Adenine-induced animal model of chronic kidney disease: current applications and future perspectives
This article reviews a widely used animal model of CKD, which is induced by adenine. While a physiologic dose of adenine is beneficial in terms of biological activity, a high dose of adenine is known to induce renal disease in the organism. Following a brief description of the procedure for disease induction by adenine, major mechanisms of adenine-induced CKD are then reviewed, including inflammation, oxidative stress, programmed cell death, metabolic disorders, and fibrillation. Finally, the application and future perspective of this adenine-induced CKD model as a platform for testing the efficacy of a variety of therapeu...
Source: Renal Failure - April 4, 2024 Category: Urology & Nephrology Authors: Qiao Yang Songya Su Nan Luo Gang Cao Source Type: research
GLIM criteria for definition of malnutrition in peritoneal dialysis: a new aspect of nutritional assessment
Conclusions: The GLIM criteria provide a viable tool for nutritional assessment in patients with PD, and malnutrition defined according to the GLIM can predict prognosis with an acceptable performance.PMID:38575339 | PMC:PMC10997366 | DOI:10.1080/0886022X.2024.2337290 (Source: Renal Failure)
Source: Renal Failure - April 4, 2024 Category: Urology & Nephrology Authors: Dao Wang Jun Yin Wen Liao Xiaoran Feng Fengping Zhang Source Type: research
Outcome of surgical parathyroidectomy for tertiary hyperparathyroidism in kidney transplant recipients: tertiary hyperparathyroidism should not be ignored, for the sake of precious allografts
Ren Fail. 2024 Dec;46(1):2333919. doi: 10.1080/0886022X.2024.2333919. Epub 2024 Apr 4.ABSTRACTTertiary hyperparathyroidism is a complication of kidney transplantation. This complicated condition carries over from the dialysis period and varies according to the function of the transplanted allograft. Treatments include pharmacotherapy (mainly using calcimimetics) and parathyroidectomy, but calcimimetics are currently not covered by the national insurance system in Japan. Two types of parathyroidectomy can be performed: subtotal parathyroidectomy; and total parathyroidectomy with partial autograft. Both types can be expected...
Source: Renal Failure - April 4, 2024 Category: Urology & Nephrology Authors: Michio Nakamura Shinya Takiguchi Saeko Uehara Yusuke Tomita Source Type: research
Myofibroblast-derived exosomes enhance macrophages to myofibroblasts transition and kidney fibrosis
Ren Fail. 2024 Dec;46(1):2334406. doi: 10.1080/0886022X.2024.2334406. Epub 2024 Apr 4.ABSTRACTA critical event in the pathogenesis of kidney fibrosis is the transition of macrophages into myofibroblasts (MMT). Exosomes play an important role in crosstalk among cells in the kidney and the development of renal fibrosis. However, the role of myofibroblast-derived exosomes in the process of MMT and renal fibrosis progression remains unknown. Here, we examined the role of myofibroblast-derived exosomes in MMT and kidney fibrogenesis. In vitro, transforming growth factor-β1 stimulated the differentiation of kidney fibroblasts i...
Source: Renal Failure - April 4, 2024 Category: Urology & Nephrology Authors: Wenqiang Yu Jinfang Song Shuangquan Chen Jiayi Nie Chujun Zhou Jiamin Huang Hua Liang Source Type: research
Adenine-induced animal model of chronic kidney disease: current applications and future perspectives
This article reviews a widely used animal model of CKD, which is induced by adenine. While a physiologic dose of adenine is beneficial in terms of biological activity, a high dose of adenine is known to induce renal disease in the organism. Following a brief description of the procedure for disease induction by adenine, major mechanisms of adenine-induced CKD are then reviewed, including inflammation, oxidative stress, programmed cell death, metabolic disorders, and fibrillation. Finally, the application and future perspective of this adenine-induced CKD model as a platform for testing the efficacy of a variety of therapeu...
