Meta-analysis of Platelet Lymphocyte Ratio as A Prognostic Factor for 
Non-small Cell Lung Cancer
Background and objective Current research shows that platelet to lymphocyte ratio (PLR) has important prognostic value in renal cell carcinoma, esophageal cancer, gastric cancer, liver cancer and colon cancer. The aim of the study is to evaluate the prognostic value of PLR in non-small cell lung cancer (NSCLC) through meta-analysis. Methods Literature search for PubMed, EMBASE, Web of Science, Medline, Cochrane Library, China National Knowledge Internet (CNKI), China Biomedical Medicine disc (CBMdisc), VIP, Wanfang Database using computer electronic system to study the association between PLR and overall survival (OS) and ...
Source: Chinese Journal of Lung Cancer - May 20, 2019 Category: Cancer & Oncology Source Type: research

Nodular lesions on the upper trunk: An uncommon anatomical site of renal tumor metastases
We present a case of a 56-year-old male with a history of RCC, followed by the development of cutaneous metastases 4 years later with an uncommon clinical presentation. RCC is the most common genitourinary cancer to metastasize to the skin and accounts for 6.8% of cutaneous metastases. These patients have a poor prognosis. It is essential for these patients to perform a complete periodic dermatologic examination for proper restaging and treatment. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - May 20, 2019 Category: Dermatology Authors: Nikolaos Kostopoulos Eftychia Platsidaki Vasiliki Tzanetakou Konstantina Petraki Maria Lekarakou Dimitrios Bafaloukos Irini Potouridou Source Type: research

Cryoablation and immunotherapy: an overview of evidence on its synergy
AbstractCancer cells can escape the immune system by different mechanisms. The evasion of cancer cells from immune surveillance is prevented by immune checkpoint inhibitors, allowing the patient ’s own immune system to attack their cancer. Immune checkpoint inhibitors have shown improvement in overall survival for melanoma, lung cancer and renal cell carcinoma in clinical trials. Unfortunately, not all patients respond to this therapy.In cancer management, percutaneous ablation techniques are well established for both cure and local control of many tumour types. Cryoablation of the tumour tissue results in cell destr...
Source: Insights into Imaging - May 20, 2019 Category: Radiology Source Type: research

Methylation Signature for Prediction of Progression Free Survival in Surgically Treated Clear Cell Renal Cell Carcinoma.
CONCLUSION: The promoter methylation of ZNF278, FAM155A and DPP6 genes are associated with aggressive tumor phenotype and early development of distant metastasis in patients with surgically treated ccRCC. These potential methylation markers, either alone, or in combination, could provide novel targets for development of individualized therapeutic and prevention regimens. PMID: 31099194 [PubMed - in process] (Source: J Korean Med Sci)
Source: J Korean Med Sci - May 18, 2019 Category: General Medicine Authors: Kang HW, Park H, Seo SP, Byun YJ, Piao XM, Kim SM, Kim WT, Yun SJ, Jang W, Shon HS, Ryu KH, Lee SC, Kim WJ, Kim YJ Tags: J Korean Med Sci Source Type: research

Circular RNA circHIAT1 inhibits cell growth in hepatocellular carcinoma by regulating miR-3171/PTEN axis
Publication date: August 2019Source: Biomedicine & Pharmacotherapy, Volume 116Author(s): Zhengmiao Wang, Yixuan Zhao, Ye Wang, Chunxiang JinAbstractCircular RNAs (circRNAs), a novel subgroup of non-coding RNAs (ncRNAs), have been reported in human cancers due to their significant regulatory roles. CircRNA Hippocampus Abundant Transcript 1 (circHIAT1) has been studied in clear cell renal cell carcinoma. However, whether it can regulate the tumorigenesis of hepatocellular carcinoma (HCC) remains unclear. The expression level of circHIAT1 in HCC samples and cell lines was measured by qRT-PCR analysis. CircHIAT1 was expres...
Source: Biomedicine and Pharmacotherapy - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Expression and clinical value of CD105 in renal cell carcinoma based on data mining in The Cancer Genome Atlas.
The objective of the present study was to assess the expression of CD105 and its association with overall survival in three subtypes of renal cell carcinoma (RCC), namely clear cell (cc)RCC, papillary (p)RCC and chromophobe (ch)RCC. Data regarding the transcriptome and copy number of genes in RCC tumor samples and survival were obtained from The Cancer Genome Atlas. Bioinformatics analysis revealed that CD105 is overexpressed in ccRCC tumor tissue vs. normal renal tissue, and a higher CD105 copy number in ccRCC tissues was significantly associated with longer patient survival. The effect of the mRNA expression of CD105 in ...
Source: Experimental and Therapeutic Medicine - May 17, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Impact of Tumor Size on Cancer-Specific Mortality Rate After Local Tumor Ablation in T1a Renal-Cell Carcinoma
Journal of Endourology, Ahead of Print. (Source: Journal of Endourology)
Source: Journal of Endourology - May 17, 2019 Category: Urology & Nephrology Authors: Carlotta Palumbo Sarah-Jeanne Cyr Elio Mazzone Francesco A. Mistretta Sophie Knipper Angela Pecoraro Zhe Tian Shahrokh F. Shariat Fred Saad Claudio Simeone Alberto Briganti Anil Kapoor Alessandro Antonelli Pierre I. Karakiewicz Source Type: research

