AMPA receptors are involved in prefrontal direct current stimulation effects on long-term working memory and GAP-43 expression.
This study investigated the influence of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) on prefrontal anodal DC-induced effects on spatial working memory and GAP-43 expression. Male Wistar rats well-trained in radial maze procedures received five sessions of anodal epidural DC stimulation (eDCS: 400 µA, 13 minutes, one daily session) over the left mPFC, or a respective sham procedure, and afterwards they received a single dose (1 mg/kg) of perampanel (PRP), an AMPARs antagonist, or vehicle 30 minutes before the performance of 4-h delayed task. The prefrontal ...
Source: Behavioural Brain Research - January 14, 2019 Category: Neurology Authors: Martins CW, de Melo Rodrigues LC, Nitsche MA, Nakamura-Palacios EM Tags: Behav Brain Res Source Type: research

Spatiotemporal Analysis of Category and Target-related Information Processing in the Brain during Object Detection.
Abstract To recognize a target object, the brain implements strategies which involve a combination of externally sensory-driven and internally task-driven mechanisms. While several studies have suggested a role for frontal brain areas in enhancing task-related representations in visual cortices, especially in the lateral-occipital cortex, they have remained silent about the type of information transferred to visual areas. However, the recently developed methods of representational connectivity analysis, allowed us to track the movement of different types of information in the brain. Accordingly, we designed an EEG...
Source: Behavioural Brain Research - January 14, 2019 Category: Neurology Authors: Karimi-Rouzbahani H, Vahab E, Ebrahimpour R, Menhaj MB Tags: Behav Brain Res Source Type: research

Special issue: serotonin.
SPECIAL ISSUE: SEROTONIN. Behav Brain Res. 2019 Jan 14;357-358:A1 Authors: Padovan CM PMID: 30526960 [PubMed - in process] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - December 13, 2018 Category: Neurology Authors: Padovan CM Tags: Behav Brain Res Source Type: research

Special Issue: Neural basis of motivation and cognitive control.
PMID: 30223945 [PubMed - in process] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - September 19, 2018 Category: Neurology Authors: O'Neill M, Brown V Tags: Behav Brain Res Source Type: research

Editorial to the Special Issue: Animal Model of the Year 2036: Novel Perspectives in Behavioral Neuroscience.
PMID: 30115300 [PubMed - in process] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - August 19, 2018 Category: Neurology Authors: Dere E, Jolkkonen J, Voikar V, Tanila H Tags: Behav Brain Res Source Type: research

Chronic corticosterone increases Δfosb and crfr1 immunoreactivity in brain regions that modulate aversive conditioning.
CHRONIC CORTICOSTERONE INCREASES ΔFOSB AND CRFR1 IMMUNOREACTIVITY IN BRAIN REGIONS THAT MODULATE AVERSIVE CONDITIONING. Behav Brain Res. 2018 Aug 14;: Authors: Scalize Hirata RY, Dos Santos TB, de Andrade JS, Le Sueur Maluf L, Antunes HKM, Britto LRG, Céspedes IC, de Barros Viana M Abstract Previous studies showed that chronic treatment with corticosterone facilitates elevated T-maze (ETM) inhibitory avoidance and a step-down avoidance task, responses that have been used to investigate aversive conditioning and memory processes. On the other hand, chronic corticosterone does not alter ETM...
Source: Behavioural Brain Research - August 14, 2018 Category: Neurology Authors: Scalize Hirata RY, Dos Santos TB, de Andrade JS, Le Sueur Maluf L, Antunes HKM, Britto LRG, Céspedes IC, de Barros Viana M Tags: Behav Brain Res Source Type: research

Neuroprotective effects of bergenin in Alzheimer's disease: Investigation through molecular docking, in vitro and in vivo studies.
Abstract Alzheimer's disease (AD) is an enervating and chronic progressive neurodegenerative disorder, occurring frequently in the elderly and adversely affecting intellectual capabilities and the cognitive processes. Bergenin possesses efficacious antioxidant, antiulcerogenic, anti-HIV, hepatoprotective, neuroprotective, anti-inflammatory and immunomodulatory activity along with antinociceptive effect and wound healing properties. Previous studies have shown that bergenin has in vitro bovine adrenal tyrosine hydroxylase inhibitory activity, mushroom tyrosinase inhibitory activities, β-secretase (BACE-1) enzy...
Source: Behavioural Brain Research - August 14, 2018 Category: Neurology Authors: Barai P, Raval N, Acharya S, Borisa A, Bhatt H, Acharya N Tags: Behav Brain Res Source Type: research

