Efficacy and safety of steroid therapy in COVID-19: A rapid systematic review and Meta-analysis
CONCLUSION: This study guides the use of steroid across patients with different severity categories of COVID-19. Among mechanically ventilated patients, steroid therapy may be beneficial in terms of reduced mortality. Among “severe and critical” patients; steroid therapy was associated with lowered mortality, decreased requirement of mechanical ventilation, and ICU. However, no benefit was observed in “mild to moderate” population. To conclude, among properly selected patient populations (based-upon clinical severity and biomarker status), steroid administration may prove beneficial in patients with...
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Phulen Sarma Anusuya Bhattacharyya Hardeep Kaur Manisha Prajapat Ajay Prakash Subodh Kumar Seema Bansal Richard Kirubakaran Dibbanti Harikrishna Reddy Gaurav Muktesh Karanvir Kaushal Saurabh Sharma Nishant Shekhar Pramod Avti Prasad Thota Bikash Medhi Source Type: research

Antiviral effect of amiodarone and its possible role in COVID-19: An appraisal
Snehal Lonare, Mythili Hazarika, Chandra Kr DasIndian Journal of Pharmacology 2020 52(6):533-534 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Snehal Lonare Mythili Hazarika Chandra Kr Das Source Type: research

Tacrolimus-induced mania in a patient with nephrotic syndrome
Alok Kumar, Dorchhom Khrime, Vivek RuhelaIndian Journal of Pharmacology 2020 52(6):531-532 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Alok Kumar Dorchhom Khrime Vivek Ruhela Source Type: research

Tropicamide abuse and regulatory measures in a Sudanese hospital
Elhassan Hussein Eltom, Mohanad Kamaleldin Mahmoud Ibrahim, Ekramy Mahmoud ElmorsyIndian Journal of Pharmacology 2020 52(6):529-530 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Elhassan Hussein Eltom Mohanad Kamaleldin Mahmoud Ibrahim Ekramy Mahmoud Elmorsy Source Type: research

Convergence of divergent approaches to control COVID-19
Shivani Desai, Shivani R Sainani, Ketki R Rode, Ramesh R BhondeIndian Journal of Pharmacology 2020 52(6):526-528 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Shivani Desai Shivani R Sainani Ketki R Rode Ramesh R Bhonde Source Type: research

Response to & #8220;A comparative study of alpha-1a blockers (tamsulosin) versus estrogens in the treatment of lower urinary tract symptoms in perimenopausal females & #8221;
Anant PatilIndian Journal of Pharmacology 2020 52(6):524-525 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Anant Patil Source Type: research

Bradyarrhythmia due to mirtazapine overdose: A case of serious adverse event in a suicidal patient
Filiz Baloglu Kaya, Caglar Kuas, Engin Ozakin, Muhammed Evvah Karakilic, Seyhmus KayaIndian Journal of Pharmacology 2020 52(6):520-523 There are a limited number of studies on postoverdose clinical findings of mirtazapine in the literature. Our case presented an unlikely junctional rhythm, which we have not seen in the previous studies, in a patient who had bradycardia and hypotension following mirtazapine intake. A 37-year old male was admitted to the emergency department (ED) after his suicide attempt with 300 mg PO of mirtazapine tablets. He took the drug 2 h prior to his ED visit. He did not have any complaints after ...
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Filiz Baloglu Kaya Caglar Kuas Engin Ozakin Muhammed Evvah Karakilic Seyhmus Kaya Source Type: research

Effectiveness and tolerability of twice daily dosing of deferasirox in unresponsive and intolerant transfusion-dependent beta-thalassemia patients: A narrative review
Tirin Babu, George Mathew Panachiyil, Juny Sebastian, Mandyam Dhati RaviIndian Journal of Pharmacology 2020 52(6):514-519 Chronic iron overload in beta-thalassemia patients after continuous blood transfusions has caused notable morbidity and mortality in these patients. The once-a-day oral iron chelator, deferasirox has established efficacy and bearable safety in adults and pediatric thalassemia patients. It is now extensively used for the management of transfusional hemosiderosis. However, a number of studies have revealed a few patients continued to be none respondent or intolerant toward the once-a-day regimen of defer...
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Tirin Babu George Mathew Panachiyil Juny Sebastian Mandyam Dhati Ravi Source Type: research

