The European Association of Urology Guideline on Renal Cell Carcinoma (RCC) is Not Concise in its Recommendation to Perform Partial Nephrectomy in T1b RCC
Publication date: Available online 23 January 2019Source: European UrologyAuthor(s): Paul C.M.S. Verhagen, Egbert R. Boevé (Source: European Urology)
Source: European Urology - January 23, 2019 Category: Urology & Nephrology Source Type: research

Efficacy of cryoablation combined with sorafenib for the treatment of advanced renal cell carcinoma.
CONCLUSION: Cryoablation combined with sorafenib had superior clinical efficacy compared with sorafenib-only for the treatment of advanced renal cell carcinoma unsuitable for surgical treatment. Moreover, this combined therapy may enhance the body's anti-tumor immunity and effectively prolong PFS and OS without compromising patient quality of life, thus representing a new treatment strategy for advanced renal cell carcinoma. PMID: 30663911 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 23, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Surgery for metastases of renal cell carcinoma: outcome of treatments and preliminary assessment of Leuven-Udine prognostic groups in the targeted therapy era.
CONCLUSIONS: Metastasectomy is an option for selected patients with mR.C.C. Complete resection should be attempted when feasible. The data failed to support the prognostic significance of the L.U. model in patients with mR.C.C. PMID: 30663485 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Urology)
Source: Scandinavian Journal of Urology - January 23, 2019 Category: Urology & Nephrology Tags: Scand J Urol Source Type: research

The De Ritis and Neutrophil-to-Lymphocyte Ratios May Aid in the Risk Assessment of Patients with Metastatic Renal Cell Carcinoma.
This study aimed to determine whether baseline blood inflammatory markers can predict progression-free survival (PFS) and overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC). Methods: The study included 158 patients with mRCC treated with first-line targeted therapy between 2002 and 2016. A multivariable cox proportional hazards model identified inflammatory factors that predict PFS and OS. Using bootstrap method, new prognostic model compared with Heng and modified MSKCC risk model (mMSKCC). The effect of inflammatory factors were investigated by comparing increased C-index adding significant...
Source: Journal of Oncology - January 22, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

RAB27A is an independent prognostic factor in clear cell renal cell carcinoma.
Authors: An HJ, Song DH, Koh HM, Ko GH, Lee JH, Kim DC, Yang JW, Kim MH, Seo DH, Jang SM, Lee JS Abstract AIM: To examine the expression of RAB27A and RAB27B in clear cell renal cell carcinoma (CCRCC). MATERIALS & METHODS: The intensity and proportion of tumor cells staining positive for RAB27A and RAB27B in a total of 304 cores were evaluated. RESULTS: The T stage showed a significant correlation with RAB27A intensity (p 
Source: Future Medicine: Biomarkers in Medicine - January 22, 2019 Category: Internal Medicine Tags: Biomark Med Source Type: research

Sources of Frustration Among Patients Diagnosed With Renal Cell Carcinoma
Cristiane Decat Bergerot, Dena Battle, Paulo Gustavo Bergerot, Nazli Dizman, Eric Jonasch, Hans J. Hammers, Daniel J. George, Axel Bex, Borje Ljungberg, Sumanta Kumar Pal, Michael D. Staehler (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 22, 2019 Category: Cancer & Oncology Source Type: research

The Expression Patterns of FAM83H and PANX2 Are Associated With Shorter Survival of Clear Cell Renal Cell Carcinoma Patients
Kyoung Min Kim, Usama Khamis Hussein, Jun Sang Bae, See-Hyoung Park, Keun Sang Kwon, Sang Hoon Ha, Ho Sung Park, Ho Lee, Myoung Ja Chung, Woo Sung Moon, Myoung Jae Kang, Kyu Yun Jang (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 22, 2019 Category: Cancer & Oncology Source Type: research

CXCL13/CXCR5 Axis Predicts Poor Prognosis and Promotes Progression Through PI3K/AKT/mTOR Pathway in Clear Cell Renal Cell Carcinoma
Zaosong Zheng, Yuhong Cai, Haicheng Chen, Zhiliang Chen, Dingjun Zhu, Qiyu Zhong, Wenlian Xie (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 22, 2019 Category: Cancer & Oncology Source Type: research

