedial nucleus of the hypothalamus: Sociosexual behaviors, fear and arousal in female rats during emotionally challenging events.
Estrogen receptors α and β in the central amygdala and the ventromedial nucleus of the hypothalamus: Sociosexual behaviors, fear and arousal in female rats during emotionally challenging events. Behav Brain Res. 2019 Mar 27;: Authors: Moëne OL, Mihaela S, Sonoko O, Sergei M, Ågmo A Abstract Estrogens receptors (ER) are involved in several sociosexual behaviors and fear responses. In particular, the ERα is important for sexual behaviors, whereas ERβ modulates anxiolytic responses. Using shRNA directed either against the ERα or the ERβ RNAs (or containing luci...
Source: Behavioural Brain Research - March 27, 2019 Category: Neurology Authors: Moëne OL, Mihaela S, Sonoko O, Sergei M, Ågmo A Tags: Behav Brain Res Source Type: research

Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders.
Abstract Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models. As rodent studies of ARBs continue to dominate the field, mounting evidence suggests that zebrafish (Danio rerio) also display ARB-like phenotypes and may therefore be a novel model organism for ARB research. In addition to practical research advantages, zebrafish share high genetic and physiological homology to humans and rodents, including multiple ARB-related genes and stereotypic behaviors relevant to ARB. Here, we discuss a wide spectrum of stereotypic repetitive beha...
Source: Behavioural Brain Research - March 26, 2019 Category: Neurology Authors: Zabegalov KN, Khatsko SL, Lakstyga AM, Demin KA, Cleal M, Fontana BD, McBride SD, Harvey BH, de Abreu MS, Parker MO, Kalueff AV Tags: Behav Brain Res Source Type: research

Impaired Amygdala-based Learning and Decreased Anxiety in a Murine Model of Pseudohypoparathyroidism type 1A.
Abstract Pseudohypoparathyroidism type 1A (PHP1A) is a genetic disorder caused by maternally inherited mutations in the gene Gnas. PHP1A is characterized by multiple hormone impairment, early onset obesity and cognitive impairment. Animal models of PHP1A are needed to investigate the mechanism of cognitive impairment. In the present study we used the cre-lox murine model to investigate behavior and cognition in maternally vs. paternally inherited gnas mutations expressed in the central nervous system. We observed a behavioral phenotype of decreased anxiety and impaired amygdala-based learning in the PHP1A mutant m...
Source: Behavioural Brain Research - March 25, 2019 Category: Neurology Authors: Shoemaker AH, Paffenroth KC, Bingham N, Harrison FE Tags: Behav Brain Res Source Type: research

Have I been here before? Complex interactions of age and test experience modulate the results of behavioural tests.
SH Abstract Recently, a discussion about the reproducibility of results from behavioural phenotyping experiments has emerged. A huge emphasis has therefore been put on the identification of those factors that might limit the reproducibility of behavioural data. As a comprehensive phenotypic characterisation can involve testing of the same animal repeatedly over a specific time period, the aim of the present study was to systematically investigate effects of two potentially confounding variables, age of the animals and test experience. For this purpose, the behaviour of 48 male C57BL/6 J mice of two differe...
Source: Behavioural Brain Research - March 25, 2019 Category: Neurology Authors: von Kortzfleisch VT, Kästner N, Prange L, Kaiser S, Sachser N, Richter SH Tags: Behav Brain Res Source Type: research