Zebrafish: An emerging whole-organism screening tool in safety pharmacology
Vandana S Nikam, Deeksha Singh, Rohan Takawale, Minal R GhanteIndian Journal of Pharmacology 2020 52(6):505-513 During the last two decades, the development in drug discovery is slackening due to drug withdrawal from the market or reported to have postmarket safety events. The vital organ toxicities, especially cardiotoxicity, hepatotoxicity, pulmonary toxicity, and neurotoxicity are the major concerns for high drug attrition rates. The pharmaceutical industry is looking for high throughput, high content analysis based novel assays that would be fast, efficient, reproducible, and cost-effective; would address toxicity, th...
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Vandana S Nikam Deeksha Singh Rohan Takawale Minal R Ghante Source Type: research

Evaluation of the possibility of selective modulation of retinal glucose transporters in diabetic complications: An experimental study
CONCLUSION: This study showed the possibility of selective upregulation of GLUT4 (independent of PPARγ activation) in the retina of diabetic rats using genistein. Selective modulation of retinal glucose transporters as therapeutic target in ocular diabetic complications can be possibly explored. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Kanuj Mishra Madhu Nath Nabanita Halder Thirumurthy Velpandian Source Type: research

Antiproliferative effect of Acacia nilotica (L.) leaf extract rich in ethyl gallate against human carcinoma cell line KB
CONCLUSIONS: ANLEE is a prospective source for cancer therapy and therefore should be highlighted to explore on its wide range of safety in rats and efficacy against human carcinoma cell line KB. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Kalaivani Thiagarajan Shalini Mohan Tapas Kumar Roy Rajasekaran Chandrasekaran Source Type: research

Nonprescription sale of schedule H1 antibiotics in a city of South India
CONCLUSIONS: The present study revealed that the antibiotics are continued to be sold without prescription even after the education program on schedule H1. The deregulation of the act is definitely the problem to be addressed by the government. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Vineela Chadalavada S Manohar Babu K Balamurugan Source Type: research

To evaluate the efficacy and safety of olopatadine 0.1 & #37; ophthalmic solution and bepotastine 1.5 & #37; ophthalmic solution in patients with vernal keratoconjunctivitis in a tertiary care hospital
CONCLUSIONS: In this study, based on the evaluation of therapeutic performance, bepotastine eye drops proved quicker relief of symptoms and signs compared to olopatadine eye drops but was not statistically significant which would prove beneficial for the patients. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Vadlakonda Sruthi Resu Neha Reddy K Sowmini Nagur Sharone Grace Source Type: research

Efficacy of valacyclovir and famciclovir in herpes zoster: A comparative study
CONCLUSION: Oral valacyclovir administered during acute zoster infection for a period of 7 days offers significant benefit compared to famciclovir by providing a well tolerated and greater resolution of pain while maintaining the favorable safety profile, making valacyclovir more efficacious and a better drug in management of Herpes Zoster in comparison to famciclovir. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Ankita Bist A Savitha Kashinath M Gumma Source Type: research

Pregnancy outcomes following exposure to efavirenz based antiretroviral therapy in indian women
CONCLUSION: There was an association of exposure to efavirenz with an increased incidence of adverse pregnancy outcomes, especially LBW infants. This study emphasizes the requirement of large prospective studies to investigate fetomaternal outcomes in pregnant women exposed to efavirenz. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Rajesh Kumar Mishra Rony Chakravarty Nilopher Siddique Kirit Rajendra Pandey Source Type: research

Regulatory approval for COVID-19 across the globe
Vidya Mahalmani, T Pugazhenthan, Niti Mittal, Shoban Babu Varthya, Bikash MedhiIndian Journal of Pharmacology 2020 52(6):457-466 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - February 19, 2021 Category: Drugs & Pharmacology Authors: Vidya Mahalmani T Pugazhenthan Niti Mittal Shoban Babu Varthya Bikash Medhi Source Type: research

Fundamentals of experimental pharmacology
Kanwaljit ChopraIndian Journal of Pharmacology 2020 52(5):443-443 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Kanwaljit Chopra Source Type: research

