Characterizing the dynamic learning process: Implications of a quantitative analysis
Behav Brain Res. 2024 Feb 16:114915. doi: 10.1016/j.bbr.2024.114915. Online ahead of print.ABSTRACTUnderstanding the neural mechanisms involved in learning processes is crucial for unraveling the complexities of behavior and cognition. Sudden change from the untrained level to the fully-learned level is a pivotal feature of instrumental learning. However, the concept of change point and suitable methods to conveniently analyze the characteristics of sudden change in groups remain elusive, which might hinder a fuller understanding of the neural mechanism underlying dynamic leaning process. In the current study, we investiga...
Source: Behavioural Brain Research - February 18, 2024 Category: Neurology Authors: Meilin Wu Fuhong Liu Hao Wang Li Yao Chunling Wei Qiaohua Zheng Jing Han Zhiqiang Liu Yihui Liu Haijun Duan Wei Ren Zongpeng Sun Source Type: research

Blocking the dopaminergic receptors within the hippocampal dentate gyrus reduced analgesic responses induced by restraint stress in the formalin test
Behav Brain Res. 2024 Feb 16:114914. doi: 10.1016/j.bbr.2024.114914. Online ahead of print.ABSTRACTPrevious studies have shown that various receptors, including dopamine receptors, are expressed in the hippocampal dentate gyrus (DG). Besides, indicatively, dopamine receptors play an essential role in the modulation of pain perception. On the other hand, stressful experiences can produce analgesia, termed stress-induced analgesia (SIA). The current study examined the probable role of dopamine receptors within the DG in antinociception induced by restraint stress (RS). Ninety-seven male albino Wistar rats were unilaterally i...
Source: Behavioural Brain Research - February 18, 2024 Category: Neurology Authors: Farzaneh Nazari-Serenjeh Mehdi Sadeghi Ronak Azizbeigi Hadi Semizeh Sajad Mazaheri Amir Haghparast Abbas Haghparast Source Type: research

Characterizing the dynamic learning process: Implications of a quantitative analysis
Behav Brain Res. 2024 Feb 16:114915. doi: 10.1016/j.bbr.2024.114915. Online ahead of print.ABSTRACTUnderstanding the neural mechanisms involved in learning processes is crucial for unraveling the complexities of behavior and cognition. Sudden change from the untrained level to the fully-learned level is a pivotal feature of instrumental learning. However, the concept of change point and suitable methods to conveniently analyze the characteristics of sudden change in groups remain elusive, which might hinder a fuller understanding of the neural mechanism underlying dynamic leaning process. In the current study, we investiga...
Source: Behavioural Brain Research - February 18, 2024 Category: Neurology Authors: Meilin Wu Fuhong Liu Hao Wang Li Yao Chunling Wei Qiaohua Zheng Jing Han Zhiqiang Liu Yihui Liu Haijun Duan Wei Ren Zongpeng Sun Source Type: research

High stability of EEG spectral power across polysomnography and multiple sleep latency tests in good sleepers and chronic insomniacs
Behav Brain Res. 2024 Feb 15:114913. doi: 10.1016/j.bbr.2024.114913. Online ahead of print.ABSTRACTTo assess the stability of electroencephalographic (EEG) spectral features across overnight polysomnography (PSG) and daytime multiple sleep latency tests (MSLTs) in chronic insomniacs (CIs) and normal controls (NCs). A total of 20 NCs and 22 CIs underwent standard PSG and MSLT. Spectral analyses were performed on EEG data from PSG and MSLTs and absolute and relative power in central, frontal and occipital channels were obtained for wake (W) and non-rapid eye movement sleep stage 1 and 2 (N1, N2). Intraclass correlation coeff...
Source: Behavioural Brain Research - February 17, 2024 Category: Neurology Authors: Yuan Shi Rong Ren Ye Zhang Haipeng Zhang Xujun Feng Larry D Sanford Xiangdong Tang Source Type: research

High stability of EEG spectral power across polysomnography and multiple sleep latency tests in good sleepers and chronic insomniacs
Behav Brain Res. 2024 Feb 15:114913. doi: 10.1016/j.bbr.2024.114913. Online ahead of print.ABSTRACTTo assess the stability of electroencephalographic (EEG) spectral features across overnight polysomnography (PSG) and daytime multiple sleep latency tests (MSLTs) in chronic insomniacs (CIs) and normal controls (NCs). A total of 20 NCs and 22 CIs underwent standard PSG and MSLT. Spectral analyses were performed on EEG data from PSG and MSLTs and absolute and relative power in central, frontal and occipital channels were obtained for wake (W) and non-rapid eye movement sleep stage 1 and 2 (N1, N2). Intraclass correlation coeff...
Source: Behavioural Brain Research - February 17, 2024 Category: Neurology Authors: Yuan Shi Rong Ren Ye Zhang Haipeng Zhang Xujun Feng Larry D Sanford Xiangdong Tang Source Type: research

