Renewal of extinguished behavior in pigeons (Columba livia) does not require memory consolidation of acquisition or extinction in one-day free-operant appetitive conditioning paradigms.
O, Pusch R Abstract Extinction learning is a fundamental capacity for adaptive and flexible behavior. As extinguished conditioned responding is prone to relapse under certain conditions, the necessity of memory consolidation for recovery phenomena to occur has been highlighted recently. Several studies have demonstrated that both acquisition and extinction training need to be properly consolidated for a relapse of the original acquired memory trace to occur. Does this imply that extinguished responses can't relapse before memory consolidation? To answer this question, we investigated the renewal effect subsequent...
Source: Behavioural Brain Research - May 15, 2019 Category: Neurology Authors: Packheiser J, Güntürkün O, Pusch R Tags: Behav Brain Res Source Type: research

Changes in the glutamate biomarker expression in rats vulnerable or resistant to the rewarding effects of cocaine and their reversal by ceftriaxone.
Abstract Literature data show diverse vulnerability to the rewarding effects of cocaine in human as well as in laboratory animals. The molecular mechanisms of these differences have not been discovered yet. While the initial effects of cocaine depend primarily on the dopamine system, numerous studies have shown that adaptation within the glutamatergic system is responsible for the development of addiction. In this paper, we used the unbiased conditioned place preference (CPP) to identify rats showing a vulnerable or resistant phenotype to the rewarding effects of cocaine. Next, we investigated the expression of me...
Source: Behavioural Brain Research - May 14, 2019 Category: Neurology Authors: Niedzielska-Andres E, Mizera J, Sadakierska-Chudy A, Pomierny-Chamioło L, Filip M Tags: Behav Brain Res Source Type: research

The formation of compensatory contextual fear memory in the absence of dorsal hippocampus does not change sleep architecture.
Abstract Although the dorsal hippocampus (DH) plays an essential role in the consolidation of contextual fear-conditioned (CxFC) memory, this consolidation may also occur in the absence of DH. It is, however, not known if the development of a compensatory circuit for CxFC memory is time-dependent. The DH-dependent contextual fear memory influences sleep architecture, but whether the compensatory fear memory can influence sleep, is not known. Here, we have studied (a) the temporal progression of compensatory contextual fear memory in the absence of DH and (b) the influence of compensatory contextual fear memory on ...
Source: Behavioural Brain Research - May 14, 2019 Category: Neurology Authors: Kant D, Jha SK Tags: Behav Brain Res Source Type: research

Voluntary alcohol access during adolescence/early adulthood, but not during adulthood, causes faster omission contingency learning.
Abstract In omission contingency training, rodents learn to suppress their natural tendency to approach or touch a reward-predictive cue (termed "autoshaping" or "sign-tracking" responses) if the approach/touching responses lead to the omission of the reward. Previous research has shown that high levels of alcohol exposure (through alcohol vapor exposure) or adolescent alcohol consumption (with some versions of the omission contingency task) can lead to faster omission contingency learning. However, the alcohol exposure procedures and/or omission contingency task parameters differed between the...
Source: Behavioural Brain Research - May 13, 2019 Category: Neurology Authors: Pickens CL, Kallenberger P, Pajser A, Fisher H Tags: Behav Brain Res Source Type: research

Chronic caffeine exposure in adolescence promotes diurnal, biphasic mood-cycling and enhanced motivation for reward in adult mice.
Abstract Adolescent's consumption of caffeine and caffeinated beverage is increasing, yet little is known about the consequences of chronic caffeine exposure during the critical development period of adolescence. In the present study, we investigated the effect of beginning chronic caffeine consumption in adolescence on locomotor, mood, sensorimotor gating, and reward seeking behaviors through adolescence and in adulthood. During the light cycle, caffeine exposed mice exhibited hypoactivity in a novel open-field box and increased anxiety-like and depressive-like behaviors, while maintaining normal home cage locomo...
Source: Behavioural Brain Research - May 13, 2019 Category: Neurology Authors: Hinton DJ, Andres-Beck LG, Nett KE, Oliveros A, Choi S, Veldic M, Choi DS Tags: Behav Brain Res Source Type: research

The aggressive spiegeldanio, carrying a mutation in the fgfr1a gene, has no advantage in dyadic fights with zebrafish of the AB strain.
g S Abstract Zebrafish which carries a mutation in the fibroblast growth factor receptor 1A (fgfr1a), also known as spiegeldanio (spd), has previously been reported to be bolder and more aggressive than wildtype (AB) zebrafish. However, in previous studies aggression has been quantified in mirror tests. In dyadic fights the behavior of the combatants is modified by the behavior of their opponent, and fighting a mirror has been reported to have different effects on brain gene expression and brain monoaminergic systems. In the present study aggression was quantified in fgfr1a mutants and AB zebrafish using a mirror ...
Source: Behavioural Brain Research - May 11, 2019 Category: Neurology Authors: Mustafa A, Thörnqvist PO, Roman E, Winberg S Tags: Behav Brain Res Source Type: research