High Membranous Expression of Fatty Acid Transport Protein 4 Is Associated with Tumorigenesis and Tumor Progression in Clear Cell Renal Cell Carcinoma.
In conclusion, the high FATP4 expression was clinically associated with poor prognostic factors of RCC. Overexpression of membranous FATP4 and CD36 combined with reduced cytoplasmic expression of ACSL1 might be a tumor-specific feature of RCC, contributing to the tumorigenesis and tumor progression. PMID: 31089396 [PubMed - in process] (Source: Disease Markers)
Source: Disease Markers - May 16, 2019 Category: Laboratory Medicine Tags: Dis Markers Source Type: research

HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells
Publication date: Available online 14 May 2019Source: Redox BiologyAuthor(s): Ruifang Teng, Zongyuan Liu, Haiping Tang, Wenhao Zhang, Yuling Chen, Renhua Xu, Liang Chen, Jiangping Song, Xiaohui Liu, Haiteng DengAbstractHSP60 is a major mitochondrial chaperone for maintaining mitochondrial proteostasis. Our previous studies showed that HSP60 was significantly downregulated in clear cell renal cell carcinoma (ccRCC), the most common type of kidney cancer characterized by the classic Warburg effect. Here, we analyzed datasets in The Cancer Genome Atlas and revealed that higher HSP60 expression correlated with better overall s...
Source: Redox Biology - May 16, 2019 Category: Biology Source Type: research

Association of an organ transplant-based approach with a dramatic reduction in postoperative complications following radical nephrectomy and tumor thrombectomy in renal cell carcinoma
Publication date: Available online 15 May 2019Source: European Journal of Surgical OncologyAuthor(s): Javier González, Jeffrey J. Gaynor, Juan I. Martínez-Salamanca, Umberto Capitanio, Derya Tilki, Joaquín A. Carballido, Venancio Chantada, Siamak Daneshmand, Christopher P. Evans, Claudia Gasch, Paolo Gontero, Axel Haferkamp, William C. Huang, Estefania Linares Espinós, Viraj A. Master, James M. McKiernan, Francesco Montorsi, Sascha Pahernik, Juan Palou, Raj S. PruthiAbstractObjectivesOur aim was to determine whether using an organ transplant-based(TB) approach reduces postoperative complications...
Source: European Journal of Surgical Oncology (EJSO) - May 16, 2019 Category: Surgery Source Type: research

c-FLIP and CD95 signaling are essential for survival of renal cell carcinoma
Cell Death & Disease, Published online: 16 May 2019; doi:10.1038/s41419-019-1609-yc-FLIP and CD95 signaling are essential for survival of renal cell carcinoma (Source: Cell death and disease)
Source: Cell death and disease - May 16, 2019 Category: Internal Medicine Authors: Tobias Luebke Lisa Schwarz Yan Yan Beer Sabrina Schumann Maria Misterek Frida Ewald Sander Carlos Plaza-Sirvent Ingo Schmitz Source Type: research

A phase II trial of intermittent nivolumab in patients with metastatic renal cell carcinoma (mRCC) who have received prior anti-angiogenic therapy
ConclusionsThis prospective experience of intermittent nivolumab dosing in mRCC supports further investigation of intermittent immunotherapy dosing strategies in RCC.Trial registrationNCT03126331 (Intermittent Nivolumab in Metastatic Renal Cell Carcinoma Patients; Date of registration 4/27/2017; (Source: Journal for Immunotherapy of Cancer)
Source: Journal for Immunotherapy of Cancer - May 16, 2019 Category: Cancer & Oncology Source Type: research

