Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child
CONCLUSIONS: Exposure in the womb to certain ASMs was associated with an increased risk of certain MCMs which, for many, is dose-dependent.PMID:37647086 | PMC:PMC10463554 | DOI:10.1002/14651858.CD010224.pub3 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - August 30, 2023 Category: General Medicine Authors: Rebecca Bromley Naghme Adab Matt Bluett-Duncan Jill Clayton-Smith Jakob Christensen Katherine Edwards Janette Greenhalgh Ruaraidh A Hill Cerian F Jackson Sonia Khanom Ronan N McGinty Catrin Tudur Smith Jennifer Pulman Anthony G Marson Source Type: research
Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child
CONCLUSIONS: Exposure in the womb to certain ASMs was associated with an increased risk of certain MCMs which, for many, is dose-dependent.PMID:37647086 | PMC:PMC10463554 | DOI:10.1002/14651858.CD010224.pub3 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - August 30, 2023 Category: General Medicine Authors: Rebecca Bromley Naghme Adab Matt Bluett-Duncan Jill Clayton-Smith Jakob Christensen Katherine Edwards Janette Greenhalgh Ruaraidh A Hill Cerian F Jackson Sonia Khanom Ronan N McGinty Catrin Tudur Smith Jennifer Pulman Anthony G Marson Source Type: research
Stevens-johnson Syndrome and Toxic Epidermal Necrolysis: An Overview of Diagnosis, Therapy Options and Prognosis of Patients
Recent Adv Inflamm Allergy Drug Discov. 2023 Aug 21. doi: 10.2174/2772270817666230821102441. Online ahead of print.ABSTRACTBoth Stevens-Johnson syndrome (SJS) and Toxic-epidermal necrolysis (TEN) are generally medication-induced pathological conditions that mostly affect the epidermis and mucus membranes. Nearly 1 to 2 patients per 1,000,000 population are affected annually with SJS and TEN, and sometimes these maladies can cause serious life-threatening events. The reported death rates for SJS range from 1 to 5%, and 25 to 35% for TEN. The mortality risk may even be higher among elderly patients, especially in those who a...
Source: Herpes - August 22, 2023 Category: Infectious Diseases Authors: Vivek Kumar Garg Harpal S Buttar Sajad Ahmad Bhat Nuftieva Ainur Tannu Priya Dharambir Kashyap Hardeep Singh Tuli Source Type: research
Stevens-johnson Syndrome and Toxic Epidermal Necrolysis: An Overview of Diagnosis, Therapy Options and Prognosis of Patients
Recent Adv Inflamm Allergy Drug Discov. 2023 Aug 21. doi: 10.2174/2772270817666230821102441. Online ahead of print.ABSTRACTBoth Stevens-Johnson syndrome (SJS) and Toxic-epidermal necrolysis (TEN) are generally medication-induced pathological conditions that mostly affect the epidermis and mucus membranes. Nearly 1 to 2 patients per 1,000,000 population are affected annually with SJS and TEN, and sometimes these maladies can cause serious life-threatening events. The reported death rates for SJS range from 1 to 5%, and 25 to 35% for TEN. The mortality risk may even be higher among elderly patients, especially in those who a...
Source: Herpes - August 22, 2023 Category: Infectious Diseases Authors: Vivek Kumar Garg Harpal S Buttar Sajad Ahmad Bhat Nuftieva Ainur Tannu Priya Dharambir Kashyap Hardeep Singh Tuli Source Type: research
New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: II. Treatments in Clinical Development
AbstractThe inhibitory neurotransmitter γ-aminobutyric acid (GABA) plays an important role in the modulation of neuronal excitability, and a disruption of GABAergic transmission contributes to the pathogenesis of some seizure disorders. Although many currently available antiseizure medications do act at least in part by potentiating GABA ergic transmission, there is an opportunity for further research aimed at developing more innovative GABA-targeting therapies. The present article summarises available evidence on a number of such treatments in clinical development. These can be broadly divided into three groups. The firs...