Are multiple sclerosis therapies safe in severe acute respiratory syndrome coronavirus 2 times ?
Francesco Ferrara, Raffaele La Porta, Priscilla Santilli, Vilma D'Aiuto, Antonio VitielloIndian Journal of Pharmacology 2020 52(5):441-442 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Francesco Ferrara Raffaele La Porta Priscilla Santilli Vilma D & #39;Aiuto Antonio Vitiello Source Type: research

Drug-induced immune-mediated thrombocytopenia
Harpreet Singh, Deba Prasad Dhibar, Deepak ChaudharyIndian Journal of Pharmacology 2020 52(5):439-440 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Harpreet Singh Deba Prasad Dhibar Deepak Chaudhary Source Type: research

Chlorambucil-induced psoriasis: A rare entity
Sumir Kumar, Priya Kapoor, Meenakshi BatraniIndian Journal of Pharmacology 2020 52(5):437-438 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Sumir Kumar Priya Kapoor Meenakshi Batrani Source Type: research

Changing drug regimen during COVID-19 pandemic lockdown: An experience from a Tertiary Eye Care Hospital as a cornea specialist
Bharat Gurnani, Kirandeep KaurIndian Journal of Pharmacology 2020 52(5):435-436 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Bharat Gurnani Kirandeep Kaur Source Type: research

Photodermatitis in a woman with infiltrating intraductal breast carcinoma: An uncommon adverse cutaneous drug reaction of paclitaxel revisited
Vikram K Mahajan, Vikas Sharma, Dhaarna WadhwaIndian Journal of Pharmacology 2020 52(5):430-434 Paclitaxel-induced photodermatitis is extremely rare despite the frequent use of paclitaxel-trastuzumab combination chemotherapy. A 70-year-old woman with infiltrating intraductal breast cancer developed photodermatitis after ten treatment courses of weekly paclitaxel-trastuzumab combination chemotherapy. Withdrawal of paclitaxel and sun avoidance led to its resolution. A combined effect of solar radiation and enhanced porphyrin synthesis is speculated for photodermatitis in paclitaxel. However, the issue of aberrant porphyrin ...
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Vikram K Mahajan Vikas Sharma Dhaarna Wadhwa Source Type: research

Organoids: An invaluable tool in pharmacology
This article discusses the various aspects of this emerging concept along with its uses, both in the present times and near future, with a special focus on pharmacological applications. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Sadasivam Balakrishnan Shubham Atal Avik Ray CA Pravin Malaya Nanda Source Type: research

Systematic review and meta-analysis of effectiveness and safety of favipiravir in the management of novel coronavirus (COVID-19) patients
Ajay Prakash, Harvinder Singh, Hardeep Kaur, Ankita Semwal, Phulen Sarma, Anusuya Bhattacharyya, Deba Prasad Dhibar, Bikash MedhiIndian Journal of Pharmacology 2020 52(5):414-421 Multiple options are being tried for the management of 2019-nCoV infection since its pandemic started. Favipiravir (FPV) is one of drugs, which is also being tried for the management of 2019-nCoV infection. The present study aimed to evaluate the efficacy and safety of FPV in published literature. Comparative randomized or nonrandomized controlled clinical trials comparing FPV to the standard of care (SOC)/control or other antiviral agent/combina...
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Ajay Prakash Harvinder Singh Hardeep Kaur Ankita Semwal Phulen Sarma Anusuya Bhattacharyya Deba Prasad Dhibar Bikash Medhi Source Type: research

Antibody & #8211;drug conjugates, cancer immunotherapy, and metronomic chemotherapy as novel approaches in cancer management
Sudhir Chandra Sarangi, Pranav Sopory, Soumya Sucharita Pattnaik, KH ReetaIndian Journal of Pharmacology 2020 52(5):402-413 Treatment of cancer is a major challenge even though the pathophysiology is becoming clearer with time. A number of new chemical entities are developed to target cancer growth inhibition, but the targeted delivery of these products still needs novel research. This is of utmost importance not only for higher efficacy but also for a reduction in systemic toxicity and cost of treatment. Although multiple novel targets and molecules are being researched, most of them could not pass the regulatory approva...
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Sudhir Chandra Sarangi Pranav Sopory Soumya Sucharita Pattnaik KH Reeta Source Type: research

