Efficacy of Levetiracetam as Add-On Therapy in the Treatment of Seizures in Neonates
DISCUSSION: Although the cumulative loading dose of LEV was low and the group of infants studied was heterogeneous, the efficacy of LEV as add-on therapy for the treatment of seizures in neonates was limited. The highest seizure reduction rate was seen after LDC administration.PMID:38113859 | DOI:10.1159/000535499 (Source: Neonatology)
Source: Neonatology - December 19, 2023 Category: Perinatology & Neonatology Authors: Mathies Rondagh Linda S De Vries Cacha M P C D Peeters-Scholte Selma C Tromp Sylke J Steggerda Source Type: research
Successful management of severe generalized tetanus in a 23 ‐year man with phenobarbital adjuvant: A case report
We reported a 23-year-old man from Afghanistan admitted to emergency department, with the chief complaint of generalized severe spasms and lockjaw. The patient had skin lesions and had never been vaccinated against tetanus. He intubated and admitted to the intensive care unit (ICU) with diagnose of severe generalized tetanus. After receiving tetanus immunoglobulin and intravenous metronidazole, a combination therapy of midazolam, propofol, atracurium, and morphine was administered. Due to the refractory muscular spasms intravenous phenobarbital started and little by little recovery was achieved. The patient receiving the f...
Source: Clinical Case Reports - December 16, 2023 Category: General Medicine Authors: Arezoo Ahmadi,
Elahe Karimpour ‐Razkenari,
Ramin Ansari,
Mahforouzalsadat Marashi,
Hamidreza Sharifnia,
Atabak Najafi,
Mojtaba Mojtahedzadeh Tags: CASE REPORT Source Type: research
A retrospective evaluation of adjunctive phenobarbital versus benzodiazepine alone for the treatment of moderate alcohol withdrawal in the emergency department
Background: Phenobarbital has been used in the emergency department (ED) as both a primary and adjunctive medication for alcohol withdrawal, but previous studies evaluating its impact on patient outcomes are limited by heterogenous symptom severity.Objectives: We compared the clinical outcomes of ED patients with moderate alcohol withdrawal who received phenobarbital, with or without benzodiazepines, to patients who received benzodiazepine treatment alone.Methods: This is a retrospective cohort study conducted at a single academic medical center utilizing chart review of ED patients with moderate alcohol withdrawal between...
Source: The Journal of Emergency Medicine - December 14, 2023 Category: Emergency Medicine Authors: Jacob A Lebin, Megan E Bass, Kennon Heard, Jason Hoppe, Gabrielle Jacknin Tags: Pharmacology in Emergency Medicine Source Type: research
A retrospective evaluation of adjunctive phenobarbital vs. benzodiazepine alone for the treatment of moderate alcohol withdrawal in the emergency department
Phenobarbital has been used in the emergency department (ED) as both a primary and adjunctive medication for alcohol withdrawal, but previous studies evaluating its impact on patient outcomes are limited by heterogenous symptom severity. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - December 14, 2023 Category: Emergency Medicine Authors: Jacob A. Lebin, Megan E. Bass, Kennon Heard, Jason Hoppe, Gabrielle Jacknin Tags: Pharmacology in Emergency Medicine Source Type: research
DSPE-PEG < sub > 2000 < /sub > -methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis
J Mol Med (Berl). 2023 Dec 4. doi: 10.1007/s00109-023-02403-7. Online ahead of print.ABSTRACTCancer is a life-threatening disease worldwide. Nanomedicine and nanodelivery systems are recently developed scientific field that employs specific materials in the nanoscale range to deliver drugs. Lipid-based nanoparticles are an ideal delivery system since they exhibit many advantages, including high bioavailability, self-assembly, formulation simplicity, and the ability to exhibit a plethora of physicochemical properties. Herein, we report that phenobarbital sodium can kill cancer cells by using the DSPE-PEG2000-methotrexate na...