Source: CNS Drugs - August 21, 2023 Category: Neurology Source Type: research
Phenobarbital for Alcohol Withdrawal Management in the Emergency Department: A Systematic Review of Direct Evidence for the SAEM GRACE Initiative
CONCLUSIONS: Relatively few studies provide direct evidence on the utility of phenobarbital for AWS in the ED, but the evidence that exists generally suggests that it is a reasonable and appropriate approach. Additional RCTs and other methodologically rigorous investigations are needed for more definitive direct evidence.PMID:37589203 | DOI:10.1111/acem.14788 (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - August 17, 2023 Category: Emergency Medicine Authors: Kiran Punia William Scott Kriti Manuja Kaitryn Campbell Iris M Balodis James MacKillop Source Type: research
Phenobarbital for Alcohol Withdrawal Management in the Emergency Department: A Systematic Review of Direct Evidence for the SAEM GRACE Initiative
CONCLUSIONS: Relatively few studies provide direct evidence on the utility of phenobarbital for AWS in the ED, but the evidence that exists generally suggests that it is a reasonable and appropriate approach. Additional RCTs and other methodologically rigorous investigations are needed for more definitive direct evidence.PMID:37589203 | DOI:10.1111/acem.14788 (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - August 17, 2023 Category: Emergency Medicine Authors: Kiran Punia William Scott Kriti Manuja Kaitryn Campbell Iris M Balodis James MacKillop Source Type: research
Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews
CONCLUSIONS: None of the reported studies had an impact on aGMH-IVH, sIVH, ACND, or MND. The certainty of the evidence ranged from moderate to very low. Large RCTs of rigorous methodology are needed to achieve an optimal information size to assess the effects of pharmacological interventions for pain and sedation management for the prevention of GMH-IVH and mortality in preterm infants. Studies might compare interventions against either placebo or other drugs. Reporting of the outcome data should include the assessment of GMH-IVH and long-term neurodevelopment.PMID:37565681 | DOI:10.1002/14651858.CD012706.pub2 (Source: Coc...
Source: Cochrane Database of Systematic Reviews - August 11, 2023 Category: General Medicine Authors: Agata Str óżyk Themistoklis Paraskevas Olga Romantsik Maria Grazia Calevo Rita Banzi David Ley Matteo Bruschettini Source Type: research
Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews
CONCLUSIONS: None of the reported studies had an impact on aGMH-IVH, sIVH, ACND, or MND. The certainty of the evidence ranged from moderate to very low. Large RCTs of rigorous methodology are needed to achieve an optimal information size to assess the effects of pharmacological interventions for pain and sedation management for the prevention of GMH-IVH and mortality in preterm infants. Studies might compare interventions against either placebo or other drugs. Reporting of the outcome data should include the assessment of GMH-IVH and long-term neurodevelopment.PMID:37565681 | DOI:10.1002/14651858.CD012706.pub2 (Source: Coc...
Source: Cochrane Database of Systematic Reviews - August 11, 2023 Category: General Medicine Authors: Agata Str óżyk Themistoklis Paraskevas Olga Romantsik Maria Grazia Calevo Rita Banzi David Ley Matteo Bruschettini Source Type: research
Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews
CONCLUSIONS: None of the reported studies had an impact on aGMH-IVH, sIVH, ACND, or MND. The certainty of the evidence ranged from moderate to very low. Large RCTs of rigorous methodology are needed to achieve an optimal information size to assess the effects of pharmacological interventions for pain and sedation management for the prevention of GMH-IVH and mortality in preterm infants. Studies might compare interventions against either placebo or other drugs. Reporting of the outcome data should include the assessment of GMH-IVH and long-term neurodevelopment.PMID:37565681 | PMC:PMC10421735 | DOI:10.1002/14651858.CD012706...
