A Non-Coronary, Peripheral Arterial Atherosclerotic Disease (Carotid, Renal, Lower Limb) in Elderly Patients-A Review PART II-Pharmacological Approach for Management of Elderly Patients with Peripheral Atherosclerotic Lesions outside Coronary Territory
J Clin Med. 2024 Mar 5;13(5):1508. doi: 10.3390/jcm13051508.ABSTRACTAging is a key risk factor for atherosclerosis progression that is associated with increased incidence of ischemic events in supplied organs, including stroke, coronary events, limb ischemia, or renal failure. Cardiovascular disease is the leading cause of death and major disability in adults ≥ 75 years of age. Atherosclerotic occlusive disease affects everyday activity, quality of life, and it is associated with reduced life expectancy. As most multicenter randomized trials exclude elderly and very elderly patients, particularly those with severe comorb...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Marcin Piechocki Tadeusz Przew łocki Piotr Pieni ążek Mariusz Trystu ła Jakub Podolec Anna Kab łak-Ziembicka Source Type: research
A Non-Coronary, Peripheral Arterial Atherosclerotic Disease (Carotid, Renal, Lower Limb) in Elderly Patients-A Review: Part I-Epidemiology, Risk Factors, and Atherosclerosis-Related Diversities in Elderly Patients
J Clin Med. 2024 Mar 3;13(5):1471. doi: 10.3390/jcm13051471.ABSTRACTAtherosclerosis is a generalized and progressive disease. Ageing is a key risk factor for atherosclerosis progression that is associated with the increased incidence of ischemic events in supplied organs, including stroke, coronary events, limb ischemia, or renal failure. Cardiovascular disease is the leading cause of death and major disability in adults ≥ 75 years of age. Atherosclerotic occlusive disease affects everyday activity and quality of life, and it is associated with reduced life expectancy. Although there is evidence on coronary artery diseas...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Marcin Piechocki Tadeusz Przew łocki Piotr Pieni ążek Mariusz Trystu ła Jakub Podolec Anna Kab łak-Ziembicka Source Type: research
A Non-Coronary, Peripheral Arterial Atherosclerotic Disease (Carotid, Renal, Lower Limb) in Elderly Patients-A Review PART II-Pharmacological Approach for Management of Elderly Patients with Peripheral Atherosclerotic Lesions outside Coronary Territory
J Clin Med. 2024 Mar 5;13(5):1508. doi: 10.3390/jcm13051508.ABSTRACTAging is a key risk factor for atherosclerosis progression that is associated with increased incidence of ischemic events in supplied organs, including stroke, coronary events, limb ischemia, or renal failure. Cardiovascular disease is the leading cause of death and major disability in adults ≥ 75 years of age. Atherosclerotic occlusive disease affects everyday activity, quality of life, and it is associated with reduced life expectancy. As most multicenter randomized trials exclude elderly and very elderly patients, particularly those with severe comorb...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Marcin Piechocki Tadeusz Przew łocki Piotr Pieni ążek Mariusz Trystu ła Jakub Podolec Anna Kab łak-Ziembicka Source Type: research
A Non-Coronary, Peripheral Arterial Atherosclerotic Disease (Carotid, Renal, Lower Limb) in Elderly Patients-A Review: Part I-Epidemiology, Risk Factors, and Atherosclerosis-Related Diversities in Elderly Patients
J Clin Med. 2024 Mar 3;13(5):1471. doi: 10.3390/jcm13051471.ABSTRACTAtherosclerosis is a generalized and progressive disease. Ageing is a key risk factor for atherosclerosis progression that is associated with the increased incidence of ischemic events in supplied organs, including stroke, coronary events, limb ischemia, or renal failure. Cardiovascular disease is the leading cause of death and major disability in adults ≥ 75 years of age. Atherosclerotic occlusive disease affects everyday activity and quality of life, and it is associated with reduced life expectancy. Although there is evidence on coronary artery diseas...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Marcin Piechocki Tadeusz Przew łocki Piotr Pieni ążek Mariusz Trystu ła Jakub Podolec Anna Kab łak-Ziembicka Source Type: research
Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients
CONCLUSIONS: High-flux hemodialysis was associated with a lower relative risk of cardiovascular mortality in elderly MHD patients. High-flux hemodialysis did not improve all-cause mortality rate. Differences in urea distribution volume, blood flow, and systemic differences in solute clearance by dialyzers were not further analyzed, which are the limitations of this study.PMID:38584147 | DOI:10.1080/0886022X.2024.2338217 (Source: Renal Failure)
Source: Renal Failure - April 7, 2024 Category: Urology & Nephrology Authors: Wanqing Huang Jiuxu Bai Yanping Zhang Dongxia Qiu Lin Wei Chen Zhao Zhuo Ren Qian Wang Kaiming Ren Ning Cao Source Type: research
Clinicopathological characteristics and gene mutations in 11 patients with lipoprotein glomerulopathy
CONCLUSION: LPG is histologically characterized by lamellated lipoprotein thrombi in glomeruli, and kidney biopsy is essential for diagnosis. Mutations in the APOE gene are the leading cause of LPG. This study revealed clinicopathological characteristics and APOE gene mutations in patients with LPG, which helps us better understand the disease.PMID:38584145 | DOI:10.1080/0886022X.2024.2332491 (Source: Renal Failure)
Source: Renal Failure - April 7, 2024 Category: Urology & Nephrology Authors: Yan Qin Xiao-Jing Sun Yi-Fang Hu Meng Jing Xiao-Juan Yu Ming-Hui Zhao Ying Tan Source Type: research
Perspectives on AI-based recommendations for mask-wearing and COVID-19 vaccination for transplant recipients in the post-COVID-19 era
Ren Fail. 2024 Dec;46(1):2337291. doi: 10.1080/0886022X.2024.2337291. Epub 2024 Apr 7.ABSTRACTIn the aftermath of the COVID-19 pandemic, the ongoing necessity for preventive measures such as mask-wearing and vaccination remains particularly critical for organ transplant recipients, a group highly susceptible to infections due to immunosuppressive therapy. Given that many individuals nowadays increasingly utilize Artificial Intelligence (AI), understanding AI perspectives is important. Thus, this study utilizes AI, specifically ChatGPT 4.0, to assess its perspectives in offering precise health recommendations for mask-weari...
Source: Renal Failure - April 7, 2024 Category: Urology & Nephrology Authors: Oscar A Garcia Valencia Charat Thongprayoon Jing Miao Jackrapong Bruminhent Iasmina M Craici Wisit Cheungpasitporn Source Type: research
Mitophagy mediated by HIF-1 α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury
In conclusion, the HIF-1α/FUNDC1 signaling pathway mediates H/R-promoted renal tubular cell mitophagy, whereas inhibition of this signaling pathway protects cells from mitophagy, thus aggravating apoptosis, and ROS production. Accordingly, roxadustat may protect against RIRI-related AKI.PMID:38584135 | DOI:10.1080/0886022X.2024.2332492 (Source: Renal Failure)
Source: Renal Failure - April 7, 2024 Category: Urology & Nephrology Authors: Wenjun Zhang Chao Guo Yi Li Hao Wang Huabing Wang Yingying Wang Tingting Wu Huinan Wang Gang Cheng Jiangwei Man Siyu Chen Shengjun Fu Li Yang Source Type: research
ELABELA-derived peptide ELA13 attenuates kidney fibrosis by inhibiting the Smad and ERK signaling pathways
In conclusion, ELA13 protected against kidney fibrosis through inhibiting the Smad and ERK signaling pathways and could thus be a promising candidate for anti-renal fibrosis treatment.PMID:38584095 | DOI:10.1631/jzus.B2300033 (Source: J Zhejiang Univ Sci ...)
