TFE3/PI3K/Akt/mTOR axis in renal cell carcinoma affects tumor microenvironment
Am J Pathol. 2024 Apr 6:S0002-9440(24)00122-6. doi: 10.1016/j.ajpath.2024.02.022. Online ahead of print.ABSTRACTThe role of the PI3K/Akt pathway in renal cell carcinoma (RCC) progression, metastasis, and resistance to therapies has not been thoroughly investigated. Transcription factor E3 (TFE3) expression is related to poorer prognosis and tumor microenvironment in patients with RCC. We aimed to determine the relationship between TFE3 and the PI3K/Akt pathway. TFE3 downregulation was achieved by transient transfection of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in UOK146 cells. TFE3 overexpression was i...
Source: Am J Pathol - April 8, 2024 Category: Pathology Authors: Chung Su Hwang Yun Kyung Kang Ji Yun Kim So Hyun Shin Joon Young Park Ji Sun Song So Young Kim Se Jin Jung Jung Hee Lee Ju-Young Na Dong Hoon Shin Jee Yeon Kim Sung Woo Park Hyun Jung Lee Source Type: research
Celastrol Elicits Antitumor Effects through Inducing Immunogenic Cell Death and Downregulating PD-L1 in ccRCC
CONCLUSION: These findings indicate that CeT not only induces ICD but also suppresses PD-L1 by down-regulating MAPK1 expression, which will provide an attractive strategy for ccRCC immunotherapy.PMID:38584553 | DOI:10.2174/0113816128288970240321073436 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Hong-Fang Li Neng Zhu Jia-Jun Wu Ya-Ning Shi Jia Gu Li Qin Source Type: research
Celastrol Elicits Antitumor Effects through Inducing Immunogenic Cell Death and Downregulating PD-L1 in ccRCC
CONCLUSION: These findings indicate that CeT not only induces ICD but also suppresses PD-L1 by down-regulating MAPK1 expression, which will provide an attractive strategy for ccRCC immunotherapy.PMID:38584553 | DOI:10.2174/0113816128288970240321073436 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Hong-Fang Li Neng Zhu Jia-Jun Wu Ya-Ning Shi Jia Gu Li Qin Source Type: research
Celastrol Elicits Antitumor Effects through Inducing Immunogenic Cell Death and Downregulating PD-L1 in ccRCC
CONCLUSION: These findings indicate that CeT not only induces ICD but also suppresses PD-L1 by down-regulating MAPK1 expression, which will provide an attractive strategy for ccRCC immunotherapy.PMID:38584553 | DOI:10.2174/0113816128288970240321073436 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Hong-Fang Li Neng Zhu Jia-Jun Wu Ya-Ning Shi Jia Gu Li Qin Source Type: research
Molecular mechanism of formation and destruction of a pseudo ‑capsule in clear cell renal cell carcinoma
In conclusion, the present study provides insights into the formation and destruction of a PC, and the results may aid the treatment and management of patients with ccRCC.PMID:38586200 | PMC:PMC10996032 | DOI:10.3892/ol.2024.14358 (Source: Oncology Letters)
Source: Oncology Letters - April 8, 2024 Category: Cancer & Oncology Authors: Takuto Shimizu Makito Miyake Kota Iida Sayuri Onishi Tomomi Fujii Yusuke Iemura Kazuki Ichikawa Chihiro Omori Fumisato Maesaka Mitsuru Tomizawa Tatsuki Miyamoto Nobumichi Tanaka Kiyohide Fujimoto Source Type: research
TFE3/PI3K/Akt/mTOR axis in renal cell carcinoma affects tumor microenvironment
Am J Pathol. 2024 Apr 6:S0002-9440(24)00122-6. doi: 10.1016/j.ajpath.2024.02.022. Online ahead of print.ABSTRACTThe role of the PI3K/Akt pathway in renal cell carcinoma (RCC) progression, metastasis, and resistance to therapies has not been thoroughly investigated. Transcription factor E3 (TFE3) expression is related to poorer prognosis and tumor microenvironment in patients with RCC. We aimed to determine the relationship between TFE3 and the PI3K/Akt pathway. TFE3 downregulation was achieved by transient transfection of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in UOK146 cells. TFE3 overexpression was i...