Imaging of Unusual Renal Tumors
AbstractPurpose of ReviewRenal masses are a wide entity and a common finding in clinical practice. Detection of these masses has increased in the last years, yet mortality rates have slightly decreased.Recent FindingsAccording to the World Health Organization classification, there are 8 types, 51 subtypes, and a lot more subsequent subclassifications of renal tumors. Histopathological analysis should always be assessed for final diagnosis of theses tumors. However, imaging can be an important diagnostic guidance. The most common diagnoses of renal tumor are clear cell carcinoma, papillary renal cell carcinoma, angiomyolipo...
Source: Current Urology Reports - January 21, 2019 Category: Urology & Nephrology Source Type: research

The correlation between the incidence of adverse events and progression-free survival in patients treated with cabozantinib for metastatic renal cell carcinoma (mRCC)
AbstractClinical practice shows significant differences in treatment outcomes across patients treated with cabozantinib for metastatic renal cell carcinoma (mRCC). It is not known whether cabozantinib-induced adverse events are predictive factors of survival as in case of drugs such as sunitinib or axitinib. The study participants were 30 adult patients with mRCC treated with cabozantinib as a second- or further line setting. All adverse events were evaluated using the National Cancer Institute Common Terminology Criteria for Adverse Events version 4.0. Progression-free survival (PFS) values were calculated by taking the b...
Source: Medical Oncology - January 21, 2019 Category: Cancer & Oncology Source Type: research

The repair using a fibular graft of cervical vertebral collapse due to renal cell carcinoma: Late results with a case report
In this study, we emphasized the importance of resection of metastasis together with a primary tumor in a metastatic RCC case to cure the patient and provide the desired quality of life. (Source: Journal of Craniovertebral Junction and Spine)
Source: Journal of Craniovertebral Junction and Spine - January 21, 2019 Category: Orthopaedics Authors: Vaner Koksal H & #252;seyin Eren Hasan G & #252; & #231;er Source Type: research

Chromosomal aberrations in renal cell carcinoma: An overview with implications for clinical practice
Muhammad Bilal Quddus, Norman Pratt, Ghulam NabiUrology Annals 2019 11(1):6-14Chromosomal instability and aberrations are known in many cancers including renal cell carcinoma. Detailed understanding of these changes has led to an improved drug discovery and continued developments in other therapeutic options. Chromosomal aberrations have a potential to be used to monitor disease including prognostication. There has been a growing experience in cytogenetic techniques and gap between clinic and laboratory has narrowed significantly in the recent past. Nevertheless, more work on validation of these techniques, establishing th...
Source: Urology Annals - January 21, 2019 Category: Urology & Nephrology Authors: Muhammad Bilal Quddus Norman Pratt Ghulam Nabi Source Type: research

Cystic renal oncocytoma mimicking renal cell carcinoma
We present a 59-year-old female who presented with a hilar Bosniak type 4 cyst in the right kidney. She underwent open exploration of the right renal tumor. The tumor was infiltrating into the renal vessels and could not be separated from the renal vein. In view of preoperative and intraoperative suspicion of malignancy, radical nephrectomy was done. Postoperative histopathological examination revealed the tumor to be an oncocytoma. The benign nature of the cyst could not be conclusively determined by preoperative investigations and intraoperative findings. Postoperative histological examination uncovered the rare cystic p...
Source: Urology Annals - January 21, 2019 Category: Urology & Nephrology Authors: AR Balaji J. V. S. Prakash Danny Darlington Source Type: research

Neoadjuvant targeted therapy for advanced renal cell carcinoma: Where do we stand ?
Nikolaos K GrivasUrology Annals 2019 11(1):115-116 (Source: Urology Annals)
Source: Urology Annals - January 21, 2019 Category: Urology & Nephrology Authors: Nikolaos K Grivas Source Type: research