Reversal elimination of morphine conditioned behavior by an anti-dopaminergic post-trial drug treatment during re-consolidation.
Abstract Morphine has potent pro-dopamine effects that can be manifested as hyper-locomotion and these behavioral effects can undergo conditioning and sensitization. The aim of the present study was to assess whether an inhibitory dopaminergic post-trial treatment (0.05 mg/kg apomorphine) given during re-consolidation could reduce morphine conditioning. To induce conditioned morphine hyperactivity and control for morphine exposure, a paired/unpaired Pavlovian conditioning protocol was used. The morphine paired groups received morphine in the open-field test arena and the unpaired groups received the same mo...
Source: Behavioural Brain Research - August 13, 2018 Category: Neurology Authors: Leite JB, de Mello Bastos JM, Samuels RI, Carey RJ, Carrera MP Tags: Behav Brain Res Source Type: research

Using the behavioral flexibility operant task to detect long-term deficits in rats following middle cerebral artery occlusion.
The objective of this study was to determine the sensitivity of certain behavioral tasks, up to seven weeks following occlusion of the middle cerebral artery (MCAo) in rats. A battery of behavioral tasks, including rotorod, cylinder, and limb-placement, was conducted weekly for seven weeks. Also, a behavioral flexibility operant task was introduced at the end of the study to measure cognitive deficits. All functional outcome measures showed significant differences between stroke and control groups, indicating that these tasks are sensitive enough to detect deficits in a long-term MCAo study in rats. This provides useful in...
Source: Behavioural Brain Research - August 11, 2018 Category: Neurology Authors: Andrews MMM, Peruzzaro S, Raupp S, Wilks J, Rossignol J, Dunbar GL Tags: Behav Brain Res Source Type: research

Social behavioral phenotyping of the zebrafish Casper mutant following embryonic alcohol exposure.
We report that exposure to 1% alcohol from either 6 to 24, or 24 to 26 hours postfertilization reduces the social behavior of adult casper zebrafish. Our findings set the stage for the use of this important zebrafish resource in studies of FASD. PMID: 30107225 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - August 11, 2018 Category: Neurology Authors: Fernandes Y, Rampersad M, Eberhart JK Tags: Behav Brain Res Source Type: research

Body composition, biochemical, behavioral and molecular alterations in overfed rats after chronic exposure to SSRI.
nha C Abstract Serotonin (5-HT) plays a regulatory role in coordinating the neural circuits regulating energy balance, with differences in both 5-HT availability at the synapse and the activity of 5-HT receptors mediating anorectic (via POMC/CART activation) and orexigenic (via NPY/AgRP activation) responses. In conditions of overweight and obesity the control of energy balance is clearly deregulated, and serotonergic modulation appears to make a significant contribution to weight gain. Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI) that increases 5-HT availability in the synaptic cleft may thus...
Source: Behavioural Brain Research - August 9, 2018 Category: Neurology Authors: da Silva AI, Braz GRF, de A Silva SC, da S Pedroza AA, de Lima-Júnior NC, de A Silva TL, Jacques Lagranha C Tags: Behav Brain Res Source Type: research

Neural correlates of liraglutide effects in persons at risk for Alzheimer's Disease.
Abstract Insulin resistance (IR) is a metabolic state preceding development of type 2 diabetes (DM2), cardiovascular disease, and neurodegenerative disorders, including Alzheimer's Disease (AD). Liraglutide, a glucagon-like peptide-1 (GLP) agonist, is an insulin-sensitizing agent with neuroprotective properties, as shown in animal studies. The purpose of this double-blinded, placebo-controlled study was to examine the neural effects of administration of liraglutide in cognitively normal late middle-aged individuals with subjective cognitive complaints (half of subjects had family history of AD). Seed-based resting...
Source: Behavioural Brain Research - August 9, 2018 Category: Neurology Authors: Watson KT, Wroolie TE, Tong G, Foland-Ross LC, Frangou S, Singh M, McIntyre R, Roat-Shumway S, Myoraku A, Reiss AL, Rasgon NL Tags: Behav Brain Res Source Type: research

Spatial information is preferentially processed by the distal part of CA3: Implication for memory retrieval.
Abstract For the past decades, CA3 was considered as a single functional entity. However, strong differences between the proximal (close to the dentate gyrus) and the distal (close to CA2) parts of CA3 in terms of connectivity patterns, gene expression and electrophysiological properties suggest that it is not the case. We recently showed that proximal CA3 (together with distal CA1) preferentially deals with non-spatial information [1]. In contrast to proximal CA3, distal CA3 mainly receives and predominantly projects to spatially tuned areas. Here, we tested if distal CA3 preferentially processes spatial informat...
Source: Behavioural Brain Research - August 8, 2018 Category: Neurology Authors: Flasbeck V, Atucha E, Nakamura NH, Yoshida M, Sauvage MM Tags: Behav Brain Res Source Type: research