Source: Renal Failure - April 4, 2024 Category: Urology & Nephrology Authors: Qiao Yang Songya Su Nan Luo Gang Cao Source Type: research
GLIM criteria for definition of malnutrition in peritoneal dialysis: a new aspect of nutritional assessment
Conclusions: The GLIM criteria provide a viable tool for nutritional assessment in patients with PD, and malnutrition defined according to the GLIM can predict prognosis with an acceptable performance.PMID:38575339 | PMC:PMC10997366 | DOI:10.1080/0886022X.2024.2337290 (Source: Renal Failure)
Source: Renal Failure - April 4, 2024 Category: Urology & Nephrology Authors: Dao Wang Jun Yin Wen Liao Xiaoran Feng Fengping Zhang Source Type: research
Outcome of surgical parathyroidectomy for tertiary hyperparathyroidism in kidney transplant recipients: tertiary hyperparathyroidism should not be ignored, for the sake of precious allografts
Ren Fail. 2024 Dec;46(1):2333919. doi: 10.1080/0886022X.2024.2333919. Epub 2024 Apr 4.ABSTRACTTertiary hyperparathyroidism is a complication of kidney transplantation. This complicated condition carries over from the dialysis period and varies according to the function of the transplanted allograft. Treatments include pharmacotherapy (mainly using calcimimetics) and parathyroidectomy, but calcimimetics are currently not covered by the national insurance system in Japan. Two types of parathyroidectomy can be performed: subtotal parathyroidectomy; and total parathyroidectomy with partial autograft. Both types can be expected...
Source: Renal Failure - April 4, 2024 Category: Urology & Nephrology Authors: Michio Nakamura Shinya Takiguchi Saeko Uehara Yusuke Tomita Source Type: research
Predictive effect of estimated glomerular filtrate rate by creatinine or cystatin C on mortality in patients with coronary artery disease
CONCLUSIONS: Estimated GFR based on both creatinine and cystatin C has highest predictive effect for cardiovascular and all-cause mortality among CAD patients. Meanwhile, supranormal eGFRcr may indicate a higher risk of mortality.PMID:38566467 | DOI:10.1080/0886022X.2024.2327494 (Source: Renal Failure)
Source: Renal Failure - April 3, 2024 Category: Urology & Nephrology Authors: Shiqun Chen Yang Zhou Guoxiao Liang Wanying Wu Zhigang Huang Lile Shi Yuwei Gao Xia Gu Dongmei Wang Source Type: research
Dapagliflozin-induced drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Followed By Acute Interstitial Nephritis (AIN): A Case Report
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.3347-23. Online ahead of print.ABSTRACTA 78-year-old male was admitted to the hospital with acute renal failure and generalized erythema after starting dapagliflozin 10 mg/day for chronic kidney disease (CKD). A skin biopsy revealed superficial perivascular dermatitis with eosinophils. A renal biopsy revealed lymphocytic and eosinophilic infiltration of the interstitium, and focal tubulitis. The patient was diagnosed with a dapagliflozin-induced drug reaction with eosinophilia and systemic symptoms (DRESS), followed by acute interstitial nephritis (AIN), and prednisolon...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Tomohisa Tsuyuki Kenta Torigoe Masatoshi Shimizu Hiroshi Taira Ryosuke Sakamoto Shinichi Abe Sayaka Kuwatsuka Kumiko Muta Hiroshi Mukae Tomoya Nishino Source Type: research
Personalized Music Therapy for Elderly Patients with Chronic Renal Failure to Improve their Quality of Life and Mental Health: A Retrospective Study
CONCLUSION: The implementation of personalized music can improve the QOL and psychological states of patients, with clinical application value.PMID:38570304 | DOI:10.4103/nah.nah_94_23 (Source: Noise and Health)
