Orexin A in the ventral tegmental area enhances saccharin-induced conditioned flavor preference: The Role of D1 receptors in central nucleus of amygdala.
Abstract In industrialized societies, food intake is largely determined by its hedonic characteristics, which can be modified by our experience via taste learning. In this learning, the hedonic value of a neutral flavor changes after its association with a motivationally significant stimulus. Experiment 1 analyzes the effect of orexin administration (53 and 107 ng) in the ventral tegmental area (VTA) on hedonic intake through acquisition of a flavor-taste preference and a flavor-taste aversion. Accordingly, animals underwent four one-bottle acquisition sessions with unilateral application of orexin-A or saline i...
Source: Behavioural Brain Research - April 20, 2018 Category: Neurology Authors: Risco S, Mediavilla C Tags: Behav Brain Res Source Type: research

The dorsal diencephalic conduction system in reward processing: spotlight on the anatomy and functions of the habenular complex.
Abstract The dorsal diencephalic conduction system (DDC) is a highly conserved pathway in vertebrates that provides a route for the neural information to flow from forebrain to midbrain structures. It contains the bilaterally paired habenular nuclei along with two fiber tracts, the stria medullaris and the fasciculus retroflexus. The habenula is the principal player in mediating the dialogue between forebrain and midbrain regions, and functional abnormalities in this structure have often been attributed to pathologies like mood disorders and substance use disorder. Following Matsumoto and Hikosaka seminal work on ...
Source: Behavioural Brain Research - April 20, 2018 Category: Neurology Authors: Fakhoury M Tags: Behav Brain Res Source Type: research

Silibinin exerts antidepressant effects by improving neurogenesis through BDNF/TrkB pathway.
In this study, we demonstrated that Silibinin (SLB), a polyphenolic flavanoid from Silybum marianum, ameliorated reserpinized mouse depressant-like behaviors. The antidepressants of SLB administration was associated with increased neural stem cells (NSCs) proliferation and further confirmed in BDNF/TrkB signaling transduction. SLB treatment reversed the decreased expression levels of BDNF and its receptor TrkB, and the reduced activation of downstream target proteins including phosphorylated extracellular-regulated protein kinase (p-ERK) and phosphorylated cAMP-response element binding protein (p-CREB) in depressived hippo...
Source: Behavioural Brain Research - April 19, 2018 Category: Neurology Authors: Li YJ, Li YJ, Yang LD, Zhang K, Zheng KY, Wei XM, Yang Q, Niu WM, Zhao MG, Wu YM Tags: Behav Brain Res Source Type: research

Effects of methamphetamine exposure on anxiety-like behavior in the open field test, corticosterone, and hippocampal tyrosine hydroxylase in adolescent and adult mice.
Abstract Methamphetamine (MA) is a psychomotor stimulant drug that can alter behavior, the stress response system, and the dopaminergic system. The effects of MA can be modulated by age, however relatively little research has examined the acute effects of MA in adolescents and how the effects compare to those found in adults. The hippocampal dopamine system is altered by MA exposure and can modulate anxiety-like behavior, but the effects of MA on the hippocampal dopamine system have not been well studied, especially in adolescent animals. In order to assess potential age differences in the effects of MA exposure, ...
Source: Behavioural Brain Research - April 19, 2018 Category: Neurology Authors: Struntz KH, Siegel JA Tags: Behav Brain Res Source Type: research

Strengthened functional connectivity among LFPs in rat medial prefrontal cortex during anxiety.
Abstract Theta oscillations in medial prefrontal cortex (mPFC) have been consistently implicated in the regulation of anxiety-related behaviors. However, the theta-band functional connectivity in mPFC is less well characterized. Therefore, we simultaneously recorded local filed potentials (LFPs) from mPFC in freely behaving rats in the elevated plus maze (EPM). Functional connectivity among LFPs was measured by directed transfer function (DTF) via spectral Granger causal connectivity analysis. Causal network was then identified based on DTF. Global efficiency (Eglob) was selected to quantitatively describe the cha...
Source: Behavioural Brain Research - April 19, 2018 Category: Neurology Authors: Lu J, Dong H, Zheng X Tags: Behav Brain Res Source Type: research

Interference in lateral masking stimuli - The effects of relative phase, position, orientation, and spatial frequency.
Abstract Lateral masking has been defined as the perception of a visual target stimulus being impaired when other stimuli are present in its adjacent surroundings. In such cases it has generally been assumed that the target stimulus presented along with a masking stimulus has the same stimulus power as when presented alone and that the reduced visibility reflects interactions in the visual system. It has, however, become clear that there may be interference between such stimuli (Skottun, 2017a, doi: 10.3758/s13428-017-0978-3). Such interference, which takes place in the stimuli and is independent of the visual sys...
Source: Behavioural Brain Research - April 17, 2018 Category: Neurology Authors: Skottun BC Tags: Behav Brain Res Source Type: research

The Long-term Effects of Cocaine Use on Cognitive Functioning: A Systematic Critical Review.
CONCLUSIONS: The current evidence does not support the view that chronic cocaine use is associated with broad cognitive deficits. The view that cocaine users have broad cognitive deficits is inaccurate based upon current evidence, and the perpetuation of this view may have negative implications for treatment programs and development of public policies. PMID: 29673580 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - April 16, 2018 Category: Neurology Authors: Frazer KM, Richards Q, Keith DR Tags: Behav Brain Res Source Type: research