The Classification of Renal Cancer in 3-Phase CT Images Using a Deep Learning Method
AbstractIn this research, we exploit an image-based deep learning framework to distinguish three major subtypes of renal cell carcinoma (clear cell, papillary, and chromophobe) using images acquired with computed tomography (CT). A biopsy-proven benchmarking dataset was built from 169 renal cancer cases. In each case, images were acquired at three phases(phase 1, before injection of the contrast agent; phase 2, 1  min after the injection; phase 3, 5 min after the injection). After image acquisition, rectangular ROI (region of interest) in each phase image was marked by radiologists. After cropping the ROIs, a com...
Source: Journal of Digital Imaging - May 16, 2019 Category: Radiology Source Type: research

HOXA6 inhibits cell proliferation and induces apoptosis by suppressing the PI3K/Akt signaling pathway in clear cell renal cell carcinoma.
Abstract Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cell carcinoma and the incidence of this disease is increasing. The present study aimed to investigate the role of homeobox A6 (HOXA6) in the proliferation and apoptosis of ccRCC cells. Analysis of the GSE6344 dataset and immunohistochemistry revealed that the mRNA and protein expression levels of HOXA6 were suppressed in ccRCC tissues. To evaluate the roles of HOXA6 in cell proliferation and apoptosis, ccRCC cell lines (786‑O and 769‑P) were transfected with plasmids expressing HOXA6, empty vector, short hairpin (sh)HOXA6 a...
Source: International Journal of Oncology - May 15, 2019 Category: Cancer & Oncology Authors: Wu F, Wu S, Tong H, He W, Gou X Tags: Int J Oncol Source Type: research

Positive/retained SDHB immunostaining in renal cell carcinomas associated to germline SDHB-deficiency: case report
According to WHO, succinate dehydrogenase (SDH) –deficient renal cell carcinoma is characterized by negative immunostaining for SDHB, which remains positive in non-tumor tissue despite germline mutations in the SD... (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - May 15, 2019 Category: Pathology Authors: Marina Ugarte-Camara, Raul Fernandez-Prado, Isabel Lorda, Gabriela Rossello, Carmen Gonzalez-Enguita, Pablo Cannata-Ortiz and Alberto Ortiz Tags: Case Report Source Type: research

Whole-Exome Sequencing Identifies Somatic Mutations Associated With Mortality in Metastatic Clear Cell Kidney Carcinoma
Clear cell renal cell carcinoma (ccRCC) is among the most aggressive histologic subtypes of kidney cancer, representing about 3% of all human cancers. Patients at stage IV have nearly 60% of mortality in 2–3 years after diagnosis. To date, most ccRCC studies have used DNA microarrays and targeted sequencing of a small set of well-established, commonly altered genes. An exception is the large multi-omics study of The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma (TCGA-KIRC), which identified new ccRCC genes based on whole exome-sequencing (WES) data, and molecular prognostic signatures based on transcriptomics...
Source: Frontiers in Genetics - May 15, 2019 Category: Genetics & Stem Cells Source Type: research

PPARG Negatively Modulates Six2 in Tumor Formation of Clear Cell Renal Cell Carcinoma
DNA and Cell Biology, Ahead of Print. (Source: DNA and Cell Biology)
Source: DNA and Cell Biology - May 15, 2019 Category: Cytology Authors: Yafei Wu Tao Song Mingwei Liu Qingling He Lei Chen Yamin Liu Dongsheng Ni Jianing Liu Yanxia Hu Yuping Gu Qianyin Li Qin Zhou Yajun Xie Source Type: research

Long Term Remission and Cardiac Toxicity of a Combination of Ipilimumab and Nivolumab in a Patient With Metastatic Head and Neck Carcinoma After Progression Following Nivolumab Monotherapy
This report is about a patient with metastastic squamous cell cancer of the head and neck refractory to nivolumab monotherapy, who showed a remarkable response to combination therapy with nivolumab and ipilimumab over a period of 2 years, but developed serious renal failure and a Takotsubo cardiomyopathy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - May 15, 2019 Category: Cancer & Oncology Source Type: research

