Association of pretreatment neutrophil-to-lymphocyte ratio with clinical outcomes in cancer immunotherapy: An evidence synthesis from 30 meta-analyses
CONCLUSIONS: Elevated pretreatment NLR correlates with poor outcomes in cancer immunotherapy, suggesting its potential as a biomarker for identifying appropriate treatment populations and predicting clinical outcomes. Nevertheless, further validation through prospective cohort studies is warranted.PMID:38579566 | DOI:10.1016/j.intimp.2024.111936 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 5, 2024 Category: Allergy & Immunology Authors: Haoyu Wang Ruiyuan Yang Dan Liu Weimin Li Source Type: research
CLO24-071: A Propensity Matched Survival Analysis Comparing Partial Versus Radical Nephrectomy in Patients with Metastatic Renal Cell Carcinoma: A National Cancer Database Study
J Natl Compr Canc Netw. 2024 Apr 5;22(2.5):CLO24-071. doi: 10.6004/jnccn.2023.7211.NO ABSTRACTPMID:38580260 | DOI:10.6004/jnccn.2023.7211 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 5, 2024 Category: Cancer & Oncology Authors: Nathan VanderVeer-Harris Aden Swayze Ronscardy Mondesir Raghuram Reddy Pushan Prabhakar Arjun Pon Avudaiappan Ahmed Eldefrawy Murugesan Manoharan Jorge Caso Source Type: research
CLO24-068: The Role of Obesity in Influencing Patient Survival in Metastatic Renal Cell Carcinoma Patients Receiving Immunotherapy: A Systematic Review and Meta-Analysis
J Natl Compr Canc Netw. 2024 Apr 5;22(2.5):CLO24-068. doi: 10.6004/jnccn.2023.7287.NO ABSTRACTPMID:38580276 | DOI:10.6004/jnccn.2023.7287 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 5, 2024 Category: Cancer & Oncology Authors: Chalothorn Wannaphut Sakditad Saowapa Natchaya Polpichai Pharit Siladech Manasawee Tanariyakul Phuuwadith Wattanachayakul Pakin Lalitnithi Source Type: research
Impact of Synchronous versus Metachronous Metastasis on Outcomes in Patients with Metastatic Renal Cell Carcinoma Treated with First-line Immune Checkpoint Inhibitor-based Combinations
CONCLUSIONS AND CLINICAL IMPLICATIONS: In this hypothesis-generating study, patients with mRCC with synchronous metastasis who were treated with first-line ICI-based combinations have a poorer OS and worse DCR than those with metachronous mRCC. If these results are externally validated, time to metastasis could be included in prognostic models for mRCC.PATIENT SUMMARY: Our study demonstrates that patients treated with current first-line immunotherapies, who present with metastasis at the initial diagnosis of kidney cancer have worse overall survival compared to those who develop metastasis later. These results can help phy...
Source: Cancer Control - April 5, 2024 Category: Cancer & Oncology Authors: Georges Gebrael Luis Meza Xiaochen Li Zeynep Zengin Nicolas Sayegh Hedyeh Ebrahimi Nishita Tripathi Daniela Castro Benjamin Mercier Regina Barragan-Carrillo Haoran Li Alexander Chehrazi-Raffle Umang Swami Abhishek Tripathi Neeraj Agarwal Benjamin L Maugha Source Type: research
CD3+ and CD8+ T cell-based immune cell score as a prognostic factor in clear-cell renal cell carcinoma
This study aims to assess the prognostic role of immune cell score in ccRCC.MATERIAL AND METHODS: All patients with ccRCC undergoing surgery between 2007 and 2020 in Central Finland Central Hospital were retrospectively identified. CD3+ and CD8+ cell densities were calculated from tissue samples to determine the immune cell score using Immunoscore® principles. Receiver-operating characteristic analysis, Kaplan-Meier survival curve, and Cox regression were used to evaluate the association between immune cell score and survival.RESULTS: A total of 203 patients (mean age 66.5 years) were identified. The median follow-up time...
