Comprehensive analysis of cuproptosis-related genes in immune infiltration and development of a novel diagnostic model for acute kidney injury
CONCLUSION: This study elucidated the role of cuproptosis in AKI and revealed the association between CRGs and infiltrated immune cells through comprehensive bioinformatic techniques. The six-gene cuproptosis-related signature exhibited remarkable predictive efficiency for AKI.PMID:38538321 | DOI:10.1080/0886022X.2024.2325035 (Source: Renal Failure)
Source: Renal Failure - March 27, 2024 Category: Urology & Nephrology Authors: Yajing Li Yingxue Ding Source Type: research
Comprehensive analysis of cuproptosis-related genes in immune infiltration and development of a novel diagnostic model for acute kidney injury
CONCLUSION: This study elucidated the role of cuproptosis in AKI and revealed the association between CRGs and infiltrated immune cells through comprehensive bioinformatic techniques. The six-gene cuproptosis-related signature exhibited remarkable predictive efficiency for AKI.PMID:38538321 | PMC:PMC10977005 | DOI:10.1080/0886022X.2024.2325035 (Source: Renal Failure)
Source: Renal Failure - March 27, 2024 Category: Urology & Nephrology Authors: Yajing Li Yingxue Ding Source Type: research
Relationship between the microenvironment and survival in kidney transplantation: a bibliometric analysis from 2013 to 2023
ConclusionThis groundbreaking bibliometric study comprehensively summarizes the research trends and advances related to the immune microenvironment and survival after kidney transplantation. It identifies recent frontiers of research and highlights promising directions for future studies, potentially offering fresh perspectives to scholars in the field. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - March 26, 2024 Category: Allergy & Immunology Source Type: research
Factors Associated With Respiratory Failure After Open Ventral Hernia Repair: An Evaluation of the NSQIP Database
Am Surg. 2024 Mar 24:31348241241731. doi: 10.1177/00031348241241731. Online ahead of print.ABSTRACTAn analysis of ACS-NSQIP open ventral hernia repair (OVHR) data (2017-2019) was performed. Respiratory failure (RF) occurred in 643 patients (1%) and not in 63,213 (99%) (nRF). Respiratory failure patients were older (63.7 vs 57 years, P < .001) and more comorbid: insulin-dependent diabetes (14.7% vs 5.8%, P < .001), COPD (19.4% vs 5.2%, P < .001), BMI (36.0 vs 32.8, P < .001), and current tobacco use (24.9% vs 17.6%, P < .001). Respiratory failure patients had greater ASA scores (ASA 3: 63.3% vs 47.8%, P < ...
Source: The American Surgeon - March 25, 2024 Category: Surgery Authors: William R Lorenz Alexis M Holland Brittany S Mead Gregory T Scarola Vedra A Augenstein B Todd Heniford Source Type: research
Protective effect of cilostazol on vascular injury in rats with acute ischemic stroke complicated with chronic renal failure
In conclusion, our results confirmed that cilostazol exerted a protective effect on the brain and kidney function, specifically in vascular injury, oxidative stress, cell apoptosis, cell autophagy, and inflammation response in CRF combined with stroke rats which were related to the upregulation of JAK/STAT3/mTOR signal pathway.SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s43188-023-00217-w.PMID:38525134 | PMC:PMC10959867 | DOI:10.1007/s43188-023-00217-w (Source: Cell Research)
Source: Cell Research - March 25, 2024 Category: Cytology Authors: Ru Sun Qun Gu Xufeng Zhang Ruiqi Zeng Dan Chen Jingjing Yao Jingjing Min Source Type: research
RfxCas13d-mediated inhibition of < em > Circ1647 < /em > alleviates renal fibrosis via PI3K/AKT signaling pathway
CONCLUSION: Our study suggests that Circ1647 plays a significant role in renal fibrosis by mediating the PI3K/AKT signaling pathway. RfxCas13d-mediated inhibition of Circ1647 may serve as a therapeutic target for renal fibrosis in CKD.PMID:38527916 | DOI:10.1080/0886022X.2024.2331612 (Source: Renal Failure)
Source: Renal Failure - March 25, 2024 Category: Urology & Nephrology Authors: Yufang Ni Hongmin Zhang Qianwen Xian Wenjie Qin Hongwei Su Li Wang Jianchun Li Source Type: research
Factors Associated With Respiratory Failure After Open Ventral Hernia Repair: An Evaluation of the NSQIP Database
Am Surg. 2024 Mar 24:31348241241731. doi: 10.1177/00031348241241731. Online ahead of print.ABSTRACTAn analysis of ACS-NSQIP open ventral hernia repair (OVHR) data (2017-2019) was performed. Respiratory failure (RF) occurred in 643 patients (1%) and not in 63,213 (99%) (nRF). Respiratory failure patients were older (63.7 vs 57 years, P < .001) and more comorbid: insulin-dependent diabetes (14.7% vs 5.8%, P < .001), COPD (19.4% vs 5.2%, P < .001), BMI (36.0 vs 32.8, P < .001), and current tobacco use (24.9% vs 17.6%, P < .001). Respiratory failure patients had greater ASA scores (ASA 3: 63.3% vs 47.8%, P < ...