Final Results of a Non-Interventional Study Evaluating the Quality of Life in Second-line Treatment of Metastatic Renal Cell Carcinoma With Everolimus: The EVERPRO Study
Conclusions: QoL was maintained during the everolimus therapy and limitations as well as time effort were acceptable for most of the patients. The study supports previous findings on switching mode of action after anti-VEGFR-targeted therapy to a mammalian target of rapamycin inhibitor.Oncol Res Treat (Source: Oncology Research and Treatment)
Source: Oncology Research and Treatment - January 18, 2019 Category: Cancer & Oncology Source Type: research

Second-line treatment after sunitinib therapy in patients with renal cell carcinoma: a comparison of axitinib and mammalian target of rapamycin inhibitors.
Authors: Tamada S, Iguchi T, Kato M, Yasuda S, Yamasaki T, Nakatani T Abstract This retrospective study compared the outcomes of sequential therapy using sunitinib followed by axitinib or the mammalian target of rapamycin (mTOR) inhibitors (everolimus or temsirolimus). Among 234 patients treated with molecular-targeted drugs for metastatic renal cell carcinoma, we selected 137 patients treated with sunitinib as the first-line therapy. We then compared patients treated with axitinib (n = 52) or mTOR inhibitors (n = 31), as the second-line treatment, and investigated the progression-free survival (PFS) and overall su...
Source: Oncotarget - January 18, 2019 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Systemic inflammation response index predicts prognosis in patients with clear cell renal cell carcinoma: a propensity score-matched analysis
(Source: Cancer Management and Research)
Source: Cancer Management and Research - January 18, 2019 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research

Elevated histone H3 acetylation and loss of the Sp1-HDAC1 complex de-repress the GM2-synthase gene in renal cell carcinoma [Gene Regulation]
GM2-synthase produces sialic acid–containing glycosphingolipids called gangliosides, and its mRNA overexpression and the gangliosides it generates are linked to tumor progression, migration, and suppression of tumor-specific host immune responses. However, the mechanism underlying GM2-synthase de-repression in renal cell carcinoma (RCC) is poorly understood. Here, we demonstrate that higher GM2-synthase mRNA expression levels in various cancer cells and in human RCC tumors correlate with higher histone acetylation levels (H3K9, H3K14, or both) at region +38/+187 relative to the transcription start site (TSS) of the G...
Source: Journal of Biological Chemistry - January 18, 2019 Category: Chemistry Authors: Avisek Banerjee, Barun Mahata, Arjun Dhir, Tapan Kumar Mandal, Kaushik Biswas Tags: Glycobiology and Extracellular Matrices Source Type: research

Overall survival and response to radiation and targeted therapies among patients with renal cell carcinoma brain metastases.
Abstract OBJECTIVEThe object of this retrospective study was to investigate the impact of targeted therapies on overall survival (OS), distant intracranial failure, local failure, and radiation necrosis among patients treated with radiation therapy for renal cell carcinoma (RCC) metastases to the brain.METHODSAll patients diagnosed with RCC brain metastasis (BM) between 1998 and 2015 at a single institution were included in this study. The primary outcome was OS, and secondary outcomes included local failure, distant intracranial failure, and radiation necrosis. The timing of targeted therapies was recorded. Multi...
Source: Journal of Neurosurgery - January 18, 2019 Category: Neurosurgery Authors: Juloori A, Miller JA, Parsai S, Kotecha R, Ahluwalia MS, Mohammadi AM, Murphy ES, Suh JH, Barnett GH, Yu JS, Vogelbaum MA, Rini B, Garcia J, Stevens GH, Angelov L, Chao ST Tags: J Neurosurg Source Type: research

The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial
AbstractFor the treatment of metastatic renal cell cancer several strategies are used among which the mTOR inhibitor everolimus. As mTOR plays an important role in the immune system, e.g., by controlling the expression of the transcription factor FoxP3 thereby regulating regulatory T cells (Tregs), it plays a key role in the balance between tolerance and inflammation. Previous reports showed stimulatory effects of mTOR inhibition on the expansion of Tregs, an effect that can be considered detrimental in terms of cancer control. Since metronomic cyclophosphamide (CTX) was shown to selectively deplete Tregs, a phase 1 clinic...
Source: Cancer Immunology, Immunotherapy - January 17, 2019 Category: Cancer & Oncology Source Type: research