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Jonne Åkerla Olli Helminen Juha P V äyrynen Anne Parkkinen Hilma J ärvenpää Jan B öhm Maarit Ahtiainen Heikki Seikkula Source Type: research
CD3+ and CD8+ T cell-based immune cell score as a prognostic factor in clear-cell renal cell carcinoma
This study aims to assess the prognostic role of immune cell score in ccRCC.MATERIAL AND METHODS: All patients with ccRCC undergoing surgery between 2007 and 2020 in Central Finland Central Hospital were retrospectively identified. CD3+ and CD8+ cell densities were calculated from tissue samples to determine the immune cell score using Immunoscore® principles. Receiver-operating characteristic analysis, Kaplan-Meier survival curve, and Cox regression were used to evaluate the association between immune cell score and survival.RESULTS: A total of 203 patients (mean age 66.5 years) were identified. The median follow-up time...
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Jonne Åkerla Olli Helminen Juha P V äyrynen Anne Parkkinen Hilma J ärvenpää Jan B öhm Maarit Ahtiainen Heikki Seikkula Source Type: research
Association of pretreatment neutrophil-to-lymphocyte ratio with clinical outcomes in cancer immunotherapy: An evidence synthesis from 30 meta-analyses
CONCLUSIONS: Elevated pretreatment NLR correlates with poor outcomes in cancer immunotherapy, suggesting its potential as a biomarker for identifying appropriate treatment populations and predicting clinical outcomes. Nevertheless, further validation through prospective cohort studies is warranted.PMID:38579566 | DOI:10.1016/j.intimp.2024.111936 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 5, 2024 Category: Allergy & Immunology Authors: Haoyu Wang Ruiyuan Yang Dan Liu Weimin Li Source Type: research
CLO24-068: The Role of Obesity in Influencing Patient Survival in Metastatic Renal Cell Carcinoma Patients Receiving Immunotherapy: A Systematic Review and Meta-Analysis
J Natl Compr Canc Netw. 2024 Apr 5;22(2.5):CLO24-068. doi: 10.6004/jnccn.2023.7287.NO ABSTRACTPMID:38580276 | DOI:10.6004/jnccn.2023.7287 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 5, 2024 Category: Cancer & Oncology Authors: Chalothorn Wannaphut Sakditad Saowapa Natchaya Polpichai Pharit Siladech Manasawee Tanariyakul Phuuwadith Wattanachayakul Pakin Lalitnithi Source Type: research
CLO24-071: A Propensity Matched Survival Analysis Comparing Partial Versus Radical Nephrectomy in Patients with Metastatic Renal Cell Carcinoma: A National Cancer Database Study
J Natl Compr Canc Netw. 2024 Apr 5;22(2.5):CLO24-071. doi: 10.6004/jnccn.2023.7211.NO ABSTRACTPMID:38580260 | DOI:10.6004/jnccn.2023.7211 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 5, 2024 Category: Cancer & Oncology Authors: Nathan VanderVeer-Harris Aden Swayze Ronscardy Mondesir Raghuram Reddy Pushan Prabhakar Arjun Pon Avudaiappan Ahmed Eldefrawy Murugesan Manoharan Jorge Caso Source Type: research
CD3+ and CD8+ T cell-based immune cell score as a prognostic factor in clear-cell renal cell carcinoma
This study aims to assess the prognostic role of immune cell score in ccRCC.MATERIAL AND METHODS: All patients with ccRCC undergoing surgery between 2007 and 2020 in Central Finland Central Hospital were retrospectively identified. CD3+ and CD8+ cell densities were calculated from tissue samples to determine the immune cell score using Immunoscore® principles. Receiver-operating characteristic analysis, Kaplan-Meier survival curve, and Cox regression were used to evaluate the association between immune cell score and survival.RESULTS: A total of 203 patients (mean age 66.5 years) were identified. The median follow-up time...