Differential activity pattern of c-Fos in the nucleus accumbens between adult and aged rats during flavor recognition memory.
B, Gallo M Abstract Previous studies have addressed the role of the nucleus accumbens core (NAcbC) and shell (NAcbSh) in taste aversion learning and in the processing of taste palatability which is affected by aging. However, little is known about its implication in safe taste memory and the aging impact. To explore the role of the NAcb in flavor neophobia and its attenuation during aging, we applied c-Fos immunohistochemistry as an index of neural activity of the NAcbC and NAcbSh. Twenty one adult (5-month-old) and 24 aged (24-month-old) male Wistar rats were exposed to a 3% cider vinegar solution for 1, 2 or 6 ...
Source: Behavioural Brain Research - May 10, 2019 Category: Neurology Authors: Grau-Perales AB, Gómez-Chacón B, Gallo M Tags: Behav Brain Res Source Type: research

Exenatide Alleviates Mitochondrial Dysfunction and Cognitive Impairment in the 5 ×FAD Mouse Model of Alzheimer's Disease.
Exenatide Alleviates Mitochondrial Dysfunction and Cognitive Impairment in the 5×FAD Mouse Model of Alzheimer's Disease. Behav Brain Res. 2019 May 10;:111932 Authors: Jingjing A, Yu Z, Mengjun Z, Yunzhen X, Sujie K, Libin L, Xiaodong P, Zhou C Abstract The role of mitochondrial dysfunction has been well-documented in Alzheimer's disease (AD). Glucagon-like peptide 1 (GLP-1) receptor agonists are being utilized as neuroprotectants in the treatment of various neurological disorders, including AD. We conducted this study to explore the effects of exenatide (a GLP-1 receptor agonist) on β-amylo...
Source: Behavioural Brain Research - May 10, 2019 Category: Neurology Authors: Jingjing A, Yu Z, Mengjun Z, Yunzhen X, Sujie K, Libin L, Xiaodong P, Zhou C Tags: Behav Brain Res Source Type: research

tDCS RECOVERS DEPTH PERCEPTION IN ADULT AMBLYOPIC RATS AND REORGANIZES VISUAL CORTEX ACTIVITY.
-Escámez F Abstract Amblyopia or lazy eye is a neurodevelopmental disorder that arises during the infancy and is caused by the interruption of binocular sensory activity before maturation of the nervous system. This impairment causes long-term deterioration of visual skills, particularly visual acuity and depth perception. Although visual function recovery has been supposed to be decreased with age as consequence of reduced neuronal plasticity, recent studies have shown that it is possible to promote plasticity and neurorestoration in the adult brain. Thus, transcranial direct current stimulation (tDCS) has...
Source: Behavioural Brain Research - May 9, 2019 Category: Neurology Authors: Castaño-Castaño S, Feijoo-Cuaresma M, Paredes-Pacheco J, Morales-Navas M, Ruiz-Guijarro JA, Sanchez-Santed F, Nieto-Escámez F Tags: Behav Brain Res Source Type: research

Morning stimulant administration reduces sleep and overnight working memory improvement.
Abstract The goal of cognitive enhancement is to improve mental functions using interventions including cognitive training, brain stimulation and pharmacology. Indeed, psychostimulants, commonly used for cognitive enhancement purposes, while preventing sleep, have been shown to increase working memory (WM) and attention. Sleep, however, is also important for cognitive function; thus, understanding the interaction between stimulants, sleep and cognition may inform current approaches to cognitive enhancement. We used a double-blind, placebo controlled, repeated measure design to investigate the effect of morning adm...
Source: Behavioural Brain Research - May 9, 2019 Category: Neurology Authors: Tselha T, Whitehurst LN, Yetton BD, Vo TT, Mednick SC Tags: Behav Brain Res Source Type: research

Pathological Attenuation of the Right Prefrontal Cortex Activity Predicts Speech and Limb Motor Timing Disorder in Parkinson's Disease.
Abstract Neurological deficits can cause a wide range of motor symptoms in patients with Parkinson's disease (PD). However, our understanding about the effects of PD on the underlying neural mechanisms of motor function has remained elusive. In the present study, we investigated the relationship between PD pathology and neurological deficits in planning and execution mechanisms of motor timing during speech production and limb movement. We used a combination of behavioral and event-related potential (ERP) measures to characterize motor timing deficits in patients with PD compared with a neurologically intact match...
Source: Behavioural Brain Research - May 6, 2019 Category: Neurology Authors: Behroozmand R, Johari K Tags: Behav Brain Res Source Type: research

The Orbitofrontal Cortex Processes Neurofeedback Failure Signals.
l C Abstract Receiving feedback from neural activity, dubbed neurofeedback, can reinforce brain self-regulation. In a real-time functional magnetic resonance imaging (fMRI) experiment, healthy participants received amygdala neurofeedback via a visual brain computer interface. The brain response to signals of reward and failure was modeled. In contrast to previous analyses, we take into account feedback that immediately preceded these signals. That means we tested whether responses were modulated while participants observed sequent reward and failure signals. The orbitofrontal cortex (OFC) showed a negative Blood O...
Source: Behavioural Brain Research - May 6, 2019 Category: Neurology Authors: Paret C, Zähringer J, Ruf M, Ende G, Schmahl C Tags: Behav Brain Res Source Type: research

