Complement activation in wasp venom-induced acute kidney injury
In this study, a complement-depleted mouse model was used to investigate the role of complement in wasp venom-induced AKI. Mice were randomly categorized into control, cobra venom factor (CVF), AKI, and CVF + AKI groups. Compared to the AKI group, the CVF + AKI group showed improved pathological changes in kidneys and reduced blood urea nitrogen (BUN) levels. The expression levels of renal complement 3 (C3), complement 5 (C5), complement 1q (C1q), factor B (FB), mannose-binding lectin (MBL), and C5b-9 in AKI group were upregulated compared with the control group. Conversely, the renal tissue expression levels of C3, C5, C1...
Source: Renal Failure - April 21, 2024 Category: Urology & Nephrology Authors: Rui Cheng Liang Xu Jianhua Gong Fanglin Yu Ying Lv Hai Yuan Fengqi Hu Source Type: research
The yield of routine laboratory examination in osteoporosis evaluation in primary care
ConclusionsWe identified a low prevalence of laboratory abnormalities in a primary care population of older women and the majority of these findings had no medical consequences. (Source: Osteoporosis International)
Source: Osteoporosis International - April 19, 2024 Category: Orthopaedics Source Type: research
The NLRP3 Inflammasome Is a Major Cause of Acute Renal Failure Induced by Polypeptide Antibiotics
J Immunol. 2024 Apr 19:ji2300193. doi: 10.4049/jimmunol.2300193. Online ahead of print.ABSTRACTDrug-induced acute renal failure (ARF) is a public health concern that hinders optimal drug therapy. However, pathological mechanisms of drug-induced ARF remain to be elucidated. Here, we show that a pathological process of drug-induced ARF is mediated by proinflammatory cross-talk between kidney tubular cells and macrophages. Both polymyxin B and colistin, polypeptide antibiotics, frequently cause ARF, stimulated the ERK and NF-κB pathways in kidney tubular cells, and thereby upregulated M-CSF and MCP-1, leading to infiltration...
Source: Journal of Immunology - April 19, 2024 Category: Allergy & Immunology Authors: Tomohiro Kagi Aya Inoue Takuya Noguchi Wakana Suzuki Saya Takano Kohei Otani Rio Naganuma Yuto Sekiguchi Yusuke Hirata Sawako Shindo Gi-Wook Hwang Atsushi Matsuzawa Source Type: research
Accuracy of Medicare Local Coverage Determination Guidelines for Chronic Renal Failure
1. Participants will self-report the ability to name LCD criteria for chronic renal failure.2. Participants will be able to evaluate the prognostic utility of LCD guidelines compared to receiving an expected six months of hospice care. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Abigail Lewis, Nathan Moore, Katherine Ast, Randi Foraker, Patrick H. White Source Type: research
The Fatigue of Cancer is Distinctly Different Than the Fatigue of Chronic Renal Fatigue (GP148)
1. Participants will be able to distinguish differences in fatigue phenotypes by using the rate of perceived effort, tapping speeds, and a fatigue scale.2. Participants will be able to appraise the difference in fatigue associated with cancer and that associated with renal failure. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Mellar P. Davis, Carlos Fernandez, Alexander Chang Source Type: research
Life Prolonging Choices in Renal Failure: A Qualitative Study Focusing on Chinese American Patients
1. Understand factors influencing patients' decision processes regarding life prolonging treatment of dialysis.2. Explore opportunities for palliative care intervention within other disciplines of medicine to improve patient care and understanding of choices. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Abigail Lebovitz, Steven Schwab, Klemens Meyer, Michelle M. Richardson, Kathleen Bungay, Tamara Vesel Source Type: research
Prognostic value of neutrophil-to-lymphocyte ratio dynamics in patients with septic acute kidney injury: a cohort study
CONCLUSIONS: High ΔNLR is independently associated with increased risk of patient mortality and adverse outcomes. ΔNLR might be utilized to facilitate risk stratification and optimize septic AKI management.PMID:38637281 | DOI:10.1080/0886022X.2024.2343818 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Wei Wei Caihong Liu Guojiao Song Letian Yang Jian Li Bo Wang Ting Yin Yingying Yang Liang Ma Ling Zhang Ping Fu Yuliang Zhao Source Type: research
Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group