Renal Medullary Carcinoma: a Report of the Current Literature
We present an updated report of renal medullary carcinoma (RMC), a rare and aggressive condition.Recent FindingsThere is a majority of male patients, of African descent, in the second or third decade of life. In differential diagnosis, other tumors, such as malignant rhabdoid tumor (MRT), vinculin-anaplastic lymphoma kinase (VCL-ALK) translocation renal cell carcinoma, and collecting duct carcinoma, may present difficulties. Abnormalities of tumor suppressor gene SMARCB1 have been found in RMC. Reported symptoms were hematuria, pain, weight loss, respiratory distress, palpable mass, cough, and fever. Most patients present ...
Source: Current Urology Reports - January 17, 2019 Category: Urology & Nephrology Source Type: research

Metachronous isolated splenic metastasis in a young patient with renal cell carcinoma: case report and literature review
Splenic metastasis is uncommon and is usually associated with widespread disease.1,2 Isolated splenic metastases from renal cancer are also rarer and are often an incidental finding. This eventuality may turn into a dangerous scenario due to a spontaneous splenic rupture leading to sudden death.2,3 At the best of our knowledge only few cases of metastasis from renal cell carcinoma (RCC) have been documented in the literature.4-11 We hereby present a literature review of these cases and report a case of isolated splenic metastasis in a young man on active follow-up for a clear cell ccRCC. (Source: Urology)
Source: Urology - January 16, 2019 Category: Urology & Nephrology Authors: M Costantini, G Tuderti, F Minisola, V Pompeo, S Sentinelli, CA Amoreo, G Vallati, ML Poeta, M Gallucci, G Simone Source Type: research

N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1 α signalling axis.
N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis. J Cell Mol Med. 2019 Jan 16;: Authors: Zhuang C, Zhuang C, Luo X, Huang X, Yao L, Li J, Li Y, Xiong T, Ye J, Zhang F, Gui Y Abstract The abundant and reversible N6-methyladenosine (m6A) RNA modification and its modulators have important roles in regulating various gene expression and biological processes. Here, we demonstrate that fat mass and obesity associated (FTO), as an m6A demethylase, plays a critical anti-tumorigenic role in clear cell renal cell carcinoma (ccRCC). FT...
Source: J Cell Mol Med - January 16, 2019 Category: Molecular Biology Authors: Zhuang C, Zhuang C, Luo X, Huang X, Yao L, Li J, Li Y, Xiong T, Ye J, Zhang F, Gui Y Tags: J Cell Mol Med Source Type: research

Expression and Mutation Patterns of PBRM1, BAP1 and SETD2 Mirror Specific Evolutionary Subtypes in Clear Cell Renal Cell Carcinoma.
Schraml P Abstract Bi-allelic inactivation of the VHL gene on chromosome 3p is the characteristic feature in most clear cell renal cell carcinomas (ccRCC). Frequent gene alterations were also identified in SETD2, BAP1 and PBRM1, all of which are situated on chromosome 3p and encode histone/chromatin regulators. The relationship between gene mutation, loss of protein expression and the correlations with clinicopathological parameters is important for the understanding of renal cancer progression. We analyzed PBRM1 and BAP1 protein expression as well as the tri-methylation state of H3K36 as a surrogate marker for SE...
Source: Neoplasia - January 16, 2019 Category: Cancer & Oncology Authors: Bihr S, Ohashi R, Moore AL, Rüschoff JH, Beisel C, Hermanns T, Mischo A, Corrò C, Beyer J, Beerenwinkel N, Moch H, Schraml P Tags: Neoplasia Source Type: research

The Microbiome and Genitourinary Cancer: A Collaborative Review
ConclusionsThe role of the microbiome in genitourinary cancer is an emerging field that merits further studies. Translating microbiome research into clinical action will require incorporation of microbiome surveillance into ongoing and future clinical trials as well as expansion of studies to include metagenomic sequencing and metabolomics.Patient summaryThis review covers recent evidence that microbial populations that reside in the genitourinary tract—and were previously not known to exist—may influence the development of genitourinary malignancies including bladder, kidney, and prostate cancers. Furthermore,...
Source: European Urology - January 15, 2019 Category: Urology & Nephrology Source Type: research