Basolateral amygdala inactivation eliminates fear-induced underestimation of time in a temporal bisection task.
We examined interval timing-time perception in the seconds-to-minutes range-of the fear-inducing stimulus and the role of the amygdala in this phenomenon. Rats were initially trained to perform a temporal bisection task, in which their responses to levers A and B were reinforced following 2-s and 8-s tones, respectively. After acquisition, the rats were also presented with tones of intermediate durations and pressed one of the two levers to indicate whether the tone duration was closer to 2 or 8 s. Subsequently, the rats underwent differential fear conditioning, in which one frequency tone (conditioned stimulus; CS+...
Source: Behavioural Brain Research - August 8, 2018 Category: Neurology Authors: Kamada T, Hata T Tags: Behav Brain Res Source Type: research

Hippo/YAP signaling pathway mitigates blood-brain barrier disruption after cerebral ischemia/reperfusion injury.
In this study, we investigated whether the Hippo/YAP pathway plays a role in I/R injury in brain, especially in regard to I/R-induced BBB breakdown. The results of our study indicate that I/R injury led to an overall decrease in activity of the core proteins, YAP and TAZ, over a 24-h period. The most dramatic change was observed 1.5 h after reperfusion. In rats that underwent 1.5 h of reperfusion, intraperitoneal injection of YAP agonist dexamethasone activated YAP and TAZ and led to improved neurologic function, smaller brain infarct sizes, increased levels of tight junction proteins, decreased BBB permeabil...
Source: Behavioural Brain Research - August 6, 2018 Category: Neurology Authors: Gong P, Zhang Z, Zou C, Tian Q, Chen X, Hong M, Liu X, Chen Q, Xu Z, Li M, Wang J Tags: Behav Brain Res Source Type: research

Cerebral and behavioural response to human voices is mediated by sex and sexual orientation.
Abstract Several studies report sex differences in sensitivity to gendered stimuli. We assume many of these to reflect differences as to the sex to which one feels attracted rather than to biological sex per se. Investigating voice perception, a function of high social relevance, we show that the behavioural and neural (BOLD) responses to male and female voices are mediated by sex and sexual orientation. In heterosexual men and women, we found an opposite-sex effect, reflected in higher classification accuracy for and a response bias towards voices of the other sex, while the effect became apparent as same-sex eff...
Source: Behavioural Brain Research - August 3, 2018 Category: Neurology Authors: Smith E, Junger J, Pauly K, Kellermann T, Dernt B, Habel U Tags: Behav Brain Res Source Type: research

Thinking about the past to shape the present: Neural activation during the recall of relationship episodes.
chter A Abstract Reflecting on oneself and others in relationships is an ability that is central to our social existence. Specifically, considering formative autobiographical experiences in relationships may contribute to more flexibility in perceiving, as well as in shaping present relationships. Reflecting on such experiences mobilizes different social cognitive and affective processes. We aim to explore the neural basis of these processes. With a newly developed functional magnetic imaging (fMRI) task, we investigated brain activation in 35 healthy individuals during recall of relationship episodes involving th...
Source: Behavioural Brain Research - August 2, 2018 Category: Neurology Authors: Wade-Bohleber LM, Böker H, Ernst J, Grimm S, Brügger N, Berwian IM, Vetter J, Preller KH, Himmighoffen H, Kleim B, Seifritz E, Richter A Tags: Behav Brain Res Source Type: research

Single prolonged stress decreases sign-tracking and cue-induced reinstatement of cocaine-seeking.
Abstract Exposure to prolonged, uncontrollable stress reduces reward-seeking behavior, resulting in anhedonia in neuropsychiatric disorders, such as posttraumatic stress disorder. However, it is unclear to what degree stressed subjects lose interest in rewards themselves or in reward-related cues that instigate reward-seeking behavior. In the present study, we investigated the effects of single prolonged stress (SPS) on cue-directed behavior in two different procedures: Pavlovian conditioned approach (PCA) and cue-induced reinstatement of cocaine-seeking. In Experiment 1, rats were exposed to SPS and tested for th...
Source: Behavioural Brain Research - August 2, 2018 Category: Neurology Authors: Fitzpatrick CJ, Jagannathan L, Lowenstein E, Robinson TE, Becker JB, Morrow JD Tags: Behav Brain Res Source Type: research

sucrose ingestion induces glutamate AMPA receptor phosphorylation in dorsal hippocampal neurons: Increased sucrose experience prevents this effect.
Abstract Evidence suggests that meal-related memory influences later eating behavior. Memory can serve as a powerful mechanism for controlling eating behavior because it provides a record of recent intake that likely outlasts most physiological signals generated by ingestion. Dorsal (dHC) and ventral hippocampal (vHC) neurons are critical for memory, and we demonstrated previously that they limit energy intake during the postprandial period. If dHC or vHC neurons control intake through a process that requires memory, then ingestion should increase events necessary for synaptic plasticity in dHC and vHC during the ...
Source: Behavioural Brain Research - August 1, 2018 Category: Neurology Authors: Ross A, Barnett N, Faulkner A, Hannapel R, Parent MB Tags: Behav Brain Res Source Type: research