En route to delineating hippocampal roles in spatial learning.
Abstract The precise role played by the hippocampus in spatial learning tasks, such as the Morris Water Maze (MWM), is not fully understood. One theory is that the hippocampus is not required for 'knowing where' but rather is crucial in 'getting there'. To explore this idea in the MWM, we manipulated 'getting there' variables, such as passive transport or active swimming towards the hidden platform, in rats with and without hippocampal lesions. Our results suggested that for intact rats, self-motion cues enroute to the hidden goal were a necessary component for 'place learning' to progress. Specifically, intact ra...
Source: Behavioural Brain Research - May 2, 2019 Category: Neurology Authors: Poulter S, Austen JM, Kosaki Y, Dachtler J, Lever C, McGregor A Tags: Behav Brain Res Source Type: research

Inhibition of RPTP β/ζ blocks ethanol-induced conditioned place preference in pleiotrophin knockout mice.
Inhibition of RPTPβ/ζ blocks ethanol-induced conditioned place preference in pleiotrophin knockout mice. Behav Brain Res. 2019 May 01;:111933 Authors: Fernández-Calle R, Gramage E, Zapico JM, de Pascual-Teresa B, Ramos A, Herradón G Abstract Pleiotrophin (PTN) and Midkine (MK) are neurotrophic factors that are upregulated in the prefrontal cortex after alcohol administration and have been shown to reduce ethanol drinking and reward. PTN and MK are endogenous inhibitors of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ. Interestingly, pharmacological inhibition of RP...
Source: Behavioural Brain Research - May 1, 2019 Category: Neurology Authors: Fernández-Calle R, Gramage E, Zapico JM, de Pascual-Teresa B, Ramos A, Herradón G Tags: Behav Brain Res Source Type: research

Young at heart: Insights into hippocampal neurogenesis in the aged brain.
Abstract While the existence and importance of adult hippocampal neurogenesis in young adult rodents has been well-established, such qualities in aged animals and humans have remained poorly understood. Most evidence in humans has come from hippocampal volumetric changes that provide no direct proof of new neurons in adulthood. Here, we review the basic neurobiological evidence for adult hippocampal neurogenesis in the aged brain of experimental animals with short and long lifespans, and humans. The rate of cell cycling and addition of new hippocampal neurons to the existing hippocampal circuit undoubtedly decreas...
Source: Behavioural Brain Research - May 1, 2019 Category: Neurology Authors: Kirschen GW, Ge S Tags: Behav Brain Res Source Type: research

Corrigendum to "Integration and segregation of functional segmented anterior and posterior hippocampal networks in memory performance" [Behav. Brain Res. 364 (2019) 256-263].
Corrigendum to "Integration and segregation of functional segmented anterior and posterior hippocampal networks in memory performance" [Behav. Brain Res. 364 (2019) 256-263]. Behav Brain Res. 2019 May 01;:111906 Authors: Xu J, Guan X, Li H, Xu X, Zhang M PMID: 31054847 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - May 1, 2019 Category: Neurology Authors: Xu J, Guan X, Li H, Xu X, Zhang M Tags: Behav Brain Res Source Type: research

Molecular Targets for the Interactive Effect of Etazolate during Post-Traumatic Stress Disorder: Role of Oxidative Stress, BDNF and Histones.
Abstract Post-traumatic stress disorder (PTSD) develops in individuals after exposure to severe, life-threatening traumatic event. Etazolate is a selective phosphodiesterase IV inhibitor that is highly specific for cAMP, which has anxiolytic and antidepressant effects. We have previously shown that PTSD induced-memory impairment, anxiety and depression were prevented via the administration of etazolate. In the current study, the effect of etazolate on oxidative stress parameters, BDNF, and histone acetylation in the hippocampus were evaluated in a rat model of PTSD. The PTSD was induced by single prolonged stress ...
Source: Behavioural Brain Research - April 29, 2019 Category: Neurology Authors: Alzoubi KH, Al Subeh Z, Khabour OF Tags: Behav Brain Res Source Type: research

Deficits in Ultrasonic Vocalization Development and Production following Neonatal Hypoxic Ischemic Insult.
This study examines the acute and long-term ultrasonic vocalization ability of mice after HI at PND 10. Pups were subjected to HI, sham, or naïve conditions; where in HI and sham surgeries the right common carotid artery was exposed, in the HI this artery was double ligated. The HI and sham pups were then exposed to 60 minutes of hypoxia. Naïve pups did not undergo surgery and were subjected to 60 minutes of room air. At 3 days following surgery, HI and sham pups vocalize less than nonsurgical naïve controls; yet "juvenile" mice of 6-8 weeks old that underwent HI at PND 10 vocalize le...
Source: Behavioural Brain Research - April 29, 2019 Category: Neurology Authors: Doran SJ, Jandzinski M, Patrizz A, Trammel C, Sharmeen R, Mamun AA, Capozzi L, Reddy Venna V, Liu F, McCullough LD Tags: Behav Brain Res Source Type: research