Corrigendum to "Acute and repeated exposure to social stress reduces gut microbiota diversity in Syrian hamsters" [Behav. Brain Res. 345 (2018) 39-48].
Corrigendum to "Acute and repeated exposure to social stress reduces gut microbiota diversity in Syrian hamsters" [Behav. Brain Res. 345 (2018) 39-48]. Behav Brain Res. 2018 Apr 16;: Authors: Partrick KA, Chassaing B, Beach LQ, McCann KE, Gewirtz AT, Huhman KL Abstract Social stress can promote a variety of neuropsychiatric illnesses, many of which have a high co-morbidity with gastrointestinal disorders. Recent data indicate that gastrointestinal microbiota can affect their host's brain and behavior. Syrian hamsters are ideal subjects for social stress research because they are territorial,...
Source: Behavioural Brain Research - April 16, 2018 Category: Neurology Authors: Partrick KA, Chassaing B, Beach LQ, McCann KE, Gewirtz AT, Huhman KL Tags: Behav Brain Res Source Type: research

Roles of the anterior basolateral amygdalar nucleus during exposure to a live predator and to a predator-associated context.
Abstract The basolateral amygdala complex, which includes the lateral, basolateral and basomedial nuclei, has been implicated in innate and contextual fear responses to predator threats. In the basolateral complex, the lateral and posterior basomedial nuclei are able to process predator odor information, and they project to the predator-responsive hypothalamic circuit; lesions in these amygdalar sites reduce innate responses and practically abolish contextual fear responses to predatory threats. In contrast to the lateral and posterior basomedial nuclei, the basolateral nucleus does not receive direct information ...
Source: Behavioural Brain Research - February 10, 2018 Category: Neurology Authors: Bindi RP, Baldo MVC, Canteras NS Tags: Behav Brain Res Source Type: research

Genetically defined fear-induced aggression: focus on bdnf and its receptors.
GENETICALLY DEFINED FEAR-INDUCED AGGRESSION: FOCUS ON BDNF AND ITS RECEPTORS. Behav Brain Res. 2018 Feb 06;: Authors: Ilchibaeva TV, Tsybko AS, Kozhemyakina RV, Kondaurova EM, Popova NK, Naumenko VS Abstract Brain-derived neurotrophic factor (BDNF), its precursor proBDNF, BDNF pro-peptide, BDNF mRNA levels, as well as TrkB and p75NTR receptors mRNA and protein levels, were studied in the brain of rats, selectively bred for more than 85 generations for either the high level or the lack of fear-induced aggressive behavior. Furthermore, we have found that rats of aggressive strain demonstrated both high ...
Source: Behavioural Brain Research - February 6, 2018 Category: Neurology Authors: Ilchibaeva TV, Tsybko AS, Kozhemyakina RV, Kondaurova EM, Popova NK, Naumenko VS Tags: Behav Brain Res Source Type: research

Incorporation of new neurons in the olfactory bulb after paced mating in the female rat.
es RG Abstract One of the regions that constantly produces neurogenesis in the adult brain is the subventricular zone (SVZ), whose new cells migrate to the olfactory bulbs (OB). When the females regulate the copulatory events (paced mating) the number of new cells in the SVZ increases, as well as those observed in the OB 15 days later. However, no changes were observed in the number of cells 45 days after the females paced the sexual interaction. Constant sensory stimulation is an important promoter of cell survival in the OB circuit. Hence, we increased the number of mating sessions in this study to cover the per...
Source: Behavioural Brain Research - February 6, 2018 Category: Neurology Authors: Alvarado-Martínez R, Paredes RG Tags: Behav Brain Res Source Type: research

Age and HIV Effects on Resting State of the Brain in Relationship to Neurocognitive Functioning.
This study examined the effects of age and HIV infection on the resting state (RS) functional connectivity (FC) of the brain and cognitive functioning. The objective was to evaluate the moderating role of age and HIV on the relationship between RS-FC and cognition. To examine RS-FC we implemented the Independent Component Analysis (ICA) and Regional Homogeneity (ReHo). Neurocognition was evaluated with comprehensive battery of standardized neuropsychological tests. Age and HIV were entered as the independent variables. The independent effects of age, HIV, and interaction effects of age-HIV on RS-fMRI measures (ICA, ReHo) w...
Source: Behavioural Brain Research - February 6, 2018 Category: Neurology Authors: Egbert AR, Biswal B, Karunakaran K, Gohel S, Pluta A, Wolak T, Szymańska B, Firląg-Burkacka E, Sobańska M, Gawron N, Bieńkowski P, Sienkiewicz-Jarosz H, Ścińska-Bieńkowska A, Bornstein R, Rao S, Łojek E Tags: Behav Brain Res Source Type: research

