Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation
CONCLUSIONS: The most intriguing interaction was that for ISOP + VPA, for which the addition of BOR evoked a transition from antagonism to synergy in the mouse MES model.PMID:37821793 | DOI:10.1007/s43440-023-00532-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 11, 2023 Category: Drugs & Pharmacology Authors: Jarogniew J Łuszczki Hubert Bojar Katarzyna Jankiewicz Magdalena Florek- Łuszczki Jaros ław Chmielewski Krystyna Skalicka-Wo źniak Source Type: research
Anticonvulsant effects of isopimpinellin and its interactions with classic antiseizure medications and borneol in the mouse tonic-clonic seizure model: an isobolographic transformation
CONCLUSIONS: The most intriguing interaction was that for ISOP + VPA, for which the addition of BOR evoked a transition from antagonism to synergy in the mouse MES model.PMID:37821793 | DOI:10.1007/s43440-023-00532-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - October 11, 2023 Category: Drugs & Pharmacology Authors: Jarogniew J Łuszczki Hubert Bojar Katarzyna Jankiewicz Magdalena Florek- Łuszczki Jaros ław Chmielewski Krystyna Skalicka-Wo źniak Source Type: research
The impact of a newly established specialized pediatric epilepsy center in Tanzania: An observational study
CONCLUSIONS: Our data depicted the epilepsy spectrum and highlighted the prognostic implications of improving the availability of ASMs such as sodium valproate and second- and third-generation ones in resource-limited countries.PMID:37776594 | DOI:10.1016/j.yebeh.2023.109454 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 30, 2023 Category: Neurology Authors: Miriam Aric ò Mario Mastrangelo Sofia Pia Di Noia Mgabo Siboti Mabusi Albino Kalolo Francesco Pisani Source Type: research
The impact of a newly established specialized pediatric epilepsy center in Tanzania: An observational study
CONCLUSIONS: Our data depicted the epilepsy spectrum and highlighted the prognostic implications of improving the availability of ASMs such as sodium valproate and second- and third-generation ones in resource-limited countries.PMID:37776594 | DOI:10.1016/j.yebeh.2023.109454 (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - September 30, 2023 Category: Neurology Authors: Miriam Aric ò Mario Mastrangelo Sofia Pia Di Noia Mgabo Siboti Mabusi Albino Kalolo Francesco Pisani Source Type: research
Grading the level of evidence of neonatal pharmacotherapy: midazolam and phenobarbital as examples
CONCLUSIONS: There is a reasonable level of evidence concerning midazolam and phenobarbital PK in neonates, although using a predefined target without integrated PK/PD evaluation. Further research is needed on midazolam use in term neonates with therapeutic hypothermia, and phenobarbital treatment in preterms.IMPACT: There is a reasonable level of evidence concerning pharmacotherapy of midazolam and phenobarbital in neonates. Most evidence is however based on PK studies, using a predefined target level or concentration range without integrated, combined PK/PD evaluation. Using the GAPPS system, final strength of recommenda...
Source: Pediatric Research - September 26, 2023 Category: Pediatrics Authors: Liam Mahoney Genny Raffaeli Serdar Beken Sezin Ünal Charalampos Kotidis Giacomo Cavallaro Felipe Garrido Aomesh Bhatt Eugene M Dempsey Karel Allegaert Sinno H P Simons Robert B Flint Anne Smits ESPR Pharmacology Section Source Type: research
Grading the level of evidence of neonatal pharmacotherapy: midazolam and phenobarbital as examples
CONCLUSIONS: There is a reasonable level of evidence concerning midazolam and phenobarbital PK in neonates, although using a predefined target without integrated PK/PD evaluation. Further research is needed on midazolam use in term neonates with therapeutic hypothermia, and phenobarbital treatment in preterms.IMPACT: There is a reasonable level of evidence concerning pharmacotherapy of midazolam and phenobarbital in neonates. Most evidence is however based on PK studies, using a predefined target level or concentration range without integrated, combined PK/PD evaluation. Using the GAPPS system, final strength of recommenda...
