Transferrin levels are associated with malnutrition markers in hemodialysis patients in KwaZulu-Natal, South Africa
CONCLUSION: Thus, transferrin levels are a valuable marker for malnutrition within the HD patient population and can be included along with clinical assessment parameters such as MUAC and skinfold thickness as primary indicators for malnutrition.PMID:38616181 | DOI:10.1080/0886022X.2024.2337292 (Source: Renal Failure)
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Sherilene Benjamin Alain Assounga Source Type: research
Text mining of hypertension researches in the west Asia region: a 12-year trend analysis
Ren Fail. 2024 Dec;46(1):2337285. doi: 10.1080/0886022X.2024.2337285. Epub 2024 Apr 14.ABSTRACTMore than half of the world population lives in Asia and hypertension (HTN) is the most prevalent risk factor found in Asia. There are numerous articles published about HTN in Eastern Mediterranean Region (EMRO) and artificial intelligence (AI) methods can analyze articles and extract top trends in each country. Present analysis uses Latent Dirichlet allocation (LDA) as an algorithm of topic modeling (TM) in text mining, to obtain subjective topic-word distribution from the 2790 studies over the EMRO. The period of checked studie...
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Mohammad Rezapour Mohsen Yazdinejad Faezeh Rajabi Kouchi Masoomeh Habibi Baghi Zahra Khorrami Morteza Khavanin Zadeh Elmira Pourbaghi Hassan Rezapour Source Type: research
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
In this study, we found that TXNIP knockout suppressed renal fibrosis and activation of mammalian target of rapamycin complex 1 (mTORC1) and restored transcription factor EB (TFEB) and autophagy activation in diabetic kidneys. Simultaneously, TXNIP interference inhibited epithelial-to-mesenchymal transformation (EMT), collagen I and fibronectin expression, and mTORC1 activation, increased TFEB nuclear translocation, and promoted autophagy restoration in HK-2 cells exposed to high glucose (HG). Rapamycin, an inhibitor of mTORC1, increased TFEB nuclear translocation and autophagy in HK-2 cells under HG conditions. Moreover, ...
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Yunxia Du Ming Wu Shan Song Yawei Bian Yonghong Shi Source Type: research
USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation
CONCLUSION: USP25 plays a crucial role in mitigating renal histopathological and functional damage during anti-GBM GN in mice. This protective effect is primarily attributed to USP25's ability to inhibit the differentiation of naïve CD4+ T cells into Th17 cells. The underlying mechanism may involve the downregulation of RORγt. Additionally, during increased inflammatory responses or Th17 cell differentiation, USP25 expression is activated, forming a negative feedback regulatory loop that attenuates immune activation.PMID:38616174 | DOI:10.1080/0886022X.2024.2338932 (Source: Renal Failure)
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Ranran Xu Fei Huang Qingquan Liu Yongman Lv Liu Hu Qian Zhang Source Type: research
Transferrin levels are associated with malnutrition markers in hemodialysis patients in KwaZulu-Natal, South Africa
CONCLUSION: Thus, transferrin levels are a valuable marker for malnutrition within the HD patient population and can be included along with clinical assessment parameters such as MUAC and skinfold thickness as primary indicators for malnutrition.PMID:38616181 | PMC:PMC11017997 | DOI:10.1080/0886022X.2024.2337292 (Source: Renal Failure)
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Sherilene Benjamin Alain Assounga Source Type: research
Text mining of hypertension researches in the west Asia region: a 12-year trend analysis
Ren Fail. 2024 Dec;46(1):2337285. doi: 10.1080/0886022X.2024.2337285. Epub 2024 Apr 14.ABSTRACTMore than half of the world population lives in Asia and hypertension (HTN) is the most prevalent risk factor found in Asia. There are numerous articles published about HTN in Eastern Mediterranean Region (EMRO) and artificial intelligence (AI) methods can analyze articles and extract top trends in each country. Present analysis uses Latent Dirichlet allocation (LDA) as an algorithm of topic modeling (TM) in text mining, to obtain subjective topic-word distribution from the 2790 studies over the EMRO. The period of checked studie...
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Mohammad Rezapour Mohsen Yazdinejad Faezeh Rajabi Kouchi Masoomeh Habibi Baghi Zahra Khorrami Morteza Khavanin Zadeh Elmira Pourbaghi Hassan Rezapour Source Type: research
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
In this study, we found that TXNIP knockout suppressed renal fibrosis and activation of mammalian target of rapamycin complex 1 (mTORC1) and restored transcription factor EB (TFEB) and autophagy activation in diabetic kidneys. Simultaneously, TXNIP interference inhibited epithelial-to-mesenchymal transformation (EMT), collagen I and fibronectin expression, and mTORC1 activation, increased TFEB nuclear translocation, and promoted autophagy restoration in HK-2 cells exposed to high glucose (HG). Rapamycin, an inhibitor of mTORC1, increased TFEB nuclear translocation and autophagy in HK-2 cells under HG conditions. Moreover, ...