Prenatal Ethanol Exposure Increases Risk of Psychostimulant Addiction.
Abstract Prenatal ethanol exposure (PE) causes many cognitive and behavioral deficits including increased drug addiction risk, demonstrated by enhanced ethanol intake and behavioral phenotypes associated with addiction risk. Additionally, preclinical studies show that PE persistently changes the function of dopaminergic neurons in the ventral tegmental area, a major neural substrate for addiction, and alters these neurons' responses to psychostimulants. Accordingly, PE could also lead to increased risk of addiction to drugs of abuse, other than ethanol. In the present study, addiction risk was examined utilizing p...
Source: Behavioural Brain Research - August 1, 2018 Category: Neurology Authors: Wang R, Shen YL, Hausknecht KA, Chang L, Haj-Dahmane S, Vezina P, Shen RY Tags: Behav Brain Res Source Type: research

Scopolamine increases perseveration in mice subjected to the detour test.
This study also shows that a mouse detour task is a suitable model for detecting the effect of anticholinergic drugs on perseveration in contrast to the previously applied tests. PMID: 30071270 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 30, 2018 Category: Neurology Authors: Juszczak GR, Stryjek R Tags: Behav Brain Res Source Type: research

Danger and safety signals independently influence persistent pathological avoidance in anxiety-vulnerable Wistar Kyoto rats: A role for impaired configural learning in anxiety vulnerability.
Abstract Pathological avoidance behavior in anxiety and anxiety-related disorders has a large role in the persistence and severity of disease. Individuals are cued to avoid potential aversive events by learned danger and safety signals in the environment. Individuals with anxiety demonstrate a bias to utilize danger signals more than safety signals, in contrast to those without these disorders. Therefore, the present study investigated if danger and safety signals differentially influenced persistent avoidance in an animal model of anxiety-vulnerability, the Wistar Kyoto (WKY) rat, relative to the outbred Sprague ...
Source: Behavioural Brain Research - July 28, 2018 Category: Neurology Authors: Spiegler KM, Smith IM, Pang KCH Tags: Behav Brain Res Source Type: research

Exploring the neuromechanism of chronic ephedrine addiction in rhesus monkeys: a behavioural and brain resting-state fMRI study.
Abstract Ephedrine is thought to exert behavioural effects primarily through actions on the central nervous system. However, the neuromechanism underlying the effects of ephedrine addiction still remains unclear. Our study aimed to establish chronic ephedrine addiction models in rhesus monkeys and to investigate the neuromechanism of chronic ephedrine addiction using the behavioural methods combined with resting-state blood oxygenation level dependent-functional magnetic resonance imaging (BOLD-fMRI). Monkeys in the ephedrine addiction group (n = 6) received intramuscular injections of ephedrine usin...
Source: Behavioural Brain Research - July 27, 2018 Category: Neurology Authors: Xie L, Ma Y, Huang J, Guo R, Wang J, Sun Z, Duan S, Wu B, Lin Z, Xiao Y, Ma S Tags: Behav Brain Res Source Type: research

Hyperbaric oxygen therapy restored traumatic stress-induced dysregulation of fear memory and related neurochemical abnormalities.
Abstract Individuals with posttraumatic stress disorder (PTSD) are characterized by fear memory problems and hypocortisolemia of which traumatic stress-induced monoaminergic disruption over infralimbic (IL) cortex is considered the key mechanism. Hyperbaric oxygen therapy (HBOT) has recently proven its utility in treating several mental disorders but remains unexplored for PTSD. The present study aimed to examine the effects of 5-day HBO paradigm on traumatic stress (single prolonged stress, SPS, an animal model of PTSD)-induced dysregulation of fear memory/anxiety profiles and related abnormalities in IL monoamin...
Source: Behavioural Brain Research - July 26, 2018 Category: Neurology Authors: Lin CC, Huang KL, Tung CS, Liu YP Tags: Behav Brain Res Source Type: research

Latency to startle is reduced in the 5xFAD mouse model of Alzheimer's disease.
Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder that results in cognitive decline and a number of other neuropsychiatric symptoms. One area that is often affected by neuropsychiatric disease is the response to sudden, loud noises, as measured by the acoustic startle response (ASR), and prepulse inhibition (PPI), which indicates sensory-gating abilities. Evidence suggests AD patients, even early in the disease, show alteration in ASR. Studies have also shown changes in this measure in transgenic mouse models of AD. To assess the homology of 5xFAD mice to AD patients, the current study ...
Source: Behavioural Brain Research - July 25, 2018 Category: Neurology Authors: Story D, Chan E, Munro N, Rossignol J, Dunbar GL Tags: Behav Brain Res Source Type: research

Combined early life stressors: prenatal nicotine and maternal deprivation interact to influence behavioral phenotypes in rats.
We report here that multiple early stressors including prenatal nicotine and MD can modulate the neuroanatomy of the amygdala and VTA. These early life stressors can interact to influence the development of depressive-like and addictive behaviors. PMID: 30055209 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 25, 2018 Category: Neurology Authors: Bassey RB, Gondré-Lewis MC Tags: Behav Brain Res Source Type: research