The Visible Burrow System: a behavioral paradigm to assess sociability and social withdrawal in BTBR and C57BL/6J mice strains.
In conclusion, our study validated the use of the VBS as an ethologically relevant behavioral paradigm in group-housed mice to investigate individual sociability and social withdrawal features and their underlying neurobiology. This paradigm may provide new insights to develop new therapeutic treatments for behavioral dysfunctions that may be relevant across neuropsychiatric diseases. PMID: 29425919 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - February 6, 2018 Category: Neurology Authors: Bove M, Ike K, Eldering A, Buwalda B, de Boer SF, Morgese MG, Schiavone S, Cuomo V, Trabace L, Kas MJH Tags: Behav Brain Res Source Type: research

Prenatal cold stress: effect on maternal hippocampus and offspring behavior in rats.
Abstract In mammals, environmental factors including cold stress exert dramatic effects on adult health during late gestation, the cold stress response refers to an organism's response to cold. Indeed, cells and organs, including the hippocampus, are coordinated to respond to prevent hypothermia. The hippocampus act as an important brain structure that regulates the activity of the hypothalamic-pituitary-adrenal (HPA) axis, and suppress the stress reaction through feedback regulation of the HPA axis. To evaluate the response of the hippocampus during prenatal cold stress, we established a prenatal cold stress rat ...
Source: Behavioural Brain Research - February 5, 2018 Category: Neurology Authors: Lian S, Wang D, Xu B, Guo W, Wang L, Li W, Ji H, Wang J, Kong F, Zhen L, Li S, Zhang L, Guo J, Yang H Tags: Behav Brain Res Source Type: research

Development of novel tasks for studying view-invariant object recognition in rodents: sensitivity to scopolamine.
Abstract The capacity to recognize objects from different view-points or angles, referred to as view-invariance, is an essential process that humans engage in daily. Currently, the ability to investigate the neurobiological underpinnings of this phenomenon is limited, as few ethologically valid view-invariant object recognition tasks exist for rodents. Here, we report two complementary, novel view-invariant object recognition tasks in which rodents physically interact with three-dimensional objects. Prior to experimentation, rats and mice were given extensive experience with a set of 'pre-exposure' objects. In a v...
Source: Behavioural Brain Research - February 2, 2018 Category: Neurology Authors: Mitchnick KA, Wideman CE, Huff AE, Palmer D, McNaughton BL, Winters BD Tags: Behav Brain Res Source Type: research

Pharmacological manipulation of GABA activity in nucleus subpretectalis/interstitio-pretecto-subpretectalis (SP/IPS) impairs figure-ground discrimination in pigeons: Running head: SP/IPS in figure-ground segregation.
Abstract Figure-ground segregation is a fundamental visual ability that allows an organism to separate an object from its background. Our earlier research has shown that nucleus rotundus (Rt), a thalamic nucleus processing visual information in pigeons, together with its inhibitory complex, nucleus subpretectalis/interstitio-pretecto-subpretectalis (SP/IPS), are critically involved in figure-ground discrimination (Acerbo et al., 2012; Scully et al., 2014). Here, we further investigated the role of SP/IPS by conducting bilateral microinjections of GABAergic receptor antagonist and agonists (bicuculline and muscimol...
Source: Behavioural Brain Research - February 2, 2018 Category: Neurology Authors: Acerbo MJ, Lazareva OF Tags: Behav Brain Res Source Type: research

Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.
Abstract Loss of function mutations in the gene ATP13A2 are associated with Kufor-Rakeb Syndrome and Neuronal Ceroid Lipofuscinosis, the former designated as an inherited form of Parkinson's disease (PD). The function of ATP13A2 is unclear but in vitro studies indicate it is a lysosomal protein and may interact with the presynaptic protein alpha-synuclein (aSyn) and certain heavy metals. Accumulation of aSyn is a major component of lewy bodies, the pathological hallmark of PD. Atp13a2-deficient (13a2) mice develop age-dependent sensorimotor deficits, and accumulation of insoluble aSyn in the brain. To better under...
Source: Behavioural Brain Research - January 31, 2018 Category: Neurology Authors: Dirr ER, Ekhator OR, Blackwood R, Holden JG, Masliah E, Schultheis PJ, Fleming SM Tags: Behav Brain Res Source Type: research

Nicotine-enhanced Pavlovian conditioned approach is resistant to omission of expected outcome.
Abstract Conditioned stimuli contribute to the resilience of nicotine addiction in that nicotine-associated cues can influence smokers and promote relapse. These stimuli are thought to acquire incentive motivational properties through a Pavlovian mechanism, and this phenomenon can be measured in animals by observing conditioned approach to the conditioned stimulus (sign-tracking) or to the location of unconditioned stimulus delivery (goal-tracking). Goal-tracking is thought to be more flexible than sign-tracking in response to changes in expected outcome. Nicotine exposure can increase the expression of conditione...
Source: Behavioural Brain Research - January 29, 2018 Category: Neurology Authors: Stringfield SJ, Boettiger CA, Robinson DL Tags: Behav Brain Res Source Type: research

