Neopterin as a potential prognostic and predictive biomarker in metastatic renal cell carcinoma treated with immune checkpoint inhibitors
Expert Rev Anticancer Ther. 2024 Apr 10. doi: 10.1080/14737140.2024.2341734. Online ahead of print.ABSTRACTINTRODUCTION: Immunotherapy represents a significant and essential component of renal carcinoma therapy, but the selection of an optimal regimen for an individual patient remains unclear. Despite significant improvements in therapeutic options for RCC, predictive biomarkers for immunotherapeutic agents remain elusive. Neopterin is a biomarker of cell-mediated immune response, with concentrations increased in different disorders, including cancer. High neopterin levels herald, in general, a poor prognosis.AREAS COVERED...
Source: Expert Review of Anticancer Therapy - April 10, 2024 Category: Cancer & Oncology Authors: Hana Studentova Katerina Hola Bohuslav Melichar Martina Spisarova Source Type: research
Choroidal metastases from primary renal cell carcinoma
J Fr Ophtalmol. 2024 Apr 9:104179. doi: 10.1016/j.jfo.2024.104179. Online ahead of print.NO ABSTRACTPMID:38599890 | DOI:10.1016/j.jfo.2024.104179 (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - April 10, 2024 Category: Opthalmology Authors: T Boutaj S Tachfouti L Sbai Y Laarif H El Ghazi A Chefchaouni H Lazaar R Benkirane S Moutamani R El Hachimi S Benchekroun Belabbes A Amazouzi O Cherkaoui Source Type: research
Pro-cancer role of CD276 as a novel biomarker for clear cell renal cell carcinoma
CONCLUSION: CD276 expression was significantly increased in ccRCC tissues and cells and positively correlated with patient prognosis. CD276 is a potential prognostic biomarker of ccRCC. Overall, this study provides a potential therapeutic strategy for ccRCC.PMID:38600002 | DOI:10.1016/j.urolonc.2024.03.018 (Source: Urologic Oncology)
Source: Urologic Oncology - April 10, 2024 Category: Urology & Nephrology Authors: Zhi-Yu Zhang Jian-Hao Xu Jiang-Lei Zhang Yu-Xin Lin Jun Ou-Yang Source Type: research
Machine learning-based integration develops a stress response stated T cell (Tstr)-related score for predicting outcomes in clear cell renal cell carcinoma
CONCLUSIONS: This study provides a Tstr cell-related score for predicting outcomes and PD-1 blockade therapy response in ccRCC. Tstr cells may exert their pro-tumoral role in ccRCC, acting against mast cells, in the acute inflammatory tumor microenvironment. TNFSF13B could serve as a key biomarker related to TCs.PMID:38599101 | DOI:10.1016/j.intimp.2024.112017 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 10, 2024 Category: Allergy & Immunology Authors: Shuai Yang Zhaodong Han Zeheng Tan Zhenjie Wu Jianheng Ye Shanghua Cai Yuanfa Feng Huichan He Biyan Wen Xuejin Zhu Yongkang Ye Huiting Huang Sheng Wang Weide Zhong Yulin Deng Source Type: research
Pro-cancer role of CD276 as a novel biomarker for clear cell renal cell carcinoma
CONCLUSION: CD276 expression was significantly increased in ccRCC tissues and cells and positively correlated with patient prognosis. CD276 is a potential prognostic biomarker of ccRCC. Overall, this study provides a potential therapeutic strategy for ccRCC.PMID:38600002 | DOI:10.1016/j.urolonc.2024.03.018 (Source: Cancer Control)
Source: Cancer Control - April 10, 2024 Category: Cancer & Oncology Authors: Zhi-Yu Zhang Jian-Hao Xu Jiang-Lei Zhang Yu-Xin Lin Jun Ou-Yang Source Type: research
Oncolytic herpes simplex virus expressing IL-2 controls glioblastoma growth and improves survival
CONCLUSIONS: Our findings illustrate that G47Δ-mIL2 is efficacious, stimulates antitumor immunity against orthotopic GBM, and may also target GSC. OHSV expressing IL-2 may represent an agent that merits further exploration in patients with GBM.PMID:38599661 | DOI:10.1136/jitc-2024-008880 (Source: Herpes)
Source: Herpes - April 10, 2024 Category: Infectious Diseases Authors: Praveen K Bommareddy Hiroaki Wakimoto Robert L Martuza Howard L Kaufman Samuel D Rabkin Dipongkor Saha Source Type: research
Neopterin as a potential prognostic and predictive biomarker in metastatic renal cell carcinoma treated with immune checkpoint inhibitors
Expert Rev Anticancer Ther. 2024 Apr 10. doi: 10.1080/14737140.2024.2341734. Online ahead of print.ABSTRACTINTRODUCTION: Immunotherapy represents a significant and essential component of renal carcinoma therapy, but the selection of an optimal regimen for an individual patient remains unclear. Despite significant improvements in therapeutic options for RCC, predictive biomarkers for immunotherapeutic agents remain elusive. Neopterin is a biomarker of cell-mediated immune response, with concentrations increased in different disorders, including cancer. High neopterin levels herald, in general, a poor prognosis.AREAS COVERED...