Source: Noise and Health - April 3, 2024 Category: Audiology Authors: Ling Wang Panpan Liu Xin He Source Type: research
Application of artificial intelligence in the management of patients with renal dysfunction
Ren Fail. 2024 Dec;46(1):2337289. doi: 10.1080/0886022X.2024.2337289. Epub 2024 Apr 3.NO ABSTRACTPMID:38570197 | PMC:PMC10993745 | DOI:10.1080/0886022X.2024.2337289 (Source: Renal Failure)
Source: Renal Failure - April 3, 2024 Category: Urology & Nephrology Authors: Bo Zhang Xiaocong Jiang Jie Yang Jiajie Huang Chaoming Hu Yucai Hong Hongying Ni Zhongheng Zhang Source Type: research
Determinants and impact of calcium oxalate crystal deposition on renal outcomes in acute kidney injury patients
CONCLUSIONS: In AKI, CaOx deposition is common despite declining GFR. Factors worsening tubular injury, not just oxalate-to-citrate ratios, are key to understanding impaired renal recovery.PMID:38570195 | PMC:PMC10993744 | DOI:10.1080/0886022X.2024.2334396 (Source: Renal Failure)
Source: Renal Failure - April 3, 2024 Category: Urology & Nephrology Authors: Weiwei Yang Tao Zhao Xuejing Chen Suxia Wang Yu Wang Tao Su Source Type: research
Predictive effect of estimated glomerular filtrate rate by creatinine or cystatin C on mortality in patients with coronary artery disease
CONCLUSIONS: Estimated GFR based on both creatinine and cystatin C has highest predictive effect for cardiovascular and all-cause mortality among CAD patients. Meanwhile, supranormal eGFRcr may indicate a higher risk of mortality.PMID:38566467 | PMC:PMC10993740 | DOI:10.1080/0886022X.2024.2327494 (Source: Renal Failure)
Source: Renal Failure - April 3, 2024 Category: Urology & Nephrology Authors: Shiqun Chen Yang Zhou Guoxiao Liang Wanying Wu Zhigang Huang Lile Shi Yuwei Gao Xia Gu Dongmei Wang Source Type: research
Atrial Fibrillation Management During Surgical vs Transcatheter Aortic Valve Replacement
CONCLUSIONS: In Medicare beneficiaries with AF requiring aortic valve replacement, SAVR+AF was associated with improved longitudinal survival and freedom from stroke compared to TAVR. SAVR with AF treatment should be considered first-line therapy for patients with AF requiring aortic valve replacement.PMID:38570109 | DOI:10.1016/j.athoracsur.2024.03.020 (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - April 3, 2024 Category: Cardiovascular & Thoracic Surgery Authors: J Hunter Mehaffey Mohammad Kawsara Vikrant Jagadeesan Dhaval Chauhan J W Awori Hayanga Christopher E Mascio Lawrence Wei J Scott Rankin Ramesh Daggubati Vinay Badhwar Source Type: research
Dapagliflozin-induced drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Followed By Acute Interstitial Nephritis (AIN): A Case Report
Intern Med. 2024 Apr 2. doi: 10.2169/internalmedicine.3347-23. Online ahead of print.ABSTRACTA 78-year-old male was admitted to the hospital with acute renal failure and generalized erythema after starting dapagliflozin 10 mg/day for chronic kidney disease (CKD). A skin biopsy revealed superficial perivascular dermatitis with eosinophils. A renal biopsy revealed lymphocytic and eosinophilic infiltration of the interstitium, and focal tubulitis. The patient was diagnosed with a dapagliflozin-induced drug reaction with eosinophilia and systemic symptoms (DRESS), followed by acute interstitial nephritis (AIN), and prednisolon...
Source: Internal Medicine - April 3, 2024 Category: Internal Medicine Authors: Tomohisa Tsuyuki Kenta Torigoe Masatoshi Shimizu Hiroshi Taira Ryosuke Sakamoto Shinichi Abe Sayaka Kuwatsuka Kumiko Muta Hiroshi Mukae Tomoya Nishino Source Type: research