Chronic amphetamine treatment affects collicular-dependent behaviour.
Abstract Distractibility can be defined as an attention deficit where orientation toward irrelevant targets cannot be inhibited. There is now mounting evidence that the superior colliculus is a key neural correlate of distractibility, with increased collicular-activity resulting in heightened distractibility. Heightened distractibility is reduced by amphetamine, which acutely suppresses collicular responsiveness. However, when amphetamine is used to treat distractibility, it is given chronically, yet no data exist on whether chronic amphetamine treatment affects the colliculus. Here, the effect of chronic amphetam...
Source: Behavioural Brain Research - January 27, 2018 Category: Neurology Authors: Turner AC, Stramek A, Kraev I, Stewart MG, Overton PG, Dommett EJ Tags: Behav Brain Res Source Type: research

Antidepressant administration modulates stress-induced DNA methylation and DNA methyltransferase expression in rat prefrontal cortex and hippocampus.
Abstract Stress and antidepressant treatment can modulate DNA methylation in promoter region of genes related to neuroplasticity and mood regulation, thus implicating this epigenetic mechanism in depression neurobiology and treatment. Accordingly, systemic administration of DNA methyltransferase (DNMT) inhibitors induces antidepressant-like effects in rodents. DNA methylation is conveyed by DNMT 1, 3a and 3b isoforms, which are differentially expressed in the brain. In order to investigate if the behavioral effects of antidepressants could be associated with changes in DNA methylation and DNMT expression, we inves...
Source: Behavioural Brain Research - January 26, 2018 Category: Neurology Authors: Sales AJ, Joca SRL Tags: Behav Brain Res Source Type: research

Glutamine/Glutamate (Glx) concentration in prefrontal cortex predicts reversal learning performance in the marmoset.
This study used Magnetic Resonance Spectroscopy (MRS) to identify potential neurometabolitic markers of cognitive performance in male (n =7) and female (n=8) middle-aged (~5 years old) common marmosets (Callithrix jacchus). Anesthetized marmosets were scanned with a 4.7 T/40cm horizontal magnet equipped with 450 mT/m magnetic field gradients and a 20-G/cm magnetic field gradient insert, within 3 months of completing the CANTAB serial Reversal Learning task. Neurometabolite concentrations of N-Acetyl Asparate, Myo-Inositol, Choline, Phosphocreatine+creatine, Glutamate and Glutamine were acquired from a 3 mm3 voxel positione...
Source: Behavioural Brain Research - January 26, 2018 Category: Neurology Authors: Lacreuse A, Moore CM, LaClair M, Payne L, King JA Tags: Behav Brain Res Source Type: research

Strategic neuronal encoding in medial prefrontal cortex of spatial working memory in the T-maze.
Abstract Strategic neuronal encoding in the medial prefrontal cortex (mPFC) of the rat was correlated with spatial working memory (sWM) assessed by behavior in the T-maze. Neurons increased their firing rate around choice, with the increase largely occurring before choice as a prospective encode of behavior. This could be classified as sensitive-to-spatial information or sensitive-to-choice outcome. The sensitivity-to-spatial choice was defined by distinct firing rate changes before left- or right-choice. The percentage of left-choice sensitive neurons was not different from the percentage of right-choice sensitiv...
Source: Behavioural Brain Research - January 26, 2018 Category: Neurology Authors: Yang Y, Mailman R Tags: Behav Brain Res Source Type: research

NMDA receptors in the avian amygdala and the premotor arcopallium mediate distinct aspects of appetitive extinction learning.
uml;rkün O Abstract Extinction learning is an essential mechanism that enables constant adaptation to ever-changing environmental conditions. The underlying neural circuit is mostly studied with rodent models using auditory cued fear conditioning. In order to uncover the variant and the invariant neural properties of extinction learning, we adopted pigeons as an animal model in an appetitive sign-tracking paradigm. The animals firstly learned to respond to two conditioned stimuli in two different contexts (CS-1 in context A and CS-2 in context B), before conditioned responses to the stimuli were extinguished ...
Source: Behavioural Brain Research - January 26, 2018 Category: Neurology Authors: Gao M, Lengersdorf D, Stüttgen Maik C, Güntürkün O Tags: Behav Brain Res Source Type: research

Morphine antinociception on thermal sensitivity and place conditioning in male and female rats treated with intraplantar complete freund's adjuvant.
This study investigated the effects of morphine one and seven days after intraplantar administration of complete freund's adjuvant (CFA) in male and female rats. Hargreaves test for thermal nociception and conditioned place preference (CPP) were performed following subcutaneous administration of saline or morphine (1.0, 4.0, 8.0, 12.0 mg/kg). Hargreaves test results revealed that male rats were more sensitive to morphine antinociceptive actions as compared to female rats one day after CFA treatment; however, this sex difference was not detected seven days after CFA treatment. One day after CFA treatment, morphine doses of ...
Source: Behavioural Brain Research - January 25, 2018 Category: Neurology Authors: Armendariz A, Nazarian A Tags: Behav Brain Res Source Type: research

Food-Induced Reinforcement is Abrogated by the Genetic Deletion of the MT1 or MT2 Melatonin Receptor in C3H/HeN Mice.
Abstract Palatable food is known for its ability to enhance reinforcing responses. Studies have suggested a circadian variation in both drug and natural reinforcement, with each following its own time course. The goal of this study was to determine the role of the MT1 and MT2 melatonin receptors in palatable snack food-induced reinforcement, as measured by the conditioned place preference (CPP) paradigm during the light and dark phases. C3H/HeN wild-type mice were trained for snack food-induced CPP at either ZT 6 - 8 (ZT: Zeitgeber time; ZT 0 = lights on), when endogenous melatonin levels are low, or ZT 19 - 21, w...
Source: Behavioural Brain Research - January 25, 2018 Category: Neurology Authors: Clough SJ, Hudson RL, Dubocovich ML Tags: Behav Brain Res Source Type: research

