Characterization of Mitoribosomal Small Subunit unit genes related immune and pharmacogenomic landscapes in renal cell carcinoma
AbstractMitoribosomes are essential for the production of biological energy. The Human Mitoribosomal Small Subunit unit (MRPS) family, responsible for encoding mitochondrial ribosomal small subunits, is actively engaged in protein synthesis within the mitochondria. Intriguingly, MRPS family genes appear to play a role in cancer. A multistep process was employed to establish a risk model associated with MRPS genes, aiming to delineate the immune and pharmacogenomic landscapes in clear cell renal cell carcinoma (ccRCC). MRPScores were computed for individual patients to assess their responsiveness to various treatment modali...
Source: IUBMB Life - March 30, 2024 Category: Research Authors: Zhihao Wei,
Chenchen Liu,
Jiaqian Liang,
Xuan Zhou,
Kaming Xue,
Keshan Wang,
Xiaoping Zhang Tags: RESEARCH ARTICLE Source Type: research
External validation of a four-tiered grading system for chromophobe renal cell carcinoma
This study aimed to validate the prognostic value of a four-tiered grading system recently proposed by Avulova et al. and to explore the prognostic ability of another four-tiered classification grading system in which there is a separate Grade 3 for tumor necrosis. Grading of chromophobe renal cell carcinoma (ChRCC) by the Fuhrman system is not feasible because of the inherent nuclear atypia in ChRCC. We collected relevant data of 263 patients with ChRCC who had undergone surgery in our hospital from 2008 to 2020. The Kaplan –Meier method was used to calculate the survival rate and Cox proportional hazard regression mode...
Source: Clinical and Experimental Medicine - March 30, 2024 Category: Research Source Type: research
[Retracted] miR ‑660‑5p is associated with cell migration, invasion, proliferation and apoptosis in renal cell carcinoma
Mol Med Rep. 2024 May;29(5):86. doi: 10.3892/mmr.2024.13210. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, the authors contacted the Editorial Office to explain that a couple of errors concerning data handling/labelling had been made, firstly during the preparation of the representative images in Fig. 3B, resulting in the wrong image being selected for the data panel showing the ACHN cells treated with 'Inhibitor NC' at 0 h experiment, and secondly in Fig. 5A, resulting in the wrong image being selected for the data panel showing the ACHN cells treated with 'Inhibitor NC' experiment. The authors ...
Source: Molecular Medicine Reports - March 29, 2024 Category: Molecular Biology Authors: Tao He Peijie Chen Lu Jin Jia Hu Yifan Li Liang Zhou Shangqi Yang Xiangming Mao Yaoting Gui Yun Chen Yongqing Lai Source Type: research
First-in-Human Phase I Trial of TPST-1120, an inhibitor of PPAR α, as Monotherapy or in Combination with Nivolumab, in Patients with Advanced Solid Tumors
CONCLUSIONS: TPST-1120 was well tolerated as monotherapy and in combination with nivolumab and the combination showed preliminary evidence of clinical activity in PD-1 inhibitor refractory and immune compromised cancers.PMID:38551394 | DOI:10.1158/2767-9764.CRC-24-0082 (Source: Cell Research)
Source: Cell Research - March 29, 2024 Category: Cytology Authors: Mark Yarchoan John D Powderly Bruno R Bastos Thomas B Karasic Oxana V Crysler Pamela N Munster Meredith A McKean Leisha A Emens Yvonne M Saenger Yasser Ged Robert Stagg Steven Smith Chan C Whiting Anne Moon Peppi Prasit Yonchu Jenkins Nathan Standifer Tho Source Type: research
[Retracted] miR ‑660‑5p is associated with cell migration, invasion, proliferation and apoptosis in renal cell carcinoma
Mol Med Rep. 2024 May;29(5):86. doi: 10.3892/mmr.2024.13210. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, the authors contacted the Editorial Office to explain that a couple of errors concerning data handling/labelling had been made, firstly during the preparation of the representative images in Fig. 3B, resulting in the wrong image being selected for the data panel showing the ACHN cells treated with 'Inhibitor NC' at 0 h experiment, and secondly in Fig. 5A, resulting in the wrong image being selected for the data panel showing the ACHN cells treated with 'Inhibitor NC' experiment. The authors ...
Source: Molecular Medicine Reports - March 29, 2024 Category: Molecular Biology Authors: Tao He Peijie Chen Lu Jin Jia Hu Yifan Li Liang Zhou Shangqi Yang Xiangming Mao Yaoting Gui Yun Chen Yongqing Lai Source Type: research
[Retracted] miR ‑660‑5p is associated with cell migration, invasion, proliferation and apoptosis in renal cell carcinoma
Mol Med Rep. 2024 May;29(5):86. doi: 10.3892/mmr.2024.13210. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, the authors contacted the Editorial Office to explain that a couple of errors concerning data handling/labelling had been made, firstly during the preparation of the representative images in Fig. 3B, resulting in the wrong image being selected for the data panel showing the ACHN cells treated with 'Inhibitor NC' at 0 h experiment, and secondly in Fig. 5A, resulting in the wrong image being selected for the data panel showing the ACHN cells treated with 'Inhibitor NC' experiment. The authors ...