Source: Pediatric Research - September 26, 2023 Category: Pediatrics Authors: Liam Mahoney Genny Raffaeli Serdar Beken Sezin Ünal Charalampos Kotidis Giacomo Cavallaro Felipe Garrido Aomesh Bhatt Eugene M Dempsey Karel Allegaert Sinno H P Simons Robert B Flint Anne Smits ESPR Pharmacology Section Source Type: research
Assessment of alcohol withdrawal syndrome: new perspectives
Orv Hetil. 2023 Sep 24;164(38):1487-1496. doi: 10.1556/650.2023.32847. Print 2023 Sep 24.ABSTRACTAlcohol withdrawal syndrome is one of the most important consequences of alcohol use disorder, a complex neuropsychiatric disorder, which is firstly treated in non-specific and secondly in psychiatric/addictive in- or outpatient units. On the other hand, alcohol withdrawal syndrome is one of the most important outcomes of the severity of alcohol use disorder, further, it can lead to the development of alcohol-related seizure and delirium tremens. Hence, early recognition and optimal treatment of alcohol withdrawal syndrome have...
Source: Orvosi Hetilap - September 24, 2023 Category: General Medicine Authors: Bettina Kata K ádár Ildik ó Katalin Pribék Janka Gajdics J ános Szemelyácz B álint Andó Bence Andr ás Lázár Source Type: research
Assessment of alcohol withdrawal syndrome: new perspectives
Orv Hetil. 2023 Sep 24;164(38):1487-1496. doi: 10.1556/650.2023.32847. Print 2023 Sep 24.ABSTRACTAlcohol withdrawal syndrome is one of the most important consequences of alcohol use disorder, a complex neuropsychiatric disorder, which is firstly treated in non-specific and secondly in psychiatric/addictive in- or outpatient units. On the other hand, alcohol withdrawal syndrome is one of the most important outcomes of the severity of alcohol use disorder, further, it can lead to the development of alcohol-related seizure and delirium tremens. Hence, early recognition and optimal treatment of alcohol withdrawal syndrome have...
Source: Orvosi Hetilap - September 24, 2023 Category: General Medicine Authors: Bettina Kata K ádár Ildik ó Katalin Pribék Janka Gajdics J ános Szemelyácz B álint Andó Bence Andr ás Lázár Source Type: research
Assessment of alcohol withdrawal syndrome: new perspectives
Orv Hetil. 2023 Sep 24;164(38):1487-1496. doi: 10.1556/650.2023.32847. Print 2023 Sep 24.ABSTRACTAlcohol withdrawal syndrome is one of the most important consequences of alcohol use disorder, a complex neuropsychiatric disorder, which is firstly treated in non-specific and secondly in psychiatric/addictive in- or outpatient units. On the other hand, alcohol withdrawal syndrome is one of the most important outcomes of the severity of alcohol use disorder, further, it can lead to the development of alcohol-related seizure and delirium tremens. Hence, early recognition and optimal treatment of alcohol withdrawal syndrome have...
Source: Orvosi Hetilap - September 24, 2023 Category: General Medicine Authors: Bettina Kata K ádár Ildik ó Katalin Pribék Janka Gajdics J ános Szemelyácz B álint Andó Bence Andr ás Lázár Source Type: research
Assessment of alcohol withdrawal syndrome: new perspectives
Orv Hetil. 2023 Sep 24;164(38):1487-1496. doi: 10.1556/650.2023.32847. Print 2023 Sep 24.ABSTRACTAlcohol withdrawal syndrome is one of the most important consequences of alcohol use disorder, a complex neuropsychiatric disorder, which is firstly treated in non-specific and secondly in psychiatric/addictive in- or outpatient units. On the other hand, alcohol withdrawal syndrome is one of the most important outcomes of the severity of alcohol use disorder, further, it can lead to the development of alcohol-related seizure and delirium tremens. Hence, early recognition and optimal treatment of alcohol withdrawal syndrome have...