Human adipose-derived stem cells reduce receptor-interacting protein 1, receptor-interacting protein 3, and mixed lineage kinase domain-like pseudokinase as necroptotic markers in rat model of Alzheimer & #8217;s disease
CONCLUSION: Our findings revealed that the intravenous injection of hADSCs reduced necroptosis and consequently declined the death of neuronal cells in the hippocampus of AD rats. Keywords: (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Mina Eftekharzadeh Sara Simorgh Maryam Doshmanziari Leila Hassanzadeh Marjan Shariatpanahi Source Type: research

Low oxygen microenvironment and cardiovascular remodeling: Role of dual L/N.type Ca2 & #43; channel blocker
CONCLUSION: The results demonstrated altered cardiovascular hemodynamics, disturbed cardiovascular autonomic balance, increased levels of VEGF and NOS3, and decreased bioavailability of NO on exposure to chronic sustained hypoxia. The histopathological examination further pointed toward cardiovascular remodeling. Treatment with Cil ameliorated the cardiovascular remodeling and endothelial dysfunction induced by CH exposure, which may be due to its blocking actions on L/N-type of calcium channels, indicating the possible therapeutic role of Cil against CH-induced cardiovascular pathophysiology. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Shrilaxmi Bagali Savitri M Nerune R Chandramouli Reddy Saeed M Yendigeri Bheemshetty S Patil Akram A Naikwadi Raghavendra V Kulkarni Kusal K Das Source Type: research

Presence of allele CYP3A4 & #42;16 does not have any bearing on carbamazepine-induced adverse drug reactions in North Indian people with epilepsy
CONCLUSION: CYP3A4*16 allele is not represented significantly in North Indian people with CBZ-induced dose-related side effects. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Vivek Kumar Garg Manoj Kumar Goyal Madhu Khullar Biman Saikia Bikash Medhi Ajay Prakash Nandita Prabhat Naresh Tandyala Karthik Vinay Mahesh Parampreet S Kharbanda Sudesh Prabhakar Manish Modi Vivek Lal Ritu Shree Julie Sachdeva Source Type: research

Outcome of hepatitis C patients in a community with predominant genotype 3 with standard-of-care treatment before and after advent of direct-acting antivirals: A retrospective-cum-prospective study
CONCLUSIONS: (i) In retrospective group: The overall efficacy (sustained viral response at 24 weeks [SVR-24]) of pegylated interferon a2a and ribavirin regimen was 90.96%. (ii) In prospective group: The efficacy (SVR) of different regimens was found to be as: sofosbuvir + ribavirin + daclatasvir (SVR-24, 83.33%); sofosbuvir + ribavirin (SVR-12, 94.57%); and sofosbuvir + daclatasvir (SVR-12, 98.00%). (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Showkat Ahmad Kadla Mohamad Amin Dar Nisar Ahmad Shah Bilal Ahmad Khan Asif Iqbal Shah Rupakshi Pathania Shagufta Parveen Source Type: research

To study impact of treatment with Rosuvastatin versus Atorvastatin on 25 hydroxy Vitamin D concentrations among adult Indian men- a randomized control trial
CONCLUSIONS: Treatment with Atorvastatin resulted in a reduction in 25OHD concentrations; further, its efficacy in reducing LDL-C concentrations was related to the 25OHD concentrations. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Vivek G Patwardhan Zulf M Mughal Raja Padidela Shashi A Chiplonkar Vaman V Khadilkar Anuradha V Khadilkar Source Type: research

Efficacy and safety of 7 days versus 10 days triple therapy based on levofloxacin-dexlansoprazole for eradication of Helicobacter pylori: A pilot randomized trial
CONCLUSION: LAD 10 days is the least duration that provides maximum efficacy for H. pylori in Egyptian participants. In addition, successful treatment of H. pylori infection may reduce the risk of anemia and dyslipidemia. Furthermore, all members of the patient’s family should be screened for H. pylori to prevent recurrent infection. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Noha Mahmoud Elkhodary Khaled Abdalkader Farrag Amany Mahmoud Elokaby Gamal Abd El-Hay Omran Source Type: research