The effect of feedback on temporal error monitoring and timing behavior.
Abstract Metacognitive processes in human timing behavior are rarely investigated, which stands in sharp contrast to the wide research field of metacognition itself. To date, little is known about the sources and the reliability of information that humans possess to judge their own timing abilities and to monitor errors in time-keeping. Here, we intended to fill this gap by determining the degree to which humans depend on external feedback to adjust their timing behavior and make metacognitive accuracy judgements. Two groups of participants performed a time reproduction task under different feedback conditions. Af...
Source: Behavioural Brain Research - April 29, 2019 Category: Neurology Authors: Riemer M, Kubik V, Wolbers T Tags: Behav Brain Res Source Type: research

Increased seizure sensitivity, emotional defects and cognitive impairment in PHD finger protein 24 (Phf24)-null rats.
Abstract Phf24 is known as Gαi-interacting protein (GINIP) and is associated with the GABAB receptor. To study the function of Phf24 protein in the central nervous system (CNS), we have newly developed Phf24-null rats and investigated their behavioral phenotypes, especially changes in seizure sensitivity, emotional responses and cognitive functions. Phf24-null rats did not exhibit any spontaneous seizures. However, they showed a higher sensitivity to pentylenetetrazol (PTZ)- or pilocarpine-induced convulsive seizures. Phf24-null rats also showed an elevated susceptibility to kindling development with repeate...
Source: Behavioural Brain Research - April 27, 2019 Category: Neurology Authors: Serikawa T, Kunisawa N, Shimizu S, Kato M, Alves Iha H, Kinboshi M, Nishikawa H, Shirakawa Y, Voigt B, Nakanishi S, Kuramoto T, Kaneko T, Yamamoto T, Mashimo T, Sasa M, Ohno Y Tags: Behav Brain Res Source Type: research

Retrosplenial cortex damage produces retrograde and anterograde context amnesia using strong fear conditioning procedures.
ci DJ Abstract Contextual fear conditioning relies upon a network of cortical and subcortical structures, including the hippocampus and the retrosplenial cortex (RSC). However, the contribution of the hippocampus is parameter-dependent. For example, with "weak" training procedures, lesions of the hippocampus produce both retrograde and anterograde context amnesia. However, with "strong" training procedures (e.g., more trials and/or higher levels of footshock), lesions of the hippocampus produce retrograde context amnesia but not anterograde amnesia [1]. Likewise, prior studies have shown that w...
Source: Behavioural Brain Research - April 27, 2019 Category: Neurology Authors: Fournier DI, Eddy MC, DeAngeli NE, Huszár R, Bucci DJ Tags: Behav Brain Res Source Type: research

Long-Lasting Effects of Repeated Ketamine Administration in Adult and Adolescent Rats.
We examined locomotor activity, as well as cognitive function, in animals that received repeated administration of ketamine. Groups of adolescent and adult male rats were treated with ketamine (25 mg/kg) once daily for 10 days. Locomotor activity was assessed following the first injection, following 10 days of injection, and following 20 days of abstinence. Acute locomotor effects and locomotor sensitization were compared in adolescents and adults; cross-sensitization to dextromethorphan, another dissociative with abusive potential, was also examined. In a separate group of animals cognitive deficits were assessed f...
Source: Behavioural Brain Research - April 26, 2019 Category: Neurology Authors: Shawn Bates ML, Trujillo KA Tags: Behav Brain Res Source Type: research

Limited effects of early life manipulations on sex-specific gene expression and behavior in adulthood.
Abstract Exposure to childhood adversity is associated with increased vulnerability to stress-related disorders in adulthood which has been replicated in rodent stress models, whereas environmental enrichment has been suggested to have beneficial effects. However, the exact neurobiological mechanisms underlying these environment influences on adult brain and behavior are not well understood. Therefore, we investigated the long-term effects of maternal separation (MS) or environmental enrichment (EE) in male and female CD1 mice. We found clear sex-specific effects, but limited influence of environmental manipulatio...
Source: Behavioural Brain Research - April 26, 2019 Category: Neurology Authors: Candemir E, Post A, Dischinger US, Palme R, Slattery DA, O'Leary A, Reif A Tags: Behav Brain Res Source Type: research

Social housing promotes cognitive function through enhancing synaptic plasticity in APP/PS1 mice.
In this study, we investigated how social interaction affected cognitive function and AD pathology in APP/PS1 (amyloid precursor protein/presenilin-1) mice. APP/PS1 mice were divided into either a social isolation (SI) group, a social contact with one mouse (SCO) group, or a social contact with five mice (SCF) group. Our results demonstrated that social housing improved the behavioral performance of APP/PS1 mice in Morris Water Maze testing, without significantly altering the rates of amyloid plaque deposition or amyloidogenic APP processes. Furthermore, the synaptic function, dendritic spine density, and complexity of neu...
Source: Behavioural Brain Research - April 26, 2019 Category: Neurology Authors: Liang F, Yang S, Zhang Y, Hao T Tags: Behav Brain Res Source Type: research