Source: Orvosi Hetilap - September 24, 2023 Category: General Medicine Authors: Bettina Kata K ádár Ildik ó Katalin Pribék Janka Gajdics J ános Szemelyácz B álint Andó Bence Andr ás Lázár Source Type: research
Assessment of alcohol withdrawal syndrome: new perspectives
Orv Hetil. 2023 Sep 24;164(38):1487-1496. doi: 10.1556/650.2023.32847. Print 2023 Sep 24.ABSTRACTAlcohol withdrawal syndrome is one of the most important consequences of alcohol use disorder, a complex neuropsychiatric disorder, which is firstly treated in non-specific and secondly in psychiatric/addictive in- or outpatient units. On the other hand, alcohol withdrawal syndrome is one of the most important outcomes of the severity of alcohol use disorder, further, it can lead to the development of alcohol-related seizure and delirium tremens. Hence, early recognition and optimal treatment of alcohol withdrawal syndrome have...
Source: Orvosi Hetilap - September 24, 2023 Category: General Medicine Authors: Bettina Kata K ádár Ildik ó Katalin Pribék Janka Gajdics J ános Szemelyácz B álint Andó Bence Andr ás Lázár Source Type: research
Epilepsy plus blindness in microdeletion of GABRA1 and GABRG2 in mouse and human
CONCLUSIONS: This study is the first report of haploinsufficiency of two GABR epilepsy genes and visual impairment due to altered axonal myelination and resultant optic nerve atrophy. The study suggests the far-reaching impact of GABR mutations and the translational significance of animal models with the same etiology.PMID:37703949 | DOI:10.1016/j.expneurol.2023.114537 (Source: Experimental Neurology)
Source: Experimental Neurology - September 13, 2023 Category: Neurology Authors: Qi Zhang Cynthia Forster-Gibson Eduard Bercovici Alexandra Bernardo Fei Ding Wangzhen Shen Katherine Langer Tonia Rex Jing-Qiong Kang Source Type: research
Epilepsy plus blindness in microdeletion of GABRA1 and GABRG2 in mouse and human
CONCLUSIONS: This study is the first report of haploinsufficiency of two GABR epilepsy genes and visual impairment due to altered axonal myelination and resultant optic nerve atrophy. The study suggests the far-reaching impact of GABR mutations and the translational significance of animal models with the same etiology.PMID:37703949 | DOI:10.1016/j.expneurol.2023.114537 (Source: Experimental Neurology)
Source: Experimental Neurology - September 13, 2023 Category: Neurology Authors: Qi Zhang Cynthia Forster-Gibson Eduard Bercovici Alexandra Bernardo Fei Ding Wangzhen Shen Katherine Langer Tonia Rex Jing-Qiong Kang Source Type: research
CAR requires Gadd45 β to promote phenobarbital-induced mouse liver tumors in early stage
Phenobarbital (PB) is an archetypal substance used as a mouse hepatocellular carcinoma (HCC) promotor in established experimental protocols. Our previous results showed CAR is the essential factor for PB induced HCC promotion. Subsequent studies suggested Gadd45β, which is induced by PB through CAR activation, is collaborating with CAR to repress TNF-α induced cell death. Here, we used Gadd45β null mice (Gadd45β KO) treated with N-diethylnitrosamine (DEN) at 5 weeks of age and kept the mice with PB supplemented drinking water from 7 to 57 weeks old. Compared with wild type mice, Gadd45β KO mice developed no HCC in the...
Source: Frontiers in Oncology - September 7, 2023 Category: Cancer & Oncology Source Type: research
Effects of bumetanide on neonatal seizures: a systematic review of animal and human studies
Seizures are the most common neurological emergency in the neonatal period. They occur more often during the neonatal period than at any other time during life, with a reported incidence of one to five per 1,000 live births. [1] Phenobarbital is the first-line medication for neonatal seizures, other drugs being levetiracetam, phenytoin, midazolam, and lignocaine. [2,3] One recent pilot RCT found that 80% of infants who received phenobarbital remained seizure free for 24 hours [4] whereas the majority of studies have reported that currently used drugs achieve complete response only in 35-50% of cases after the initial loadi...
Source: Seizure: European Journal of Epilepsy - September 7, 2023 Category: Neurology Authors: Shripada Rao, Asifa Farhat, Abhijeet Rakshasbhuvankar, Sam Athikarisamy, Soumya Ghosh, Lakshmi Nagarajan Source Type: research