CONCLUSION: CS can significantly improve remission in high-risk Turkish IgAN patients, despite the reliance on non-quantitative endpoints for favorable renal outcomes. Key predictors of remission include baseline proteinuria and specific histological markers. It is crucial to carefully weigh the risks and benefits of immunosuppressive therapy for these patients.PMID:38637275 | DOI:10.1080/0886022X.2024.2341787 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Aysegul Oruc Abdullah Sumnu Ayd ın Turkmen Taner Basturk Egemen Cebeci Kenan Turgutalp Hakk ı Cetinkaya M üge Uzerk Kibar Nurhan Seyahi Erhan Tatar Metin Ergul Ülver Derici Mehmet Deniz Ayl ı Musa P ınar Bet ül Bakar R ümeyza Kazancıoglu Abd ülm Source Type: research
Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study
CONCLUSION: HFR treatment effectively eliminates uremic toxins from the bloodstream of patients undergoing MHD, especially protein-bound toxins and large middle-molecule toxins. Additionally, it retains essential physiological compounds like albumin and branched-chain amino acids, underscoring its commendable safety profile.PMID:38632963 | DOI:10.1080/0886022X.2024.2338929 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Renhua Lu Yan Fang Wangshu Wu Xiaojun Zeng Tingting Liu Yue Qian Yuanyuan Xie Yijun Zhou Leyi Gu Source Type: research
Prognostic value of neutrophil-to-lymphocyte ratio dynamics in patients with septic acute kidney injury: a cohort study
CONCLUSIONS: High ΔNLR is independently associated with increased risk of patient mortality and adverse outcomes. ΔNLR might be utilized to facilitate risk stratification and optimize septic AKI management.PMID:38637281 | PMC:PMC11028010 | DOI:10.1080/0886022X.2024.2343818 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Wei Wei Caihong Liu Guojiao Song Letian Yang Jian Li Bo Wang Ting Yin Yingying Yang Liang Ma Ling Zhang Ping Fu Yuliang Zhao Source Type: research
Immunosuppressive treatment results in patients with primary IgA nephropathy in Turkiye; the data from TSN-GOLD working group
CONCLUSION: CS can significantly improve remission in high-risk Turkish IgAN patients, despite the reliance on non-quantitative endpoints for favorable renal outcomes. Key predictors of remission include baseline proteinuria and specific histological markers. It is crucial to carefully weigh the risks and benefits of immunosuppressive therapy for these patients.PMID:38637275 | PMC:PMC11028022 | DOI:10.1080/0886022X.2024.2341787 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Aysegul Oruc Abdullah Sumnu Ayd ın Turkmen Taner Basturk Egemen Cebeci Kenan Turgutalp Hakk ı Cetinkaya M üge Uzerk Kibar Nurhan Seyahi Erhan Tatar Metin Ergul Ülver Derici Mehmet Deniz Ayl ı Musa P ınar Bet ül Bakar R ümeyza Kazancıoglu Abd ülm Source Type: research
Hemodiafiltration with endogenous reinfusion for uremic toxin removal in patients undergoing maintenance hemodialysis: a pilot study
CONCLUSION: HFR treatment effectively eliminates uremic toxins from the bloodstream of patients undergoing MHD, especially protein-bound toxins and large middle-molecule toxins. Additionally, it retains essential physiological compounds like albumin and branched-chain amino acids, underscoring its commendable safety profile.PMID:38632963 | PMC:PMC11028005 | DOI:10.1080/0886022X.2024.2338929 (Source: Renal Failure)
Source: Renal Failure - April 18, 2024 Category: Urology & Nephrology Authors: Renhua Lu Yan Fang Wangshu Wu Xiaojun Zeng Tingting Liu Yue Qian Yuanyuan Xie Yijun Zhou Leyi Gu Source Type: research
Clinical effectiveness of cefiderocol for the treatment of bloodstream infections due to carbapenem-resistant Acinetobacter baumannii during the COVID-19 era: a single center, observational study
ConclusionsCFDC could represent an effective and safe treatment option for CRAB BSI, especially in patients with bacteremic HAP/VAP and frail patients where the risk of acute renal failure during therapy should be avoided. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - April 18, 2024 Category: Microbiology Source Type: research
Deep lymph node enlargement and renal failure caused by hypercalcemia ‑associated sarcoidosis: A case report
Exp Ther Med. 2024 Mar 27;27(5):235. doi: 10.3892/etm.2024.12524. eCollection 2024 May.ABSTRACTSarcoidosis is a rare disease that severely affects the lungs and superficial lymph nodes. In addition, this disease can also affect the skin, eyes and kidneys to varying degrees. The present report described a 32-year-old male patient who was admitted to Renmin Hospital of Wuhan University (Wuhan, China) due to joint pain in the extremities. He was diagnosed with uncorrectable hypercalcemia. A lymph node biopsy revealed the hypercalcemia to be associated with sarcoidosis, with the patient also demonstrating renal failure and lym...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Zezhou Liu Zhigang Tang Jingping Yuan Ke Su Yonghong Jian Hongyan Liu Source Type: research