Inequity aversion is observed in common marmosets but not in marmoset models of autism induced by prenatal exposure to valproic acid.
Abstract Humans and various nonhuman primates respond negatively to inequity not in their favor (i.e., inequity aversion), when inequity between two individuals is introduced. Common marmosets, a highly prosocial species, further discriminated between human actors who reciprocated in social exchanges, and those who did not. Conversely, marmoset models of autism, induced via prenatal exposure to valproic acid (VPA marmosets), did not discriminate. Interestingly, previous studies of inequity aversion in marmosets have produced negative results, or were limited to males. Recent studies suggest that inequity aversion ...
Source: Behavioural Brain Research - January 24, 2018 Category: Neurology Authors: Yasue M, Nakagami A, Nakagaki K, Ichinohe N, Kawai N Tags: Behav Brain Res Source Type: research

Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect.
Abstract Our previous study implied the role of central high mobility group box 1 (HMGB1) in lipopolysaccharide (LPS)-induced depressive behavior that could partially abrogate by glycyrrhizic acid (GZA). Here, we considered the potential mechanism underlying GZA ameliorating chronic stress-induced depression both in vivo and in vitro. Depression model was established with the 4-week chronic unpredictable mild stress (CUMS) mice or low dose of LPS/HMGB1 administration slices. Sucrose preference test, tail suspension test and open field test were performed to reflect depressive behaviors. Enzyme activity of indoleam...
Source: Behavioural Brain Research - January 20, 2018 Category: Neurology Authors: Wang B, Lian YJ, Dong X, Peng W, Liu LL, Su WJ, Gong H, Zhang T, Jiang CL, Li JS, Wang YX Tags: Behav Brain Res Source Type: research

Anxiety-like behavior and neuropeptide receptor expression in male and female prairie voles: the effects of stress and social buffering.
Abstract Strong social support can negate negative health outcomes - an effect defined as 'social buffering'. In the present study, using the socially monogamous prairie vole (Microtus ochrogaster), we examined whether the presence of a bonded partner during a stressful event can reduce stress responses. Adult, pair-bonded female and male voles were assigned into experimental groups that were either handled (Control), experienced a 1-hr immobilization (IMO) stress alone (IMO-Alone), or experienced IMO with their partner (IMO-Partner). Thereafter, subjects were tested for anxiety-like behavior, and brain sections w...
Source: Behavioural Brain Research - January 18, 2018 Category: Neurology Authors: Donovan M, Liu Y, Wang Z Tags: Behav Brain Res Source Type: research

Intermittent intense exercise protects against cognitive decline in a similar manner to moderate exercise in chronically stressed mice.
Abstract It is well known that regular low or mild exercise helps to improve and maintain cognition. On the other hand, ever thought many people prefer high-intensity exercise (e.g., running, swimming, biking, soccer, basketball, etc.) to get rid of stress or improve their health, the previous studies reported that intense exercise either impairs cognition or has no effect on cognitive function. However, we previously showed that intermittent intense exercise prevents stress-induced depressive behavior in mice in a similar manner to moderate exercise. On the basis of this finding, we investigated the effect of int...
Source: Behavioural Brain Research - January 18, 2018 Category: Neurology Authors: Lee H, Nagata K, Nakajima S, Ohno M, Ohta S, Mikami T Tags: Behav Brain Res Source Type: research

Reversible inactivation of Interpeduncular nucleus impairs memory consolidation and retrieval but not learning in rats: A behavioral and molecular study.
In this study we aimed to investigate how reversible inactivation of IPN could affect the acquisition, consolidation and retrieval phases of memory in passive avoidance (PA) and Morris water maze (MWM) tasks. To support our data, molecular studies were performed in order to detect possible changes in the expression of proteins related to learning and memory in the hippocampus. To address this issue rats' IPN was reversibly inactivated by microinjection of lidocaine hydrochloride (4%). After the behavioral studies, the phosphorylation of CREB and P70, and c-fos expression levels in the hippocampus were determined using west...
Source: Behavioural Brain Research - January 17, 2018 Category: Neurology Authors: Khatami L, Khodagholi F, Motamedi F Tags: Behav Brain Res Source Type: research

Assessment of Impulsivity in Adolescent Mice: A New Training Procedure for a 3-Choice Serial Reaction Time Task.
Abstract Immaturity in impulse control among adolescents could result in substance abuse, criminal involvement, and suicide. The brains of adolescents and adults are anatomically, neurophysiologically, and pharmacologically different. Therefore, preclinical models of adolescent impulsivity are required to screen drugs for adolescents and elucidate the neural mechanisms underlying age-related differences in impulsivity. The conventional 3- or 5-choice serial reaction time task, which is a widely used task to assess impulsivity in adult rodents, cannot be used for young mice because of two technical problems: impair...
Source: Behavioural Brain Research - January 17, 2018 Category: Neurology Authors: Sasamori H, Ohmura Y, Kubo T, Yoshida T, Yoshioka M Tags: Behav Brain Res Source Type: research

