Phenobarbital as a Sedation Strategy to Reduce Opioid and Benzodiazepine Burden in Neonatal Extracorporeal Membrane Oxygenation
Conclusion In this cohort, short-term use of phenobarbital as primary sedation strategy during neonatal ECMO was associated with reduced opioid and midazolam burden. Such reduction, however, did not affect in-hospital outcomes.
Key Points
[...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - February 16, 2024 Category: Perinatology & Neonatology Authors: Cardona, Vilmaris Quinones Byrne, Emma Mejia, Michelle Joshi, Swosti Menkiti, Ogechukwu Tags: Original Article Source Type: research
Efficacy and Tolerability of Adjunctive Brivaracetam in Patients with Focal-Onset Seizures on Specific Concomitant Antiseizure Medications: Pooled Analysis of Double-Blind, Placebo-Controlled Trials
CONCLUSION: BRV was efficacious and well tolerated regardless of the specific concomitant ASMs used as part of their treatment regimen. These data show that in patients with focal-onset seizures, BRV provides additional efficacy to a broad range of ASMs.PMID:38356105 | DOI:10.1007/s12325-024-02795-z (Source: Adv Data)
Source: Adv Data - February 15, 2024 Category: Epidemiology Authors: Brian Moseley Dimitrios Bourikas Svetlana Dimova Sami Elmoufti Simon Borghs Source Type: research
Efficacy and Tolerability of Adjunctive Brivaracetam in Patients with Focal-Onset Seizures on Specific Concomitant Antiseizure Medications: Pooled Analysis of Double-Blind, Placebo-Controlled Trials
CONCLUSION: BRV was efficacious and well tolerated regardless of the specific concomitant ASMs used as part of their treatment regimen. These data show that in patients with focal-onset seizures, BRV provides additional efficacy to a broad range of ASMs.PMID:38356105 | DOI:10.1007/s12325-024-02795-z (Source: Adv Data)
Source: Adv Data - February 15, 2024 Category: Epidemiology Authors: Brian Moseley Dimitrios Bourikas Svetlana Dimova Sami Elmoufti Simon Borghs Source Type: research
Efficacy and Tolerability of Adjunctive Brivaracetam in Patients with Focal-Onset Seizures on Specific Concomitant Antiseizure Medications: Pooled Analysis of Double-Blind, Placebo-Controlled Trials
ConclusionBRV was efficacious and well tolerated regardless of the specific concomitant ASMs used as part of their treatment regimen. These data show that in patients with focal-onset seizures, BRV provides additional efficacy to a broad range of ASMs. (Source: Advances in Therapy)
Source: Advances in Therapy - February 15, 2024 Category: Drugs & Pharmacology Source Type: research
Phenibut: Review and Pharmacologic Approaches to Treating Withdrawal
J Clin Pharmacol. 2024 Feb 10. doi: 10.1002/jcph.2414. Online ahead of print.ABSTRACTβ-Phenyl-γ-aminobutyric acid (phenibut) is an analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that was first synthesized in Russia in the early 1960s. It is marketed as a nootropic (smart drug) to improve cognitive performance, and to treat generalized and social anxiety, insomnia, and alcohol withdrawal. The use of phenibut is legal in the USA and it is widely available online without a prescription. Increased public awareness of phenibut has led to a growing number of reports of acute intoxication and withdrawal. ...
Source: The Journal of Clinical Pharmacology - February 10, 2024 Category: Drugs & Pharmacology Authors: Scott R Penzak Marilyn Bulloch Source Type: research
The possible clinical utility of the alcohol biomarker phosphatidylethanol for managing suspected alcohol withdrawal in hospitalized patients: A case report
CONCLUSION: PEth can be a useful tool if available without delay. PEth can be used to quickly rule out alcohol withdrawal and avoid misdiagnoses and prolonged hospital stays.SCIENTIFIC SIGNIFICANCE: This is a clinical case study available looking at PEth and withdrawal in hospitalized patients. It proposes that PEth can be used as a way to quickly rule out alcohol withdrawal to avoid misdiagnoses and the possibility of a prolonged hospital stay.PMID:38319035 | DOI:10.1111/ajad.13516 (Source: American Journal on Addictions)
Source: American Journal on Addictions - February 6, 2024 Category: Addiction Authors: Amber N Edinoff David B Hathaway David Martinez Garza Jordan H Rosen Joji Suzuki Source Type: research
The possible clinical utility of the alcohol biomarker phosphatidylethanol for managing suspected alcohol withdrawal in hospitalized patients: A case report
CONCLUSION: PEth can be a useful tool if available without delay. PEth can be used to quickly rule out alcohol withdrawal and avoid misdiagnoses and prolonged hospital stays.SCIENTIFIC SIGNIFICANCE: This is a clinical case study available looking at PEth and withdrawal in hospitalized patients. It proposes that PEth can be used as a way to quickly rule out alcohol withdrawal to avoid misdiagnoses and the possibility of a prolonged hospital stay.PMID:38319035 | DOI:10.1111/ajad.13516 (Source: The American Journal on Addictions)
Source: The American Journal on Addictions - February 6, 2024 Category: Addiction Authors: Amber N Edinoff David B Hathaway David Martinez Garza Jordan H Rosen Joji Suzuki Source Type: research
Pharmacological Treatment of GHB Withdrawal Syndrome
AbstractPurpose of ReviewGamma-hydroxybutyrate (GHB) is an illicit drug used for many reasons: during music festivals or parties, for self-management of sleep and anxiety, or in combination with other drugs to facilitate chemsex. Most people who use GHB do so occasionally, without harm. However, a minority of users experience dependence or withdrawal symptoms. GHB withdrawal syndrome often has a specific course, with rapid onset and swift progression of severe complications. In this narrative review, we aimed to summarize recent evidence related to the pharmacological treatment of GHB withdrawal syndrome.Recent FindingsThe...