Regulation of OCT2 transcriptional repression by histone acetylation in renal cell carcinoma
. (Source: Epigenetics)
Source: Epigenetics - May 15, 2019 Category: Genetics & Stem Cells Authors: Qianying Zhu Lushan Yu Zhiyuan Qin Lu Chen Haihong Hu Xiaoli Zheng Su Zeng Source Type: research

[Renal cell carcinoma diagnosis and prognosis within the context of the WHO classification 2016].
DISCUSSION: The complexity of the 2016 WHO classification of RCC put high demands on histopathological diagnostics. At University Medicine Center Rostock morphological distinct RCC entities have been mostly diagnosed by conventional means via hematoxillin and eosin stained slides, but beyond immunohistochemistry additionally molecular techniques were established. The histologic subtyping of RCC according to 2016 WHO classification has prognostic significance and might have predictive significance for unique therapeutic approaches. PMID: 31093717 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)
Source: Der Urologe. Ausg. A - May 15, 2019 Category: Urology & Nephrology Authors: Zimpfer A, Glass Ä, Zettl H, Maruschke M, Hakenberg OW, Erbersdobler A Tags: Urologe A Source Type: research

Failed immune responses across multiple pathologies share pan-tumor and circulating lymphocytic targets
Tumor-infiltrating lymphocytes (TILs) are widely associated with positive outcomes, yet carry key indicators of a systemic failed immune response against unresolved cancer. Cancer immunotherapies can reverse their tolerance phenotypes while preserving tumor reactivity and neoantigen specificity shared with circulating immune cells. We performed comprehensive transcriptomic analyses to identify gene signatures common to circulating and TILs in the context of clear cell renal cell carcinoma. Modulated genes also associated with disease outcome were validated in other cancer types. Through comprehensive bioinformatics analyse...
Source: Journal of Clinical Investigation - May 14, 2019 Category: Biomedical Science Authors: Anne Monette, Antigoni Morou, Nadia A. Al-Banna, Louise Rousseau, Jean-Baptiste Lattouf, Sara Rahmati, Tomas Tokar, Jean-Pierre Routy, Jean-François Cailhier, Daniel E. Kaufmann, Igor Jurisica, Réjean Lapointe Source Type: research

Smooth Muscle Tumors of the Female Genital Tract
This article provides an overview of smooth muscle tumors of each major organ of the gynecologic tract and discusses diagnostic challenges. (Source: Surgical Pathology Clinics)
Source: Surgical Pathology Clinics - May 14, 2019 Category: Pathology Authors: Kelly A. Devereaux, J. Kenneth Schoolmeester Source Type: research

Overexpression of SNHG12 regulates the viability and invasion of renal cell carcinoma cells through modulation of HIF1 α
Cumulative evidences demonstrated the aberrant overexpression of Small Nucleolar RNA Host Gene 12 (SNHG12) in diverse human cancer. However, the expression status and involvement of SNHG12 in renal cell carcin... (Source: Cancer Cell International)
Source: Cancer Cell International - May 14, 2019 Category: Cancer & Oncology Authors: Qiguang Chen, Wei Zhou, Shu-qi Du, Da-xin Gong, Jun Li, Jian-bin Bi, Zhen-hua Li, Zhe Zhang, Ze-liang Li, Xian-kui Liu and Chui-ze Kong Tags: Primary research Source Type: research

Recurrent pseudogout after therapy with immune checkpoint inhibitors: a case report with immunoprofiling of synovial fluid at each flare
ConclusionsThis case suggests a potential influence of Th17 cells on the neutrophil recruitment and neutrophil-driven inflammatory events leading to pseudogout induced by immune checkpoint inhibitor therapy. (Source: Journal for Immunotherapy of Cancer)
Source: Journal for Immunotherapy of Cancer - May 14, 2019 Category: Cancer & Oncology Source Type: research

Abscopal Effects in Radio-Immunotherapy —Response Analysis of Metastatic Cancer Patients With Progressive Disease Under Anti-PD-1 Immune Checkpoint Inhibition
Immune checkpoint inhibition (ICI) targeting the programmed death receptor 1 (PD-1) has shown promising results in the fight against cancer. Systemic anti-tumor reactions due to radiation therapy (RT) can lead to regression of non-irradiated lesions (NiLs), termed "abscopal effect" (AbE). Combination of both treatments can enhance this effect. The aim of this study was to evaluate AbEs during anti-PD-1 therapy and irradiation. We screened 168 patients receiving pembrolizumab or nivolumab at our center. Inclusion criteria were start of RT within 1 month after the first or last application of pembrolizumab (2mg/kg...
Source: Frontiers in Pharmacology - May 14, 2019 Category: Drugs & Pharmacology Source Type: research