Source: Expert Review of Anticancer Therapy - April 10, 2024 Category: Cancer & Oncology Authors: Hana Studentova Katerina Hola Bohuslav Melichar Martina Spisarova Source Type: research
Pro-cancer role of CD276 as a novel biomarker for clear cell renal cell carcinoma
CONCLUSION: CD276 expression was significantly increased in ccRCC tissues and cells and positively correlated with patient prognosis. CD276 is a potential prognostic biomarker of ccRCC. Overall, this study provides a potential therapeutic strategy for ccRCC.PMID:38600002 | DOI:10.1016/j.urolonc.2024.03.018 (Source: Urologic Oncology)
Source: Urologic Oncology - April 10, 2024 Category: Urology & Nephrology Authors: Zhi-Yu Zhang Jian-Hao Xu Jiang-Lei Zhang Yu-Xin Lin Jun Ou-Yang Source Type: research
GSE248774 Immune modulation with RANKL-blockade through denosumab treatment in cancer patients
We examined whether administering denosumab could modify modulate circulating immune cells in c ancer patients. Blood was collected from 23 prostate cancer patients and 3 renal cell carcinoma patients, who provided written informed consent, with advanced disease who were receiving denosumab, prior to and during denosumab treatment. Using high-dimensional mass cytometry, we found that denosumab treatment by itself induced modest effects on circulating immune cell frequency and activation. We also found minimal changes in the circulating T cell repertoire and the frequency of new thymic emigrants with denosumab treatment. H...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Development and validation of a clinical and ultrasound features-based nomogram for preoperative differentiation of renal urothelial carcinoma and central renal cell carcinoma
ConclusionA noninvasive clinical and US-based nomogram combining conventional US and CEUS features possesses good predictive value for differentiating rUC from c-RCC. (Source: World Journal of Urology)
Source: World Journal of Urology - April 10, 2024 Category: Urology & Nephrology Source Type: research
Cancers, Vol. 16, Pages 1454: Radiomics Machine Learning Analysis of Clear Cell Renal Cell Carcinoma for Tumour Grade Prediction Based on Intra-Tumoural Sub-Region Heterogeneity
Conclusions: Radiomics signatures combined with ML have the potential to predict the WHO/ISUP grade of ccRCC with superior performance, when compared to pre-operative biopsy. Moreover, tumour sub-regions contain useful information that should be analysed independently when determining the tumour grade. Therefore, it is possible to distinguish the grade of ccRCC pre-operatively to improve patient care and management. (Source: Cancers)
Source: Cancers - April 10, 2024 Category: Cancer & Oncology Authors: Abeer J. Alhussaini J. Douglas Steele Adel Jawli Ghulam Nabi Tags: Article Source Type: research
Advanced renal cell carcinoma management: the Latin American Cooperative Oncology Group (LACOG) and the Latin American Renal Cancer Group (LARCG) consensus update
CONCLUSION: Immunotherapy and targeted therapy are the standards of care for advanced disease. The utilization and sequencing of these therapeutic agents hinge upon individual risk scores and responses to previous treatments. This consensus reflects a commitment to informed decision-making, drawn from professional expertise and evidence in the medical literature.PMID:38594593 | DOI:10.1007/s00432-024-05663-z (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Andrey Soares Fernando Sabino Marques Monteiro Karine Martins da Trindade Adriano Gon çalves E Silva Ana Paula Garcia Cardoso Andr é Deeke Sasse Andr é P Fay Andr é Paternò Castello Dias Carneiro Antonio Machado Alencar Junior Augusto C ésar de Andr Source Type: research
Associations Between Inflammatory Indexes, Coagulation Indexes, and Fuhrman Grade of Clear Cell Renal Cell Carcinoma
Ann Surg Oncol. 2024 Apr 9. doi: 10.1245/s10434-024-15251-7. Online ahead of print.NO ABSTRACTPMID:38592621 | DOI:10.1245/s10434-024-15251-7 (Source: Ann Oncol)
Source: Ann Oncol - April 9, 2024 Category: Cancer & Oncology Authors: Yumei Zhang Zehua Sun Zhongyi Wang Hao Guo Jing Liu Heng Ma Source Type: research
Associations Between Inflammatory Indexes, Coagulation Indexes, and Fuhrman Grade of Clear Cell Renal Cell Carcinoma
Ann Surg Oncol. 2024 Apr 9. doi: 10.1245/s10434-024-15251-7. Online ahead of print.NO ABSTRACTPMID:38592621 | DOI:10.1245/s10434-024-15251-7 (Source: Ann Oncol)
Source: Ann Oncol - April 9, 2024 Category: Cancer & Oncology Authors: Yumei Zhang Zehua Sun Zhongyi Wang Hao Guo Jing Liu Heng Ma Source Type: research