Cross-cultural differences in prefrontal cortex activity in moral judgment: A functional near-infrared spectroscopy (fNIRS) study based on the CNI model
CONCLUSIONS: Our study revealed significant differences in the PFC activation between Japanese and Chinese individuals in the CNI moral judgment task context. Specifically, during the CNI task, Chinese men exhibited higher right dorsolateral prefrontal cortex (R-DLPFC) activity than Chinese women. In contrast, Japanese women showed greater left dorsolateral prefrontal cortex (L-DLPFC) activity than Japanese men. In an international comparison, R-DLPFC activity was higher in Chinese men than in Japanese men. Conversely, the left ventrolateral prefrontal cortex activity was higher in Japanese men compared to Chinese men. Add...
Source: Behavioural Brain Research - February 14, 2024 Category: Neurology Authors: Yachun Qian Yoshiyuki Takimoto Akira Yasumura Source Type: research

Cross-cultural differences in prefrontal cortex activity in moral judgment: A functional near-infrared spectroscopy (fNIRS) study based on the CNI model
CONCLUSIONS: Our study revealed significant differences in the PFC activation between Japanese and Chinese individuals in the CNI moral judgment task context. Specifically, during the CNI task, Chinese men exhibited higher right dorsolateral prefrontal cortex (R-DLPFC) activity than Chinese women. In contrast, Japanese women showed greater left dorsolateral prefrontal cortex (L-DLPFC) activity than Japanese men. In an international comparison, R-DLPFC activity was higher in Chinese men than in Japanese men. Conversely, the left ventrolateral prefrontal cortex activity was higher in Japanese men compared to Chinese men. Add...
Source: Behavioural Brain Research - February 14, 2024 Category: Neurology Authors: Yachun Qian Yoshiyuki Takimoto Akira Yasumura Source Type: research

Cross-cultural differences in prefrontal cortex activity in moral judgment: A functional near-infrared spectroscopy (fNIRS) study based on the CNI model
CONCLUSIONS: Our study revealed significant differences in the PFC activation between Japanese and Chinese individuals in the CNI moral judgment task context. Specifically, during the CNI task, Chinese men exhibited higher right dorsolateral prefrontal cortex (R-DLPFC) activity than Chinese women. In contrast, Japanese women showed greater left dorsolateral prefrontal cortex (L-DLPFC) activity than Japanese men. In an international comparison, R-DLPFC activity was higher in Chinese men than in Japanese men. Conversely, the left ventrolateral prefrontal cortex activity was higher in Japanese men compared to Chinese men. Add...
Source: Behavioural Brain Research - February 14, 2024 Category: Neurology Authors: Yachun Qian Yoshiyuki Takimoto Akira Yasumura Source Type: research

Line- and Sex-Dependent Effects of Juvenile Stress on Contextual Fear- and Anxiety-related Behavior in High- and Low-Alcohol-Preferring Mouse Lines
Behav Brain Res. 2024 Feb 9:114899. doi: 10.1016/j.bbr.2024.114899. Online ahead of print.ABSTRACTJuvenile stress (JS) is a known risk factor for the development of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD), both of which are frequently co-morbid. Data suggest there may be common, genetically-influenced biological responses to stress that contribute to the development of both AUD and PTSD. The present study investigated the impact of JS on contextual fear learning and extinction, as well as corticosterone (CORT) responses before and after JS, before and after contextual fear conditioning (CFC), a...
Source: Behavioural Brain Research - February 11, 2024 Category: Neurology Authors: Arbaaz A Mukadam Julia A Chester Source Type: research

Longitudinal MRI analysis using a hybrid DenseNet-BiLSTM method for Alzheimer's disease prediction
Behav Brain Res. 2024 Feb 8:114900. doi: 10.1016/j.bbr.2024.114900. Online ahead of print.ABSTRACTAlzheimer's disease is a progressive neurological disorder characterized by brain atrophy and cell death, leading to cognitive decline and impaired functioning. Previous research has primarily focused on using cross-sectional data for Alzheimer's disease identification, but analyzing longitudinal sequential MR images is crucial for improved diagnostic accuracy and understanding disease progression. However, existing deep learning models face challenges in learning spatial and temporal features from such data. To address these ...
Source: Behavioural Brain Research - February 10, 2024 Category: Neurology Authors: Alireza Jomeiri Ahmad Habibizad Navin Mahboubeh Shamsi Source Type: research

