A novel approach to seizures in neonates
Eur J Paediatr Neurol. 2023 Jul 27;46:89-97. doi: 10.1016/j.ejpn.2023.07.006. Online ahead of print.ABSTRACTTHE CHALLENGE OF SEIZURE RECOGNITION: Recognition of seizures in neonates remains the foremost challenge to overcome. All neonates at risk for seizures, especially the critically ill, should undergo video-EEG monitoring. The initial step toward an accurate diagnosis is the accurate description and interpretation of the electro-clinical phenotype. THE IMPORTANCE OF SEIZURE SEMIOLOGY AND ASSOCIATION WITH ETIOLOGY: The early distinction between acute provoked seizures and neonatal-onset epilepsies serves as the primary ...
Source: European Journal of Paediatric Neurology - August 6, 2023 Category: Neurology Authors: Evelina Carapancea Maria Roberta Cilio Source Type: research
Acute Valproate-Induced Encephalopathy in Status Epilepticus: A Registry-Based Assessment
ConclusionPending larger studies, VIE in SE seems relatively frequent and difficult to foresee; clinical alertness to symptoms is mandatory, even without hyperammonemia, and valproate withdrawal should be considered in suspected cases. (Source: CNS Drugs)
Source: CNS Drugs - July 19, 2023 Category: Neurology Source Type: research
Paediatric medicine issues and gaps from healthcare workers point of view: survey results and a narrative review from the global accelerator for paediatric formulations project
The WHO Model List of Essential Medicines for Children (EMLc) has not been systematically revised in the last few years. We conducted a survey addressed to healthcare professionals prescribing, preparing, or administering medicines to children and a narrative review to identify problematic paediatric formulations or missing medicines in all therapeutic fields to inform the review of the EMLc in 2023. A total of 285 physicians (63%), 28 nurses (6%) and 142 pharmacists (31%), mostly working in the hospital setting, reported at least one problematic medicine. 290 medicines were reported as missing (completely or the child-app...
Source: Frontiers in Pharmacology - July 17, 2023 Category: Drugs & Pharmacology Source Type: research
Using the LeiCNS-PK3.0 Physiologically-Based Pharmacokinetic Model to Predict Brain Extracellular Fluid Pharmacokinetics in Mice
ConclusionThe current version of the mouse LeiCNS-PK3.0 model seems to reasonably predict available information on brainECF from healthy mice for most drugs. This brings the translation between mouse and human brain PK one step further. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - July 13, 2023 Category: Drugs & Pharmacology Source Type: research
Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): Interest of skin tests in cross-reactivity to phenobarbital
Therapie. 2023 Jun 16:S0040-5957(23)00085-9. doi: 10.1016/j.therap.2023.06.005. Online ahead of print.NO ABSTRACTPMID:37407309 | DOI:10.1016/j.therap.2023.06.005 (Source: Therapie)
Source: Therapie - July 5, 2023 Category: Psychiatry & Psychology Authors: Jawhar Rebai Haifa Ben Romdhane Khadija Mansour Najah Ben Fadhel Ines Lahouel Zohra Chadly Amel Chaabane Nadia Ben Fredj Karim Aouam Source Type: research
Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): Interest of skin tests in cross-reactivity to phenobarbital
Therapie. 2023 Jun 16:S0040-5957(23)00085-9. doi: 10.1016/j.therap.2023.06.005. Online ahead of print.NO ABSTRACTPMID:37407309 | DOI:10.1016/j.therap.2023.06.005 (Source: Therapie)
Source: Therapie - July 5, 2023 Category: Psychiatry & Psychology Authors: Jawhar Rebai Haifa Ben Romdhane Khadija Mansour Najah Ben Fadhel Ines Lahouel Zohra Chadly Amel Chaabane Nadia Ben Fredj Karim Aouam Source Type: research
Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): Interest of skin tests in cross-reactivity to phenobarbital
Therapie. 2023 Jun 16:S0040-5957(23)00085-9. doi: 10.1016/j.therap.2023.06.005. Online ahead of print.NO ABSTRACTPMID:37407309 | DOI:10.1016/j.therap.2023.06.005 (Source: Therapie)