Source: Molecular Medicine - December 4, 2023 Category: Molecular Biology Authors: Fengyue Yin Xiao Xu Julia Qi Mengyu Guo Yubo Wang Yun Wang Roumei Ye Qian Lin Daowei Yang Xuan Zhu Jinling Wang Source Type: research
DSPE-PEG < sub > 2000 < /sub > -methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis
J Mol Med (Berl). 2023 Dec 4. doi: 10.1007/s00109-023-02403-7. Online ahead of print.ABSTRACTCancer is a life-threatening disease worldwide. Nanomedicine and nanodelivery systems are recently developed scientific field that employs specific materials in the nanoscale range to deliver drugs. Lipid-based nanoparticles are an ideal delivery system since they exhibit many advantages, including high bioavailability, self-assembly, formulation simplicity, and the ability to exhibit a plethora of physicochemical properties. Herein, we report that phenobarbital sodium can kill cancer cells by using the DSPE-PEG2000-methotrexate na...
Source: Molecular Medicine - December 4, 2023 Category: Molecular Biology Authors: Fengyue Yin Xiao Xu Julia Qi Mengyu Guo Yubo Wang Yun Wang Roumei Ye Qian Lin Daowei Yang Xuan Zhu Jinling Wang Source Type: research
DSPE-PEG2000-methotrexate nanoparticles encapsulating phenobarbital sodium kill cancer cells by inducing pyroptosis
AbstractCancer is a life-threatening disease worldwide. Nanomedicine and nanodelivery systems are recently developed scientific field that employs specific materials in the nanoscale range to deliver drugs. Lipid-based nanoparticles are an ideal delivery system since they exhibit many advantages, including high bioavailability, self-assembly, formulation simplicity, and the ability to exhibit a plethora of physicochemical properties. Herein, we report that phenobarbital sodium can kill cancer cells by using the DSPE-PEG2000-methotrexate nanoparticle delivery system, which can target folate receptors that are usually overex...
Source: Journal of Molecular Medicine - December 4, 2023 Category: Molecular Biology Source Type: research
Cenobamate enhances the anticonvulsant effect of other antiseizure medications in the DBA/2 mouse model of reflex epilepsy
This study aimed to detect the role of CNB on generalized seizures using the DBA/2 mouse model. We have also studied the effects of an adjunctive CNB treatment on the antiseizure properties of some ASMs against reflex seizures. The effects of this adjunctive treatment on motor performance, body temperature, and brain levels of ASMs were also evaluated. CNB was able to antagonize seizures in DBA/2 mice. CNB, at 5 mg/kg, enhanced the antiseizure activity of ASMs, such as diazepam, clobazam, levetiracetam, perampanel, phenobarbital, topiramate, and valproate. No synergistic effects were observed when CNB was co-administered w...
Source: European Journal of Pharmacology - November 29, 2023 Category: Drugs & Pharmacology Authors: Antonio Leo Francesca Bosco Lorenza Guarnieri Caterina De Sarro Vincenzo Rania Luca Gallelli Rita Citraro Giovambattista De Sarro Source Type: research
Cenobamate enhances the anticonvulsant effect of other antiseizure medications in the DBA/2 mouse model of reflex epilepsy
This study aimed to detect the role of CNB on generalized seizures using the DBA/2 mouse model. We have also studied the effects of an adjunctive CNB treatment on the antiseizure properties of some ASMs against reflex seizures. The effects of this adjunctive treatment on motor performance, body temperature, and brain levels of ASMs were also evaluated. CNB was able to antagonize seizures in DBA/2 mice. CNB, at 5 mg/kg, enhanced the antiseizure activity of ASMs, such as diazepam, clobazam, levetiracetam, perampanel, phenobarbital, topiramate, and valproate. No synergistic effects were observed when CNB was co-administered w...