A role for CA3 in social recognition memory.
Abstract Social recognition memory is crucial for survival across species, underlying the need to correctly identify conspecifics, mates and potential enemies. In humans the hippocampus is engaged in social and episodic memory, however the circuit mechanisms of social memory in rodent models has only recently come under scrutiny. Work in mice has established that the dorsal CA2 and ventral CA1 regions play critical roles, however a more comprehensive comparative analyses of the circuits and mechanisms required has not been reported. Here we employ conditional genetics to examine the differential contributions of t...
Source: Behavioural Brain Research - January 17, 2018 Category: Neurology Authors: Chiang MC, Huang AJY, Wintzer ME, Ohshima T, McHugh TJ Tags: Behav Brain Res Source Type: research

Sex differences in rat decision-making: The confounding role of extraneous feeder sampling between trials.
Abstract Although male and female rats appear to perform differently in some tasks, a clear picture of sex differences in decision-making has yet to develop. This is in part due to significant variability arising from differences in strains and tasks. The aim of this study was to characterize the effects of sex on specific response elements in a reinforcement learning task so as to help identify potential explanations for this variability. We found that the primary difference between sexes was the propensity to approach feeders out of the task context. This extraneous feeder sampling affects choice on subsequent t...
Source: Behavioural Brain Research - January 17, 2018 Category: Neurology Authors: Donovan CH, Wong SA, Randolph SH, Stark RA, Gibb RL, Gruber AJ Tags: Behav Brain Res Source Type: research

Effects of exercise and enrichment on behaviour in CD-1 mice.
Abstract A host of scholarly work has characterized the positive effects of exercise and environmental enrichment on behaviour and cognition in animal studies. The purpose of this study was to investigate the uptake and longitudinal impact of exercise and enrichment on the behavioural phenotype of male and female CD-1 mice. CD-1 mice housed in standard (STD) or exercise and enrichment (EE) conditions post-weaning were tested in the 3-chamber sociability test, open field, and elevated plus maze and exercise activity was monitored throughout the enrichment protocol. Male and female EE mice both showed reduced anxiet...
Source: Behavioural Brain Research - January 12, 2018 Category: Neurology Authors: Aujnarain AB, Luo OD, Taylor N, Lai JKY, Foster JA Tags: Behav Brain Res Source Type: research

Food allergy induces alteration in brain inflammatory status and cognitive impairments.
Abstract Accumulating evidence supports an increase in emotional and behavioral problems in patients with food allergy, but the underlying mechanism remains poorly understood. Here we found that in addition to inducing an increase of allergic factors in serum, food allergy also increased levels of antigen-specific immunoglobulins and mast cell marker in the brain. In particular, food allergy increased the number of total microglia and the percentage of active microglia in the cerebral cortex and hippocampal CA1 areas, and induced the increase of TNF-α in the cerebral cortex. Importantly, these brain allergic...
Source: Behavioural Brain Research - January 12, 2018 Category: Neurology Authors: Zhou L, Chen L, Li X, Li T, Dong Z, Wang YT Tags: Behav Brain Res Source Type: research

Genetic biomarkers for differential diagnosis of major depressive disorder and bipolar disorder: a systematic and critical review.
Abstract Depressive symptoms are present in the depressive mood state of bipolar disorder (BPD) and major depression disorder (MDD). Often, in clinical practice, BPD patients are misdiagnosed with MDD. Therefore, genetic biomarkers could contribute to the improvement of differential diagnosis between BPD and MDD. This systematic and critical review aimed to find in literature reliable genetic biomarkers that may show differences between BPD and MDD. This systematic review followed the PRISMA-P method. The terms used to search PubMed, Scopus, PsycINFO, and Web of Science were depress*, bipolar, diagnos*, genetic*, ...
Source: Behavioural Brain Research - January 10, 2018 Category: Neurology Authors: Menezes IC, von Werne Baes C, Lacchini R, Juruena MF Tags: Behav Brain Res Source Type: research

Effects of 5-HT5A receptor blockade on amnesia or forgetting.
, Meneses A Abstract Previously the effects (0.01-3.0 mg/kg) of post-training SB-699551 (a 5-HT5A receptor antagonist) were reported in the associative learning task of autoshaping, showing that SB-699551 (0.1 mg/kg) decreased lever-press conditioned responses (CR) during short-term (STM; 1.5-h) or (3.0 mg/kg) long-term memory (LTM; 24-h); relative to the vehicle animals. Moreover, as pro-cognitive efficacy of SB-699551 was reported in the ketamine-model of schizophrenia. Hence, firstly aiming improving performance (conditioned response, CR), in this work autoshaping lever-press vs. nose-poke response was compared...
Source: Behavioural Brain Research - January 9, 2018 Category: Neurology Authors: Aparicio-Nava L, Márquez-García LA, Meneses A Tags: Behav Brain Res Source Type: research