Effects of early postnatal MK-801 treatment on behavioral properties in rats: differences according to treatment schedule.
In this study, we compared the behavioral effects of long-term (14-day) and short-term (5-day) early postnatal treatment of the NMDA receptor antagonist MK-801 (dizocilpine; 5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine). In addition, different drug treatment periods were applied to the short-term treatment study in order to determine the critical developmental period of drug effects. For experiment 1, rats were treated with MK-801 (0.2 or 0.4 mg/kg, twice daily) during postnatal days (PNDs) 7-20. For experiment 2, MK-801 (0.2 mg/kg, twice daily) was administered during the periods of PNDs 7-1...
Source: Behavioural Brain Research - April 25, 2019 Category: Neurology Authors: Kawabe K, Miyamoto E Tags: Behav Brain Res Source Type: research

Voluntary exercise enables stress resistance in females.
Abstract Stress-related disorders are more common in females than males. This difference could arise from differential responses to behavioral interventions that enable stress resistance between sexes. In male rats, regular physical activity prevents the behavioral consequences of uncontrollable stress, such as social avoidance and exaggerated fear conditioning. However, it is unknown if these protective effects are also present in females. Here we demonstrate for the first time in female rats that six weeks of voluntary wheel running buffers against the behavioral sequelae of uncontrollable stress. This observati...
Source: Behavioural Brain Research - April 24, 2019 Category: Neurology Authors: Tanner MK, Fallon IP, Baratta MV, Greenwood BN Tags: Behav Brain Res Source Type: research

Existence of working memory in teleosts: establishment of the delayed matching-to-sample task in adult zebrafish.
In this study, zebrafish learned to perform the simultaneous-matching-to-sample (SMTS) within 15 sessions. After the SMTS training, working memory was tested by inserting a delay period (delayed matching-to-sample; DMTS). Zebrafish could perform the DMTS with a delay of at least 3-4 seconds. They could also learn to perform the DMTS even with a delay period from the beginning of the training session. These results strongly suggest that adult zebrafish possess working memory. However, our study also indicates limitations of zebrafish in cognitive flexibility or attention: they could perform SMTS/DMTS only in a certain set-u...
Source: Behavioural Brain Research - April 24, 2019 Category: Neurology Authors: Bloch S, Froc C, Pontiggia A, Yamamoto K Tags: Behav Brain Res Source Type: research

Cholinergic modulation of motor neurons through the C-boutons are necessary for the locomotor compensation for severe motor neuron loss during amyotrophic lateral sclerosis disease progression.
Abstract Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease characterized by progressive motor neuron (MN) death that leads to muscle weakness, paralysis, and eventually death. When symptoms become clinically evident, patients and ALS model animals (mSod1G93A mice) have already lost a large portion of motor units, suggesting the existence of a compensatory mechanism that allows for reactively normal movement despite denervation. Furthermore, it has been shown that specialized cholinergic synapses, the C-boutons, regulate activity strength of motor output in a task dependent manner. We ...
Source: Behavioural Brain Research - April 22, 2019 Category: Neurology Authors: Landoni LM, Myles JR, Wells TL, Mayer WP, Akay T Tags: Behav Brain Res Source Type: research

Rodent models of social stress and neuronal plasticity: relevance to depressive-like disorders.
Abstract Exposure to severe or persistent social stress may lead to the development of psychiatric disorders such as anxiety and depression. These mood disorders are associated with structural alterations of neural architecture in limbic brain regions that control emotion, mood and cognition. Structural remodeling may either be a sign of successful adaptation, or of failure to do so. In neuropsychiatric disorders like depression structural remodeling involves apoptosis, reduced neurogenesis, and structural remodeling of neuronal dendrites which most likely reflects the latter. Here we review key findings from anim...
Source: Behavioural Brain Research - April 22, 2019 Category: Neurology Authors: Patel D, Kas MJ, Chattarji S, Buwalda B Tags: Behav Brain Res Source Type: research

Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition.
We examined whether spatial T-maze and inclined beam tests distinguish cognitive and motor differences between HI and sham piglets and correlate with neuropathologic injury. Neonatal piglets were randomized to whole-body HI or sham procedure, and they began T-maze and inclined beam testing 17 days later. HI piglets had more incorrect T-maze turns than did shams. Beam walking time did not differ between groups. Neuropathologic evaluations at 33 days validated the injury with putamen neuron loss after HI to below that of sham procedure. HI decreased the numbers of CA3 pyramidal neurons but not CA1 pyramidal neurons or dentat...
Source: Behavioural Brain Research - April 19, 2019 Category: Neurology Authors: Singh R, Kulikowicz E, Santos PT, Koehler RC, Martin LJ, Lee JK Tags: Behav Brain Res Source Type: research

Behavioral profile of intermittent vs continuous access to a high fat diet during adolescence.
cute;guez-Arias M Abstract Over the past few years, the effects of a high-fat diet (HFD) on cognitive functions have been broadly studied as a model of obesity, although no studies have evaluated whether these effects are maintained after the cessation of this diet. In addition, the behavioral effects of having a limited access to an HFD (binge-eating pattern) are mostly unknown, although they dramatically increase the vulnerability to drug use in contrast to having continuous access. Thus, the aim of the present study was to compare the effects of an intermittent versus a continuous exposure to an HFD during adol...
Source: Behavioural Brain Research - April 19, 2019 Category: Neurology Authors: Blanco-Gandía MC, Miñarro J, Rodríguez-Arias M Tags: Behav Brain Res Source Type: research

