Age-dependent effects of acute stress on the behavior, blood parameters, immunity, and enteric nerves of mice
Behav Brain Res. 2024 Jan 5:114848. doi: 10.1016/j.bbr.2024.114848. Online ahead of print.ABSTRACTThe impact of stress on mental and digestive health has been extensively studied, with chronic stress being associated with various disorders. However, age-related differences in the response to acute stress, both behaviorally and physiologically, remain poorly understood. Therefore, this study aimed to develop a model to detect transient stress in mice of different ages. The stressor employed in our experiments was a restraint stress procedure, where mice were subjected to brief periods of immobilization to induce an acute st...
Source: Behavioural Brain Research - January 7, 2024 Category: Neurology Authors: Yi-Chen Huang Pin-Hao Ko Li-Ling Wu Source Type: research
Muscarinic receptor activation promotes destabilization and updating of object location memories in mice
Behav Brain Res. 2024 Jan 5:114847. doi: 10.1016/j.bbr.2024.114847. Online ahead of print.ABSTRACTThe storage of long-term memories is a dynamic process. Reminder cues can destabilize previously consolidated memories, rendering them labile and modifiable. However, memories that are strongly encoded or relatively remote at the time of reactivation can resist destabilization only being rendered labile under conditions that favour memory updating. Using the object location recognition task, here we show in male C57BL/6 mice that novelty-induced destabilization of strongly-encoded memories requires muscarinic acetylcholine rec...
Source: Behavioural Brain Research - January 7, 2024 Category: Neurology Authors: Andrew Ethan Huff Olivia S O'Neill William S Messer Boyer D Winters Source Type: research
Evaluating the effects of single, multiple, and delayed systemic rapamycin injections to contextual fear reconsolidation: Implications for the neurobiology of memory and the treatment of PTSD-like re-experiencing
Behav Brain Res. 2024 Jan 5:114855. doi: 10.1016/j.bbr.2024.114855. Online ahead of print.ABSTRACTThe mechanistic target of rapamycin (mTOR) kinase is known to mediate the formation and persistence of aversive memories. Rapamycin, an mTOR inhibitor, administered around the time of reactivation blocks retrieval-induced mTOR activity and de novo protein synthesis in the brains of rodents, while correspondingly diminishing subsequent fear memory. The goal of the current experiments was to further explore rapamycin's effects on fear memory persistence. First, we examined whether mTOR blockade at different time-points after rea...
Source: Behavioural Brain Research - January 7, 2024 Category: Neurology Authors: Phillip E MacCallum Jane B Cooze Joshua Ward Kelsey Am Moore Jacqueline Blundell Source Type: research
Muscarinic receptor activation promotes destabilization and updating of object location memories in mice
Behav Brain Res. 2024 Jan 5:114847. doi: 10.1016/j.bbr.2024.114847. Online ahead of print.ABSTRACTThe storage of long-term memories is a dynamic process. Reminder cues can destabilize previously consolidated memories, rendering them labile and modifiable. However, memories that are strongly encoded or relatively remote at the time of reactivation can resist destabilization only being rendered labile under conditions that favour memory updating. Using the object location recognition task, here we show in male C57BL/6 mice that novelty-induced destabilization of strongly-encoded memories requires muscarinic acetylcholine rec...
Source: Behavioural Brain Research - January 7, 2024 Category: Neurology Authors: Andrew Ethan Huff Olivia S O'Neill William S Messer Boyer D Winters Source Type: research
Age-dependent effects of acute stress on the behavior, blood parameters, immunity, and enteric nerves of mice
Behav Brain Res. 2024 Jan 5:114848. doi: 10.1016/j.bbr.2024.114848. Online ahead of print.ABSTRACTThe impact of stress on mental and digestive health has been extensively studied, with chronic stress being associated with various disorders. However, age-related differences in the response to acute stress, both behaviorally and physiologically, remain poorly understood. Therefore, this study aimed to develop a model to detect transient stress in mice of different ages. The stressor employed in our experiments was a restraint stress procedure, where mice were subjected to brief periods of immobilization to induce an acute st...