Source: European Journal of Pharmacology - November 29, 2023 Category: Drugs & Pharmacology Authors: Antonio Leo Francesca Bosco Lorenza Guarnieri Caterina De Sarro Vincenzo Rania Luca Gallelli Rita Citraro Giovambattista De Sarro Source Type: research
Molecules, Vol. 28, Pages 7830: Simple HPLC-UV Method for Therapeutic Drug Monitoring of 12 Antiepileptic Drugs and Their Main Metabolites in Human Plasma
The objective of the present report was to develop and validate a simple, selective, and reproducible high-performance liquid chromatography method with UV detection suitable for routine therapeutic drug monitoring of the most commonly used antiepileptic drugs and some of their metabolites. Simple precipitation of plasma proteins with acetonitrile was used for sample preparation. 10,11-dihydrocarbamazepine was used as an internal standard. Chromatographic separation of the analytes was achieved by gradient elution on a Phenyl&ndash;Hexyl column at 40 &deg;C, using methanol and potassium phosphate buffer (25...
Source: Molecules - November 28, 2023 Category: Chemistry Authors: Daniela Milosheska Robert Ro škar Tags: Article Source Type: research
Physiologically-based pharmacokinetic modeling for maribavir to inform dosing in drug-drug interaction scenarios with cyp3a4 Inducers and Inhibitors
This article is protected by copyright. All rights reserved.PMID:38009271 | DOI:10.1002/jcph.2385 (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - November 27, 2023 Category: Drugs & Pharmacology Authors: Grace Chen Kefeng Sun Ingrid Michon Zoe Barter Sibylle Neuhoff Lipika Ghosh Katarina Ilic Ivy H Song Source Type: research
Phenobarbital does not worsen outcomes of neonatal hypoxia on hippocampal LTP on rats
DiscussionThese results point to different susceptibility to hypoxia as a function of sex and age, and a non-detrimental effect of PB when administered after hypoxic seizures. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - November 21, 2023 Category: Neurology Source Type: research
Trends and Differences in Status Epilepticus Treatment of Children and Adults Over 10 Years: A Comparative Study of Medical Records (2012 –2021) from a University Hospital in Germany
ConclusionMidazolam has become the preferred benzodiazepine in pre- and in-hospital settings, both in children and adults. The same applies to the increased use of levetiracetam and lacosamide over time in children and adults, while phenobarbital, phenytoin, and valproate use decreased. Continuous midazolam infusion and propofol remain the most frequently used anesthetic drugs. Mortality and outcome remain stable despite changes in medication patterns. (Source: CNS Drugs)
Source: CNS Drugs - November 18, 2023 Category: Neurology Source Type: research
Neonatal seizures and progression to epilepsy in a tertiary hospital
CONCLUSIONS: Diagnosis of neonatal seizures requires high clinical suspicion and electroclinical confirmation. Most of them progress favourably, but a percentage constitute the onset of epilepsy, the identification of which will determine their therapeutic management.PMID:37962536 | DOI:10.33588/rn.7710.2023218 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 14, 2023 Category: Neurology Authors: A Hern ández-Prieto M Garrido-Mart ín H G ómez-Martín A Pablos-L ópez C Alonso-D íez A Hern ández-Fabián M Justel-Rodr íguez J M Garrido-Pedraz P Prieto-Matos Source Type: research
Neonatal seizures and progression to epilepsy in a tertiary hospital
CONCLUSIONS: Diagnosis of neonatal seizures requires high clinical suspicion and electroclinical confirmation. Most of them progress favourably, but a percentage constitute the onset of epilepsy, the identification of which will determine their therapeutic management.PMID:37962536 | DOI:10.33588/rn.7710.2023218 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 14, 2023 Category: Neurology Authors: A Hern ández-Prieto M Garrido-Mart ín H G ómez-Martín A Pablos-L ópez C Alonso-D íez A Hern ández-Fabián M Justel-Rodr íguez J M Garrido-Pedraz P Prieto-Matos Source Type: research