Corrigendum to "FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia" [Behav. Brain Res. 356 (2019) 98-106].
Corrigendum to "FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia" [Behav. Brain Res. 356 (2019) 98-106]. Behav Brain Res. 2019 Apr 18;:111839 Authors: Jiang X, Niu X, Guo Q, Dong Y, Xu J, Yin N, Qianqian Q, Jia Y, Gao L, He Q, Lv P PMID: 31005352 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 18, 2019 Category: Neurology Authors: Jiang X, Niu X, Guo Q, Dong Y, Xu J, Yin N, Qianqian Q, Jia Y, Gao L, He Q, Lv P Tags: Behav Brain Res Source Type: research

Responsivity of Lateral Septum-mPFC Connections in Alloxan-induced Hyperglycemia.
-Cortés ML Abstract The lateral septal nucleus (LSN) is related to the actions of antidepressants, and the prelimbic cortex (PL) and infralimbic cortex (IL) modulate responses to fear. However, unknown is whether experimental diabetes that is induced by alloxan alters the responsivity of these regions. We used a method in which one forebrain region (LSN) was electrically stimulated while single-unit extracellular recordings were performed in another mPFC region (PL and IL). Several experimental groups were tested: (a) animals that were subjected to long-term (42-day) alloxan-hyperglycemia and protected with...
Source: Behavioural Brain Research - April 18, 2019 Category: Neurology Authors: Contreras CM, Gutiérrez-García AG, Moreno-Cortés ML Tags: Behav Brain Res Source Type: research

Tauopathy in the periaqueductal gray, k ölliker-fuse nucleus and nucleus retroambiguus is not predicted by ultrasonic vocalization in tau-P301L mice.
Tauopathy in the periaqueductal gray, kölliker-fuse nucleus and nucleus retroambiguus is not predicted by ultrasonic vocalization in tau-P301L mice. Behav Brain Res. 2019 Apr 17;:111916 Authors: Trevizan-Baú P, Dhingra RR, Burrows EL, Dutschmann M, Stanić D Abstract Upper airway and vocalization control areas such as the periaqueductal gray (PAG), kölliker-fuse nucleus (KF) and nucleus retroambiguus (NRA) are prone to developing tauopathy in mice expressing the mutant human tau P301 L protein. Consequently, impaired ultrasonic vocalization (USV) previously identified in tau-P3...
Source: Behavioural Brain Research - April 17, 2019 Category: Neurology Authors: Trevizan-Baú P, Dhingra RR, Burrows EL, Dutschmann M, Stanić D Tags: Behav Brain Res Source Type: research

The effects of short-term and long-term environmental enrichment on locomotion, mood-like behavior, cognition and hippocampal gene expression.
Abstract BACKGROUND: Environmental enrichment (EE) has been shown to modulate behavior and hippocampal gene expression; however, the currently available literature does not explain the differential effects that may relate to the duration of EE. AIM: To investigate the differential effects of short- and long-term EE on locomotion, anxiety-, depressive- and cognition-like behaviors, and hippocampal gene expression under physiological conditions. METHODS: We assigned either short-term or long-term intervention with respective controls to healthy C57BL/6 mice (n = 12-16/group). The short-term E...
Source: Behavioural Brain Research - April 17, 2019 Category: Neurology Authors: Singhal G, Morgan J, Jawahar MC, Corrigan F, Jaehne EJ, Toben C, Breen J, Pederson SM, Hannan AJ, Baune BT Tags: Behav Brain Res Source Type: research

Physical activity sustains memory retrieval in dopamine-depleted mice previously treated with L-Dopa.
In conclusion, physical activity did not develop its full pro-neurogenic potential in mice previously treated with L-Dopa but sustained spatial cognition in Parkinson's disease. PMID: 30998993 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 15, 2019 Category: Neurology Authors: Iggena D, Klein C, Rasińska J, Sparenberg M, Winter Y, Steiner B Tags: Behav Brain Res Source Type: research

Anhedonia following mild traumatic brain injury in rats: A behavioral economic analysis of positive and negative reinforcement.
Abstract Psychiatric disorders affect nearly 50% of individuals who have experienced a traumatic brain injury (TBI). Anhedonia is a major symptom of numerous psychiatric disorders and is a diagnostic criterion for depression. It has recently been appreciated that reinforcement may be separated into consummatory (hedonic), motivational and decisional components, all of which may be affected differently in disease. Although anhedonia is typically assessed using positive reinforcement, the importance of stress in psychopathology suggests the study of negative reinforcement (removal or avoidance of aversive events) ma...
Source: Behavioural Brain Research - April 15, 2019 Category: Neurology Authors: Avcu P, Fortress AM, Fragale JE, Spiegler KM, Pang KCH Tags: Behav Brain Res Source Type: research

