Elevation of creatine phosphokinase in moderate-to-severe atopic dermatitis is associated with the use of JAK inhibitors but not dupilumab: A systematic review and meta-analysis
To the Editor: Recently, many novel advanced systemic therapies have been approved for the treatment of moderate-to-severe atopic dermatitis (AD), including interleukin (IL)-4/IL-13 inhibitors (dupilumab), IL-13 inhibitors (tralokinumab), and selective Janus kinase (JAK)-1 inhibitors (abrocitinib and upadacitinib). There is uncertainty regarding the potential elevation of creatine phosphokinase (CPK) levels with these therapies, and whether this increase is linked to clinically significant outcomes, such as rhabdomyolysis and renal failure. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - March 28, 2024 Category: Dermatology Authors: Daud Manzar, Emmanuel Suntres, Nikhil Nair, Yash Patel, Mohannad Abu-Hilal Tags: Research letter Source Type: research
Bilateral Retinal Venous Occlusion in Atypical Hemolytic-Uremic Syndrome Due to Complement Factor H Mutation
CONCLUSION: Diagnosis of aHUS is challenging especially during pregnancy and the postpartum period. Although ocular involvement is quite rare, we described bilateral RVO in aHUS case with homozygous nonsense mutation (c.2134 G > T p.G712). Dexamethasone implant should be considered for the treatment of RVO in aHUS cases.PMID:38536978 | DOI:10.1080/09273948.2024.2333401 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - March 27, 2024 Category: Allergy & Immunology Authors: Saban Gonul Serhat Eker Source Type: research
Comprehensive analysis of cuproptosis-related genes in immune infiltration and development of a novel diagnostic model for acute kidney injury
CONCLUSION: This study elucidated the role of cuproptosis in AKI and revealed the association between CRGs and infiltrated immune cells through comprehensive bioinformatic techniques. The six-gene cuproptosis-related signature exhibited remarkable predictive efficiency for AKI.PMID:38538321 | DOI:10.1080/0886022X.2024.2325035 (Source: Renal Failure)
Source: Renal Failure - March 27, 2024 Category: Urology & Nephrology Authors: Yajing Li Yingxue Ding Source Type: research
Comprehensive analysis of cuproptosis-related genes in immune infiltration and development of a novel diagnostic model for acute kidney injury
CONCLUSION: This study elucidated the role of cuproptosis in AKI and revealed the association between CRGs and infiltrated immune cells through comprehensive bioinformatic techniques. The six-gene cuproptosis-related signature exhibited remarkable predictive efficiency for AKI.PMID:38538321 | PMC:PMC10977005 | DOI:10.1080/0886022X.2024.2325035 (Source: Renal Failure)
Source: Renal Failure - March 27, 2024 Category: Urology & Nephrology Authors: Yajing Li Yingxue Ding Source Type: research