Recovery of stress-impaired social behavior by an antagonist of the CRF binding protein, CRF6-33, in the bed nucleus of the stria terminalis of male rats.
PMID: 29330004 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 9, 2018 Category: Neurology Authors: Vasconcelos M, Stein DJ, Albrechet-Souza L, Miczek KA, de Almeida RMM Tags: Behav Brain Res Source Type: research

Antidepressant effects of focused ultrasound induced blood-brain-barrier opening.
Abstract In many cases, hippocampal neurogenesis appears to be a hallmark of antidepressant treatments. One novel technique for inducing this type of neurogenesis is using focused ultrasound waves, in conjunction with circulating microbubbles, to open the blood-brain-barrier. The present experiment aimed to test whether this technique has antidepressant effects in a rodent model. Rats were subjected to 1, 2 or 3 weekly treatments of magnetic resonance-guided focused ultrasound in order to open the blood-brain-barrier in the hippocampal region. Before and after treatments, animals went through modified forced swim ...
Source: Behavioural Brain Research - January 8, 2018 Category: Neurology Authors: Mooney SJ, Nobrega JN, Levitt AJ, Hynynen K Tags: Behav Brain Res Source Type: research

Sleep architecture is altered in the reserpine-induced fibromyalgia model in ovariectomized rats.
In conclusion, our results support the face validity of the RES-induced pain-related behavior as FM model showing nociceptive behavioral responses associated to sleep alterations observed as symptoms in FM patients; thus, these evidences substantiate its usefulness to look for alternatives of treatment for FM symptoms. PMID: 29326058 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 8, 2018 Category: Neurology Authors: Hernandez-Leon A, Fernández-Guasti A, Martínez A, Pellicer F, González-Trujano ME Tags: Behav Brain Res Source Type: research

Differential requirement of de novo Arc protein synthesis in the insular cortex and the amygdala for safe and aversive taste long-term memory formation.
In this study, we sought to evaluate a possible role for de novo Arc protein synthesis in the insular cortex (IC) and in the amygdala (AMY) during long-term taste memory formation. We found that acute inhibition of Arc protein synthesis through the infusion of antisense oligonucleotides administered in the IC before a novel taste presentation, affected consolidation of a safe taste memory trace (ST) but spared consolidation of conditioned taste aversion (CTA). Conversely, blocking Arc synthesis within the AMY impaired CTA consolidation but had no effect on ST long-term memory formation. Our results suggest that Arc-depende...
Source: Behavioural Brain Research - January 8, 2018 Category: Neurology Authors: Kioko GR, Archana V, Jean-Pascal M, Daniel OG, Federico BR Tags: Behav Brain Res Source Type: research

Cognitive decline and increased hippocampal p-tau expression in mice with hearing loss.
Abstract Hearing and cognition are commonly involved in both normal and pathological aging. Current clinical interest lies in whether peripheral hearing loss promotes cognitive decline. In our previous publication, the authors have shown a causal relationship between hearing and cognitive impairments in C57BL/6 mice. Here we extended the follow-up to 12 months to determine the long-term effects of hearing loss on cognition and to observe hippocampal p-tau and lipofuscin. One month old male mice were randomly allocated into two groups, the control (n = 12) and noise-induced hearing loss (NIHL) (n = 12). After basel...
Source: Behavioural Brain Research - January 6, 2018 Category: Neurology Authors: Park SY, Kim MJ, Kim HL, Kim DK, Yeo SW, Park SN Tags: Behav Brain Res Source Type: research

Chronic nicotine differentially alters spontaneous recovery of contextual fear in male and female mice.
Abstract Post-traumatic stress disorder (PTSD) is a devastating disorder with symptoms such as flashbacks, hyperarousal, and avoidance of reminders of the traumatic event. Exposure therapy, which attempts to extinguish fear responses, is a commonly used treatment for PTSD but relapse following successful exposure therapy is a frequent problem. In rodents, spontaneous recovery (SR), where extinguished fear responses resurface following extinction treatment, is used as a model of fear relapse. Previous studies from our lab showed that chronic nicotine impaired fear extinction and acute nicotine enhanced SR of contex...
Source: Behavioural Brain Research - January 5, 2018 Category: Neurology Authors: Tumolo JM, Kutlu MG, Gould TJ Tags: Behav Brain Res Source Type: research

Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: therapeutic implications for Parkinson's disease.
In conclusion, the substantia nigra lesion with 6-hydroxydopamine induced subtle motor and non-motor manifestations, reflecting key features of the wide clinical spectrum of early Parkinson's disease. Furthermore, the present results suggest a potential efficacy of ketamine on depression and gait alterations in Parkinson's disease. PMID: 29307665 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 4, 2018 Category: Neurology Authors: Vecchia DD, Kanazawa LKS, Wendler E, de Almeida Soares Hocayen P, Bruginski E, Campos FR, Stern CAJ, Vital MABF, Miyoshi E, Wöhr M, Schwarting RKW, Andreatini R Tags: Behav Brain Res Source Type: research

