Neonatal seizures and progression to epilepsy in a tertiary hospital
CONCLUSIONS: Diagnosis of neonatal seizures requires high clinical suspicion and electroclinical confirmation. Most of them progress favourably, but a percentage constitute the onset of epilepsy, the identification of which will determine their therapeutic management.PMID:37962536 | DOI:10.33588/rn.7710.2023218 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 14, 2023 Category: Neurology Authors: A Hern ández-Prieto M Garrido-Mart ín H G ómez-Martín A Pablos-L ópez C Alonso-D íez A Hern ández-Fabián M Justel-Rodr íguez J M Garrido-Pedraz P Prieto-Matos Source Type: research
Neonatal seizures and progression to epilepsy in a tertiary hospital
CONCLUSIONS: Diagnosis of neonatal seizures requires high clinical suspicion and electroclinical confirmation. Most of them progress favourably, but a percentage constitute the onset of epilepsy, the identification of which will determine their therapeutic management.PMID:37962536 | DOI:10.33588/rn.7710.2023218 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 14, 2023 Category: Neurology Authors: A Hern ández-Prieto M Garrido-Mart ín H G ómez-Martín A Pablos-L ópez C Alonso-D íez A Hern ández-Fabián M Justel-Rodr íguez J M Garrido-Pedraz P Prieto-Matos Source Type: research
Neonatal seizures and progression to epilepsy in a tertiary hospital
CONCLUSIONS: Diagnosis of neonatal seizures requires high clinical suspicion and electroclinical confirmation. Most of them progress favourably, but a percentage constitute the onset of epilepsy, the identification of which will determine their therapeutic management.PMID:37962536 | DOI:10.33588/rn.7710.2023218 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 14, 2023 Category: Neurology Authors: A Hern ández-Prieto M Garrido-Mart ín H G ómez-Martín A Pablos-L ópez C Alonso-D íez A Hern ández-Fabián M Justel-Rodr íguez J M Garrido-Pedraz P Prieto-Matos Source Type: research
Neonatal seizures and progression to epilepsy in a tertiary hospital
CONCLUSIONS: Diagnosis of neonatal seizures requires high clinical suspicion and electroclinical confirmation. Most of them progress favourably, but a percentage constitute the onset of epilepsy, the identification of which will determine their therapeutic management.PMID:37962536 | DOI:10.33588/rn.7710.2023218 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 14, 2023 Category: Neurology Authors: A Hern ández-Prieto M Garrido-Mart ín H G ómez-Martín A Pablos-L ópez C Alonso-D íez A Hern ández-Fabián M Justel-Rodr íguez J M Garrido-Pedraz P Prieto-Matos Source Type: research
Neonatal seizures and progression to epilepsy in a tertiary hospital
CONCLUSIONS: Diagnosis of neonatal seizures requires high clinical suspicion and electroclinical confirmation. Most of them progress favourably, but a percentage constitute the onset of epilepsy, the identification of which will determine their therapeutic management.PMID:37962536 | DOI:10.33588/rn.7710.2023218 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 14, 2023 Category: Neurology Authors: A Hern ández-Prieto M Garrido-Mart ín H G ómez-Martín A Pablos-L ópez C Alonso-D íez A Hern ández-Fabián M Justel-Rodr íguez J M Garrido-Pedraz P Prieto-Matos Source Type: research
Neonatal seizures and progression to epilepsy in a tertiary hospital
CONCLUSIONS: Diagnosis of neonatal seizures requires high clinical suspicion and electroclinical confirmation. Most of them progress favourably, but a percentage constitute the onset of epilepsy, the identification of which will determine their therapeutic management.PMID:37962536 | DOI:10.33588/rn.7710.2023218 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 14, 2023 Category: Neurology Authors: A Hern ández-Prieto M Garrido-Mart ín H G ómez-Martín A Pablos-L ópez C Alonso-D íez A Hern ández-Fabián M Justel-Rodr íguez J M Garrido-Pedraz P Prieto-Matos Source Type: research