Source: The American Journal of Pathology - April 8, 2024 Category: Pathology Authors: Chung Su Hwang Yun Kyung Kang Ji Yun Kim So Hyun Shin Joon Young Park Ji Sun Song So Young Kim Se Jin Jung Jung Hee Lee Ju-Young Na Dong Hoon Shin Jee Yeon Kim Sung Woo Park Hyun Jung Lee Source Type: research
Celastrol Elicits Antitumor Effects through Inducing Immunogenic Cell Death and Downregulating PD-L1 in ccRCC
CONCLUSION: These findings indicate that CeT not only induces ICD but also suppresses PD-L1 by down-regulating MAPK1 expression, which will provide an attractive strategy for ccRCC immunotherapy.PMID:38584553 | DOI:10.2174/0113816128288970240321073436 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Hong-Fang Li Neng Zhu Jia-Jun Wu Ya-Ning Shi Jia Gu Li Qin Source Type: research
Molecular mechanism of formation and destruction of a pseudo ‑capsule in clear cell renal cell carcinoma
In conclusion, the present study provides insights into the formation and destruction of a PC, and the results may aid the treatment and management of patients with ccRCC.PMID:38586200 | PMC:PMC10996032 | DOI:10.3892/ol.2024.14358 (Source: Oncology Letters)
Source: Oncology Letters - April 8, 2024 Category: Cancer & Oncology Authors: Takuto Shimizu Makito Miyake Kota Iida Sayuri Onishi Tomomi Fujii Yusuke Iemura Kazuki Ichikawa Chihiro Omori Fumisato Maesaka Mitsuru Tomizawa Tatsuki Miyamoto Nobumichi Tanaka Kiyohide Fujimoto Source Type: research
Celastrol Elicits Antitumor Effects through Inducing Immunogenic Cell Death and Downregulating PD-L1 in ccRCC
CONCLUSION: These findings indicate that CeT not only induces ICD but also suppresses PD-L1 by down-regulating MAPK1 expression, which will provide an attractive strategy for ccRCC immunotherapy.PMID:38584553 | DOI:10.2174/0113816128288970240321073436 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Hong-Fang Li Neng Zhu Jia-Jun Wu Ya-Ning Shi Jia Gu Li Qin Source Type: research
TFE3/PI3K/Akt/mTOR axis in renal cell carcinoma affects tumor microenvironment
Am J Pathol. 2024 Apr 6:S0002-9440(24)00122-6. doi: 10.1016/j.ajpath.2024.02.022. Online ahead of print.ABSTRACTThe role of the PI3K/Akt pathway in renal cell carcinoma (RCC) progression, metastasis, and resistance to therapies has not been thoroughly investigated. Transcription factor E3 (TFE3) expression is related to poorer prognosis and tumor microenvironment in patients with RCC. We aimed to determine the relationship between TFE3 and the PI3K/Akt pathway. TFE3 downregulation was achieved by transient transfection of small interfering RNA (siRNA) and short hairpin RNA (shRNA) in UOK146 cells. TFE3 overexpression was i...
Source: Am J Pathol - April 8, 2024 Category: Pathology Authors: Chung Su Hwang Yun Kyung Kang Ji Yun Kim So Hyun Shin Joon Young Park Ji Sun Song So Young Kim Se Jin Jung Jung Hee Lee Ju-Young Na Dong Hoon Shin Jee Yeon Kim Sung Woo Park Hyun Jung Lee Source Type: research
Fumarate hydratase mutation associated uterine leiomyomas: A case report and literature review
Key Clinical MessageThe patient was found to have multiple uterine myomas at the age of 19, underwent laparoscopic myomectomy at the age of 20, and underwent laparotomic myomectomy again at the age of 23 due to the recurrence of uterine myoma. At the age of 25, the patient reappeared with symptoms and recurrence, and was diagnosed with uterine leiomyomas (ULMs) of FH mutation and high-grade squamous intraepithelial lesion (HSIL/CIN III) with gland involvement, after complete examination. Fumarate hydratase (FH) mutation screening is important when gynecologists encounter patients with early onset and multiple ULMs, it can ...
Source: Clinical Case Reports - April 8, 2024 Category: General Medicine Authors: Junyan Zhu,
Shanji Li,
Zhiguo Zhuang,
Hao Chen,
Chao Chen,
Jie Zhu Tags: CASE REPORT Source Type: research
Validation of the Lung Immune Prognostic Index (LIPI) as a prognostic biomarker in metastatic renal cell carcinoma
The Lung Immune Prognostic Index (LIPI) is associated with immune checkpoint inhibitors (ICI) outcomes across different solid tumors, particularly in non-small cell lung cancer. Data regarding the prognostic and/or predictive role of LIPI in metastatic renal cell carcinoma (mRCC) are still scarce. The aim of this study was to evaluate whether LIPI could be predictive of survival in mRCC patients. (Source: European Journal of Cancer)
Source: European Journal of Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Luci ́a Carril-Ajuria, Pernelle Lavaud, Cecile Dalban, Sylvie Negrier, Gwénaëlle Gravis, Robert J. Motzer, Christine Chevreau, Nizar M. Tannir, Stéphane Oudard, David F. McDermott, Brigitte Laguerre, Hans J. Hammers, Philippe Barthelemy, Elizabeth R. Tags: Original Research Source Type: research
Radiomics-based discriminant analysis of principal components to stratify the treatment response of lung metastases following stereotactic body radiation therapy
The lung is the second most common site for metastases for most solid tumor (such as primary lung cancer itself, colorectal, head and neck, renal cell and breast cancer), with 20 –54 % of cancer patients developing lung metastases during their disease [1]. If patients with aggressive metastatic dissemination are usually treated with systemic therapy, patients with a modest metastatic burden, also known as oligometastatic disease, are more likely to benefit from local trea tment [2]. Stereotactic body radiation therapy (SBRT) is a potentially effective alternative treatment modality that is now regarded as being equally ...
Source: Physica Medica: European Journal of Medical Physics - April 8, 2024 Category: General Medicine Authors: Savino Cilla, Francesco Deodato, Carmela Romano, Gabriella Macchia, Milly Buwenge, Alessio G. Morganti Tags: Original paper Source Type: research
Ginsenoside Rh4 Facilitates the Sensitivity of Renal Cell Carcinoma to Ferroptosis via the NRF2 Pathway
CONCLUSIONS: Rh4 made RCC cells more sensitive to ferroptosis by inhibiting the NRF2 signaling and suppressing the expression of antioxidant enzymes. Therefore, combining Rh4 with ferroptosis-inducing reagents to treat RCC had potential therapeutic application.PMID:38583003 | DOI:10.56434/j.arch.esp.urol.20247702.16 (Source: Archivos Espanoles de Urologia)
Source: Archivos Espanoles de Urologia - April 7, 2024 Category: Urology & Nephrology Authors: Huandong Zhao Ruimin Ding Jiarui Han Source Type: research