Involvement of D1- and D2-like dopamine receptors in the dentate gyrus in the acquisition, expression, and extinction of the morphine-induced conditioned place preference in rats.
Abstract In the current study, we investigated the role of intra-dentate gyrus (DG) administration of D1 and/or D2 receptor antagonists on the expression, acquisition, and extinction of morphine-CPP. Cannulae were implanted bilaterally into the DG region in male Wistar rats and CPP was induced by the subcutaneous injection of morphine (5 mg/kg) during a 3-day conditioning phase. Three experimental designs were separately employed in the CPP paradigm during the acquisition, expression and extinction phases, and different doses (0.25, 1, or 4 μg/0.5 μl saline) of SCH23390, as a selective D...
Source: Behavioural Brain Research - July 24, 2018 Category: Neurology Authors: Katebi N, Farahimanesh S, Fatahi Z, Zarrabian S, Haghparast A Tags: Behav Brain Res Source Type: research

5-Methoxy- α-methyltryptamine (5-MeO-AMT), a tryptamine derivative, induces head-twitch responses in mice through the activation of serotonin receptor 2a in the prefrontal cortex.
This study shows that 5-MeO-AMT induces HTR through 5-HTR2a activation in the prefrontal cortex, and may have low potential for abuse. PMID: 30053461 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 24, 2018 Category: Neurology Authors: Abiero A, Botanas CJ, Val Sayson L, Custodio RJ, de la Peña JB, Kim M, Lee HJ, Seo JW, Ryu IS, Min Chang C, Yang JS, Sup Lee Y, Jang CG, Kim HJ, Cheong JH Tags: Behav Brain Res Source Type: research

Adolescent and adult nicotine exposure differentially impacts oral nicotine and oral saccharin self-administration in mice.
Abstract Smokers that begin during adolescence are more likely to develop nicotine dependence than those who begin as adults. However, the factors that contribute to this remain largely unknown. Here we utilized a novel operant oral nicotine self-administration procedure in mice to assess the consequences of adolescent nicotine exposure on nicotine and saccharin (non-drug) reinforcement in adults. Animals were given non-contingent exposure to either saline or nicotine using the osmotic minipumps during both adolescence and adulthood for 2 weeks. Reinforcing efficacy for oral nicotine and saccharin was assessed usi...
Source: Behavioural Brain Research - July 24, 2018 Category: Neurology Authors: Cole RD, Wolsh C, Zimmerman M, Harrington E, Gould TJ, Parikh V Tags: Behav Brain Res Source Type: research

G-1 exhibit antidepressant effect, increase of hippocampal ERs expression and improve hippocampal redox status in aged female rats.
Abstract Postmenopausal depression has been shown to be related to the reduction of ovarian hormones produced as a woman transitions from a menopausal to a post-menopausal stage. What remains to be known is which type of estrogen receptor plays a key role in estrogen neuroprotection, a process that may be mediated by potentiating brain mitochondrial function and inhibiting mitochondria-associated apoptosis. In order to better imitate the condition of postmenopause, we conducted our research on aged female rats. Plasma estrogen levels declined significantly in ovariectomized rats and 16-month-old female rats, while...
Source: Behavioural Brain Research - July 21, 2018 Category: Neurology Authors: Wang J, Yu R, Han QQ, Huang HJ, Wang YL, Li HY, Wang HM, Chen XR, Ma SL, Yu J Tags: Behav Brain Res Source Type: research

Altered neural responsivity to food cues in relation to food preferences, but not appetite-related hormone concentrations after RYGB-surgery.
CONCLUSIONS: RYGB leads to changed responsivity of the frontoparietal control network that orchestrates top-down control to high-energy food compared to low-energy food and non-food cues, rather than in reward related brain regions, in a satiated state. Together with correlations with the shift in food preference from high- to low-energy foods this indicates a possible role in new food preference formation. PMID: 30041007 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 21, 2018 Category: Neurology Authors: Zoon HFA, de Bruijn SEM, Smeets PAM, de Graaf C, Janssen IMC, Schijns W, Aarts EO, Jager G, Boesveldt S Tags: Behav Brain Res Source Type: research

Single Session, High-Intensity Aerobic Exercise Fails to Affect Plasticity-Related Protein Expression in the Rat Sensorimotor Cortex.
We examined immediate responses in animals following either a GXT, or two resting conditions: non-exercising treadmill controls (TC), and acclimatization controls (AC). Young, male Sprague-Dawley rats (n = 20) on a reverse light cycle (12 h/12 h) were exposed to a treadmill acclimatization procedure consisting of 8 days of increasing exercise intensity (10 m/min up to 25 m/min) for 10 minutes at the same time each day. The acclimatization was followed by 2 days of rest to reduce any carryover effects. On testing day, rats performed either a GXT, or rested (TC and AC), were then sacrificed and sensorimotor cor...
Source: Behavioural Brain Research - July 21, 2018 Category: Neurology Authors: Thacker JS, Yeung D, Chambers PJ, Tupling AR, Staines WR, Mielke JG Tags: Behav Brain Res Source Type: research