Anxiolytic-like effect of chalcone N-{(4'-[(E)-3-(4-fluorophenyl)-1-(phenyl) prop-2-en-1-one]} acetamide on adult zebrafish (Danio rerio): involvement of the GABAergic system.
The objective of this study was to evaluate the possible anxiolytic-simile effect of synthetic chalcone N-{(4'-[(E)-3-(4-fluorophenyl)-1-(phenyl) prop-2-en-1-one]} acetamide (PAAPFBA) on adult zebrafish (Danio rerio). PAAPFBA was synthesized with an 88.21 % yield and its chemical structure was determined by 1H and 13C NMR. Initially, animals (n = 6/group) were treated (4 or 12 or 40 mg/kg, intraperitoneal) with PAAPFBA and were submitted to acute toxicity and open field tests. Then, other groups (n = 6/each) received PAAPFBA for the analysis of its effect on the Light & Dark Test. The...
Source: Behavioural Brain Research - March 25, 2019 Category: Neurology Authors: Ferreira MKA, da Silva AW, Silva FCO, Holanda CLA, Barroso SM, Dos Reis Lima J, Neto AEV, Campos AR, Bandeira PN, Dos Santos HS, de Lemos TLG, Siqueira SMC, Magalhães FEA, de Menezes JESA Tags: Behav Brain Res Source Type: research

Resveratrol synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson disease in mice.
Abstract L-DOPA (L-3,4-dihydroxyphenylalanine) relieves symptoms of Parkinson disease (PD), but long-term use can cause serious side effects. Resveratrol (3,5,4'-trihydroxy-trans-stilbene, RV), a polyphenolic compound derived from grapes and red wine that has antioxidant activity, has been shown to have neuroprotective effects. RV was investigated to enhance the therapeutic effect of L-DOPA in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse model of Parkinson disease. Mice received a saline or RV injection (10 mg/kg/day), then 2 h later, saline or MPTP (15 mg/kg/day) was ad...
Source: Behavioural Brain Research - March 25, 2019 Category: Neurology Authors: Liu Q, Zhu D, Jiang P, Tang X, Lang Q, Yu Q, Zhang S, Che Y, Feng X Tags: Behav Brain Res Source Type: research

That does not sound right: Sounds affect visual ERPs during a piano sight-reading task.
Abstract Prolonged musical training induces important audio-visuo-motor plastic processes. However, little is known about how the musicians' brain resolves multimodal conflicts while preparing for musical action. We run an electroencephalographic (EEG) investigation on how visual processing for action (score reading) is affected by preceding task-irrelevant piano sounds, usually associated to the same or to a different action. Presentation of an incongruent sound, 100 msec before a musical score with one single note, reduces Event-Related Potentials (ERPs) associated to score reading (N170) localised in the...
Source: Behavioural Brain Research - March 25, 2019 Category: Neurology Authors: Delogu F, Brunetti R, Inuggi A, Campus C, Del Gatto C, D'Ausilio A Tags: Behav Brain Res Source Type: research

MGluR5 activity is required for the induction of ethanol behavioral sensitization and associated changes in ERK MAP kinase phosphorylation in the nucleus accumbens shell and lateral habenula.
Abstract Metabotropic glutamate receptor subtype-5 (mGluR5) activity regulates a variety of behavioral pathologies associated with alcohol addiction. The main goal of this study was to determine if mGluR5 regulates the induction of ethanol-induced locomotor sensitization, which is a model of experience-dependent plasticity following initial exposure to drugs of abuse. The extracellular signal-regulated kinase (ERK1/2) pathway is downstream of mGluR5 and implicated in alcohol addiction; however, its role in sensitization remains unexplored. We sought to determine if mGluR5-mediated changes in ethanol-induced sensit...
Source: Behavioural Brain Research - March 23, 2019 Category: Neurology Authors: Stevenson RA, Hoffman JL, Maldonado-Devincci AM, Faccidomo S, Hodge CW Tags: Behav Brain Res Source Type: research