Unusual metastasis of papillary renal cell carcinoma to the pyriform sinus: Case report
Renal cell carcinoma is the third most common cause of distant metastasis to the head and neck. Renal cell carcinoma metastasis should be considered in differential diagnosis when patients with a clinical history of renal cell carcinoma show a head and neck mass. AbstractRenal cell carcinoma is the third most common cause of distant metastasis to the head and neck. Renal cell carcinoma metastasis should be considered in differential diagnosis when patients with a clinical history of renal cell carcinoma show a head and neck mass. (Source: Clinical Case Reports)
Source: Clinical Case Reports - May 14, 2019 Category: General Medicine Authors: Edoardo Gioia, Filippo Carta, Cinzia Mariani, Clara Gerosa, Roberto Puxeddu Tags: CASE REPORT Source Type: research

Evaluating the Strength of the Association Between Industry Payments and Prescribing Practices in Oncology
Conclusion.The association between industry payments and cancer drug prescribing was greatest among physicians who received payments consistently (within each calendar year). Receipt of payments for compensation purposes, such as for consulting or travel, and higher dollar value of payments were also associated with increased prescribing.Implications for Practice.Financial payments from pharmaceutical companies are common among oncologists. It is known from prior work that oncologists tend to prescribe more of the drugs made by companies that have given them money. By combining records of industry gifts with prescribing re...
Source: The Oncologist - May 14, 2019 Category: Cancer & Oncology Authors: Aaron P. Mitchell, Aaron N. Winn, Jennifer L. Lund, Stacie B. Dusetzina Tags: Health Outcomes and Economics of Cancer Care Source Type: research

When Surgery Is Not an Option in Renal Cell Carcinoma: The Evolving Role of Stereotactic Body Radiation Therapy.
Abstract Historically, radiation therapy has played a limited role in the management of renal cell carcinoma because early studies showed that it had no benefit in the neoadjuvant or adjuvant settings. Thus, radiation has typically been employed for only palliation of metastatic sites. As the ability to deliver conformal high-dose-per-fraction radiation became available, studies began to show excellent local control when treating oligometastatic sites of renal cell carcinoma with stereotactic body radiation therapy (SBRT). Recently, SBRT has been studied in the management of the primary tumor in nonsurgical patien...
Source: Oncology (Williston Park, N.Y.) - May 14, 2019 Category: Cancer & Oncology Authors: Miccio J, Johung K Tags: Oncology (Williston Park) Source Type: research

Preoperative neutrophil-lymphocyte ratio as a predictor of overall survival in patients with localized renal cell carcinoma.
Abstract PURPOSE: The neutrophil-to-lymphocyte ratio (NLR), as an indicator of the systemic inflammatory response, predicts adverse outcomes in many malignancies. We investigated its prognostic significance in patients with non-metastatic renal cell carcinoma. MATERIALS AND METHODS: We retrospectively evaluated data of 196 consecutive non-metastatic RCC patients who underwent radical or partial nephrectomy between 2010 and 2012 at a single center. Overall survival (OS) was assessed using the Kaplan-Meier method and compared using the log-rank test. We applied univariate and multivariate Cox regression models ...
Source: Urology Journal - May 13, 2019 Category: Urology & Nephrology Authors: Widz D, Mitura P, Buraczynski P, Plaza P, Bar M, Cabanek M, Nowak G, Ostrowska A, Bar K Tags: Urol J Source Type: research

Safety of nivolumab in metastatic renal cell carcinoma patients: A real-life experience in a Spanish urology setting.
CONCLUSION: In the real-life clinical setting, nivolumab shows favourable outcomes, similar to those reported by other studies. PMID: 31097211 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - May 13, 2019 Category: Urology & Nephrology Authors: Amores Bermúdez J, Osman García I, Unda Urzáiz M, Jiménez Marrero P, Ledo Cepero MJ, Llarena R, Flores Martín J, Abad Vivas-Pérez JI, Rodrigo Aliaga M, Juarez Soto A Tags: Actas Urol Esp Source Type: research

