Expression of HIF ‑α and their association with clinicopathological parameters in clinical renal cell carcinoma
CONCLUSION: The expression levels of the three primary HIF-α proteins were found to be higher in the nucleus than in the cytoplasm. Furthermore, the results indicated that HIF-3α and HIF-1α expression levels were significant univariate factors associated with CSS in patients with clear cell RCC. These results highlight the critical role that HIF-3α and HIF-1α play in the hypoxia pathway.PMID:38571885 | PMC:PMC10989218 | DOI:10.48101/ujms.v129.9407 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Raviprakash T Sitaram B örje Ljungberg Source Type: research
Expression of HIF ‑α and their association with clinicopathological parameters in clinical renal cell carcinoma
CONCLUSION: The expression levels of the three primary HIF-α proteins were found to be higher in the nucleus than in the cytoplasm. Furthermore, the results indicated that HIF-3α and HIF-1α expression levels were significant univariate factors associated with CSS in patients with clear cell RCC. These results highlight the critical role that HIF-3α and HIF-1α play in the hypoxia pathway.PMID:38571885 | PMC:PMC10989218 | DOI:10.48101/ujms.v129.9407 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Raviprakash T Sitaram B örje Ljungberg Source Type: research
Expression of HIF ‑α and their association with clinicopathological parameters in clinical renal cell carcinoma
CONCLUSION: The expression levels of the three primary HIF-α proteins were found to be higher in the nucleus than in the cytoplasm. Furthermore, the results indicated that HIF-3α and HIF-1α expression levels were significant univariate factors associated with CSS in patients with clear cell RCC. These results highlight the critical role that HIF-3α and HIF-1α play in the hypoxia pathway.PMID:38571885 | PMC:PMC10989218 | DOI:10.48101/ujms.v129.9407 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Raviprakash T Sitaram B örje Ljungberg Source Type: research
Expression of HIF ‑α and their association with clinicopathological parameters in clinical renal cell carcinoma
CONCLUSION: The expression levels of the three primary HIF-α proteins were found to be higher in the nucleus than in the cytoplasm. Furthermore, the results indicated that HIF-3α and HIF-1α expression levels were significant univariate factors associated with CSS in patients with clear cell RCC. These results highlight the critical role that HIF-3α and HIF-1α play in the hypoxia pathway.PMID:38571885 | PMC:PMC10989218 | DOI:10.48101/ujms.v129.9407 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Raviprakash T Sitaram B örje Ljungberg Source Type: research
Expression of HIF ‑α and their association with clinicopathological parameters in clinical renal cell carcinoma
CONCLUSION: The expression levels of the three primary HIF-α proteins were found to be higher in the nucleus than in the cytoplasm. Furthermore, the results indicated that HIF-3α and HIF-1α expression levels were significant univariate factors associated with CSS in patients with clear cell RCC. These results highlight the critical role that HIF-3α and HIF-1α play in the hypoxia pathway.PMID:38571885 | PMC:PMC10989218 | DOI:10.48101/ujms.v129.9407 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Raviprakash T Sitaram B örje Ljungberg Source Type: research
Expression of HIF ‑α and their association with clinicopathological parameters in clinical renal cell carcinoma
CONCLUSION: The expression levels of the three primary HIF-α proteins were found to be higher in the nucleus than in the cytoplasm. Furthermore, the results indicated that HIF-3α and HIF-1α expression levels were significant univariate factors associated with CSS in patients with clear cell RCC. These results highlight the critical role that HIF-3α and HIF-1α play in the hypoxia pathway.PMID:38571885 | PMC:PMC10989218 | DOI:10.48101/ujms.v129.9407 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Raviprakash T Sitaram B örje Ljungberg Source Type: research
Outcomes of thyroidectomy for secondary thyroid malignancies, a single center experience
ConclusionsMetastasis to the thyroid gland is a rare phenomenon with an incidence of 0.22% in all thyroid malignancies. It may occur before the detection of the primary tumor or during the follow-up of the primary malignancy. Although the overall prognosis is poor, it can be treated surgically. (Source: Hormones and Cancer)