Role of Silent Information Regulator 1 in the Protective Effect of Hydrogen Sulfide on Homocysteine-Induced Cognitive Dysfunction: Involving Reduction of Hippocampal ER Stress.
Abstract Homocysteine (Hcy) causes cognitive deficits and hippocampal endoplasmic reticulum (ER) stress. Our previous study has confirmed that Hydrogen sulfide (H2S) attenuates Hcy-induced cognitive dysfunction and hippocampal ER stress. Silent information regulator 1 (Sirt-1) is indispensable in the formation of learning. Therefore, the aim of this study was to explore the role of Sirt-1 in the protective effect of H2S against Hcy-induced cognitive dysfunction. We found that NaHS (a donor of H2S) markedly up-regulated the expression of Sirt-1 in the hippocampus of Hcy-exposed rats. Sirtinol, a specific inhibitor ...
Source: Behavioural Brain Research - January 4, 2018 Category: Neurology Authors: Tang YY, Wang AP, Wei HJ, Li MH, Zou W, Li X, Wang CY, Zhang P, Tang XQ Tags: Behav Brain Res Source Type: research

Behavioral phenotyping of calcium channel (CACN) subunit α2δ3 knockout mice: Consequences of sensory cross-modal activation.
Behavioral phenotyping of calcium channel (CACN) subunit α2δ3 knockout mice: Consequences of sensory cross-modal activation. Behav Brain Res. 2018 Jan 02;: Authors: Landmann J, Richter F, Classen J, Richter A, Penninger JM, Bechmann I Abstract Sensory cross-activation is still ill-defined and research concerning the consequences of sensory mergence on normal brain function is very limited. Human studies describe behavioral benefits of people with synesthesia- a peculiar form of perception possibly due to cross-modal activation- regarding sensory and memory abilities. Here, we studied behav...
Source: Behavioural Brain Research - January 2, 2018 Category: Neurology Authors: Landmann J, Richter F, Classen J, Richter A, Penninger JM, Bechmann I Tags: Behav Brain Res Source Type: research

The monoamine-oxidase B inhibitor deprenyl increases selection of high-effort activity in rats tested on a progressive ratio/chow feeding choice procedure: Implications for treating motivational dysfunctions.
Abstract Motivated behaviors often are characterized by a high degree of behavioral activation and work output, and organisms frequently make effort-related decisions based upon cost/benefit analyses. Moreover, people with depression and other disorders frequently show effort-related motivational symptoms, such as anergia, psychomotor retardation, and fatigue. Tasks measuring effort-related choice are being used as animal models of these motivational symptoms. The present studies characterized the ability of the monoamine oxidase -B (MAO-B) inhibitor deprenyl (selegiline) to enhance selection of high-effort lever ...
Source: Behavioural Brain Research - December 29, 2017 Category: Neurology Authors: Yohn SE, Reynolds S, Tripodi G, Correa M, Salamone JD Tags: Behav Brain Res Source Type: research

Using c-Jun to identify fear extinction learning-specific patterns of neural activity that are affected by single prolonged stress.
Abstract Neural circuits via which stress leads to disruptions in fear extinction is often explored in animal stress models. Using the single prolonged stress (SPS) model of post traumatic stress disorder and the immediate early gene (IEG) c-Fos as a measure of neural activity, we previously identified patterns of neural activity through which SPS disrupts extinction retention. However, none of these stress effects were specific to fear or extinction learning and memory. C-Jun is another IEG that is sometimes regulated in a different manner to c-Fos and could be used to identify emotional learning/memory specific ...
Source: Behavioural Brain Research - December 29, 2017 Category: Neurology Authors: Knox D, Stanfield BR, Staib JM, David NP, DePietro T, Chamness M, Schneider EK, Keller SM, Lawless C Tags: Behav Brain Res Source Type: research

Monoacylglycerol lipase inhibition alters social behavior in male and female rats after post-weaning social isolation.
Abstract Post-weaning social isolation (PSI) has been shown to increase aggressive behavior and alter medial prefrontal cortex (mPFC) function in rats. The present study sought to determine whether this phenotype would be normalized by increasing levels of the endocannabinoid 2-arachidonoylglycerol (2-AG) using pharmacological inhibition of monoacylglycerol lipase (MAGL). Male and female Sprague-Dawley rats were exposed to either 4 weeks of PSI or social rearing (SR) starting on postnatal day 21, then underwent a 15 min trial of social interaction with a novel, same-sex juvenile rat. Rats were administered an acut...
Source: Behavioural Brain Research - December 29, 2017 Category: Neurology Authors: Fontenot J, Loetz E, Ishiki M, Bland ST Tags: Behav Brain Res Source Type: research

Neuronal activity pattern defects in the striatum in awake mouse model of Parkinson's disease.
Abstract Previous studies showed the loss of dopaminergic neurons directly leads to both changes in firing rate and neuronal synchrony in the striatum by pharmacogenetic approach, but physiological observation of striatal neurons in awake animal is rare up to now due to the limitation of recording methods. We use multichannel in vivo recording system, to record the activity pattern of both medium spiny projecting neurons (MSNs) and fast spiking interneurons (FSIs) in awake mouse model of Parkinson's disease (PD), created by injection of 6-hydroxyl-dopamine (6-OHDA) into dorsolateral striatum bilaterally and unilat...
Source: Behavioural Brain Research - December 28, 2017 Category: Neurology Authors: Chen H, Lei H, Xu Q Tags: Behav Brain Res Source Type: research