Integrative analysis and risk model construction for super ‑enhancer‑related immune genes in clear cell renal cell carcinoma
Oncol Lett. 2024 Mar 1;27(5):190. doi: 10.3892/ol.2024.14323. eCollection 2024 May.ABSTRACTClear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer associated with poor prognosis, and accounts for the majority of RCC-related deaths. The lack of comprehensive diagnostic and prognostic biomarkers has limited further understanding of the pathophysiology of ccRCC. Super-enhancers (SEs) are congregated enhancer clusters that have a key role in tumor processes such as epithelial-mesenchymal transition, metabolic reprogramming, immune escape and resistance to apoptosis. RCC may also be immunogenic and sens...
Source: Oncology Letters - March 18, 2024 Category: Cancer & Oncology Authors: Zhenyu Bi Jinghao Zhou Yan Ma Qingxin Guo Boyang Ju Haoran Zou Zuhao Zhan Feihong Yang Han Du Xiuguo Gan Erlin Song Source Type: research
CRYL1 is a Potential Prognostic Biomarker of Clear Cell Renal Cell Carcinoma Correlated with Immune Infiltration and Cuproptosis
CONCLUSIONS: CRYL1 is a robust predictive marker for clinicopathological characteristics and survival status in ccRCC patients.PMID:38497139 | PMC:PMC10946081 | DOI:10.1177/15330338241237439 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 18, 2024 Category: Cancer & Oncology Authors: Peng Li Qiangqiang Xu Ken Liu Junjie Ye Source Type: research
CRYL1 is a Potential Prognostic Biomarker of Clear Cell Renal Cell Carcinoma Correlated with Immune Infiltration and Cuproptosis
CONCLUSIONS: CRYL1 is a robust predictive marker for clinicopathological characteristics and survival status in ccRCC patients.PMID:38497139 | DOI:10.1177/15330338241237439 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 18, 2024 Category: Cancer & Oncology Authors: Peng Li Qiangqiang Xu Ken Liu Junjie Ye Source Type: research
Integrative analysis and risk model construction for super ‑enhancer‑related immune genes in clear cell renal cell carcinoma
Oncol Lett. 2024 Mar 1;27(5):190. doi: 10.3892/ol.2024.14323. eCollection 2024 May.ABSTRACTClear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer associated with poor prognosis, and accounts for the majority of RCC-related deaths. The lack of comprehensive diagnostic and prognostic biomarkers has limited further understanding of the pathophysiology of ccRCC. Super-enhancers (SEs) are congregated enhancer clusters that have a key role in tumor processes such as epithelial-mesenchymal transition, metabolic reprogramming, immune escape and resistance to apoptosis. RCC may also be immunogenic and sens...
Source: Oncology Letters - March 18, 2024 Category: Cancer & Oncology Authors: Zhenyu Bi Jinghao Zhou Yan Ma Qingxin Guo Boyang Ju Haoran Zou Zuhao Zhan Feihong Yang Han Du Xiuguo Gan Erlin Song Source Type: research
Endolymphatic sac tumor misdiagnosed as metastatic renal cell carcinoma: Pitfalls in morphology and immunohistochemistry
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301603. Online ahead of print.ABSTRACTEndolymphatic sac tumor (ELST) is a rare disease that originates from the endolymphatic sac system of the inner ear. Being a low-grade malignant tumor, ELST has a mild morphology and is characterized by a slow but aggressive growth. Most clinicians and pathologists are unfamiliar with this disease. ELST can be misdiagnosed as metastatic renal cancer because of the similarity in morphology and expression of nephrogenic markers such as PAX8. The presented case of a 27-year-old man revealed that observing the characteristic location and confir...