Source: Cochrane Database of Systematic Reviews - August 11, 2023 Category: General Medicine Authors: Agata Str óżyk Themistoklis Paraskevas Olga Romantsik Maria Grazia Calevo Rita Banzi David Ley Matteo Bruschettini Source Type: research
A novel approach to seizures in neonates
Eur J Paediatr Neurol. 2023 Jul 27;46:89-97. doi: 10.1016/j.ejpn.2023.07.006. Online ahead of print.ABSTRACTTHE CHALLENGE OF SEIZURE RECOGNITION: Recognition of seizures in neonates remains the foremost challenge to overcome. All neonates at risk for seizures, especially the critically ill, should undergo video-EEG monitoring. The initial step toward an accurate diagnosis is the accurate description and interpretation of the electro-clinical phenotype. THE IMPORTANCE OF SEIZURE SEMIOLOGY AND ASSOCIATION WITH ETIOLOGY: The early distinction between acute provoked seizures and neonatal-onset epilepsies serves as the primary ...
Source: European Journal of Paediatric Neurology - August 6, 2023 Category: Neurology Authors: Evelina Carapancea Maria Roberta Cilio Source Type: research
A novel approach to seizures in neonates
Eur J Paediatr Neurol. 2023 Jul 27;46:89-97. doi: 10.1016/j.ejpn.2023.07.006. Online ahead of print.ABSTRACTTHE CHALLENGE OF SEIZURE RECOGNITION: Recognition of seizures in neonates remains the foremost challenge to overcome. All neonates at risk for seizures, especially the critically ill, should undergo video-EEG monitoring. The initial step toward an accurate diagnosis is the accurate description and interpretation of the electro-clinical phenotype. THE IMPORTANCE OF SEIZURE SEMIOLOGY AND ASSOCIATION WITH ETIOLOGY: The early distinction between acute provoked seizures and neonatal-onset epilepsies serves as the primary ...
Source: European Journal of Paediatric Neurology - August 6, 2023 Category: Neurology Authors: Evelina Carapancea Maria Roberta Cilio Source Type: research
A novel approach to seizures in neonates
Eur J Paediatr Neurol. 2023 Jul 27;46:89-97. doi: 10.1016/j.ejpn.2023.07.006. Online ahead of print.ABSTRACTTHE CHALLENGE OF SEIZURE RECOGNITION: Recognition of seizures in neonates remains the foremost challenge to overcome. All neonates at risk for seizures, especially the critically ill, should undergo video-EEG monitoring. The initial step toward an accurate diagnosis is the accurate description and interpretation of the electro-clinical phenotype. THE IMPORTANCE OF SEIZURE SEMIOLOGY AND ASSOCIATION WITH ETIOLOGY: The early distinction between acute provoked seizures and neonatal-onset epilepsies serves as the primary ...
Source: European Journal of Paediatric Neurology - August 6, 2023 Category: Neurology Authors: Evelina Carapancea Maria Roberta Cilio Source Type: research
A novel approach to seizures in neonates
Eur J Paediatr Neurol. 2023 Jul 27;46:89-97. doi: 10.1016/j.ejpn.2023.07.006. Online ahead of print.ABSTRACTTHE CHALLENGE OF SEIZURE RECOGNITION: Recognition of seizures in neonates remains the foremost challenge to overcome. All neonates at risk for seizures, especially the critically ill, should undergo video-EEG monitoring. The initial step toward an accurate diagnosis is the accurate description and interpretation of the electro-clinical phenotype. THE IMPORTANCE OF SEIZURE SEMIOLOGY AND ASSOCIATION WITH ETIOLOGY: The early distinction between acute provoked seizures and neonatal-onset epilepsies serves as the primary ...
Source: European Journal of Paediatric Neurology - August 6, 2023 Category: Neurology Authors: Evelina Carapancea Maria Roberta Cilio Source Type: research