Novel therapeutic approaches toward Hantaan virus and its clinical features & #8217; similarity with COVID-19
Harvinder Singh, Harpinder Kaur, Bikash MedhiIndian Journal of Pharmacology 2020 52(5):347-355 Zoonotic virus spill over in human community has been an intensive area of viral pathogenesis and the outbreak of Hantaan virus and severe acute respiratory syndrome coronavirus 2 (SARS CoV2) after late December 2019 caused a global threat. Hantaan virus is second to the COVID-19 outbreak in China with seven cases positive and one death. Both RNA viruses have opposite sense as in (−) for Hantaan virus and (+) for SARS CoV2 but have similarity in the pathogenesis and relevant clinical features including dry cough, high ...
Source: Indian Journal of Pharmacology - December 5, 2020 Category: Drugs & Pharmacology Authors: Harvinder Singh Harpinder Kaur Bikash Medhi Source Type: research

Chlorpromazine-induced lenticular opacity
Kavitha Srinivasan, Megha GopalakrishnaIndian Journal of Pharmacology 2020 52(4):339-340 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Kavitha Srinivasan Megha Gopalakrishna Source Type: research

Decreased mortality among hospitalized coronavirus disease 2019 patients who underwent anticoagulant therapy with heparin
Vityala Yethindra, Tugolbai TagaevIndian Journal of Pharmacology 2020 52(4):337-338 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Vityala Yethindra Tugolbai Tagaev Source Type: research

Human immunodeficiency virus, neuroinflammation, CD16 & #43; pathobiological process, and haloperidol drug
Beuy Joob, Viroj WiwanitkitIndian Journal of Pharmacology 2020 52(4):335-336 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Beuy Joob Viroj Wiwanitkit Source Type: research

The narrow road to a COVID-19 vaccine
Shesh Prakash Maurya, Namrata Das, Hitender Gautam, Ravinder Singh, Bimal Kumar DasIndian Journal of Pharmacology 2020 52(4):333-334 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Shesh Prakash Maurya Namrata Das Hitender Gautam Ravinder Singh Bimal Kumar Das Source Type: research

Need for national strategies for snake envenomations in India
Yogendra Kumar Gupta, Sharda Shah PeshinIndian Journal of Pharmacology 2020 52(4):331-332 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Yogendra Kumar Gupta Sharda Shah Peshin Source Type: research

Change in jaw occlusive power by paralysis of masseter muscle with a neuromuscular blocker: Sion & #39;s masseter muscle paralysis
CONCLUSION: Jaw occlusive power was decreased after SMP with succinylcholine, without inducing respiratory complication. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Sion Jo Jae Baek Lee Youngho Jin Taeoh Jeong Jae Chol Yoon Boyoung Park Source Type: research

Safety and efficacy of lopinavir/ritonavir combination in COVID-19: A systematic review, meta-analysis, and meta-regression analysis
CONCLUSION: In our study, no difference was seen between the L/R combination and the SOC arm in terms of “progression to more severe state,” “mortality,” and virological cure on days 7–10;” however, some benefits in terms of “duration of hospital stay” and “time to virological cure” were seen. No significant difference in efficacy was seen when L/R was compared to arbidol and HCQ monotherapy. Except for the occurrence of diarrhea, which was higher in the L/R group, safety profile of L/R is comparable to SOC. Compared to L/R combination, CQ, L/R + arbidol, L/R ...
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Anusuya Bhattacharyya Subodh Kumar Phulen Sarma Hardeep Kaur Manisha Prajapat Nishant Shekhar Seema Bansal Pramod Avti Mythili Hazarika Saurabh Sharma Dhruv Mahendru Ajay Prakash Bikash Medhi Source Type: research

Silk fibroin nanofibers enhance cell adhesion of blood-derived fibroblast-like cells: A potential application for wound healing
CONCLUSION: The composite scaffold of SF nanofibers with blood-derived fibroblast-like cells would be a potential healing patch for many types of wounds. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Vandana S Nikam Dhanshree S Punde Raviraj S Bhandari Source Type: research

Mangiferin ameliorates intracerebroventricular-quinolinic acid-induced cognitive deficits, oxidative stress, and neuroinflammation in Wistar rats
CONCLUSION: The results suggest that MGF offers the neuroprotective potential that may be a promising pharmacological approach to ameliorate cognitive deficits associated with neurodegeneration. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Mandeep Kumar Arora Anglina Kisku Ashok Jangra Source Type: research