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Wenjia Sun Manxiang Wang Junqiu Yue Source Type: research
CRYL1 is a Potential Prognostic Biomarker of Clear Cell Renal Cell Carcinoma Correlated with Immune Infiltration and Cuproptosis
CONCLUSIONS: CRYL1 is a robust predictive marker for clinicopathological characteristics and survival status in ccRCC patients.PMID:38497139 | PMC:PMC10946081 | DOI:10.1177/15330338241237439 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 18, 2024 Category: Cancer & Oncology Authors: Peng Li Qiangqiang Xu Ken Liu Junjie Ye Source Type: research
Integrative analysis and risk model construction for super ‑enhancer‑related immune genes in clear cell renal cell carcinoma
Oncol Lett. 2024 Mar 1;27(5):190. doi: 10.3892/ol.2024.14323. eCollection 2024 May.ABSTRACTClear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer associated with poor prognosis, and accounts for the majority of RCC-related deaths. The lack of comprehensive diagnostic and prognostic biomarkers has limited further understanding of the pathophysiology of ccRCC. Super-enhancers (SEs) are congregated enhancer clusters that have a key role in tumor processes such as epithelial-mesenchymal transition, metabolic reprogramming, immune escape and resistance to apoptosis. RCC may also be immunogenic and sens...
Source: Oncology Letters - March 18, 2024 Category: Cancer & Oncology Authors: Zhenyu Bi Jinghao Zhou Yan Ma Qingxin Guo Boyang Ju Haoran Zou Zuhao Zhan Feihong Yang Han Du Xiuguo Gan Erlin Song Source Type: research
CRYL1 is a Potential Prognostic Biomarker of Clear Cell Renal Cell Carcinoma Correlated with Immune Infiltration and Cuproptosis
CONCLUSIONS: CRYL1 is a robust predictive marker for clinicopathological characteristics and survival status in ccRCC patients.PMID:38497139 | PMC:PMC10946081 | DOI:10.1177/15330338241237439 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - March 18, 2024 Category: Cancer & Oncology Authors: Peng Li Qiangqiang Xu Ken Liu Junjie Ye Source Type: research
Integrative analysis and risk model construction for super ‑enhancer‑related immune genes in clear cell renal cell carcinoma
Oncol Lett. 2024 Mar 1;27(5):190. doi: 10.3892/ol.2024.14323. eCollection 2024 May.ABSTRACTClear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer associated with poor prognosis, and accounts for the majority of RCC-related deaths. The lack of comprehensive diagnostic and prognostic biomarkers has limited further understanding of the pathophysiology of ccRCC. Super-enhancers (SEs) are congregated enhancer clusters that have a key role in tumor processes such as epithelial-mesenchymal transition, metabolic reprogramming, immune escape and resistance to apoptosis. RCC may also be immunogenic and sens...
Source: Oncology Letters - March 18, 2024 Category: Cancer & Oncology Authors: Zhenyu Bi Jinghao Zhou Yan Ma Qingxin Guo Boyang Ju Haoran Zou Zuhao Zhan Feihong Yang Han Du Xiuguo Gan Erlin Song Source Type: research
CPA4 as a biomarker promotes the proliferation, migration and metastasis of clear cell renal cell carcinoma cells
J Cell Mol Med. 2024 Apr;28(7):e18165. doi: 10.1111/jcmm.18165.ABSTRACTClear cell renal cell carcinoma (ccRCC) is a commonly occurring and highly aggressive urological malignancy characterized by a significant mortality rate. Current therapeutic options for advanced ccRCC are limited, necessitating the discovery of novel biomarkers and therapeutic targets. Carboxypeptidase A4 (CPA4) is a zinc-containing metallocarboxypeptidase with implications in various cancer types, but its role in ccRCC remains unexplored. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were utilized in order to investigate t...
