Machine learning-driven prognostic analysis of cuproptosis and disulfidptosis-related lncRNAs in clear cell renal cell carcinoma: a step towards precision oncology
In this study, we analyzed RNA-seq data, clinical information, and mutation data from The Cancer Genome Atlas (TCGA) on ccRCC and cross-referenced it with known cuproptosis and disulfidptosis-related genes (CDRGs). Using the LASSO machine learning algorithm, we identified four CDRLRs —ACVR2B-AS1, AC095055.1, AL161782.1, and MANEA-DT—that are strongly associated with prognosis and used them to construct a prognostic risk model. To verify the model's reliability and validate these four CDRLRs as significant prognostic factors, we performed dataset grouping validation, followed by RT-qPCR and external database validation ...
Source: European Journal of Medical Research - March 16, 2024 Category: Research Source Type: research
Rapid identification of inflammatory arthritis and associated adverse events following immune checkpoint therapy: a machine learning approach
The objective of this study was to rapidly identify ICI-IA patients in clinical data and assess associated immune-related adverse events (irAEs) and risk factors.MethodsWe conducted a retrospective study of the electronic health records (EHRs) of 89 patients who developed ICI-IA out of 2451 cancer patients who received ICI therapy at Northwestern University between March 2011 to January 2021. Logistic regression and random forest machine learning models were trained on all EHR diagnoses, labs, medications, and procedures to identify ICI-IA patients and EHR codes indicating ICI-IA. Multivariate logistic regression was then ...
Source: Frontiers in Immunology - March 15, 2024 Category: Allergy & Immunology Source Type: research
microRNA-141-3p Suppressed the Progression of the Clear Cell Renal Cell Carcinoma by Targeting Transforming Growth Factor Beta 2 Gene Expression
DNA and Cell Biology, Ahead of Print. (Source: DNA and Cell Biology)
Source: DNA and Cell Biology - March 15, 2024 Category: Cytology Authors: Xinming Hu Desheng Li Jiangtao Zhan Changmin Yang Pengfei Wang Xusong Meng Sheng Xu Xianping Che Lei Xu Source Type: research
Case report: Isolated eyelid metastasis of ccRCC 5 years after receiving radical nephrectomy
ConclusionsAlthough the probability of eyelid metastasis rate is very low, tumor metastasis to the eyelid skin is possible after radical nephrectomy. Therefore, any rash like changes on the skin during the review procedure cannot be ignored by the physician. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 15, 2024 Category: Cancer & Oncology Source Type: research
A nomogram based on TFE3 IHC results and clinical factors as a preliminary screening scheme for TFE3 ‐rearranged renal cell carcinoma
ConclusionsTFE3 IHC has high accuracy in the diagnosis of TFE3-rearranged RCC. Clinical information such as age and lymph node metastasis are independent risk factors, which can be used as a supplement to the results of TFE3 IHC. This study confirms the value of IHC in the diagnosis of TFE3-rearranged RCC. The accuracy of the diagnosis can be improved by incorporating IHC with other clinical risk factors. (Source: Cancer Medicine)
Source: Cancer Medicine - March 14, 2024 Category: Cancer & Oncology Authors: Pengju Li,
Quanhui Xu,
Minyu Chen,
Jiangquan Zhu,
Yinghan Wang,
Mukhtar A. Mumin,
Kangbo Huang,
Zeying Jiang,
Hui Liang,
Qiong Deng,
Zhu Wang,
Bing Liao,
Wenfang Chen,
Yun Cao,
Jiazheng Cao,
Junhang Luo Tags: RESEARCH ARTICLE Source Type: research
Recent development of VEGFR small molecule inhibitors as anticancer agents: A patent review (2021-2023)
Bioorg Chem. 2024 Mar 9;146:107278. doi: 10.1016/j.bioorg.2024.107278. Online ahead of print.ABSTRACTVEGFR, a receptor tyrosine kinase inhibitor (TKI), is an important regulatory factor that promotes angiogenesis and vascular permeability. It plays a significant role in processes such as tumor angiogenesis, tumor cell invasion, and metastasis. VEGFR is mainly composed of three subtypes: VEGFR-1, VEGFR-2, and VEGFR-3. Among them, VEGFR-2 is the crucial signaling receptor for VEGF, which is involved in various pathological and physiological functions. At present, VEGFR-2 is closely related to a variety of cancers, such as no...
Source: Bioorganic Chemistry - March 14, 2024 Category: Chemistry Authors: Jing Zeng Qichuan Deng Zheng Chen Shuang Yan Qin Dong Yuyu Zhang Yuan Cui Ling Li Yuxin He Jianyou Shi Source Type: research
