Evaluation of Clinical Outcomes Associated With Phenobarbital With Taper Compared to No Taper for the Management of Alcohol Withdrawal Syndrome
CONCLUSION AND RELEVANCE: The use of a PHB loading dose without a taper may be comparable to a taper strategy on clinical outcomes. Prospective studies are needed to further delineate the optimal dose of PHB for AWS.PMID:38501811 | DOI:10.1177/10600280241236412 (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - March 19, 2024 Category: Drugs & Pharmacology Authors: Matthew Thaller Adrian Wong Tuyen Yankama Ifeoma Mary Eche Pansy Elsamadisi Source Type: research
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy
CONCLUSION: Our study shows that enhanced CREB expression promotes the development of DRE and negatively regulates GABAA receptor levels and that the inhibition of CREB expression may reduce the incidence of DRE.PMID:38468526 | DOI:10.2174/0115672026290996240307072539 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - March 12, 2024 Category: Neurology Authors: Jing-Xuan Li Dai Shi Si-Ying Ren Guo-Feng Wu Source Type: research
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy
CONCLUSION: Our study shows that enhanced CREB expression promotes the development of DRE and negatively regulates GABAA receptor levels and that the inhibition of CREB expression may reduce the incidence of DRE.PMID:38468526 | DOI:10.2174/0115672026290996240307072539 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Jing-Xuan Li Dai Shi Si-Ying Ren Guo-Feng Wu Source Type: research
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy
CONCLUSION: Our study shows that enhanced CREB expression promotes the development of DRE and negatively regulates GABAA receptor levels and that the inhibition of CREB expression may reduce the incidence of DRE.PMID:38468526 | DOI:10.2174/0115672026290996240307072539 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - March 12, 2024 Category: Neurology Authors: Jing-Xuan Li Dai Shi Si-Ying Ren Guo-Feng Wu Source Type: research
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy
CONCLUSION: Our study shows that enhanced CREB expression promotes the development of DRE and negatively regulates GABAA receptor levels and that the inhibition of CREB expression may reduce the incidence of DRE.PMID:38468526 | DOI:10.2174/0115672026290996240307072539 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Jing-Xuan Li Dai Shi Si-Ying Ren Guo-Feng Wu Source Type: research
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy
CONCLUSION: Our study shows that enhanced CREB expression promotes the development of DRE and negatively regulates GABAA receptor levels and that the inhibition of CREB expression may reduce the incidence of DRE.PMID:38468526 | DOI:10.2174/0115672026290996240307072539 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - March 12, 2024 Category: Neurology Authors: Jing-Xuan Li Dai Shi Si-Ying Ren Guo-Feng Wu Source Type: research
Increased Cyclic Adenosine Monophosphate Responsive Element is Closely Associated with the Pathogenesis of Drug-resistant Epilepsy
CONCLUSION: Our study shows that enhanced CREB expression promotes the development of DRE and negatively regulates GABAA receptor levels and that the inhibition of CREB expression may reduce the incidence of DRE.PMID:38468526 | DOI:10.2174/0115672026290996240307072539 (Source: Epilepsy Curr)
Source: Epilepsy Curr - March 12, 2024 Category: Neurology Authors: Jing-Xuan Li Dai Shi Si-Ying Ren Guo-Feng Wu Source Type: research
Genes, Vol. 15, Pages 350: Leukodystrophy with Macrocephaly, Refractory Epilepsy, and Severe Hyponatremia & mdash;The Neonatal Type of Alexander Disease
Conclusion: AxD should be considered in the differential diagnosis in all neonates with progressive, intractable seizures accompanied by macrocephaly. (Source: Genes)
Source: Genes - March 11, 2024 Category: Genetics & Stem Cells Authors: Justyna Paprocka Magdalena Nowak Magdalena Machnikowska-Soko łowska Karolina Rutkowska Rafa ł Płoski Tags: Case Report Source Type: research
The effects of drug-drug interaction on linezolid pharmacokinetics: A systematic review
ConclusionsThis systematic review found that numerous drugs have an impact on the pharmacokinetics of linezolid, and the purported main mechanism may be that linezolid is the substrate of P-glycoprotein. In clinical practice, it is prudent to pay attention to the changes in linezolid pharmacokinetics caused by interactions. Conducting therapeutic drug monitoring (TDM) is beneficial to improve efficacy and reduce adverse reactions of linezolid. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 29, 2024 Category: Drugs & Pharmacology Source Type: research
Managing Selected Chronic Conditions in Hospitalized Patients
Am Fam Physician. 2024 Feb;109(2):134-142.ABSTRACTThe management of chronic illnesses should continue during hospitalization. Some chronic conditions require immediate intervention, whereas intensification of therapy for other conditions may be delayed until after discharge. Factors such as pain, anxiety, poor sleep hygiene, and concurrent illness can result in a transient elevation of blood pressure. Acute lowering of blood pressure in hospitalized patients who do not have target-organ damage is not recommended and may lead to harm. If treatment is needed, intravenous antihypertensive agents should be avoided. Patients wi...
Source: Pain Physician - February 23, 2024 Category: Anesthesiology Authors: Robert L Gauer Alain Abellada Matthew Stewart Ryan Kozloski Source Type: research
Managing Selected Chronic Conditions in Hospitalized Patients
Am Fam Physician. 2024 Feb;109(2):134-142.ABSTRACTThe management of chronic illnesses should continue during hospitalization. Some chronic conditions require immediate intervention, whereas intensification of therapy for other conditions may be delayed until after discharge. Factors such as pain, anxiety, poor sleep hygiene, and concurrent illness can result in a transient elevation of blood pressure. Acute lowering of blood pressure in hospitalized patients who do not have target-organ damage is not recommended and may lead to harm. If treatment is needed, intravenous antihypertensive agents should be avoided. Patients wi...
Source: American Family Physician - February 23, 2024 Category: Primary Care Authors: Robert L Gauer Alain Abellada Matthew Stewart Ryan Kozloski Source Type: research
Managing Selected Chronic Conditions in Hospitalized Patients
Am Fam Physician. 2024 Feb;109(2):134-142.ABSTRACTThe management of chronic illnesses should continue during hospitalization. Some chronic conditions require immediate intervention, whereas intensification of therapy for other conditions may be delayed until after discharge. Factors such as pain, anxiety, poor sleep hygiene, and concurrent illness can result in a transient elevation of blood pressure. Acute lowering of blood pressure in hospitalized patients who do not have target-organ damage is not recommended and may lead to harm. If treatment is needed, intravenous antihypertensive agents should be avoided. Patients wi...
Source: Pain Physician - February 23, 2024 Category: Anesthesiology Authors: Robert L Gauer Alain Abellada Matthew Stewart Ryan Kozloski Source Type: research
Managing Selected Chronic Conditions in Hospitalized Patients
Am Fam Physician. 2024 Feb;109(2):134-142.ABSTRACTThe management of chronic illnesses should continue during hospitalization. Some chronic conditions require immediate intervention, whereas intensification of therapy for other conditions may be delayed until after discharge. Factors such as pain, anxiety, poor sleep hygiene, and concurrent illness can result in a transient elevation of blood pressure. Acute lowering of blood pressure in hospitalized patients who do not have target-organ damage is not recommended and may lead to harm. If treatment is needed, intravenous antihypertensive agents should be avoided. Patients wi...
Source: American Family Physician - February 23, 2024 Category: Primary Care Authors: Robert L Gauer Alain Abellada Matthew Stewart Ryan Kozloski Source Type: research