Response control correlates of anomalous basal ganglia morphology in boys, but not girls, with attention-deficit/hyperactivity disorder.
This study expands upon recent evidence of sex differences in subcortical morphology and motor response control deficits among children with ADHD to examine basal ganglia volume and shape in relation to motor response control. Participants included 8-12 year-old children with ADHD (n = 52, 21 girls) and typically developing (TD) controls (n = 45, 19 girls). High resolution T1-weighted 3D MPRAGE images covering the whole brain were acquired for all participants on a 3 T scanner. Participants performed two computer-based go/no-go tasks that differed in the extent to which working memory was...
Source: Behavioural Brain Research - March 23, 2019 Category: Neurology Authors: Tang X, Seymour KE, Crocetti D, Miller MI, Mostofsky SH, Rosch KS Tags: Behav Brain Res Source Type: research

Sustained overexpression of neuropeptide S in the amygdala reduces anxiety-like behavior in rats.
Woldbye DPD Abstract Neuropeptide S (NPS) has shown anxiolytic-like effects in rodents after acute administration, but its long-term effects remain unknown. Gene therapy enables the targeted delivery of DNA to cell nuclei, and recombinant adeno-associated viral (rAAV) vectors have been identified as suitable tools for stable overexpression. Thus, to explore the effects of long-term expression of NPS, the present study examined anxiety- and depressive-like effects after rAAV-mediated NPS overexpression in the rat amygdala. Compared to rats injected with an empty control vector (rAAV-Empty), rAAV-NPS treatment was a...
Source: Behavioural Brain Research - March 23, 2019 Category: Neurology Authors: Tillmann S, Skibdal HE, Christiansen SH, Gøtzsche CR, Hassan M, Mathé AA, Wegener G, Woldbye DPD Tags: Behav Brain Res Source Type: research

Epigenetic Effects of Paternal Cocaine on Reward Stimulus Behavior and Accumbens Gene Expression in Mice.
This study, utilizing a murine (C57BL/6 J) oral cocaine model, examines the effects of paternal cocaine exposure on fundamental characteristics of offspring reward responses, including: 1) the extent of cocaine-induced effects after different durations of sire drug withdrawal; 2) sex- and drug-dependent differences in F1 reward preference; 3) effects on second generation (F2) cocaine preference; and 4) corresponding changes in reward area (nucleus accumbens) mRNA expression. We demonstrate that paternal cocaine intake over a single ˜40-day spermatogenic cycle significantly decreased cocaine (but not ethanol or...
Source: Behavioural Brain Research - March 22, 2019 Category: Neurology Authors: Yaw AM, Prosser RA, Jones PC, Garcia BJ, Jacobson DA, Glass JD Tags: Behav Brain Res Source Type: research

Neuro-Restorative Effect of Sertoli Cell Transplants in a Rat Model of Amyloid Beta Toxicity.
Abstract Alzheimer's disease (AD) is a degenerative nerve disease which adversely affects memory and learning skills. Currently, there is no disease-modifying therapeutic approach for AD. However, a growing body of literature suggests cell based therapies as a promising remedy for neurological disorders. Among the potential cell sources, testis- derived Sertoli cells (SCs) appear to be an attractive choice due to their immune-privileged capacities. Herein, we investigated the neuro-restorative/protective effects of SC transplants in a rat model of amyloid beta toxicity. To this end, GATA-4 and vimentin positive SC...
Source: Behavioural Brain Research - March 21, 2019 Category: Neurology Authors: Aliaghaei A, Meymand AZ, Boroujeni ME, Khodagoli F, Meftahi GH, Hadipour MM, Abdollahifar MA, Mesgar S, Ahmadi H, Danyali S, Hasani S, Sadeghi Y Tags: Behav Brain Res Source Type: research

Stress-Induced Neural Activation is Altered During Early Withdrawal from Chronic Methamphetamine.
Abstract Chronic methamphetamine (MA) use can lead to increased symptoms of depression and anxiety during abstinence. Less is known about the specific brain regions that are altered following repeated MA that may be associated with these behavioral perturbations. Furthermore, MA has been reported to recruit and activate microglia in the brain, which may exacerbate stress-associated behavioral changes. In the present study, male and female mice were injected with MA (5 mg/kg) or saline once daily for 10 days, and during early withdrawal were assessed for alterations in immediate early gene (c-Fos) responses ...
Source: Behavioural Brain Research - March 19, 2019 Category: Neurology Authors: Jacobskind JS, Rosinger ZJ, Brooks ML, Zuloaga DG Tags: Behav Brain Res Source Type: research

