Novel therapeutic targets for amyotrophic lateral sclerosis
Gitika Batra, Manav Jain, Rahul Soloman Singh, Amit Raj Sharma, Ashutosh Singh, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2019 51(6):418-425 Amyotrophic lateral sclerosis (ALS) is an untreatable and fatal neurodegenerative disease that is identified by the loss of motor neurons in the spinal cord, brain stem, and motor cortex which theatrically reduces life expectancy. Although the primary cause of ALS remains unclear, its heterogeneity put forward for consideration of association with various factors, including endogenous and/or environmental ones, which may be involved in progressive motor neuron stress t...
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Gitika Batra Manav Jain Rahul Soloman Singh Amit Raj Sharma Ashutosh Singh Ajay Prakash Bikash Medhi Source Type: research

Fluorescence spectra of chloroquine suspension: A probable tool for quality assessment of the most common antimalarial in a user-friendly manner
Sumanpreet Kaur, Nikhil Prasad, Abhikarsh Srivastava, Monu Kumari, Sukhpreet Singh, Deepak Kumar, Rajasris Bhattacharyya, Dibyajyoti BanerjeeIndian Journal of Pharmacology 2019 51(6):416-417 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Sumanpreet Kaur Nikhil Prasad Abhikarsh Srivastava Monu Kumari Sukhpreet Singh Deepak Kumar Rajasris Bhattacharyya Dibyajyoti Banerjee Source Type: research

Is there a place for angiotensin receptor-neprilysin inhibitors in the treatment of heart failure patients after heart transplantation ?
We present a case report of a heart failure patient after heart transplantation due to end-stage ischemic cardiomyopathy with significant clinical and echocardiographic improvement 3 months after the introduction of sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor. This new class of drugs is proved to be beneficial in heart failure patients, especially with reduced ejection fraction (HFrEF), but they have not yet been used in heart failure patients after heart transplantation. We believe that the increase of left ventricular systolic function, improvement of global longitudinal strain, and reduction of pu...
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Dario Gulin Zrinka Planinic Jasna Cerkez Habek Jozica Sikic Source Type: research

Clozapine-induced seizure
We report a case in which intial titration of low dose clozapine developed seizure. A 42-year-old female who did not have any history of seizure and had normal blood parameters and normal computed tomography brain at the baseline developed seizure while on clozapine 300 mg/day. Reduction of the dose of clozapine to 250 mg/day led to the return to baseline, with having another episode of seizure on again increasing the dose of clozapine, requiring tablet haloperidol 10 mg/day as an add-on therapy for normalization of behavioral problems. Later, clozapine was maintained on 250 mg/day, with no recurrence of seizure episodes. ...
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Ankur Jyoti Borah Abhijit Kalita Satya Kumar Dutta Source Type: research

A curious finding of skin blebs: A case report
Nisha Toteja, Bharat Choudhary, Daisy Khera, Suryanarayanan BhaskarIndian Journal of Pharmacology 2019 51(6):407-409 Mannitol has been the cornerstone of osmotherapy in the treatment of raised intracranial pressure for the past several decades. We discuss here a case of subcutaneous mannitol extravasation, leading to bullous eruptions and swelling in the forearm of a postoperative patient of arteriovenous malformation. We emphasize the importance of careful selection of peripheral intravenous catheter site, especially when infusing hypertonic solutions with propensity for subcutaneous leaks and tissue damage. (Source: Ind...
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Nisha Toteja Bharat Choudhary Daisy Khera Suryanarayanan Bhaskar Source Type: research

Perception of postgraduate students in pharmacology toward animal simulation model
CONCLUSION: CSM should be integrated alongside LAE to complement, reinforce, and enhance learning from other techniques. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Sharmila V Jalgaonkar Shirish S Joshi Snehalata V Gajbhiye Kritarth Naman M. Singh Mohsin P Sayyed Source Type: research

Investigation of hub genes and their nonsynonymous single nucleotide polymorphism analysis in Plasmodium falciparum for designing therapeutic methodologies using next-generation sequencing approach
CONCLUSION: Hub genes identified in this study serve as potential targets to develop therapy to suppress the pathogenic action of P. falciprum through experimental techniques. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Sanjay Kumar Singh Sudhakara M Reddy Source Type: research

Influence of cytochrome P450 3A5 (CYP3A5) genetic polymorphism on dose-adjusted plasma levels of carbamazepine in epileptic patients in South Indian population
CONCLUSION: There is a significant influence of CYP3A5*3 genetic polymorphism (6986A>G) on dose-adjusted plasma levels of CBZ in epileptic patients in the South Indian population. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Mahalakshmi Ganesapandian Kesavan Ramasamy Surendiran Adithan Sunil K Narayan Source Type: research