Source: Molecular Medicine - March 29, 2024 Category: Molecular Biology Authors: Tao He Peijie Chen Lu Jin Jia Hu Yifan Li Liang Zhou Shangqi Yang Xiangming Mao Yaoting Gui Yun Chen Yongqing Lai Source Type: research
[Retracted] miR ‑660‑5p is associated with cell migration, invasion, proliferation and apoptosis in renal cell carcinoma
Mol Med Rep. 2024 May;29(5):86. doi: 10.3892/mmr.2024.13210. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, the authors contacted the Editorial Office to explain that a couple of errors concerning data handling/labelling had been made, firstly during the preparation of the representative images in Fig. 3B, resulting in the wrong image being selected for the data panel showing the ACHN cells treated with 'Inhibitor NC' at 0 h experiment, and secondly in Fig. 5A, resulting in the wrong image being selected for the data panel showing the ACHN cells treated with 'Inhibitor NC' experiment. The authors ...
Source: Molecular Medicine Reports - March 29, 2024 Category: Molecular Biology Authors: Tao He Peijie Chen Lu Jin Jia Hu Yifan Li Liang Zhou Shangqi Yang Xiangming Mao Yaoting Gui Yun Chen Yongqing Lai Source Type: research
Retracted: A New Survival Model Based on Cholesterol Biosynthesis-Related Genes for Prognostic Prediction in Clear Cell Renal Cell Carcinoma
Biomed Res Int. 2024 Mar 20;2024:9838460. doi: 10.1155/2024/9838460. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.1155/2021/9972968.].PMID:38550156 | PMC:PMC10977301 | DOI:10.1155/2024/9838460 (Source: Cell Research)
Source: Cell Research - March 29, 2024 Category: Cytology Authors: BioMed Research International Source Type: research
[Retracted] miR ‑660‑5p is associated with cell migration, invasion, proliferation and apoptosis in renal cell carcinoma
Mol Med Rep. 2024 May;29(5):86. doi: 10.3892/mmr.2024.13210. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, the authors contacted the Editorial Office to explain that a couple of errors concerning data handling/labelling had been made, firstly during the preparation of the representative images in Fig. 3B, resulting in the wrong image being selected for the data panel showing the ACHN cells treated with 'Inhibitor NC' at 0 h experiment, and secondly in Fig. 5A, resulting in the wrong image being selected for the data panel showing the ACHN cells treated with 'Inhibitor NC' experiment. The authors ...
Source: Molecular Medicine Reports - March 29, 2024 Category: Molecular Biology Authors: Tao He Peijie Chen Lu Jin Jia Hu Yifan Li Liang Zhou Shangqi Yang Xiangming Mao Yaoting Gui Yun Chen Yongqing Lai Source Type: research
[Retracted] miR ‑660‑5p is associated with cell migration, invasion, proliferation and apoptosis in renal cell carcinoma
Mol Med Rep. 2024 May;29(5):86. doi: 10.3892/mmr.2024.13210. Epub 2024 Mar 29.ABSTRACTFollowing the publication of the above article, the authors contacted the Editorial Office to explain that a couple of errors concerning data handling/labelling had been made, firstly during the preparation of the representative images in Fig. 3B, resulting in the wrong image being selected for the data panel showing the ACHN cells treated with 'Inhibitor NC' at 0 h experiment, and secondly in Fig. 5A, resulting in the wrong image being selected for the data panel showing the ACHN cells treated with 'Inhibitor NC' experiment. The authors ...
Source: Molecular Medicine - March 29, 2024 Category: Molecular Biology Authors: Tao He Peijie Chen Lu Jin Jia Hu Yifan Li Liang Zhou Shangqi Yang Xiangming Mao Yaoting Gui Yun Chen Yongqing Lai Source Type: research
A novel risk signature based on liquid-liquid phase separation-related genes reveals prognostic and tumour microenvironmental features in clear cell renal cell carcinoma
CONCLUSIONS: We developed a risk signature constructed based on the five LLPS-related genes and can have a high ability to predict the prognosis of ccRCC patients, further providing a strong support for clinical decision-making.PMID:38546385 | DOI:10.18632/aging.205691 (Source: Aging)
Source: Aging - March 28, 2024 Category: Biomedical Science Authors: Qing Lu Ping Xi Suling Xu Zhicheng Zhang Binbin Gong Ji Liu Qiqi Zhu Ting Sun Shaoxing Zhu Ru Chen Source Type: research
CASC19: An Oncogenic Long Non-coding RNA in Different Cancers
Curr Pharm Des. 2024 Mar 27. doi: 10.2174/0113816128300061240319034243. Online ahead of print.ABSTRACTA 324 bp lncRNA called CASC19 is found on chromosome 8q24.21. Recent research works have revealed that CASC19 is involved in the prognosis of tumors and related to the regulation of the radiation tolerance mechanisms during tumor radiotherapy (RT). This review sheds light on the changes and roles that CASC19 plays in many tumors and diseases, such as nasopharyngeal carcinoma (NPC), cervical cancer, colorectal cancer (CRC), non-small cell lung cancer (NSCLC), clear cell renal cell carcinoma (ccRCC), gastric cancer (GC), pan...
Source: Current Pharmaceutical Design - March 28, 2024 Category: Drugs & Pharmacology Authors: Yinxin Wu Jie Mou Gang Zhou Chengfu Yuan Source Type: research
A novel risk signature based on liquid-liquid phase separation-related genes reveals prognostic and tumour microenvironmental features in clear cell renal cell carcinoma
CONCLUSIONS: We developed a risk signature constructed based on the five LLPS-related genes and can have a high ability to predict the prognosis of ccRCC patients, further providing a strong support for clinical decision-making.PMID:38546385 | DOI:10.18632/aging.205691 (Source: Aging)
Source: Aging - March 28, 2024 Category: Biomedical Science Authors: Qing Lu Ping Xi Suling Xu Zhicheng Zhang Binbin Gong Ji Liu Qiqi Zhu Ting Sun Shaoxing Zhu Ru Chen Source Type: research