Neonatal seizures and progression to epilepsy in a tertiary hospital
CONCLUSIONS: Diagnosis of neonatal seizures requires high clinical suspicion and electroclinical confirmation. Most of them progress favourably, but a percentage constitute the onset of epilepsy, the identification of which will determine their therapeutic management.PMID:37962536 | DOI:10.33588/rn.7710.2023218 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 14, 2023 Category: Neurology Authors: A Hern ández-Prieto M Garrido-Mart ín H G ómez-Martín A Pablos-L ópez C Alonso-D íez A Hern ández-Fabián M Justel-Rodr íguez J M Garrido-Pedraz P Prieto-Matos Source Type: research
Neonatal seizures and progression to epilepsy in a tertiary hospital
CONCLUSIONS: Diagnosis of neonatal seizures requires high clinical suspicion and electroclinical confirmation. Most of them progress favourably, but a percentage constitute the onset of epilepsy, the identification of which will determine their therapeutic management.PMID:37962536 | DOI:10.33588/rn.7710.2023218 (Source: Revista de Neurologia)
Source: Revista de Neurologia - November 14, 2023 Category: Neurology Authors: A Hern ández-Prieto M Garrido-Mart ín H G ómez-Martín A Pablos-L ópez C Alonso-D íez A Hern ández-Fabián M Justel-Rodr íguez J M Garrido-Pedraz P Prieto-Matos Source Type: research
Phenobarbital Treatment of Alcohol Withdrawal in the Emergency Department: A Systematic Review and Meta-analysis
CONCLUSIONS: The current literature base does not show that treatment with phenobarbital significantly reduces ICU admissions, hospital admissions, ED readmissions, or adverse events in ED patients with AWS compared with benzodiazepines alone.PMID:37923363 | DOI:10.1111/acem.14825 (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - November 3, 2023 Category: Emergency Medicine Authors: Carmen M Lee David G Dillon Peggy M Tahir Charles E Murphy Source Type: research
Seizures after initiation of rewarming in cooled infants with hypoxic ischaemic encephalopathy
CONCLUSION: Overall, just over a quarter of infants with prior seizures had cEEG evidence of at least one seizure in the 24 h after initiation of rewarming but no seizure-naive infant had cEEG evidence of seizure(s) on rewarming. Critically, by reporting the two groups separately, the data can provide guidance on the duration of EEG monitoring.IMPACT: Infants with hypoxic ischaemic encephalopathy who have cEEG evidence of seizures during therapeutic hypothermia have a significant risk of further seizures on rewarming. For infants with hypoxic ischaemic encephalopathy but no cEEG evidence of seizures during therapeutic hypo...
Source: Pediatric Research - November 2, 2023 Category: Pediatrics Authors: Malcolm R Battin Suzanne L Davis Marisa Gardner Priscilla Joe Maynard Rasmussen Richard Haas Cynthia Sharpe Source Type: research
Seizures after initiation of rewarming in cooled infants with hypoxic ischaemic encephalopathy
CONCLUSION: Overall, just over a quarter of infants with prior seizures had cEEG evidence of at least one seizure in the 24 h after initiation of rewarming but no seizure-naive infant had cEEG evidence of seizure(s) on rewarming. Critically, by reporting the two groups separately, the data can provide guidance on the duration of EEG monitoring.IMPACT: Infants with hypoxic ischaemic encephalopathy who have cEEG evidence of seizures during therapeutic hypothermia have a significant risk of further seizures on rewarming. For infants with hypoxic ischaemic encephalopathy but no cEEG evidence of seizures during therapeutic hypo...