Source: Behavioural Brain Research - January 7, 2024 Category: Neurology Authors: Yi-Chen Huang Pin-Hao Ko Li-Ling Wu Source Type: research
Perineuronal nets are associated with decision making under conditions of uncertainty in female but not male mice
Behav Brain Res. 2024 Jan 4:114845. doi: 10.1016/j.bbr.2024.114845. Online ahead of print.ABSTRACTBiological sex influences decision-making processes in significant ways, differentiating the responses animals choose when faced with a range of stimuli. The neurobiological underpinnings that dictate sex differences in decision-making tasks remains an important open question, yet single-sex studies of male mice form most studies in behavioural neuroscience. Here we used female and male BALB/c mice on two spatial learning and memory tasks and examined the expression of perineuronal nets (PNNs) and parvalbumin interneurons (PV)...
Source: Behavioural Brain Research - January 6, 2024 Category: Neurology Authors: Phoebe Mayne Joyosmita Das Simin Zou Robert Kp Sullivan Thomas Hj Burne Source Type: research
Sign-tracking and goal-tracking in humans: utilising eye-tracking in clinical and non-clinical populations
CONCLUSIONS: Sign-tracking is associated with CS+ trials only. There may be both dispositional and learned components to sign-tracking, potentially more common in those with ADHD. This holds translational potential for understanding individual differences in reward-learning.PMID:38184207 | DOI:10.1016/j.bbr.2024.114846 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 6, 2024 Category: Neurology Authors: Larisa-Maria Dinu Alexandra-Livia Georgescu Samriddhi N Singh Nicola C Byrom Paul G Overton Bryan F Singer Eleanor J Dommett Source Type: research
Relationship between neuroimaging and emotion recognition in Mild Cognitive Impairment patients
DISCUSSION: Different neuroimaging parameters were found to be related to an emotion recognition task in MCI. This analysis identified potential minimally-invasive biomarkers providing some knowledge about the physiopathological mechanisms in MCI.PMID:38176615 | DOI:10.1016/j.bbr.2023.114844 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 4, 2024 Category: Neurology Authors: Maria Teresa Gandia-Ferrero Jes ús Adrián-Ventura Consuelo Ch áfer-Pericás Lourdes Alvarez-Sanchez In és Ferrer-Cairols Bego ña Martinez-Sanchis Irene Torres-Espallardo Miquel Baquero-Toledo Luis Marti-Bonmati Source Type: research
MHC-I in the hippocampus promotes comorbid depressive symptoms in bone cancer pain via the upregulation of microglial TREM2/DAP12 signaling
Behav Brain Res. 2024 Jan 2;461:114843. doi: 10.1016/j.bbr.2023.114843. Online ahead of print.ABSTRACTPain and depression comorbidity affects patients' physical and mental health, as well as quality of life. Comorbid depressive symptoms in cancer pain have a severe impact on the recognition and treatment of pain. Similarly, cancer pain patients with depression are inclined towards more despair and greater impairment. The mechanisms responsible for the comorbid depressive symptoms in bone cancer pain (BCP) have not been fully delineated. Here, it was reported that the implantation of carcinoma cells into the femoral cavity ...
Source: Behavioural Brain Research - January 4, 2024 Category: Neurology Authors: Xiaohui Li Yifu Jia Mengyuan Xiong Yan Gao Xueqin Xu Changbin Ke Source Type: research
Relationship between neuroimaging and emotion recognition in Mild Cognitive Impairment patients
DISCUSSION: Different neuroimaging parameters were found to be related to an emotion recognition task in MCI. This analysis identified potential minimally-invasive biomarkers providing some knowledge about the physiopathological mechanisms in MCI.PMID:38176615 | DOI:10.1016/j.bbr.2023.114844 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 4, 2024 Category: Neurology Authors: Maria Teresa Gandia-Ferrero Jes ús Adrián-Ventura Consuelo Ch áfer-Pericás Lourdes Alvarez-Sanchez In és Ferrer-Cairols Bego ña Martinez-Sanchis Irene Torres-Espallardo Miquel Baquero-Toledo Luis Marti-Bonmati Source Type: research
MHC-I in the hippocampus promotes comorbid depressive symptoms in bone cancer pain via the upregulation of microglial TREM2/DAP12 signaling
Behav Brain Res. 2024 Jan 2;461:114843. doi: 10.1016/j.bbr.2023.114843. Online ahead of print.ABSTRACTPain and depression comorbidity affects patients' physical and mental health, as well as quality of life. Comorbid depressive symptoms in cancer pain have a severe impact on the recognition and treatment of pain. Similarly, cancer pain patients with depression are inclined towards more despair and greater impairment. The mechanisms responsible for the comorbid depressive symptoms in bone cancer pain (BCP) have not been fully delineated. Here, it was reported that the implantation of carcinoma cells into the femoral cavity ...