Effects of Cacna1c Haploinsufficiency on Social Interaction Behavior and 50-kHz Ultrasonic Vocalizations in Adult Female Rats.
r M Abstract The risk gene CACNA1C is strongly implicated in the etiology of all major psychiatric disorders, such as depressive disorder, bipolar disorder, autism spectrum disorder, and schizophrenia. These disorders feature high levels of comorbidity and share an overlap of symptoms; in particular, deficits in social functioning are common. Intriguingly, sex-dependent effects of CACNA1C single nucleotide polymorphisms on prevalence, health outcomes, and psychological traits have been reported, typically suggesting that women are more affected by CACNA1C mutations than men. In rodents, genetic modifications speci...
Source: Behavioural Brain Research - March 19, 2019 Category: Neurology Authors: Redecker TM, Kisko TM, Schwarting RKW, Wöhr M Tags: Behav Brain Res Source Type: research

Contribution of cognitive functions to postural control in anticipating self-paced and externally-triggered lower-limb perturbations.
DISCUSSION: We confirm that the preparatory activity of premotor areas is associated with the intentional engagement of upcoming actions since it occurs only before self-paced perturbations. The PFC anticipating both perturbations can be interpreted as an unintentional top-down cognitive control required by the tasks, especially involving attention and inhibition. However, before externally-triggered perturbations also other cognitive resources are required. The EBA activity anticipating externally-triggered perturbation may represent a visual prediction of the desired posture. PMID: 30898679 [PubMed - as supplied by ...
Source: Behavioural Brain Research - March 18, 2019 Category: Neurology Authors: Quinzi F, Berchicci M, Perri RL, Bianco V, Labanca L, Macaluso A, Di Russo F Tags: Behav Brain Res Source Type: research

Enhanced Executive Attention Efficiency after Adaptive Force Control Training: Behavioural and Physiological Results.
In this study, fingertip-based adaptive force control tasks (AFCT) were explored for attention training, and the visual-channel task called an attention network test (ANT) was used to measure the level of attention before and after AFCT. The purposes of this study were to investigate whether AFCT can enhance the attention level on the ANT task and to elucidate the underlying electrophysiological mechanisms. The results showed that the efficiency of the executive control network during ANT was significantly improved by the AFCT training, indicating that the AFCT training may enhance the executive attention level during visu...
Source: Behavioural Brain Research - March 18, 2019 Category: Neurology Authors: Liu M, Zhang J, Jia W, Chang Q, Shan S, Hu Y, Wang D Tags: Behav Brain Res Source Type: research

Effects of a rat model of gestational hypothyroidism on forebrain dopaminergic, gabaergic, and serotonergic systems and related behaviors.
EFFECTS OF A RAT MODEL OF GESTATIONAL HYPOTHYROIDISM ON FOREBRAIN DOPAMINERGIC, GABAERGIC, AND SEROTONERGIC SYSTEMS AND RELATED BEHAVIORS. Behav Brain Res. 2019 Mar 18;: Authors: da Cunha Menezes E, Dos Santos PR, Costa Goes T, de Carvalho VCB, Teixeira-Silva F, Stevens HE, Badauê-Passos D Abstract We investigated the effects of maternal hypothyroidism on forebrain dopaminergic, GABAergic, and serotonergic systems and related behavior in adult rat offspring. Experimental gestational hypothyroidism (EGH) was induced by administering 0.02% methimazole (MMI) to pregnant rats from gestational day 9 ...
Source: Behavioural Brain Research - March 18, 2019 Category: Neurology Authors: da Cunha Menezes E, Dos Santos PR, Costa Goes T, de Carvalho VCB, Teixeira-Silva F, Stevens HE, Badauê-Passos D Tags: Behav Brain Res Source Type: research