Chronic forced exercise inhibits stress-induced reinstatement of cocaine conditioned place preference.
Abstract Stress increases the likelihood of cocaine relapse in humans and animals, even following a prolonged extinction/abstinence period. Exercise has previously been shown to reduce stress and decrease the likelihood of drug dependence, while also reducing cravings in humans and inhibiting relapse behaviors due to other risk factors in rodents. The present study evaluated the efficacy of exercise to reduce stress-induced relapse to cocaine in a rodent model. Young adult female Sprague Dawley rats were tested for cocaine conditioned place preference (CPP), then split into sedentary or exercise (six weeks of one-...
Source: Behavioural Brain Research - July 20, 2018 Category: Neurology Authors: Robison LS, Alessi L, Thanos PK Tags: Behav Brain Res Source Type: research

High nursing demand reduces depression-like behavior despite increasing glucocorticoid concentrations and reducing hippocampal neurogenesis in late postpartum rats.
Abstract Approximately 15% of women who give birth develop postpartum depression (PPD) and the risk is greater in women who do not breastfeed or who cease breastfeeding early. In some women, early cessation or absence of breastfeeding precedes PPD, but the neuroendocrine mechanisms of this relationship are unknown. We tested whether nursing demand would alter behavioral and endocrine endpoints relevant for depression in postpartum rats. Adult female Sprague-Dawley rats underwent thelectomy (thel; removal of teats), sham surgery (sham), or no surgery (control). Litters were rotated between thel and sham rats every ...
Source: Behavioural Brain Research - July 19, 2018 Category: Neurology Authors: De Guzman RM, Saulsbery AI, Workman JL Tags: Behav Brain Res Source Type: research

The α5-GABAAR inverse agonist MRK-016 upregulates hippocampal BDNF expression and prevents cognitive deficits in LPS-treated mice, despite elevations in hippocampal Aβ.
The α5-GABAAR inverse agonist MRK-016 upregulates hippocampal BDNF expression and prevents cognitive deficits in LPS-treated mice, despite elevations in hippocampal Aβ. Behav Brain Res. 2018 Jul 19;: Authors: Eimerbrink MJ, Pendry RJ, Hodges SL, Wiles JD, Peterman JL, White JD, Hayes HB, Chumley MJ, Boehm GW Abstract Alzheimer's disease is marked by the presence of amyloid-beta (Aβ) plaques, elevated central cytokine levels, dysregulation of BDNF-related gene expression, and cognitive decline. Previously, our laboratory has demonstrated that repeated administration of peripheral LPS is...
Source: Behavioural Brain Research - July 19, 2018 Category: Neurology Authors: Eimerbrink MJ, Pendry RJ, Hodges SL, Wiles JD, Peterman JL, White JD, Hayes HB, Chumley MJ, Boehm GW Tags: Behav Brain Res Source Type: research

Predicting Antidepressant Response Using Early Changes in Cognition: A Systematic Review.
CONCLUSION: The identification of reliable early treatment predictors of antidepressant response would be clinically significant, enabling clinicians to more accurately evaluate the efficacy of selected treatment avenues. PMID: 30031025 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 18, 2018 Category: Neurology Authors: Park C, Pan Z, Brietzke E, Subramaniapillai M, Rosenblat JD, Zuckerman H, Lee Y, Fus D, McIntyre RS Tags: Behav Brain Res Source Type: research

Rosmarinic acid reverses the deleterious effects of repetitive stress and tat protein.
Abstract Human immunodeficiency virus type 1 (HIV) has infected more than 40 million people worldwide and is associated with central nervous system (CNS) disruption in at least 30% of these persons. The use of highly active antiretroviral therapy (HAART) has significantly reduced the systemic immunopathology associated with HIV, but the occurrence of neurological disorders continues to be reported in notable numbers. The present study evaluated the potential of rosmarinic acid to reverse the detrimental effects of an intracerebral injection of the viral protein tat. Control and tat-injected rats were also subjecte...
Source: Behavioural Brain Research - July 17, 2018 Category: Neurology Authors: Makhathini KB, Mabandla MV, Daniels WMU Tags: Behav Brain Res Source Type: research

Integrating Genome-Wide Association Study, Chromosomal Enhancer Maps and Element-gene Interaction Networks Detected Brain Regions Related Associations between Elements and ADHD/IQ.
CONCLUSION: Our study results provide novel clues for understanding the associations between elements and ADHD/IQ. This study also illustrated the good performance of ERGSEA approach for complex diseases. PMID: 30016737 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 14, 2018 Category: Neurology Authors: Ma M, Liang X, Cheng S, Zhang L, Cheng B, Yang J, Ding M, Zhao Y, Li P, Du Y, Liu L, Wen Y, He A, Fan Q, Guo X, Zhang F Tags: Behav Brain Res Source Type: research