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Zhibin Yan Ying Shi Runling Yang Jijun Xue Caiyun Fu Source Type: research
Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients
CONCLUSIONS: High-flux hemodialysis was associated with a lower relative risk of cardiovascular mortality in elderly MHD patients. High-flux hemodialysis did not improve all-cause mortality rate. Differences in urea distribution volume, blood flow, and systemic differences in solute clearance by dialyzers were not further analyzed, which are the limitations of this study.PMID:38584147 | PMC:PMC11000600 | DOI:10.1080/0886022X.2024.2338217 (Source: Renal Failure)
Source: Renal Failure - April 7, 2024 Category: Urology & Nephrology Authors: Wanqing Huang Jiuxu Bai Yanping Zhang Dongxia Qiu Lin Wei Chen Zhao Zhuo Ren Qian Wang Kaiming Ren Ning Cao Source Type: research
Clinicopathological characteristics and gene mutations in 11 patients with lipoprotein glomerulopathy
CONCLUSION: LPG is histologically characterized by lamellated lipoprotein thrombi in glomeruli, and kidney biopsy is essential for diagnosis. Mutations in the APOE gene are the leading cause of LPG. This study revealed clinicopathological characteristics and APOE gene mutations in patients with LPG, which helps us better understand the disease.PMID:38584145 | PMC:PMC10967672 | DOI:10.1080/0886022X.2024.2332491 (Source: Renal Failure)
Source: Renal Failure - April 7, 2024 Category: Urology & Nephrology Authors: Yan Qin Xiao-Jing Sun Yi-Fang Hu Meng Jing Xiao-Juan Yu Ming-Hui Zhao Ying Tan Source Type: research
Perspectives on AI-based recommendations for mask-wearing and COVID-19 vaccination for transplant recipients in the post-COVID-19 era
Ren Fail. 2024 Dec;46(1):2337291. doi: 10.1080/0886022X.2024.2337291. Epub 2024 Apr 7.ABSTRACTIn the aftermath of the COVID-19 pandemic, the ongoing necessity for preventive measures such as mask-wearing and vaccination remains particularly critical for organ transplant recipients, a group highly susceptible to infections due to immunosuppressive therapy. Given that many individuals nowadays increasingly utilize Artificial Intelligence (AI), understanding AI perspectives is important. Thus, this study utilizes AI, specifically ChatGPT 4.0, to assess its perspectives in offering precise health recommendations for mask-weari...
Source: Renal Failure - April 7, 2024 Category: Urology & Nephrology Authors: Oscar A Garcia Valencia Charat Thongprayoon Jing Miao Jackrapong Bruminhent Iasmina M Craici Wisit Cheungpasitporn Source Type: research
Mitophagy mediated by HIF-1 α/FUNDC1 signaling in tubular cells protects against renal ischemia/reperfusion injury
In conclusion, the HIF-1α/FUNDC1 signaling pathway mediates H/R-promoted renal tubular cell mitophagy, whereas inhibition of this signaling pathway protects cells from mitophagy, thus aggravating apoptosis, and ROS production. Accordingly, roxadustat may protect against RIRI-related AKI.PMID:38584135 | PMC:PMC11000611 | DOI:10.1080/0886022X.2024.2332492 (Source: Renal Failure)
Source: Renal Failure - April 7, 2024 Category: Urology & Nephrology Authors: Wenjun Zhang Chao Guo Yi Li Hao Wang Huabing Wang Yingying Wang Tingting Wu Huinan Wang Gang Cheng Jiangwei Man Siyu Chen Shengjun Fu Li Yang Source Type: research
ELABELA-derived peptide ELA13 attenuates kidney fibrosis by inhibiting the Smad and ERK signaling pathways
In conclusion, ELA13 protected against kidney fibrosis through inhibiting the Smad and ERK signaling pathways and could thus be a promising candidate for anti-renal fibrosis treatment.PMID:38584095 | DOI:10.1631/jzus.B2300033 (Source: J Zhejiang Univ Sci ...)
Source: J Zhejiang Univ Sci ... - April 7, 2024 Category: Science Authors: Zhibin Yan Ying Shi Runling Yang Jijun Xue Caiyun Fu Source Type: research
Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients
CONCLUSIONS: High-flux hemodialysis was associated with a lower relative risk of cardiovascular mortality in elderly MHD patients. High-flux hemodialysis did not improve all-cause mortality rate. Differences in urea distribution volume, blood flow, and systemic differences in solute clearance by dialyzers were not further analyzed, which are the limitations of this study.PMID:38584147 | PMC:PMC11000600 | DOI:10.1080/0886022X.2024.2338217 (Source: Renal Failure)
Source: Renal Failure - April 7, 2024 Category: Urology & Nephrology Authors: Wanqing Huang Jiuxu Bai Yanping Zhang Dongxia Qiu Lin Wei Chen Zhao Zhuo Ren Qian Wang Kaiming Ren Ning Cao Source Type: research