Source: Behavioural Brain Research - January 4, 2024 Category: Neurology Authors: Xiaohui Li Yifu Jia Mengyuan Xiong Yan Gao Xueqin Xu Changbin Ke Source Type: research
Relationship between neuroimaging and emotion recognition in Mild Cognitive Impairment patients
DISCUSSION: Different neuroimaging parameters were found to be related to an emotion recognition task in MCI. This analysis identified potential minimally-invasive biomarkers providing some knowledge about the physiopathological mechanisms in MCI.PMID:38176615 | DOI:10.1016/j.bbr.2023.114844 (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - January 4, 2024 Category: Neurology Authors: Maria Teresa Gandia-Ferrero Jes ús Adrián-Ventura Consuelo Ch áfer-Pericás Lourdes Alvarez-Sanchez In és Ferrer-Cairols Bego ña Martinez-Sanchis Irene Torres-Espallardo Miquel Baquero-Toledo Luis Marti-Bonmati Source Type: research
MHC-I in the hippocampus promotes comorbid depressive symptoms in bone cancer pain via the upregulation of microglial TREM2/DAP12 signaling
Behav Brain Res. 2024 Jan 2:114843. doi: 10.1016/j.bbr.2023.114843. Online ahead of print.ABSTRACTPain and depression comorbidity affects patients' physical and mental health, as well as quality of life. Comorbid depressive symptoms in cancer pain have a severe impact on the recognition and treatment of pain. Similarly, cancer pain patients with depression are inclined towards more despair and greater impairment. The mechanisms responsible for the comorbid depressive symptoms in bone cancer pain (BCP) have not been fully delineated. Here, it was reported that the implantation of carcinoma cells into the femoral cavity of m...
Source: Behavioural Brain Research - January 4, 2024 Category: Neurology Authors: Xiaohui Li Yifu Jia Mengyuan Xiong Yan Gao Xueqin Xu Changbin Ke Source Type: research
Multiparity favors same-sex partner preference in male rats
In this study, partner preference (tested in a three compartments box) and female and male sexual behavior (studied in a cylindrical arena) were evaluated in young male rats (3 months) born to multiparous mothers that had 4-6 previous gestations and around 12 months of age. Control groups were young male rats born to primiparous young (4 months) or aged (12 months) mothers. In the partner preference test, the males born to multiparous dams spent less time interacting with the receptive female and more time interacting with the sexually active male, and a 39% exhibited same-sex partner preference. This high percentage seems...
Source: Behavioural Brain Research - December 31, 2023 Category: Neurology Authors: Alejandra Hern ández Kurt Hoffman Rebeca Reyes Alonso Fern ández-Guasti Source Type: research
Multiparity favors same-sex partner preference in male rats
In this study, partner preference (tested in a three compartments box) and female and male sexual behavior (studied in a cylindrical arena) were evaluated in young male rats (3 months) born to multiparous mothers that had 4-6 previous gestations and around 12 months of age. Control groups were young male rats born to primiparous young (4 months) or aged (12 months) mothers. In the partner preference test, the males born to multiparous dams spent less time interacting with the receptive female and more time interacting with the sexually active male, and a 39% exhibited same-sex partner preference. This high percentage seems...
Source: Behavioural Brain Research - December 31, 2023 Category: Neurology Authors: Alejandra Hern ández Kurt Hoffman Rebeca Reyes Alonso Fern ández-Guasti Source Type: research