Observational threat conditioning is induced by circa-strike activity burst but not freezing and requires visual attention.
Abstract Social transmission refers to a process in which an observer (OB) acquires new information about the environment including threat situations, through the action of familiar conspecifics. Recently, a number of studies employing observational threat conditioning (OTC) in which OB mice expressed defensive responses following indirect exposure to pair-housed partner mice (demonstrator: DE) which were receiving repeated footshocks, have produced interesting insights into the social mechanisms of emotional transfer. However, the nature of the transmitted information or the critical cognitive processes involved ...
Source: Behavioural Brain Research - July 14, 2018 Category: Neurology Authors: Hong EH, Choi JS Tags: Behav Brain Res Source Type: research

Depressive- and anxiety-like phenotypes in young adult APPSwe/PS1dE9 transgenic mice with insensitivity to chronic mild stress.
Abstract Early Alzheimer's disease (AD) and depression share many symptoms, but the underlying mechanisms are not clear. Therefore, characterizing the shared and different biological changes between the two disorders will be helpful in making an early diagnosis and planning treatment. In the present study, 8-week-old APPSwe/PS1dE9 transgenic mice received chronic mild stress (CMS) for 8 weeks followed by a series of behavioral, biochemical and pathological analyses. APPSwe/PS1dE9 mice showed depressive- and anxiety-like behaviors, and reduced sociability, accompanied by high levels of soluble beta-amyloid, glial a...
Source: Behavioural Brain Research - July 13, 2018 Category: Neurology Authors: Gao JY, Chen Y, Su DY, Marshall C, Xiao M Tags: Behav Brain Res Source Type: research

Saccade latency delays in young apolipoprotein E (APOE) epsilon 4 carriers.
This study aimed to assess the association between APOE genotype and saccade latency using a prosaccade and antisaccade task in young individuals (N = 97, age: 17-35 years). Results showed that prosaccade latency was significantly delayed in a group of ε4 carriers in comparison to non-carriers, which was due to a lower rate of signal accumulation rather than a change in the criterion threshold. In contrast, there was no significant genotype difference for antisaccade latency in this young cohort. These results indicate that prosaccade latency may be useful in establishing the APOE behavioural phenotype, which c...
Source: Behavioural Brain Research - July 9, 2018 Category: Neurology Authors: Niechwiej-Szwedo E, Tapper A, Gonzalez D, Bradley RM, Duncan R Tags: Behav Brain Res Source Type: research

Low-frequency repetitive transcranial magnetic stimulation inhibits the development of methamphetamine-induced conditioned place preference.
Abstract The abuse of amphetamine-type stimulants (ATS) has become a global public health issue in recent years, these new-type drugs can cause addiction and serious cognitive impairment. However, there are no effective methods for the prevention and treatment of ATS addiction at present. Repetitive transcranial magnetic stimulation (rTMS) is a painless and non-invasive new therapeutic approach that has been used for the treatment of depression and other neuropsychiatric disorders, but whether it can be used to treat drug addiction is unclear. In the present study, we investigated the possible effects of rTMS on m...
Source: Behavioural Brain Research - July 9, 2018 Category: Neurology Authors: Wu XQ, Zan GY, Ju YY, Chen TZ, Guo LB, Jiao DL, Jiang HF, Deng YZ, Liu JG, Zhao M Tags: Behav Brain Res Source Type: research

Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat.
In conclusion, CUMS-induced depression- and anxiety-like behavior may result from imbalance between M1 and M2 and suppressed astrocyte function since minocycline treatment reversed M1 response, which was associated with behavioral normalization. PMID: 30003978 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - July 9, 2018 Category: Neurology Authors: Zhang C, Zhang YP, Li YY, Liu BP, Wang HY, Li KW, Song C Tags: Behav Brain Res Source Type: research

Reconsolidation of human motor memory: From boundary conditions to behavioral interventions-How far are we from clinical applications?
Abstract The memory reconsolidation hypothesis states that a previously consolidated and stable memory can return to a temporary labile state after retrieved, requiring a new stabilization process. During the labile period, the memory trace is vulnerable to modification, which provides a potential therapeutic opportunity to weaken, updated or strengthen that memory. As such, reconsolidation has been the subject of numerous studies in different domains of human memory that seek strategies to treat post-traumatic disorders and erase or modify pathological memories. A few studies have also investigated the impairment...
Source: Behavioural Brain Research - July 3, 2018 Category: Neurology Authors: Silva MB, Soares AB Tags: Behav Brain Res Source Type: research