Source: Current Addiction Reports - January 26, 2024 Category: Addiction Source Type: research
Impact of a Divided Phenobarbital Load and Taper Compared With Lorazepam Symptom Triggered Therapy in Hospitalized Patients
CONCLUSION AND RELEVANCE: This study is novel because of the broad application of a phenobarbital order set across multiple levels of care and patient admission diagnoses. A risk targeted split load intravenous phenobarbital order set can safely be administered to patients with fewer escalations of care, seizures, delirium tremens, and respiratory care escalation.PMID:38258797 | DOI:10.1177/10600280231222294 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 23, 2024 Category: Drugs & Pharmacology Authors: Alyson M Esteves Matthew C Buchfellner Brooke M Holmes Joseph A Berndsen Matthew A Roginski Source Type: research
Phenobarbital Versus Benzodiazepines for the Treatment of Severe Alcohol Withdrawal
CONCLUSION AND RELEVANCE: Scheduled phenobarbital was associated with decreased hospital LOS compared to benzodiazepines for SAWS. This was the first study to compare outcomes of fixed-dose, nonoverlapping phenobarbital to benzodiazepines in patients with clearly defined SAWS and details a readily implementable protocol.PMID:38247044 | DOI:10.1177/10600280231221241 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - January 22, 2024 Category: Drugs & Pharmacology Authors: Katherine M Kessel Logan M Olson Derek A Kruse Elizabeth R Lyden Kelsey E Whiston Mindy M Blodgett Alena A Balasanova Source Type: research
Risk Factors and Nomogram Model of Postoperative Delirium in Children with Congenital Heart Disease: A Single-Center Prospective Study
AbstractDelirium is a common postoperative complication in children with congenital heart disease, which affects their postoperative recovery. The purpose of this study is to explore the risk factors of delirium and construct a nomogram model to provide novel references for the prevention and management of postoperative delirium in children with congenital heart disease. 470 children after congenital heart surgery treated in the cardiac intensive care unit (CICU) of Shanghai Children ’s Medical Center were divided into a model and a validation cohort according to the principle of 7:3 distribution temporally. Then, the de...
Source: Mammalian Genome - January 1, 2024 Category: Genetics & Stem Cells Source Type: research
Risk Factors and Nomogram Model of Postoperative Delirium in Children with Congenital Heart Disease: A Single-Center Prospective Study
AbstractDelirium is a common postoperative complication in children with congenital heart disease, which affects their postoperative recovery. The purpose of this study is to explore the risk factors of delirium and construct a nomogram model to provide novel references for the prevention and management of postoperative delirium in children with congenital heart disease. 470 children after congenital heart surgery treated in the cardiac intensive care unit (CICU) of Shanghai Children ’s Medical Center were divided into a model and a validation cohort according to the principle of 7:3 distribution temporally. Then, the de...
Source: Pediatric Cardiology - January 1, 2024 Category: Cardiology Source Type: research
Fixed-Dose Phenobarbital Versus As-Needed Benzodiazepines for the Management of Alcohol Withdrawal in Acute Care General Internal Medicine
CONCLUSIONS: Phenobarbital is as safe and effective as benzodiazepine-based protocols for the treatment of high-risk alcohol withdrawal, with lower rates of delirium.PMID:38151248 | DOI:10.14423/SMJ.0000000000001640 (Source: Southern Medical Journal)
Source: Southern Medical Journal - December 27, 2023 Category: General Medicine Authors: Samuel Hundert Jillian McLlarky Andrew S Dunn William Markle Source Type: research