Age, but not severity of injury, mediates decline in executive function: Validation of the rodent touchscreen paradigm for preclinical models of traumatic brain injury.
Abstract Increasingly, it is being recognised that traumatic brain injury (TBI) is not just an acute event but instead results in ongoing neuronal injury that may lead to chronic impairments in multiple cognitive domains. Of these, deficits in executive function are one of the more common changes reported following TBI, and are a major predictor of well-being, social function and quality of life in individuals with a history of TBI. In order to fully understand the relationship between TBI and executive dysfunction, including brain mechanisms that may account for this, experimental models are clearly needed. Howev...
Source: Behavioural Brain Research - April 15, 2019 Category: Neurology Authors: Arulsamy A, Corrigan F, Collins-Praino LE Tags: Behav Brain Res Source Type: research

A search for cortical correlates of trait impulsivity in Parkinson ´s Disease.
A search for cortical correlates of trait impulsivity in Parkinson´s Disease. Behav Brain Res. 2019 Apr 13;:111911 Authors: Kubera KM, Schmitgen MM, Nagel S, Hess K, Herweh C, Hirjak D, Sambataro F, Wolf RC Abstract BACKGROUND: Impulsivity is an enduring personality trait that is highly relevant for the development of neuropsychiatric disorders. Although impulse control disorders (ICD) are well-characterized non-motor features in Parkinson's disease (PD), mainly related to medication, little is known about neural correlates reflecting trait aspects of impulsivity in PD patients. Here, we address...
Source: Behavioural Brain Research - April 13, 2019 Category: Neurology Authors: Kubera KM, Schmitgen MM, Nagel S, Hess K, Herweh C, Hirjak D, Sambataro F, Wolf RC Tags: Behav Brain Res Source Type: research

Contribution of sensorimotor beta oscillations during value-based action selection.
Abstract Choosing a course of daily-life actions requires an accurate assessment of the associated risks and potential rewards. We investigated the neural dynamics of this decision process by analyzing the neural electrical signals acquired from electroencephalography (EEG) during a value-based action-selection task. In particular, we determined whether sensorimotor beta oscillations, traditionally studied in the context of motor control, are also involved in value-based decision making for actions. Additionally, we examined the involvement of this beta signal relative to other neural signals such as the ERP compo...
Source: Behavioural Brain Research - April 12, 2019 Category: Neurology Authors: Chen XJ, McCarthy M, Kwak Y Tags: Behav Brain Res Source Type: research

Maternal manipulation during late gestation (GDs 17-20) enhances ethanol consumption and promotes changes and opioid mRNA expression in infant rats.
ate P PMID: 30986490 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 12, 2019 Category: Neurology Authors: Guttlein L, Macchione AF, Fonseca KH, Haymal OB, Molina JC, Méndez UM, Abate P Tags: Behav Brain Res Source Type: research

Spontaneous and light-induced lateralization of immediate early genes expression in domestic chicks.
Abstract Exposure of domestic chicks' eggs to light during embryo incubation stimulates asymmetrically the two eye-systems, reaching selectively the right eye (left hemisphere) and inducing asymmetries at the behavioral and neural level. Surprisingly, though, some types of lateralization have been observed also in dark incubated chicks, especially at the behavioral level. Here we investigate the mechanisms subtending the development of lateralization, in the presence and in the absence of embryonic light exposure. We measured the baseline level of expression for the immediate early gene product c-Fos, used as an i...
Source: Behavioural Brain Research - April 12, 2019 Category: Neurology Authors: Lorenzi E, Mayer U, Rosa-Salva O, Morandi-Raikova A, Vallortigara G Tags: Behav Brain Res Source Type: research

Investigating the reciprocal relationships between locomotor sensitization to ethanol and PTSD-like clusters in DBA/2J mice.
CONCLUSION: PTSDLC did not reduce the dose threshold for the acquisition of ethanol sensitization but strengthened the development of ethanol sensitization with effective doses. This suggests that PTSD might interact with one of the mechanisms underlying the development of alcohol sensitization. When the relationship between ethanol sensitization and PTSDLC is tested in the reverse direction, the present study only shows a significant effect of ethanol administration on the "sensitized fear" PTSD cluster. PMID: 30986492 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 12, 2019 Category: Neurology Authors: Matonda-Ma-Nzuzi T, Didone V, Seutin V, Tirelli E, Quertemont E Tags: Behav Brain Res Source Type: research

Sex differences in fear regulation and reward-seeking behaviors in a fear-safety-reward discrimination task.
a S Abstract Reward availability and the potential for danger or safety potently regulate emotion. Despite women being more likely than men to develop emotion dysregulation disorders, there are comparatively few studies investigating fear, safety and reward regulation in females. Here, we show that female Long Evans rats did not suppress conditioned freezing in the presence of a safety cue, nor did they extinguish their freezing response, whereas males did both. Females were also more reward responsive during the reward cue until the first footshock exposure, at which point there were no sex differences in reward ...
Source: Behavioural Brain Research - April 11, 2019 Category: Neurology Authors: Greiner EM, Müller I, Norris MR, Ng KH, Sangha S Tags: Behav Brain Res Source Type: research