A prospective study to assess the medication adherence pattern among hypertensives and to evaluate the use of cellular phone text messaging as a tool to improve adherence to medications in a tertiary health-care center
CONCLUSION: Nonadherence to medication is a global phenomenon to be tackled at the earliest. Our study clearly brings out the importance of improving adherence by regular reminders as messages. Hence, there is a wide scope to avail means to improve the adherence pattern and maximize the health benefits. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Garima Shukla A Tejus R Vishnuprasad Sapna Pradhan MS Prakash Source Type: research

Prescription pattern of antiepileptic drugs in a tertiary care center of India
CONCLUSIONS: Polytherapy is a very common practice in our tertiary care center. Sodium VPA, a highly prescribed AED, results in good control of generalized seizures, whereas focal seizures are well controlled by CBZ alone as well as in combination. The present study highlights the commonly prescribed combinations of AEDs resulting in control of different types of seizures. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Rupa Joshi Manjari Tripathi Pooja Gupta Sheffali Gulati Yogendra Kumar Gupta Source Type: research

Clinical Trials Registry & #8211; India: A decadal perspective
CONCLUSIONS: The CTRI has a strong global presence and has enhanced the transparency of regulatory trials as well as academic research particularly thesis-based work. The latter is expected to help improve standard of research and prevent repetitive research. Additional support from Indian journal editors by strict implementation of prospective registration is crucial for increasing compliance by researchers. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Mendu Vishnu Vardhana Rao Mohua Maulik Atul Juneja Tulsi Adhikari Saurabh Sharma Jyotsna Gupta Yashmin Panchal Neha Yadav Source Type: research

A comparative study of the effect of 10-day esomeprazole containing levofloxacin versus clarithromycin sequential regimens on the treatment of Iranian patients with Helicobacter pylori infection
CONCLUSIONS: Both esomeprazole containing sequential regimens including levofloxacin and clarithromycin showed good eradication rates in spite of significant differences in antimicrobial resistance patterns in vitro. The efficacy of esomeprazole in lowering gastric acidity beside its antimicrobial effect should be considered in H. pylori regimens. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Marjan Mokhtare Mehdi Nikkhah Behdad Behnam Shahram Agah Mansour Bahardoust Mohsen Masoodi Amirhosein Faghihi Source Type: research

Medication errors in neonatal intensive care unit of a tertiary care hospital in South India: A prospective observational study
CONCLUSIONS: MEs were common in NICU setting. The occurrence of life-threatening MEs was minimal. Longer duration of hospital stay, polypharmacy, and babies born outside were significantly associated with occurrence of MEs. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: B Prakadeesh Bharathi Jeffrey Pradeep Raj Kevin Saldanha PN Suman Rao D Padmini Devi Source Type: research

Comparison of medication acceptance of intranasal midazolam administered by parents versus doctors in children & #8211; A randomized trial
CONCLUSION: Intranasal midazolam when given by parents produces better preoperative anxiolysis and easier parental separation as compared with administration by a medical staff. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: M V. S Satya Prakash S Sivasankar Lenin Babu Elakkumanan VK Mohan Rithu Krishna Kamaladevi Source Type: research

Pattern of clinical research in the era of COVID-19 pandemic: A new learning experience for the present as well as future
Vidya M Mahalmani, Ankita Semwal, Harpinder Kaur, Sukhmeet Kaur, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2020 52(4):249-253 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - October 14, 2020 Category: Drugs & Pharmacology Authors: Vidya M Mahalmani Ankita Semwal Harpinder Kaur Sukhmeet Kaur Ajay Prakash Bikash Medhi Source Type: research

Sofosbuvir for COVID-19 infection: A potential candidate
Rohit Gupta, Puneet DhamijaIndian Journal of Pharmacology 2020 52(3):232-233 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Rohit Gupta Puneet Dhamija Source Type: research

Psychiatric implications of the use of hydroxychloroquine in COVID-19 patients
Seema Rani, Sandeep Grover, Aseem Mehra, Swapnajeet SahooIndian Journal of Pharmacology 2020 52(3):229-231 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 3, 2020 Category: Drugs & Pharmacology Authors: Seema Rani Sandeep Grover Aseem Mehra Swapnajeet Sahoo Source Type: research