Differences in Tumor VHL Mutation and Hypoxia-inducible Factor 2α Expression Between African American and White Patients with Clear Cell Renal Cell Carcinoma
Publication date: Available online 15 January 2019Source: European UrologyAuthor(s): Catherine L. Callahan, Lee Moore, Petra Lenz, W. Marston Linehan, Michael L. Nickerson, Nathaniel Rothman, Mark P. Purdue (Source: European Urology)
Source: European Urology - January 15, 2019 Category: Urology & Nephrology Source Type: research

A Return to the Days of Radical Nephrectomy as the “Gold Standard” for Localized Renal Cell Carcinoma? Not So Fast
Publication date: Available online 14 January 2019Source: European UrologyAuthor(s): Ithaar H. Derweesh, Michael Staehler, Robert G. Uzzo (Source: European Urology)
Source: European Urology - January 15, 2019 Category: Urology & Nephrology Source Type: research

A Critical Insight into the Clinical Translation of PD-1/PD-L1 Blockade Therapy in Clear Cell Renal Cell Carcinoma
AbstractPurpose of ReviewTargeting PD-1/PD-L1 immune checkpoints is a new therapeutic tool in patients with locally advanced and metastatic clear cell renal cell carcinoma (CCRCC). The purpose of this review is to offer clinicians an updated translational insight into the current status of a therapeutic alternative that may impact significantly patient ’s life.Recent FindingsImmune checkpoint inhibition has recently demonstrated promising results in selected CCRCC patients with respect to tumor progression and survival. The decision to treat these patients with immune checkpoint inhibitors (ICI) relies on the immunoh...
Source: Current Urology Reports - January 15, 2019 Category: Urology & Nephrology Source Type: research

Serum Hepcidin and GDF-15 levels as prognostic markers in urothelial carcinoma of the upper urinary tract and renal cell carcinoma
Cancer is a life-threatening disease that causes every fourth death. It is often hard to determine the time point of progression. Therefore, biomarkers for cancer entities that indicate disease progression or ... (Source: BMC Cancer)
Source: BMC Cancer - January 15, 2019 Category: Cancer & Oncology Authors: Lisa Traeger, Ines Ellermann, Helene Wiethoff, Janina Ihbe, Inka Gallitz, Maria Eveslage, Rudolf Moritz, Edwin Herrmann, Andres Jan Schrader and Andrea U. Steinbicker Tags: Research article Source Type: research

Body mass index as an independent risk factor for inferior vena cava resection during thrombectomy for venous tumor thrombus of renal cell carcinoma
To define preoperative clinical and radiographic risk factors for the need of inferior vena cava (IVC) resection in patients with renal cell carcinoma (RCC) and IVC tumor thrombus. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - January 15, 2019 Category: Cancer & Oncology Authors: Bin-Shuai Wang, Run-Zhuo Ma, Yu-Qing Liu, Zhuo Liu, Li-Yuan Tao, Min Lu, Guo-Liang Wang, Shu-Dong Zhang, Jian Lu and Lu-Lin Ma Tags: Research Source Type: research

Usefulness of rapid kV-switching dual energy CT in renal tumor characterization
AbstractPurposeTo investigate whether iodine content can discriminate between benign or malignant renal tumors, malign tumor subtypes, low-grade and high-grade tumors on rapid kv-switching dual-energy CT (rsDECT).MethodsThis prospective study enrolled 95 patients with renal tumors who underwent rsDECT for tumor characterization between 2016 and 2018. Attenuation on true and virtual unenhanced images, absolute enhancement and enhancement ratio and iodine content of each lesion on nephrographic phase iodine density images were measured. Histopathological diagnosis was obtained following either surgery or core biopsy.ResultsE...
Source: Abdominal Imaging - January 14, 2019 Category: Radiology Source Type: research