Disruption of latent inhibition by subchronic phencyclidine pretreatment in rats.
This study investigated whether subchronic phencyclidine pretreatment affected latent inhibition: impaired conditioning following repeated preexposure of the to-be-conditioned stimulus. Female Lister-hooded rats were pretreated with phencyclidine or saline twice/day for 5 days, then remained drug-free for 10 days before latent inhibition testing. Saline pretreated animals showed latent inhibition, as expected. However, phencyclidine pretreated animals showed no latent inhibition: the effect of preexposure was attenuated, with no change in basic learning. Thus subchronic phencyclidine pretreatment does disrupt latent inhibi...
Source: Behavioural Brain Research - April 11, 2019 Category: Neurology Authors: Al-Ali AM, Young AMJ Tags: Behav Brain Res Source Type: research

The presence of elevated circulating trimethylamine N-oxide exaggerates postoperative cognitive dysfunction in aged rats.
Abstract Surgical trauma can cause brain oxidative stress and neuroinflammation, leading to postoperative cognitive dysfunction (POCD), especially in the elderly. Additionally, the pre-existing risk factors may enhance POCD. Gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) has recently been shown to contribute to the pathogenesis of many diseases by increasing oxidative stress and inflammation in the peripheral tissues. Here we examined whether the presence of elevated circulating TMAO would influence surgery-induced cognitive decline. Aged rats were treated with vehicle or TMAO for 3 weeks. After t...
Source: Behavioural Brain Research - April 10, 2019 Category: Neurology Authors: Meng F, Li N, Li D, Song B, Li L Tags: Behav Brain Res Source Type: research

Beneficial effects of (R)-ketamine, but not its metabolite (2R,6R)-hydroxynorketamine, in the depression-like phenotype, inflammatory bone markers, and bone mineral density in a chronic social defeat stress model.
In this study, we compared the effects of (R)-ketamine and its final metabolite (2R,6R)-hydroxynorketamine (HNK) in depression-like phenotypes, inflammatory bone markers and bone mineral density (BMD) in CSDS susceptible mice. We measured plasma levels of inflammatory bone markers, which included osteoprotegerin (OPG), receptor activator of nuclear factor κB ligand (RANKL), and osteopontin after behavioral tests. (R)-ketamine, but not (2R,6R)-HNK, elicited rapid and sustained antidepressant effects in CSDS susceptible mice. Furthermore, (R)-ketamine, but not (2R,6R)-HNK, significantly improved the increased plasma le...
Source: Behavioural Brain Research - April 10, 2019 Category: Neurology Authors: Xiong Z, Fujita Y, Zhang K, Pu Y, Chang L, Ma M, Chen J, Hashimoto K Tags: Behav Brain Res Source Type: research

Administration of protocatechuic acid affects memory and restores hippocampal and cortical serotonin turnover in rat model of oral D-galactose-induced memory impairment.
Abstract Protocatechuic acid (PCA) is a phenolic compound believed to have neuroprotective and procognitive activity. D-Galactose (D-Gal) is a sugar, which administered to mammals can induce cognitive deficits. The first aim of this study was to confirm the effectiveness of D-Gal administered orally in inducing cognitive impairment in rats and describe how it affects the concentration of neurotransmitters in rats' brain. The second aim was to evaluate the influence of PCA on learning, memory and neurotransmission in D-Gal-exposed rats. Memory impairment was induced by long-term administration of D-Gal (100 ...
Source: Behavioural Brain Research - April 9, 2019 Category: Neurology Authors: Krzysztoforska K, Widy-Tyszkiewicz E Tags: Behav Brain Res Source Type: research

New evidence for refinement of anesthetic choice in procedures preceding the forced swimming test and the elevated plus-maze.
Abstract Previous studies indicated that some general anesthetics induce long-term antidepressant and/or anxiolytic-like effects. This raises the concern about the use of anesthesia in surgeries that precede psychopharmacological tests, since it may be a potential bias on results depending on the experimental design used. Thus, we evaluated whether general anesthetics used in surgeries preceding psychopharmacological tests would affect rats behavior in tests predictive of antidepressant or anxiolytic-like effects. We tested if a single exposure to sub-anesthetic or anesthetic doses of tribromoethanol, chloral hydr...
Source: Behavioural Brain Research - April 9, 2019 Category: Neurology Authors: Herbst LS, Gaigher T, Siqueira AA, Joca S, Sampaio KN, Beijamini V Tags: Behav Brain Res Source Type: research

10 Hz transcranial alternating current stimulation over posterior parietal cortex facilitates tactile temporal order judgment.
Abstract The temporal order judgment (TOJ) task has been widely used to investigate spatial attentional bias and the sensitivity of temporal discrimination during the processing of bilateral tactile information. Previous studies have shown that TOJ is impaired in patients who are suffering from chronic pain, stroke, and Parkinson's disease. In addition, studies have indicated that the posterior parietal cortex (PPC) is involved in the TOJ task. However, the neural basis of the TOJ task has not been fully elucidated. To investigate the causal relationship between cortical oscillation and certain behaviors, transcra...
Source: Behavioural Brain Research - April 9, 2019 Category: Neurology Authors: Otsuru N, Kamijo K, Otsuki T, Kojima S, Miyaguchi S, Saito K, Inukai Y, Onishi H Tags: Behav Brain Res Source Type: research