TNF signalling via the TNF receptors mediates the effects of exercise on cognition-like behaviours.
DISCUSSION: TNF receptor signalling via the TNFR1 and TNFR2 appears to mediate the effects of exercise on cognitive-like behaviours. The potential for exercise to regulate human TNF and TNF signalling and cognitive dysfunction needs investigation under inflammatory conditions including depression and neuropsychiatric disorders. PMID: 29969604 [PubMed - as supplied by publisher] (Source: Behavioural Brain Research)
Source: Behavioural Brain Research - June 30, 2018 Category: Neurology Authors: Morgan JA, Singhal G, Corrigan F, Jaehne EJ, Jawahar MC, Baune BT Tags: Behav Brain Res Source Type: research

The contribution of contextual fear in the anxiolytic effect of chlordiazepoxide in the fear-potentiated startle test.
This study evaluated the extent to which a reduction in contextual fear contributes to the anxiolytic effect of benzodiazepines in the fear-potentiated startle response. To this end, chlordiazepoxide, an anxiolytic often used as positive control in preclinical drug studies, and zolpidem, known to have sedative properties and to be devoid of anxiolytic effects, were tested in two contexts: the same context as training had taken place and an alternative context. In addition, the level of muscle relaxation was assessed in a grip strength test. Chlordiazepoxide (2.5-10 mg/kg) decreased the fear-potentiated startle response, ...
Source: Behavioural Brain Research - June 30, 2018 Category: Neurology Authors: Zhao Y, Bijlsma EY, Verdouw PM, Garssen J, Groenink L Tags: Behav Brain Res Source Type: research

Effects of combined pre- and post-natal enrichment on anxiety-like, social, and cognitive behaviours in juvenile and adult rat offspring.
Abstract The pre- and post-natal periods are characterized by unrivalled growth and are sensitive to environmental changes. A correctly stimulating early environment is essential for developing natural behaviors and maintaining affective wellness. Five litters of rat progeny were co-housed through gestation until juvenile age in housing providing physical and social enrichment. Five control litters were housed separately in standard conditions. Half of the offspring were tested in the elevated plus-maze and the social interaction test as juveniles (five weeks old) with the other half tested in the Morris water maz...
Source: Behavioural Brain Research - June 29, 2018 Category: Neurology Authors: Sparling JE, Baker SL, Bielajew C Tags: Behav Brain Res Source Type: research

Agmatine attenuates depressive-like behavior and hippocampal oxidative stress following amyloid β (Aβ1-40) administration in mice.
Agmatine attenuates depressive-like behavior and hippocampal oxidative stress following amyloid β (Aβ1-40) administration in mice. Behav Brain Res. 2018 Jun 28;: Authors: de Souza ACG, Gonçalves CL, de Souza V, Hartwig JM, Farina M, Prediger RD Abstract Depression is one of the most common psychiatric symptoms in Alzheimer's disease (AD), and several studies have shown that oxidative stress plays a key role in the etiopathology of both AD and depression. Clinical studies indicate reduced efficacy of the current antidepressants for the treatment of depression in AD. In this regard, agm...
Source: Behavioural Brain Research - June 28, 2018 Category: Neurology Authors: de Souza ACG, Gonçalves CL, de Souza V, Hartwig JM, Farina M, Prediger RD Tags: Behav Brain Res Source Type: research

Causal and functional interpretation of mu- and delta-opioid receptor profiles in mesoaccumbens and nigrostriatal pathways of an oral stereotypy phenotype.
Abstract Spontaneous stereotypic behaviours are repetitive, compulsive, topographically invariant response patterns commonly observed in captive or domestic animals, which have been linked to dysfunction of basal ganglia input/output pathways. There is evidence that endogenous opioids play a key regulatory role in basal ganglia direct and indirect pathways, but their precise role, both causally and functionally, in spontaneous stereotypic behaviour is unclear. Here we examined the profile of mu- and delta-opioid receptors (density [Bmax] and affinity [Kd]) of basal ganglia structures in stereotypy (n = 10) and...
Source: Behavioural Brain Research - June 28, 2018 Category: Neurology Authors: Hemmings A, Parker MO, Hale C, McBride SD Tags: Behav Brain Res Source Type: research

Maternal stress during pregnancy induces depressive-like behavior only in female offspring and correlates to their hippocampal Avp and Oxt receptor expression.
r N Abstract The majority of studies examining the consequences of prenatal stress in rodent models analyze pups having been raised by their biological mother, i.e. the female which experienced stress during her pregnancy. To test whether pregnancy stress changes maternal behavior and thereby - in addition to stress exposure in utero - influences behavior and brain function of offspring, we implemented a fostering model, in which mouse pups that were not stressed in utero, are raised by dams which were exposed to stress during their pregnancy. We found that dams, which were stressed during pregnancy (PS foster dam...
Source: Behavioural Brain Research - June 26, 2018 Category: Neurology Authors: Schmidt M, Braun K, Brandwein C, Rossetti AC, Guara Ciurana S, Riva MA, Deuschle M, Bock J, Gass P, Gröger N Tags: Behav Brain Res Source Type: research