Source: The American Surgeon - March 25, 2024 Category: Surgery Authors: William R Lorenz Alexis M Holland Brittany S Mead Gregory T Scarola Vedra A Augenstein B Todd Heniford Source Type: research
RfxCas13d-mediated inhibition of < em > Circ1647 < /em > alleviates renal fibrosis via PI3K/AKT signaling pathway
CONCLUSION: Our study suggests that Circ1647 plays a significant role in renal fibrosis by mediating the PI3K/AKT signaling pathway. RfxCas13d-mediated inhibition of Circ1647 may serve as a therapeutic target for renal fibrosis in CKD.PMID:38527916 | PMC:PMC10964833 | DOI:10.1080/0886022X.2024.2331612 (Source: Renal Failure)
Source: Renal Failure - March 25, 2024 Category: Urology & Nephrology Authors: Yufang Ni Hongmin Zhang Qianwen Xian Wenjie Qin Hongwei Su Li Wang Jianchun Li Source Type: research
Successful treatment of generalized pustular psoriasis with guselkumab
Conclusions: Our results support the evidence that guselkumab could provide an effective therapeutic approach in the treatment of GPP.PMID:38522861 | DOI:10.1080/09546634.2024.2331807 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 24, 2024 Category: Dermatology Authors: Martina Part Source Type: research
Effect of angiotensin-converting enzyme inhibitors < em > versus < /em > that of angiotensin receptor blockers on survival in patients undergoing hemodialysis: a nationwide observational cohort study
CONCLUSIONS: Our study found that patients receiving ACEI and ARB had comparable survival. However, patients receiving ARB had better survival in the subgroups of patients with DM or heart disease, and patients receiving ACEI had better survival in the subgroup of young patients or patients without diabetes or heart disease.PMID:38522955 | PMC:PMC10962295 | DOI:10.1080/0886022X.2024.2313173 (Source: Renal Failure)
Source: Renal Failure - March 24, 2024 Category: Urology & Nephrology Authors: Seok Hui Kang Gui Ok Kim Bo Yeon Kim Eun Jung Son Jun Young Do Source Type: research
The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional study
CONCLUSION: Elevated MHR level was independently associated with the presence of CKD, suggesting that it might serve as a useful clinical tool for risk stratification, offering valuable insights to inform preventive and therapeutic approaches for clinicians in their routine medical practice.PMID:38522954 | PMC:PMC10962299 | DOI:10.1080/0886022X.2024.2331614 (Source: Renal Failure)
Source: Renal Failure - March 24, 2024 Category: Urology & Nephrology Authors: Lingling Xu Dongling Li Zongwei Song Jin Liu Yang Zhou Junwei Yang Ping Wen Source Type: research
Recent advances in the application of Mendelian randomization to chronic kidney disease
CONCLUSION: This review not only presents the recent achievements of MR in CKD research but also illuminates the path forwards, underscoring critical unanswered questions and proposing future research directions in this dynamic field.PMID:38522953 | DOI:10.1080/0886022X.2024.2319712 (Source: Renal Failure)
Source: Renal Failure - March 24, 2024 Category: Urology & Nephrology Authors: Chaofan Wen Lanlan Chen Dan Jia Ziqi Liu Yidan Lin Guan Liu Shuo Zhang Baoshan Gao Source Type: research