Source: Pediatric Research - November 2, 2023 Category: Pediatrics Authors: Malcolm R Battin Suzanne L Davis Marisa Gardner Priscilla Joe Maynard Rasmussen Richard Haas Cynthia Sharpe Source Type: research
Study of fingolimod, nitric oxide inhibitor, and P-glycoprotein inhibitor in modulating the P-glycoprotein expression via an endothelin & #8211;sphingolipid pathway in an animal model of pharmacoresistant epilepsy
CONCLUSION: The modulation of the P-gp expression by Fingolimod improved drug delivery to the brain in an animal model of refractory epilepsy. Therefore, S1P signaling could serve as an additional therapeutic target to overcome refractoriness. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 2, 2023 Category: Drugs & Pharmacology Authors: Nitika Garg Rupa Joshi Alka Bhatia Seema Bansal Amitava Chakrabarti Ajay Prakash Biman Saikia Manish Modi Bikash Medhi Source Type: research
Differentiated and non-differentiated HepaRG < sup > TM < /sup > cells: a possible in-vitro model system for early hepatocarcinogenesis and non-genotoxic carcinogens
Toxicol Lett. 2023 Oct 25:S0378-4274(23)01077-9. doi: 10.1016/j.toxlet.2023.10.014. Online ahead of print.ABSTRACTMany xenobiotics are non-genotoxic carcinogens (NGC) in rodent liver. Their mode of action (MoA) and health risks for humans are unclear and no in-vitro tests are available to predict NGC. Human HepaRGTM cells in the differentiated (d-HepaRG) and non-differentiated state (nd-HepaRG) were studied as new approach methodology (NAM) for NGC. Cell-biological assays were performed with d-/nd-HepaRG and human hepatoma/hepatocarcinoma cell-lines to characterize the benign/malignant phenotype. Reaction of d-/nd-HepaRG t...
Source: Toxicology Letters - October 27, 2023 Category: Toxicology Authors: Michael Gutmann Emily Stimpfl Gregor Langmann Helga Koudelka Birgit Mir-Karner Bettina Grasl-Kraupp Source Type: research
Differentiated and non-differentiated HepaRG < sup > TM < /sup > cells: a possible in-vitro model system for early hepatocarcinogenesis and non-genotoxic carcinogens
Toxicol Lett. 2023 Oct 25:S0378-4274(23)01077-9. doi: 10.1016/j.toxlet.2023.10.014. Online ahead of print.ABSTRACTMany xenobiotics are non-genotoxic carcinogens (NGC) in rodent liver. Their mode of action (MoA) and health risks for humans are unclear and no in-vitro tests are available to predict NGC. Human HepaRGTM cells in the differentiated (d-HepaRG) and non-differentiated state (nd-HepaRG) were studied as new approach methodology (NAM) for NGC. Cell-biological assays were performed with d-/nd-HepaRG and human hepatoma/hepatocarcinoma cell-lines to characterize the benign/malignant phenotype. Reaction of d-/nd-HepaRG t...
Source: Toxicology Letters - October 27, 2023 Category: Toxicology Authors: Michael Gutmann Emily Stimpfl Gregor Langmann Helga Koudelka Birgit Mir-Karner Bettina Grasl-Kraupp Source Type: research
Differentiated and non-differentiated HepaRG < sup > TM < /sup > cells: a possible in-vitro model system for early hepatocarcinogenesis and non-genotoxic carcinogens
Toxicol Lett. 2023 Oct 25:S0378-4274(23)01077-9. doi: 10.1016/j.toxlet.2023.10.014. Online ahead of print.ABSTRACTMany xenobiotics are non-genotoxic carcinogens (NGC) in rodent liver. Their mode of action (MoA) and health risks for humans are unclear and no in-vitro tests are available to predict NGC. Human HepaRGTM cells in the differentiated (d-HepaRG) and non-differentiated state (nd-HepaRG) were studied as new approach methodology (NAM) for NGC. Cell-biological assays were performed with d-/nd-HepaRG and human hepatoma/hepatocarcinoma cell-lines to characterize the benign/malignant phenotype. Reaction of d-/nd-HepaRG t...
Source: Toxicology Letters - October 27, 2023 Category: Toxicology Authors: Michael Gutmann Emily Stimpfl Gregor Langmann Helga Koudelka Birgit Mir-Karner Bettina Grasl-Kraupp Source Type: research