Source: Therapie - July 5, 2023 Category: Psychiatry & Psychology Authors: Jawhar Rebai Haifa Ben Romdhane Khadija Mansour Najah Ben Fadhel Ines Lahouel Zohra Chadly Amel Chaabane Nadia Ben Fredj Karim Aouam Source Type: research
Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): Interest of skin tests in cross-reactivity to phenobarbital
Therapie. 2023 Jun 16:S0040-5957(23)00085-9. doi: 10.1016/j.therap.2023.06.005. Online ahead of print.NO ABSTRACTPMID:37407309 | DOI:10.1016/j.therap.2023.06.005 (Source: Therapie)
Source: Therapie - July 5, 2023 Category: Psychiatry & Psychology Authors: Jawhar Rebai Haifa Ben Romdhane Khadija Mansour Najah Ben Fadhel Ines Lahouel Zohra Chadly Amel Chaabane Nadia Ben Fredj Karim Aouam Source Type: research
Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): Interest of skin tests in cross-reactivity to phenobarbital
Therapie. 2023 Jun 16:S0040-5957(23)00085-9. doi: 10.1016/j.therap.2023.06.005. Online ahead of print.NO ABSTRACTPMID:37407309 | DOI:10.1016/j.therap.2023.06.005 (Source: Therapie)
Source: Therapie - July 5, 2023 Category: Psychiatry & Psychology Authors: Jawhar Rebai Haifa Ben Romdhane Khadija Mansour Najah Ben Fadhel Ines Lahouel Zohra Chadly Amel Chaabane Nadia Ben Fredj Karim Aouam Source Type: research
Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): Interest of skin tests in cross-reactivity to phenobarbital
Therapie. 2023 Jun 16:S0040-5957(23)00085-9. doi: 10.1016/j.therap.2023.06.005. Online ahead of print.NO ABSTRACTPMID:37407309 | DOI:10.1016/j.therap.2023.06.005 (Source: Therapie)
Source: Therapie - July 5, 2023 Category: Psychiatry & Psychology Authors: Jawhar Rebai Haifa Ben Romdhane Khadija Mansour Najah Ben Fadhel Ines Lahouel Zohra Chadly Amel Chaabane Nadia Ben Fredj Karim Aouam Source Type: research
Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): Interest of skin tests in cross-reactivity to phenobarbital
Therapie. 2023 Jun 16:S0040-5957(23)00085-9. doi: 10.1016/j.therap.2023.06.005. Online ahead of print.NO ABSTRACTPMID:37407309 | DOI:10.1016/j.therap.2023.06.005 (Source: Therapie)
Source: Therapie - July 5, 2023 Category: Psychiatry & Psychology Authors: Jawhar Rebai Haifa Ben Romdhane Khadija Mansour Najah Ben Fadhel Ines Lahouel Zohra Chadly Amel Chaabane Nadia Ben Fredj Karim Aouam Source Type: research
Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): Interest of skin tests in cross-reactivity to phenobarbital
Therapie. 2023 Jun 16:S0040-5957(23)00085-9. doi: 10.1016/j.therap.2023.06.005. Online ahead of print.NO ABSTRACTPMID:37407309 | DOI:10.1016/j.therap.2023.06.005 (Source: Therapie)
Source: Therapie - July 5, 2023 Category: Psychiatry & Psychology Authors: Jawhar Rebai Haifa Ben Romdhane Khadija Mansour Najah Ben Fadhel Ines Lahouel Zohra Chadly Amel Chaabane Nadia Ben Fredj Karim Aouam Source Type: research
Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS): Interest of skin tests in cross-reactivity to phenobarbital
Therapie. 2023 Jun 16:S0040-5957(23)00085-9. doi: 10.1016/j.therap.2023.06.005. Online ahead of print.NO ABSTRACTPMID:37407309 | DOI:10.1016/j.therap.2023.06.005 (Source: Therapie)
Source: Therapie - July 5, 2023 Category: Psychiatry & Psychology Authors: Jawhar Rebai Haifa Ben Romdhane Khadija Mansour Najah Ben Fadhel Ines Lahouel Zohra Chadly Amel Chaabane Nadia Ben Fredj Karim Aouam Source Type: research
Treatment of pediatric convulsive status epilepticus
Status epilepticus is one of the most common life-threatening neurological emergencies in childhood with the highest incidence in the first 5 years of life and high mortality and morbidity rates. Although it is known that a delayed treatment and a prolonged seizure can cause permanent brain damage, there is evidence that current treatments may be delayed and the medication doses administered are insufficient. Here, we summarize current knowledge on treatment of convulsive status epilepticus in childhood and propose a treatment algorithm. We performed a structured literature search via PubMed and ClinicalTrails.org and id...
Source: Frontiers in Neurology - June 29, 2023 Category: Neurology Source Type: research