Evolving Clinical Picture of Renal Cell Carcinoma: A Population-Based Study from Helsinki
Conclusions: The size of renal tumors continued to decrease, while the percentage of patients with significant comorbidity or frailty increased. Active surveillance emerged as the initial strategy. Tyrosine kinase inhibitors with CN remained the primary option in patients with metastatic RCC.Urol Int (Source: Urologia Internationalis)
Source: Urologia Internationalis - January 13, 2019 Category: Urology & Nephrology Source Type: research

Impaired Retinal Circulation during Axitinib Treatment for Metastatic Renal Cell Carcinoma
Conclusion: Clinicians should be aware of retinal circulatory disorder that can occur in patients under axitinib treatment.Case Rep Ophthalmol 2019;10:5 –10 (Source: Case Reports in Ophthalmology)
Source: Case Reports in Ophthalmology - January 13, 2019 Category: Opthalmology Source Type: research

Clinical Significance of Preoperative Embolization for Non-Hypervascular Metastatic Spine Tumors.
CONCLUSION: Preoperative embolization for non-hypervascular MSD did not reduce perioperative blood loss. However, the embolization significantly reduced intraoperative bleeding and total transfusion in corpectomy group. Moreover, the procedure provided insights into the anatomy of tumor and spinal cord vasculature. PMID: 30630297 [PubMed] (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - January 12, 2019 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

The Associations of Fruit and Vegetable Intakes with Burden of Diseases: A Systematic Review of Meta-Analyses
ConclusionsThis systematic review supports existing recommendations for fruit and vegetable intakes. Current comparative risk assessments might significantly underestimate the protective associations of fruit and vegetable intakes. (Source: Journal of the Academy of Nutrition and Dietetics)
Source: Journal of the Academy of Nutrition and Dietetics - January 12, 2019 Category: Nutrition Source Type: research

Metastatic renal cell carcinoma presenting with both acute stroke and an oral lesion
Publication date: Available online 11 January 2019Source: Urology Case ReportsAuthor(s): Alexander L. Nesbitt, Zhong Li Titus Lim, Kit June Chan, Ibrahim Zardawi, Simon W. Pridgeon (Source: Urology Case Reports)
Source: Urology Case Reports - January 12, 2019 Category: Urology & Nephrology Source Type: research

Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis).
In this study, we established a cell line that is applicable to the study of tree shrew innate immune responses against viral infections. The Chinese tree shrew primary renal cells (TSPRCs) were immortalized by simian virus 40 large T antigen (SV40LT) transduction, and the immortalized cells were termed TSR6 (tree shrew renal cell #6). TSR6 showed a similar morphology to TSPRCs and expressed the epithelial cell-specific marker cytokeratin 18 (KRT18). In addition, TSR6 could be transfected by transfection reagent and was suitable for CRISPR/Cas9-mediated gene editing. Infection of Newcastle disease virus (NDV) or herpes sim...
Source: Applied Microbiology and Biotechnology - January 12, 2019 Category: Microbiology Authors: Gu T, Yu D, Li Y, Xu L, Yao YL, Yao YG Tags: Appl Microbiol Biotechnol Source Type: research

Autophagy inhibition to augment mTOR inhibition: A phase I/II trial of everolimus and hydroxychloroquine in patients with previously treated renal cell carcinoma.
Conclusion Combined HCQ 600mg twice daily with 10 mg daily everolimus was tolerable. The primary endpoint of>40% 6 month PFS rate was met. HCQ is a tolerable autophagy inhibitor in future RCC or other trials. PMID: 30635337 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - January 11, 2019 Category: Cancer & Oncology Authors: Haas NB, Appleman LJ, Stein M, Redlinger M, Wilks M, Xu X, Onorati A, Kalavacharla A, Kim T, Zhen CJ, Kadri S, Segal JP, Gimotty PA, Davis LE, Amaravadi RK Tags: Clin Cancer Res Source Type: research

Trend of Surgical Treatment of Localized Renal Cell Carcinoma.
Authors: Jabaji RB, Fischer H, Kern T, Chien GW Abstract INTRODUCTION: Rapid adoption of robotics has introduced a paradigm change in prostate cancer treatment, with more than 80% of prostatectomies performed robotically in 2015. For treatment of renal cell carcinoma (RCC), this change has not previously been reported. We evaluated trends in surgical management of RCC in Kaiser Permanente Southern California (KPSC) within the last 16 years, especially after adoption of robotics. METHODS: From January 1999 to September 2015, all KPSC members who underwent surgical treatment of suspected RCC were included retrosp...
Source: The Permanente journal - January 10, 2019 Category: General Medicine Tags: Perm J Source Type: research