Source: J Cell Mol Med - March 18, 2024 Category: Molecular Biology Authors: Kongjia Wang Yixin Ding Yunbo Liu Mingyu Ma Ji Wang Zengshun Kou Shuo Liu Bo Jiang Sichuan Hou Source Type: research
Efficacy Assessment of Post-nephrectomy Adjuvant Therapies in Patients with Renal Cell Carcinoma
CONCLUSIONS: Our results suggest that post-nephrectomy RCC patients with sarcomatoid differentiation and high PD-L1 expression were more responsive to ICIs. Furthermore, pembrolizumab monotherapy exhibited superior DFS and OS results over other adjuvant therapies.PMID:38494564 | DOI:10.1245/s10434-024-15121-2 (Source: Ann Oncol)
Source: Ann Oncol - March 18, 2024 Category: Cancer & Oncology Authors: Kaiyue Ding Zhixuan Yang Danyan Zhang Lin Sun Source Type: research
CPA4 as a biomarker promotes the proliferation, migration and metastasis of clear cell renal cell carcinoma cells
J Cell Mol Med. 2024 Apr;28(7):e18165. doi: 10.1111/jcmm.18165.ABSTRACTClear cell renal cell carcinoma (ccRCC) is a commonly occurring and highly aggressive urological malignancy characterized by a significant mortality rate. Current therapeutic options for advanced ccRCC are limited, necessitating the discovery of novel biomarkers and therapeutic targets. Carboxypeptidase A4 (CPA4) is a zinc-containing metallocarboxypeptidase with implications in various cancer types, but its role in ccRCC remains unexplored. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were utilized in order to investigate t...
Source: Molecular Medicine - March 18, 2024 Category: Molecular Biology Authors: Kongjia Wang Yixin Ding Yunbo Liu Mingyu Ma Ji Wang Zengshun Kou Shuo Liu Bo Jiang Sichuan Hou Source Type: research
Endolymphatic sac tumor misdiagnosed as metastatic renal cell carcinoma: Pitfalls in morphology and immunohistochemistry
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301603. Online ahead of print.ABSTRACTEndolymphatic sac tumor (ELST) is a rare disease that originates from the endolymphatic sac system of the inner ear. Being a low-grade malignant tumor, ELST has a mild morphology and is characterized by a slow but aggressive growth. Most clinicians and pathologists are unfamiliar with this disease. ELST can be misdiagnosed as metastatic renal cancer because of the similarity in morphology and expression of nephrogenic markers such as PAX8. The presented case of a 27-year-old man revealed that observing the characteristic location and confir...
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Wenjia Sun Manxiang Wang Junqiu Yue Source Type: research
CPA4 as a biomarker promotes the proliferation, migration and metastasis of clear cell renal cell carcinoma cells
J Cell Mol Med. 2024 Apr;28(7):e18165. doi: 10.1111/jcmm.18165.ABSTRACTClear cell renal cell carcinoma (ccRCC) is a commonly occurring and highly aggressive urological malignancy characterized by a significant mortality rate. Current therapeutic options for advanced ccRCC are limited, necessitating the discovery of novel biomarkers and therapeutic targets. Carboxypeptidase A4 (CPA4) is a zinc-containing metallocarboxypeptidase with implications in various cancer types, but its role in ccRCC remains unexplored. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were utilized in order to investigate t...
Source: J Cell Mol Med - March 18, 2024 Category: Molecular Biology Authors: Kongjia Wang Yixin Ding Yunbo Liu Mingyu Ma Ji Wang Zengshun Kou Shuo Liu Bo Jiang Sichuan Hou Source Type: research
Endolymphatic sac tumor misdiagnosed as metastatic renal cell carcinoma: Pitfalls in morphology and immunohistochemistry
Clin Neuropathol. 2024 Mar 15. doi: 10.5414/NP301603. Online ahead of print.ABSTRACTEndolymphatic sac tumor (ELST) is a rare disease that originates from the endolymphatic sac system of the inner ear. Being a low-grade malignant tumor, ELST has a mild morphology and is characterized by a slow but aggressive growth. Most clinicians and pathologists are unfamiliar with this disease. ELST can be misdiagnosed as metastatic renal cancer because of the similarity in morphology and expression of nephrogenic markers such as PAX8. The presented case of a 27-year-old man revealed that observing the characteristic location and confir...
Source: Clinical Neuropathology - March 18, 2024 Category: Pathology Authors: Wenjia Sun Manxiang Wang Junqiu Yue Source Type: research