Pros and cons of narrow- versus wide-compartment rotarod apparatus: an experimental study in mice
Behav Brain Res. 2024 Feb 8:114901. doi: 10.1016/j.bbr.2024.114901. Online ahead of print.ABSTRACTThe rotarod test, a sensorimotor assessment that allows for quantitative evaluation of motor coordination in rodents, has extensive application in many research fields. The test results exhibit extreme between-study variability, sometimes making it challenging to conclude the validity of certain disease models and related therapeutic effects. Although the variation in test paradigms may account for this disparity, some features of rotarod apparatus including rod diameter make differences. However, it is unknown whether the wid...
Source: Behavioural Brain Research - February 10, 2024 Category: Neurology Authors: Sachiko P Keane Kathryn K Chadman Andres R Gomez Wen Hu Source Type: research

Physical training improves inhibitory control in children aged 7-12 years: An fNIRS study
Behav Brain Res. 2024 Feb 8:114902. doi: 10.1016/j.bbr.2024.114902. Online ahead of print.ABSTRACTPhysical exercise plays a crucial role in the development of cognition and brain functions in children. Inhibitory control is an advanced cognition that affects children's life and learning. In the current study, the relationship between physical training and inhibitory control was explored. In total, 80 children were randomly but equally assigned to the experimental and control groups. The experimental group underwent physical training (volleyball) for 60min, thrice a week for 12 weeks. In contrast, the control group did not ...
Source: Behavioural Brain Research - February 10, 2024 Category: Neurology Authors: Xiaoke Zhong Chen Wang Mingchao Xu Xiaoxia Yuan Changhao Jiang Source Type: research

Oral administration of bacterial probiotics improves Helicobacter pylori-induced memory impairment in rats: Insights from behavioral and biochemical investigations
Behav Brain Res. 2024 Feb 8:114903. doi: 10.1016/j.bbr.2024.114903. Online ahead of print.ABSTRACTThere are numerous evidence supporting the association between Helicobacter pylori (H. pylori) infection and the occurrence of cognitive deficits in humans. In this regard, treatment of H. pylori infection has been suggested as an effective strategy to decelerate the neurodegenerative processes of memory deficits in AD patients. Numerous studies support the beneficial effects of probiotics on various pathological conditions, particularly cognitive deficits, however, this concern has not been addressed in relation to the memory...
Source: Behavioural Brain Research - February 10, 2024 Category: Neurology Authors: Nazanin Sadat Seddighi Farimah Beheshti Maha Masoudi Amir Mohammad Ali Tabrizi Ahad Ali Harati Asl S Mohammad Ahmadi-Soleimani Omid Azizi Source Type: research

Assessing effects of tamoxifen on tolerance, dependence, and glutamate and glutamine levels in frontal cortex and hippocampus in chronic morphine treatment
This study, therefore, evaluated effects of tamoxifen on development of analgesic tolerance and dependence, and brain glutamate and glutamine levels in chronic morphine administration. Mice implanted with placebo or morphine pellets were injected with tamoxifen (0.6-2mg/kg) or vehicle twice daily for 3 days. Nociceptive response was evaluated in the hot plate and tail immersion tests, 4, 48 and 72h post-implant, and following a challenge dose of morphine (10mg/kg). Withdrawal signs were determined after naloxone (1mg/kg) administration. Morphine increased nociceptive threshold which declined over time. At 72h, acute morphi...
Source: Behavioural Brain Research - February 8, 2024 Category: Neurology Authors: Asiye Nurten M Zafer G ören Nurdan Tekin Mert Ka şkal Nurhan Enginar Source Type: research

Inhibitory effects of β-asarone on lncRNA BACE1-mediated induction of autophagy in a model of Alzheimer's disease
Behav Brain Res. 2024 Feb 3:114896. doi: 10.1016/j.bbr.2024.114896. Online ahead of print.ABSTRACTThe primary aim of this study was to examine the correlation between the formation of Aβ plaques and autophagy, which is regulated by β-asarone and the lncRNA BACE1-AS. Additionally, the study sought to explore potential targets of the drug in inhibiting the deposition of toxic AD-related proteins and restoring impaired mitochondrial and autophagic functions. SHY5Y cells were utilized to construct a stable Alzheimer's disease (AD) model, followed by the utilization of interference and overexpression lentiviruses targeting BA...
Source: Behavioural Brain Research - February 5, 2024 Category: Neurology Authors: Zhifang Wang Jingpei Zhou Bin Zhang Zhanqiong Xu Haoyu Wang Quan Sun Nanbu Wang Source Type: research