Sex effects on behavioral markers of emergence from propofol and isoflurane anesthesia in rats.
This study aimed to characterize the emergence pattern following two anesthesia regimens in both sexes of rats. We considered six different markers of emergence from anesthesia: sigh, eye blinking, forelimb movement, mastication, neck extension, and recovery of the righting reflex (RORR). Spontaneous motor activity 24 hours after the anesthesia induction was also examined. Our results showed that the rank order of the emergence latency after intraperitoneal propofol, PRO, exposure was forelimb movement 
Source: Behavioural Brain Research - March 18, 2019 Category: Neurology Authors: Mansouri MT, Fidler JA, Meng QC, Eckenhoff RG, García PS Tags: Behav Brain Res Source Type: research

Nitric oxide donor molsidomine promotes retrieval of object recognition memory in a model of cognitive deficit induced by 192 IgG-saporin.
doza A, Ríos C, Pérez-Severiano F Abstract Nitric oxide (NO) plays a leading role in learning and memory processes. Previously, we showed its ability to modify the deleterious effect of immunotoxin 192 IgG-saporin (192-IgG-SAP) in the cholinergic system. The aim of this study was to analyze the potential of a NO donor (molsidomine, MOLS) to prevent the recognition memory deficits resulting from the septal cholinergic denervation by 192 IgG-SAP in rats. Quantification of neuronal and endothelial nitric oxide synthase (nNOS and eNOS, respectively) expression was evaluated in striatum, prefrontal cortex...
Source: Behavioural Brain Research - March 18, 2019 Category: Neurology Authors: Hernández-Melesio MA, Alcaraz-Zubeldia M, Jiménez-Capdeville ME, Martínez-Lazcano JC, Santoyo-Pérez ME, Quevedo-Corona L, Gerónimo-Olvera C, Sánchez-Mendoza A, Ríos C, Pérez-Severiano F Tags: Behav Brain Res Source Type: research

MicroRNA-132 regulates total protein of Nav1.1 and Nav1.2 in the hippocampus and cortex of rat with chronic cerebral hypoperfusion.
In this study, the expression of miR-132 was decreased in both the hippocampus and cortex of ratsfollowing CCH generated by bilateral common carotid artery occlusion (2VO). Lentiviral-mediated overexpression of miR-132 ameliorated dementia vulnerability induced by 2VO. At the molecular level, miR-132 repressed the increased protein expression of Nav1.1 and Nav1.2in both the hippocampus and cortex induced by 2VO.MiR-132 suppressed, while AMO-miR-132 enhanced, the level of Nav1.1 and Nav1.2 in primary cultured neonatal rat neurons (NRNs) detected by both western blot analysis and immunofluorescence analysis.Results obtained ...
Source: Behavioural Brain Research - March 15, 2019 Category: Neurology Authors: Hu XL, Wang XX, Zhu YM, Xuan LN, Peng LW, Liu YQ, Yang H, Yang C, Jiao L, Hang PZ, Sun LH Tags: Behav Brain Res Source Type: research

A dyad shows mutual changes during social buffering of conditioned fear responses in male rats.
Abstract The presence of an affiliative conspecific reduces stress responses to a wide variety of stimuli. This phenomenon is termed "social buffering". We previously found that the presence of another naïve rat (associate) reduced conditioned fear responses to an auditory conditioned stimulus in a conditioned subject rat. Although we subsequently conducted a series of studies to examine behavioral, physiological, and neural changes during social buffering in the conditioned subject, the changes in the associate remained unclear. Therefore, in the present study, we investigated the behavioral and ne...
Source: Behavioural Brain Research - March 14, 2019 Category: Neurology Authors: Kiyokawa Y, Yasong L, Takeuchi Y Tags: Behav Brain Res Source Type: research