[Laparoscopic renal cyst excision: Large simple renal cyst treatment with renal cell carcinoma cells in its wall. Histogenetic considerations and bibliographic review.]
CONCLUSION: The development of a renal cell carcinoma in simple renal cysts is a very infrequent pathology.Laparoscopic total cystectomy is a minimally invasive therapeutic option for the treatment of renal cell carcinoma originating in a simple renal cyst, although it is of an important size. We establish the hypothesis of migration of the cells of the renal collecting tubes into the cyst wall to explain the malignant transformation of the renal simple cyst. PMID: 31070139 [PubMed - in process] (Source: Archivos Espanoles de Urologia)
Source: Archivos Espanoles de Urologia - May 11, 2019 Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

Durable complete response in renal cell carcinoma clinical trials
Publication date: Available online 9 May 2019Source: The LancetAuthor(s): Patrick G Pilié, Eric Jonasch (Source: The Lancet)
Source: The Lancet - May 11, 2019 Category: General Medicine Source Type: research

Atezolizumab plus bevacizumab versus sunitinib in patients with previously untreated metastatic renal cell carcinoma (IMmotion151): a multicentre, open-label, phase 3, randomised controlled trial
Publication date: Available online 9 May 2019Source: The LancetAuthor(s): Brian I Rini, Thomas Powles, Michael B Atkins, Bernard Escudier, David F McDermott, Cristina Suarez, Sergio Bracarda, Walter M Stadler, Frede Donskov, Jae Lyun Lee, Robert Hawkins, Alain Ravaud, Boris Alekseev, Michael Staehler, Motohide Uemura, Ugo De Giorgi, Begoña Mellado, Camillo Porta, Bohuslav Melichar, Howard GurneySummaryBackgroundA phase 2 trial showed improved progression-free survival for atezolizumab plus bevacizumab versus sunitinib in patients with metastatic renal cell carcinoma who express programmed death-ligand 1 (PD-L1). Her...
Source: The Lancet - May 11, 2019 Category: General Medicine Source Type: research

Surgical Resection for Metastatic Tumors in the Pancreas: A Single-Center Experience and Systematic Review
AbstractBackgroundMetastatic lesion to the pancreas accounts for approximately 2% of pancreatic neoplasms. There is no prospective, randomized or case-controlled study evaluating the role of pancreatic metastasectomy.MethodsThe PubMed, EMBASE, and Cochrane Library electronic databases were searched for studies published between January 1, 2001 and December 31, 2017. Studies with five or more patients who received pancreatic metastasectomy and data from our institution (29 patients) were included. The Kaplan –Meier method was used for survival analysis.ResultsA total of 414 patients from 20 institutions who underwent ...
Source: Annals of Surgical Oncology - May 11, 2019 Category: Cancer & Oncology Source Type: research

Renal tuberculosis mimicking renal cell carcinoma: a  case report
ConclusionsThe pseudotumoral form of urinary tuberculosis can be difficult to diagnose. Only bacteriological or histological confirmation allows diagnosis for adequate treatment. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 11, 2019 Category: General Medicine Source Type: research

Immune suppression by PD-L2 against spontaneous and treatment-related antitumor immunity.
CONCLUSIONS: We propose that PD-L2 as well as PD-L1 play important roles in evading antitumor immunity, suggesting that PD-1/PD-L2 blockade must be considered for optimal immunotherapy in PD-L2-expressing cancers, such as RCC and LUSC. PMID: 31076547 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - May 10, 2019 Category: Cancer & Oncology Authors: Nishikawa H, Tanegashima T, Togashi Y, Azuma K, Kawahara A, Ideguchi K, Sugiyama D, Kinoshita F, Akiba J, Kashiwagi E, Takeuchi A, Irie T, Tatsugami K, Hoshino T, Eto M Tags: Clin Cancer Res Source Type: research