The Evolving Landscape of Immunotherapy-Based Combinations for Frontline Treatment of Advanced Renal Cell Carcinoma
Asim Amin, Hans Hammers (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - January 10, 2019 Category: Allergy & Immunology Source Type: research

Gallbladder Metastasis from Renal Cell Carcinoma: A Case Report and Literature Review
Publication date: Available online 8 January 2019Source: Urology Case ReportsAuthor(s): Kimiaki Takagi, Kota Kawase, Kenichi Minoshima, Masayoshi Yamaha, Yuka Maekawa, Shigeaki Yokoi, Mitsuhiko Kusakabe, Masanobu Horie (Source: Urology Case Reports)
Source: Urology Case Reports - January 9, 2019 Category: Urology & Nephrology Source Type: research

Upregulation of miR-489-3p and miR-630 inhibits oxaliplatin uptake in renal cell carcinoma by targeting OCT2
In this study, we observed that miR-489-3p and miR-630 suppress OCT2 expression by directly binding to the OCT2 3ʹ-UTR. Meanwhile, via 786-O-OCT2-miRNAs stable expression cell models, we found that miRNAs could repress the classic substrate 1-methyl-4-phenylpyridinium (MPP+), fluorogenic substrate N,N-dimethyl-4-(2-pyridin-4-ylethenyl) aniline (ASP+), and oxaliplatin uptake by OCT2 both in vitro and in xenografts. In 33 clinical samples, miR-489-3p and miR-630 were significantly upregulated in RCC, negatively correlating with the OCT2 expression level compared to that in adjacent normal tissues, using tissue microarray an...
Source: Acta Pharmaceutica Sinica B - January 9, 2019 Category: Cancer & Oncology Source Type: research

Dual-Tracer PET/CT Differentiates 2 Types of Primary Cancers and Metastases in a Patient With Crossed Fused Renal Ectopia
A patient was found incidentally on dual-tracer (11C-acetate [ACT] and 18F-FDG [FDG]) PET/CT for having crossed fused renal ectopia and 2 types of malignant tumors, colonic carcinoma and renal cell carcinoma (RCC), each having its own characteristic tracer avidity. Multiple liver metastases were also mutually exclusive, with a purely ACT-avid group of metastatic lesions from RCC and another FDG-avid group from colonic carcinoma. Bone and lung metastases, however, could not be readily distinguishable in terms of primary origins. Crossed fused renal ectopia is a rare anomaly, even rarer to have RCC coexisting with a second p...
Source: Clinical Nuclear Medicine - January 9, 2019 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation
Publication date: 8 January 2019Source: Cell Reports, Volume 26, Issue 2Author(s): Yuting Sun, Madhavi Bandi, Timothy Lofton, Melinda Smith, Christopher A. Bristow, Alessandro Carugo, Norma Rogers, Paul Leonard, Qing Chang, Robert Mullinax, Jing Han, Xi Shi, Sahil Seth, Brooke A. Meyers, Meredith Miller, Lili Miao, Xiaoyan Ma, Ningping Feng, Virginia Giuliani, Mary Geck DoSummaryThe plasticity of a preexisting regulatory circuit compromises the effectiveness of targeted therapies, and leveraging genetic vulnerabilities in cancer cells may overcome such adaptations. Hereditary leiomyomatosis renal cell carcinoma (HLRCC) is ...
Source: Cell Reports - January 9, 2019 Category: Cytology Source Type: research