Social isolation and social support at adulthood affect epigenetic mechanisms, brain-derived neurotrophic factor levels and behavior of chronically stressed rats.
In conclusion, social isolation at adulthood induced epigenetic alterations and exacerbated the effects of chronic stress on HDAC5. Notwithstanding, social support counteracted the adverse effects of stress on HDAC5 expression. PMID: 30880220 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - March 14, 2019 Category: Neurology Authors: Borges JV, de Freitas BS, Antoniazzi V, de Souza Dos Santos C, Vedovelli K, Pires VN, Paludo L, de Lima MNM, Bromberg E Tags: Behav Brain Res Source Type: research

The immediate and delayed effects of single tDCS session over posterior parietal cortex on face-word associative memory.
Abstract Associative memory (AM), an ability to form and retrieve associations between information units is crucial for everyday functioning and is affected by ageing as well as by different neurological conditions. It was shown that rTMS over posterior parietal cortex (PPC) can improve AM of face-word pairs. Therefore, we examined if tDCS will produce comparable effects and explore whether the effect would persist one and five days following the stimulation. Thirty-seven healthy participants took part in cross-over sham-controlled study in which they received 20 minutes of anodal (1.5 mA) or sham tD...
Source: Behavioural Brain Research - March 14, 2019 Category: Neurology Authors: Bjekić J, Vulić K, Živanović M, Vujičić J, Ljubisavljević M, Filipović SR Tags: Behav Brain Res Source Type: research

The Attention Set-Shifting Test is Sensitive for Revealing Sex-based Impairments in Executive Functions Following Developmental Lead Exposure in Rats.
This study examined the effects of perinatal (PERI) and early postnatal (EPN) developmental low-level Pb-exposures in rats on frontoexecutive functions, using the Attention Set-Shift Test (ASST). Control males and females performed the ASST similarly. Male EPN rats had difficulty with simple discrimination (SD) of odors and failed to complete the compound discrimination (CD) stage of the ASST. All other Pb-exposed rats completed the training and testing. Male PERI rats performed worse on the SD, intradimensional (ID), and intradimensional-reversal (ID-Rev) ASST stages when compared to male Control rats. Female EPN rats per...
Source: Behavioural Brain Research - March 13, 2019 Category: Neurology Authors: Neuwirth LS, Masood S, Anderson DW, Schneider JS Tags: Behav Brain Res Source Type: research

Alpha-7 nicotinic receptor allosteric modulator PNU120596 prevents lipopolysaccharide-induced anxiety, cognitive deficit and depression-like behaviors in mice.
Abstract Neuroinflammation is often associated with the development of major depressive disorder (MDD)-related symptoms. Previous studies have indicated that activation of glial cells, upregulation of proinflammatory cytokines and dysregulation of adrenergic system in the central nervous system (CNS) could be the key mediators to modulate depression-related behaviors after peripheral immune activation. Central α7 nicotinic acetylcholine receptor (α7 nAChR) has a role in the regulation of the cholinergic anti-inflammatory pathway. The present study determined the effects of PNU120596, α7 nAChR pos...
Source: Behavioural Brain Research - March 12, 2019 Category: Neurology Authors: Alzarea S, Rahman S Tags: Behav Brain Res Source Type: research

MMP-9-BDNF pathway is implicated in cognitive impairment of male individuals with methamphetamine addiction during early withdrawal.
Abstract Cognitive impairment is often concomitant with current and abstinent methamphetamine (METH) misuse. However, the mechanism underlying the pathogenesis of cognitive impairment induced by METH remains unclear. As evidence indicates that brain-derived neurotrophic factor (BDNF) is associated with METH addiction, the present study aimed to investigate whether BDNF and the proteins regulating the BDNF signaling pathway might be implicated in the cognitive impairment of the METH abusers during early withdrawal. A total of 171 male subjects were recruited, including 85 METH abstainers and 86 healthy controls. Co...
Source: Behavioural Brain Research - March 12, 2019 Category: Neurology Authors: Cheng M, Liu Q, Wang Y, Hao Y, Jing P, Jiao S, Ma L, Pan C, Wu Y Tags: Behav Brain Res Source Type: research

Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice.
CA, Savegnago L Abstract In the last decades, selenium-containing compounds have received increasing attention because of their various biological and pharmacological properties. In the present study, we investigated the effects of 3-[(4-methoxyphenyl) selanyl]-2-phenylimidazo[1,2-a] pyridine (MPI; 1, 10 or 50 mg/kg, i.g.) on the acute restraint stress (ARS)-induced depressive- and anxiety-like behaviors in mice and the underlying mechanism. We used open filed test, forced swimming test, and splash test to evaluate depressive-like behavior, and marble burying and elevated plus maze test to measure anxiety-l...
Source: Behavioural Brain Research - March 12, 2019 Category: Neurology Authors: Domingues M, Casaril AM, Birmann PT, Bampi SR, Lourenço DA, Vieira BM, Dapper LH, Lenardão EJ, Sonego M, Collares T, Seixas FK, Brüning CA, Savegnago L Tags: Behav Brain Res Source Type: research

Dysregulation of miR-142 results in anxiety-like behaviors following single prolonged stress.
Abstract Posttraumatic stress disorder (PTSD) is a prevalent mental disorder that is classified as a trauma- and stressor-related disorder. While numerous epigenetic factors are related to the risk for PTSD, the precise mechanisms underlying this disorder remain unclear. However, accumulating evidence has demonstrated that dysregulation of microRNAs is involved in stress-related psychiatric disorders, resulting in anxiety-like behavior, memory-related deficits and aberrant neuronal plasticity. Here, rats exposed to single prolonged stress showed increased microRNA-142-5p levels in the amygdala and a concurrent red...
Source: Behavioural Brain Research - March 8, 2019 Category: Neurology Authors: Ji LL, Ye Y, Nie PY, Peng JB, Fu CH, Wang ZY, Tong L Tags: Behav Brain Res Source Type: research

Role of dorsal raphe nucleus GHS-R1a receptors in the regulation of inhibitory avoidance and escape behaviors in rats.
Abstract Ghrelin is a recently discovered peptide, mainly produced in the stomach and involved in body's energy-maintenance processes. Ghrelin exerts its actions by activating the growth hormone secretagogue receptor (GHS-R). Recent analyses indicate that ghrelin targets the brain to regulate a wealth of functions, including behavioral responses that have been associated with stress and anxiety mechanisms. In this context, evidence shows the presence of GHS-R receptors in the dorsal raphe nucleus (DRN), the main source of serotonergic neurons that innervate encephalic structures involved in emotional control. Our ...
Source: Behavioural Brain Research - March 8, 2019 Category: Neurology Authors: Cavalcante DP, Turones LC, Camargo-Silva G, Santana JS, Colugnati DB, Pansani AP, Xavier CH, Henschel Pobbe RL Tags: Behav Brain Res Source Type: research

Sex and estrous cycle dependent changes in locomotor activity, anxiety and memory performance in aged mice after exposure of light at night.
Abstract Light-at-night (LAN) can affect mammalian behaviour. But, the effects of LAN on aged rodents remain undefined yet. In the present investigation, aged Swiss Albino mice, habituated in regular light-dark cycle, were exposed to bright-light-pulse (1-hr) at night on the day of study followed by experimentations for assessment of locomotor activities in the open field, anxiety in the elevated plus maze and short-term memory for novel object recognition (NOR) in the habituated field. Under without-bright-light exposure, (a) aged proestrous females showed greater locomotor activities and less anxiety than in age...
Source: Behavioural Brain Research - March 7, 2019 Category: Neurology Authors: Chakrabarti N Tags: Behav Brain Res Source Type: research