The effectiveness of RENAL nephrometry score in ablated renal tumors via radiofrequency ablation or cryoablation
Conclusion: Ablative therapies are minimally invasive and effective methods for treating small renal tumors. RENAL nephrometry scoring is a valuable system for standardizing renal tumors and evaluating the success of ablative therapies, possible complications, and oncological results. PMID: 31062941 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - May 9, 2019 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Survival and clinical prognostic factors in metastatic non ‐clear cell renal cell carcinoma treated with targeted therapy: A multi‐institutional, retrospective study using the Korean metastatic renal cell carcinoma registry
To the best of our knowledge, the current study is the largest nationwide study to investigate mNCCRCC treated with TT in Asian population. Also, the current study included the largest number of patients to date for comparing the efficacy of temsirolimus with other agents in mNCCRCC patients as first ‐line treatment. Even with significant improvement of survival, for the majority, survival in mNCCRCC patients is still inferior to that in mCCRCC patients in the current TT era, and we also found survival benefits in patients treated with first‐line VEGF‐TKIs/cytoreductive nephrectomy/metasta sectomy and metachronous me...
Source: Cancer Medicine - May 9, 2019 Category: Cancer & Oncology Authors: Jung Kwon Kim, Sung Han Kim, Mi Kyung Song, Jungnam Joo, Seong Il Seo, Cheol Kwak, Chang Wook Jeong, Cheryn Song, Eu Chang Hwang, Ill Young Seo, Hakmin Lee, Sung ‐Hoo Hong, Jae Young Park, Jinsoo Chung Tags: ORIGINAL RESEARCH Source Type: research

Current Status of Immunotherapy for Localized and Locally Advanced Renal Cell Carcinoma.
This article reviews the current status and future prospects of adjuvant and neoadjuvant immunotherapy in localized and locally advanced RCC. PMID: 31057615 [PubMed] (Source: Journal of Oncology)
Source: Journal of Oncology - May 8, 2019 Category: Cancer & Oncology Tags: J Oncol Source Type: research

Significance of PTEN Mutation in Cellular Process, Prognosis, and Drug Selection in Clear Cell Renal Cell Carcinoma
It is well established that PTEN (Phosphatase and Tensin Homolog) mutant is a frequently mutated gene in clear cell renal cell carcinoma (ccRCC), making it a potential biomarker for individualized treatment opinions. Here, in the present study, we designed to evaluate the significance of PTEN mutations in prognosis and drug selection in ccRCC, and to find out potential changing pathways and genes associated with the mechanisms. Latest TCGA data showed PTEN mutations in 5% ccRCC patients. In total, 2569 genes were identified as DEGs. GO and KEGG analysis suggested that DEGs were significantly enriched in categories associat...
Source: Frontiers in Oncology - May 8, 2019 Category: Cancer & Oncology Source Type: research

Use of Iodine Concentration in the Lipid-Poor Portion of the Renal Mass for Differentiation of Angiomyolipoma from Renal Cell Carcinoma
Cancer Biotherapy and Radiopharmaceuticals,Volume 34, Issue 4, Page 224-230, May 2019. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Source: Cancer Biotherapy and Radiopharmaceuticals - May 8, 2019 Category: Cancer & Oncology Authors: Jia Sun Xiao-Yan Zhang Xiao-Ting Li Yan-Ling Li Zhi-Long Wang Source Type: research

Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes
Trichloroethylene (TCE) and inorganic arsenic (iAs) are environmental contaminants that can target the kidney. Chronic exposure to TCE is associated with increased incidence of renal cell carcinoma, while co-exposure to TCE and iAs likely occurs in exposed human populations, such as those near Superfund sites. In order to better understand the kidney health consequences of TCE and/or iAs exposure, a genetically heterogeneous mouse population derived from FVB/NJ and CAST/EiJ mouse strains and deficient for multidrug resistance genes (Abcb1atm1Bor, Abcb1btm1Bor) was chronically exposed for 52-weeks to varying concentrations ...
Source: G3: Genes Genomes Genetics - May 7, 2019 Category: Genetics & Stem Cells Authors: Perry, A., Lynch, R. M., Rusyn, I., Threadgill, D. W. Tags: Investigations Source Type: research

Two cases of intrahepatic cholangiocellular carcinoma with high insertion-deletion ratios that achieved a complete response following chemotherapy combined with PD-1 blockade
ConclusionsThese two cases suggest that indels might be a new predictor of PD-1 blockade response for ICC patients beside PD-L1 expression, TMB, MSI, and dMMR, warranting further clinical investigation. (Source: Journal for Immunotherapy of Cancer)
Source: Journal for Immunotherapy of Cancer - May 7, 2019 Category: Cancer & Oncology Source Type: research