Source: Hormones and Cancer - April 4, 2024 Category: Cancer & Oncology Source Type: research
Curcumin prevents high glucose-induced stimulatory effects of renal cell secretome on fibroblast activation via mitigating intracellular free radicals and TGF- β secretion
Biomed Pharmacother. 2024 Apr 2;174:116536. doi: 10.1016/j.biopha.2024.116536. Online ahead of print.ABSTRACTDiabetic kidney disease (DKD) is a leading cause of kidney failure. However, the involvement of renal fibroblasts and their communications with renal epithelial cells during DKD remain poorly understood. We investigated the potential role of renal proximal tubular epithelial cells (PTECs) in renal fibroblast activation that might lead to DKD. Additionally, the protective effects of curcumin, a known antioxidant, against renal fibroblast activation induced by high glucose-treated PTECs were investigated. Secretome wa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 3, 2024 Category: Drugs & Pharmacology Authors: Chadanat Noonin Visith Thongboonkerd Source Type: research
Curcumin prevents high glucose-induced stimulatory effects of renal cell secretome on fibroblast activation via mitigating intracellular free radicals and TGF- β secretion
Biomed Pharmacother. 2024 Apr 2;174:116536. doi: 10.1016/j.biopha.2024.116536. Online ahead of print.ABSTRACTDiabetic kidney disease (DKD) is a leading cause of kidney failure. However, the involvement of renal fibroblasts and their communications with renal epithelial cells during DKD remain poorly understood. We investigated the potential role of renal proximal tubular epithelial cells (PTECs) in renal fibroblast activation that might lead to DKD. Additionally, the protective effects of curcumin, a known antioxidant, against renal fibroblast activation induced by high glucose-treated PTECs were investigated. Secretome wa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 3, 2024 Category: Drugs & Pharmacology Authors: Chadanat Noonin Visith Thongboonkerd Source Type: research
Radical nephrectomy for a giant chromophobe renal cell carcinoma diagnosed > 17 years previously: a case report and literature review
We report a case involving a 59-year-old female who underwent a difficult radical nephrectomy 17 years after being diagnosed with malignant tumors due to primary renal cell carcinoma. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
CCDC25 suppresses clear cell renal cell carcinoma progression by LATS1/YAP-mediated regulation of the hippo pathway
Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent renal cancers, and the molecular mechanisms underlying its progression are still not fully understood. The expression of CCDC25, a notably u... (Source: Cancer Cell International)
Source: Cancer Cell International - April 3, 2024 Category: Cancer & Oncology Authors: Hongpei Tan, Jiahao Liu, Yanan Li, Ze Mi, Baiying Liu and Pengfei Rong Tags: Research Source Type: research
Characterization of Mitoribosomal Small Subunit unit genes related immune and pharmacogenomic landscapes in renal cell carcinoma
AbstractMitoribosomes are essential for the production of biological energy. The Human Mitoribosomal Small Subunit unit (MRPS) family, responsible for encoding mitochondrial ribosomal small subunits, is actively engaged in protein synthesis within the mitochondria. Intriguingly, MRPS family genes appear to play a role in cancer. A multistep process was employed to establish a risk model associated with MRPS genes, aiming to delineate the immune and pharmacogenomic landscapes in clear cell renal cell carcinoma (ccRCC). MRPScores were computed for individual patients to assess their responsiveness to various treatment modali...
Source: IUBMB Life - April 2, 2024 Category: Research Authors: Zhihao Wei,
Chenchen Liu,
Jiaqian Liang,
Xuan Zhou,
Kaming Xue,
Keshan Wang,
Xiaoping Zhang Tags: RESEARCH ARTICLE Source Type: research
Nephroprotective effect of Ginsenoside Rg1 in lipopolysaccharide-induced sepsis in mice through the SIRT1/NF- κB signaling
CONCLUSIONS: Rg1 ameliorates LPS-induced kidney injury and suppresses renal inflammation, apoptosis, and oxidative stress in mice via regulating the SIRT1/NF-κB signaling.PMID:38563049 | DOI:10.5603/fhc.97140 (Source: Folia Histochemica et Cytobiologica)
Source: Folia Histochemica et Cytobiologica - April 2, 2024 Category: Cytology Authors: Yadan Hu Chao Xiang Dong Zhang Fang Zhou Dede Zhang Source Type: research