Soluble Ligand of the Immune Checkpoint Receptor (sPD-L1) in Blood Serum of Patients with Renal Cell Carcinoma
The content of the soluble ligand of the immune checkpoint receptor (sPD-L1) was determined in the blood serum of 106 patients with renal cell carcinoma and 11 patients with benign kidney tumors by direct ELISA (Human sPD-L1 Platinum ELISA; Affimetrix, eBioscience). The control group included 19 healthy men and 18 women. Serum level of sPD-L1 significantly surpassed the control values in both patients with primary renal cancer (p
Source: Bulletin of Experimental Biology and Medicine - January 9, 2019 Category: Biology Source Type: research

[Follow-up of renal cell carcinoma in a nonmetastatic stage].
Abstract Postoperative follow-up care after curative surgery or ablative treatment is the standard of care in patients with nonmetastatic renal cell carcinoma. The goal is to identify and treat postoperative complications and local recurrences early on. Follow-up investigations and their relevance are widely acknowledged and validated and patients undergoing follow-up seem to benefit from a longer survival in nonmetastatic renal cell carcinoma. Hence there is no consensus on a standardized follow-up strategy. The most disputed question is around the frequency of the investigations and the duration of the foll...
Source: Der Urologe. Ausg. A - January 9, 2019 Category: Urology & Nephrology Authors: Szabados B, Foller S, Schulz GB, Staehler M, Grimm MO, Stief CG, Casuscelli J Tags: Urologe A Source Type: research

Long non-coding RNA ZFAS1 promotes proliferation and metastasis of clear cell renal cell carcinoma via targeting miR-10a/SKA1 pathway
ConclusionsTaken together, our findings suggest that ZFAS1 promotes growth and metastasis of ccRCC via targeting miR-10a/SKA1 pathway, which may represent a novel therapeutic target or biomarker for ccRCC.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - January 8, 2019 Category: Drugs & Pharmacology Source Type: research

Hypoxia, angiogenesis, and metabolism in the hereditary kidney cancers
The field of hereditary kidney cancer has begun to mature following the identification of several germline syndromes that define genetic and molecular features of this cancer. Molecular defects within these hereditary syndromes demonstrate consistent deficits in angiogenesis and metabolic signaling, largely driven by altered hypoxia signaling. The classical mutation, loss of function of the von Hippel-Lindau (VHL) tumor suppressor, provides a human pathogenesis model for critical aspects of pseudohypoxia. These features are mimicked in a less common hereditary renal tumor syndrome, known as hereditary leiomyomatosis and re...
Source: Journal of Clinical Investigation - January 8, 2019 Category: Biomedical Science Authors: John C. Chappell, Laura Beth Payne, W. Kimryn Rathmell Source Type: research

Tubulocystic renal cell carcinoma: a distinct clinicopathologic entity with a characteristic genomic profile
Tubulocystic renal cell carcinoma: a distinct clinicopathologic entity with a characteristic genomic profile, Published online: 08 January 2019; doi:10.1038/s41379-018-0185-5Tubulocystic renal cell carcinoma: a distinct clinicopathologic entity with a characteristic genomic profile (Source: Modern Pathology)
Source: Modern Pathology - January 8, 2019 Category: Pathology Authors: Judy Sarungbam Rohit Mehra Scott A. Tomlins Steven C. Smith Gowtham Jayakumaran Hikmat Al- Ahmadie Anuradha Gopalan Sahussapont J. Sirintrapun Samson W. Fine Yanming Zhang Mahul B. Amin Victor E. Reuter Ying-Bei Chen Satish K. Tickoo Source Type: research

NEAT1-TFE3 and KAT6A-TFE3 renal cell carcinomas, new members of MiT family translocation renal cell carcinoma
NEAT1-TFE3 and KAT6A-TFE3 renal cell carcinomas, new members of MiT family translocation renal cell carcinoma, Published online: 08 January 2019; doi:10.1038/s41379-018-0191-7NEAT1-TFE3 and KAT6A-TFE3 renal cell carcinomas, new members of MiT family translocation renal cell carcinoma (Source: Modern Pathology)
Source: Modern Pathology - January 8, 2019 Category: Pathology Authors: Jianming Pei Harry Cooper Douglas B. Flieder Jacqueline N. Talarchek Tahseen Al-Saleem Robert G. Uzzo Essel Dulaimi Arthur S. Patchefsky Joseph R. Testa Shuanzeng Wei Source Type: research