Prognostic value of serum C-reactive protein level prior to second-line treatment in intermediate risk metastatic renal cell carcinoma patients
ConclusionsThe serum CRP levels after first-line treatment termination could divide intermediate risk group mRCC patients into two prognostic subgroups in second-line targeted treatment setting. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - May 7, 2019 Category: Cancer & Oncology Source Type: research

Extent of lymph node dissection improves overall survival in pT3N0 non-metastatic renal cell carcinoma patients treated with radical nephrectomy: a propensity score-based analysis
AbstractBackgroundTo assess the impact of lymph node dissection (LND) extent on overall survival (OS) and cancer-specific survival (CSS) in patients with pN0M0 renal cell carcinoma (RCC) treated with radical nephrectomy (RN).Materials and methodsData queried for this study include RCC (2010 –2014) from the Surveillance, Epidemiology, and End Results (SEER) program. Kaplan–Meier analyses and multivariate Cox regression models tested the effect of number of removed lymph node (NRN) ≥ 50th percentile on OS and CSS. The associations were evaluated using propensity score (PS) matchi ng adjustment.ResultsA ...
Source: World Journal of Urology - May 7, 2019 Category: Urology & Nephrology Source Type: research

Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review
This article summarizes the structural characteristics of amygdalin, its antitumor mechanisms, and recent progress and achievement in the research of amygdalin, hoping that it could provide theoretical clues for exploring the clinical value of amygdal in against tumors. Amygdalin is known to have an antitumor effect in solid tumors such as lung cancer, bladder cancer and renal cell carcinoma by affecting cell cycle, inducing apoptosis and cytotoxicity, and regulating immune function. Further research is needed to elucidate the pharmacological mec hanisms of amygdalin in terms of the optimal dosage, the feasibility of combi...
Source: Cancer Medicine - May 7, 2019 Category: Cancer & Oncology Authors: Jiamin Shi, Qianqian Chen, Meng Xu, Qing Xia, Tiansheng Zheng, Junliang Teng, Ming Li, Lihong Fan Tags: REVIEW Source Type: research

Establishment of epithelial and fibroblast cell cultures and cell lines from primary renal cancer nephrectomies.
This study details a fast and easy protocol of establishing epithelial and fibroblast cell cultures or cell lines concurrently from renal cancer nephrectomy tissue. The protocol involves mechanical disaggregation, collagenase digestion and cell sieving for establishing epithelial cells while fibroblast cells were grown from explants. This protocol has been modified from previous published reports with additional antibiotics and washing steps added to eliminate microbial contamination from the surgical source. Cell characterisation was carried out using immunofluorescence and quantitative polymerase chain reaction. Eleven s...
Source: Cell Biology International - May 6, 2019 Category: Cytology Authors: Yap NY, Ong TA, Morais C, Pailoor J, Gobe GC, Rajandram R Tags: Cell Biol Int Source Type: research

The Role of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Platelets in the Prognosis of Metastatic Renal Cell Carcinoma
Conclusion: Elevated pretreatment NLR, PLR, PLT, and neutrophil count are associated with shorter OS and PFS in patients with mRCC. NLR and PLR are independent prognostic factors for OS. However, PLR and neutrophil count are independent prognostic factors for PFS.Oncology (Source: Oncology)
Source: Oncology - May 5, 2019 Category: Cancer & Oncology Source Type: research

Oncologic Outcomes Following Partial Nephrectomy and Percutaneous Ablation for cT1 Renal Masses
ConclusionsWith mature follow-up at a single institution, percutaneous ablation appears to have acceptable results for cT1 renal tumors and is appropriate for patients with a contraindication for surgery. For cT1a patients, clinically relevant differences between PN and ablation are unlikely, and treatment choice should involve shared decision making. For cT1b patients, death from RCC was more common with cryoablation, and large differences in this outcome cannot be ruled out. Further research is needed to confirm the oncologic effectiveness of cryoablation in the cT1b setting.Patient summaryWith appropriate patient triage...
Source: European Urology - May 5, 2019 Category: Urology & Nephrology Source Type: research

Renal cell carcinoma in a horseshoe kidney treated with robot-assisted partial nephrectomy
We describe for the first time the safety and the utility of RAPN in a horseshoe kidney with renal cell carcinoma. (Source: Urology Case Reports)
Source: Urology Case Reports - May 4, 2019 Category: Urology & Nephrology Source Type: research