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Yunxia Du Ming Wu Shan Song Yawei Bian Yonghong Shi Source Type: research
USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation
CONCLUSION: USP25 plays a crucial role in mitigating renal histopathological and functional damage during anti-GBM GN in mice. This protective effect is primarily attributed to USP25's ability to inhibit the differentiation of naïve CD4+ T cells into Th17 cells. The underlying mechanism may involve the downregulation of RORγt. Additionally, during increased inflammatory responses or Th17 cell differentiation, USP25 expression is activated, forming a negative feedback regulatory loop that attenuates immune activation.PMID:38616174 | PMC:PMC11018034 | DOI:10.1080/0886022X.2024.2338932 (Source: Renal Failure)
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Ranran Xu Fei Huang Qingquan Liu Yongman Lv Liu Hu Qian Zhang Source Type: research
The Impact of Valve Surgery on the Safety and Cardiac Function of Patients with Valvular Heart Disease Complicated by Pulmonary Arterial Hypertension
CONCLUSION: Valve surgery in valvular heart disease with PAH is influenced by patient age, functional status, and PAH severity. Despite advances in surgical techniques, there remains a notable gap in understanding the nuanced interplay between these conditions and the variable outcomes of valve surgery. This study addresses this research gap, offering comprehensive insights into how age, heart function, and PAH severity influence postoperative outcomes. These findings are crucial for clinicians, providing a more informed basis for tailored treatment strategies, and ultimately enhancing patient care in this complex clinical...
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Shiliang Li Zijun Chen Kunsheng Li Ziyue Zhang Yan Zhou Source Type: research
Reverse flow anterolateral thigh free flap in a case with significant atherosclerosis: A viable alternative for arterial microvascular anastomosis
CONCLUSION: This report uniquely describes applying the distally based, reverse arterial flow principle in an ALT flap to circumvent an atherosclerotic proximal pedicle.PMID:38606699 | DOI:10.1002/hed.27770 (Source: Atherosclerosis)
Source: Atherosclerosis - April 12, 2024 Category: Cardiology Authors: Jonathan C Garneau Rod Rezaee Source Type: research
The Impact of Valve Surgery on the Safety and Cardiac Function of Patients with Valvular Heart Disease Complicated by Pulmonary Arterial Hypertension
CONCLUSION: Valve surgery in valvular heart disease with PAH is influenced by patient age, functional status, and PAH severity. Despite advances in surgical techniques, there remains a notable gap in understanding the nuanced interplay between these conditions and the variable outcomes of valve surgery. This study addresses this research gap, offering comprehensive insights into how age, heart function, and PAH severity influence postoperative outcomes. These findings are crucial for clinicians, providing a more informed basis for tailored treatment strategies, and ultimately enhancing patient care in this complex clinical...
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Shiliang Li Zijun Chen Kunsheng Li Ziyue Zhang Yan Zhou Source Type: research
The Impact of Valve Surgery on the Safety and Cardiac Function of Patients with Valvular Heart Disease Complicated by Pulmonary Arterial Hypertension
CONCLUSION: Valve surgery in valvular heart disease with PAH is influenced by patient age, functional status, and PAH severity. Despite advances in surgical techniques, there remains a notable gap in understanding the nuanced interplay between these conditions and the variable outcomes of valve surgery. This study addresses this research gap, offering comprehensive insights into how age, heart function, and PAH severity influence postoperative outcomes. These findings are crucial for clinicians, providing a more informed basis for tailored treatment strategies, and ultimately enhancing patient care in this complex clinical...
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Shiliang Li Zijun Chen Kunsheng Li Ziyue Zhang Yan Zhou Source Type: research
The Impact of Valve Surgery on the Safety and Cardiac Function of Patients with Valvular Heart Disease Complicated by Pulmonary Arterial Hypertension
CONCLUSION: Valve surgery in valvular heart disease with PAH is influenced by patient age, functional status, and PAH severity. Despite advances in surgical techniques, there remains a notable gap in understanding the nuanced interplay between these conditions and the variable outcomes of valve surgery. This study addresses this research gap, offering comprehensive insights into how age, heart function, and PAH severity influence postoperative outcomes. These findings are crucial for clinicians, providing a more informed basis for tailored treatment strategies, and ultimately enhancing patient care in this complex clinical...
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Shiliang Li Zijun Chen Kunsheng Li Ziyue Zhang Yan Zhou Source Type: research
Risk factors and outcomes in patients who switched from peritoneal dialysis to physician-oriented or patient-oriented kidney replacement therapy
CONCLUSION: Compared to patient-oriented KRT conversion, PD patients who underwent physician-oriented conversion had higher risks of cardiovascular events and all-cause mortality. Factors included age at catheterization, education level, annual household income, and history of diabetes mellitus.PMID:38604972 | DOI:10.1080/0886022X.2024.2337286 (Source: Renal Failure)
Source: Renal Failure - April 11, 2024 Category: Urology & Nephrology Authors: Liu Zhang Xu Guan Liang Liu Yinghui Huang Jiachuan Xiong Jinghong Zhao Source Type: research
Relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort study
Conclusions: In MHD patients in southern China, higher TC levels were associated with higher risk of mortality, while higher TG levels were related to lower risk of mortality. Patients with lower TC and higher TG levels had the best survival prognosis.PMID:38604971 | DOI:10.1080/0886022X.2024.2334912 (Source: Renal Failure)
Source: Renal Failure - April 11, 2024 Category: Urology & Nephrology Authors: Yan Huang Qiuxia Zhong Junzhi Chen Xianhui Qin Yaya Yang Yanhuan He Zizhen Lin Yumin Li Shenglin Yang Yongxin Lu Yanhong Zhao Yaozhong Kong Qijun Wan Qi Wang Sheng Huang Yan Liu Aiqun Liu Fanna Liu Fanfan Hou Min Liang Source Type: research