Source: Acta Oncologica - April 5, 2024 Category: Cancer & Oncology Authors: Jonne Åkerla Olli Helminen Juha P V äyrynen Anne Parkkinen Hilma J ärvenpää Jan B öhm Maarit Ahtiainen Heikki Seikkula Source Type: research
Pan-Cancer Analysis Identifies BCLAF1 as a Potential Biomarker for Renal Cell Carcinoma
Biochem Genet. 2024 Apr 4. doi: 10.1007/s10528-024-10773-x. Online ahead of print.ABSTRACTB-cell lymphoma-2-associated transcription factor 1 (BCLAF1) is a versatile protein involved in the regulation of gene transcription and post-transcriptional processing. Although BCLAF1 exerts a broad tumor suppressor effect or tumor promoter effect in many cancer types, the specific roles concerning its expression levels, and its impact on tumorigenesis in Renal cell carcinoma (RCC) remain unclear. Here, we utilized the Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx) datasets alongside R software and online tools to ...
Source: Biochemical Genetics - April 4, 2024 Category: Genetics & Stem Cells Authors: Huan Yan Xiang Wu Hong Li Zongdong Yu Xiaofeng Jin Source Type: research
Expression of HIF ‑α and their association with clinicopathological parameters in clinical renal cell carcinoma
CONCLUSION: The expression levels of the three primary HIF-α proteins were found to be higher in the nucleus than in the cytoplasm. Furthermore, the results indicated that HIF-3α and HIF-1α expression levels were significant univariate factors associated with CSS in patients with clear cell RCC. These results highlight the critical role that HIF-3α and HIF-1α play in the hypoxia pathway.PMID:38571885 | PMC:PMC10989218 | DOI:10.48101/ujms.v129.9407 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Raviprakash T Sitaram B örje Ljungberg Source Type: research
Expression of HIF ‑α and their association with clinicopathological parameters in clinical renal cell carcinoma
CONCLUSION: The expression levels of the three primary HIF-α proteins were found to be higher in the nucleus than in the cytoplasm. Furthermore, the results indicated that HIF-3α and HIF-1α expression levels were significant univariate factors associated with CSS in patients with clear cell RCC. These results highlight the critical role that HIF-3α and HIF-1α play in the hypoxia pathway.PMID:38571885 | PMC:PMC10989218 | DOI:10.48101/ujms.v129.9407 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Raviprakash T Sitaram B örje Ljungberg Source Type: research
Expression of HIF ‑α and their association with clinicopathological parameters in clinical renal cell carcinoma
CONCLUSION: The expression levels of the three primary HIF-α proteins were found to be higher in the nucleus than in the cytoplasm. Furthermore, the results indicated that HIF-3α and HIF-1α expression levels were significant univariate factors associated with CSS in patients with clear cell RCC. These results highlight the critical role that HIF-3α and HIF-1α play in the hypoxia pathway.PMID:38571885 | PMC:PMC10989218 | DOI:10.48101/ujms.v129.9407 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Raviprakash T Sitaram B örje Ljungberg Source Type: research
Expression of HIF ‑α and their association with clinicopathological parameters in clinical renal cell carcinoma
CONCLUSION: The expression levels of the three primary HIF-α proteins were found to be higher in the nucleus than in the cytoplasm. Furthermore, the results indicated that HIF-3α and HIF-1α expression levels were significant univariate factors associated with CSS in patients with clear cell RCC. These results highlight the critical role that HIF-3α and HIF-1α play in the hypoxia pathway.PMID:38571885 | PMC:PMC10989218 | DOI:10.48101/ujms.v129.9407 (Source: Upsala Journal of Medical Sciences)
Source: Upsala Journal of Medical Sciences - April 4, 2024 Category: General Medicine Authors: Raviprakash T Sitaram B örje Ljungberg Source Type: research