Bevacizumab for eye diseases & #8211; Legal, regulatory, and ethical overview
Vinu Jose, Swetha Radhakrishna, Parag Pipalava, Inderjeet SinghIndian Journal of Pharmacology 2019 51(6):377-383 Vascular endothelial growth factor (VEGF) inhibitors, ranibizumab, aflibercept, and pegaptanib are approved treatments for certain eye diseases that occurs especially in the elderly. These drugs are mostly inaccessible due to their high cost. Bevacizumab is a VEGF inhibitor, approved for cancer treatment. Being a cheaper alternative, it is extensively used off-label as an intravitreal injection for the treatment of eye diseases. In this article, we have analyzed similarities and differences between bevacizumab ...
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Vinu Jose Swetha Radhakrishna Parag Pipalava Inderjeet Singh Source Type: research

Artificial intelligence in pharmacovigilance: Practical utility
Kotni Murali, Sukhmeet Kaur, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2019 51(6):373-376 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Kotni Murali Sukhmeet Kaur Ajay Prakash Bikash Medhi Source Type: research

Novel targets for drug discovery in celiac disease
Rahul Soloman Singh, Ashutosh Singh, Gitika Batra, Hardeep Kaur, Bikash MedhiIndian Journal of Pharmacology 2019 51(5):359-365 Celiac disease is a lifelong, immunological disorder induced by dietary protein-gluten, in a genetically susceptible populations, resulting in different clinical manifestations, the release of antibodies, and damage to the intestinal mucosa. The only recommended therapy for the disease is to strictly follow a gluten-free diet (GFD), which is difficult to comply with. A GFD is found to be ineffective in some active Celiac disease cases. Therefore, there is an unmet need for an alternative nondietar...
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Rahul Soloman Singh Ashutosh Singh Gitika Batra Hardeep Kaur Bikash Medhi Source Type: research

Acute dystonia with metoclopramide: A common manifestation of its unscientific use in India!
Dipanjan Bhattacharjee, G Shivaprakash, Sereen Rose ThomsonIndian Journal of Pharmacology 2019 51(5):357-358 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Dipanjan Bhattacharjee G Shivaprakash Sereen Rose Thomson Source Type: research

Low-dose oxytocin - a safe strategy in postpartum hemorrhage
Pugazhenthan Thangaraju, Shoban Babu Varthya, Sajitha VenkatesanIndian Journal of Pharmacology 2019 51(5):355-356 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Pugazhenthan Thangaraju Shoban Babu Varthya Sajitha Venkatesan Source Type: research

Comment on & #8220;scrutinizing predatory journals in pharmacology and calculating their predatory rate & #8221;
Fahmi Hussein Kakamad, Shvan Hussein Mohammed, Abdulwahid Mohammed SalihIndian Journal of Pharmacology 2019 51(5):354-354 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Fahmi Hussein Kakamad Shvan Hussein Mohammed Abdulwahid Mohammed Salih Source Type: research

Carbamazepine-induced hyperglycemia: A rare case report
We reported a case of a 17-year-old girl had an increase in glucose levels after voluntary ingestion carbamazepine tablets. After ingestion, her gross random blood sugar level was increased, then physician suspected that she might be a Type I diabetic,but HbA1C[glycosylated hemoglobin] levels was found normal.Carbamazepine was discontinued and patient received symptomatic therapy. The patient had decreased levels of blood sugar level,after removal of the drug within the next day after ingestion of carbamazepine. A Naranjo assessment was obtained, indicating a definite relationship between the patient's increased in blo...
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: V Harika S Parveen M Venkatasubbaiah KV Satish Varma S Devasree Source Type: research

Anaphylactic reaction induced by intravenous diclofenac: A case report
Dinesh Kumar Badyal, Gaurav Gulrez, Divya MahindruIndian Journal of Pharmacology 2019 51(5):350-351 Among the immune-mediated reactions, anaphylaxis is the most severe form. As a postoperative analgesia, diclofenac sodium, and nonsteroidal anti-inflammatory drug is commonly used. Intravenous (IV) diclofenac sodium-induced anaphylaxis is very rare. We are presenting a case of IV diclofenac-induced anaphylactic reaction, occurred during the surgery in a female patient of 21 years of age. The sign and symptoms of the reaction resembled an anaphylactic reaction. Temporal relationship with IV diclofenac administration and deve...
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Dinesh Kumar Badyal Gaurav Gulrez Divya Mahindru Source Type: research

Case report on premature hair graying treated with Melitane 5 & #37; and oral hair supplements
Jagdish J Sakhiya, Dhruv J Sakhiya, Mehul R Patel, Feral R DaruwalaIndian Journal of Pharmacology 2019 51(5):346-349 With chronological aging, hair turns gray. Untimely premature hair graying (PHG) may tremendously influence on cosmesis, self-credibility, and social life of the affected individuals. Consequently, early treatment is required to improve cosmetic appearance. To the best of our knowledge, until today, only one case of PHG is reported in the literature, and it occurred due to iron deficiency and successfully treated with ferrous sulfate. Herein, we delineate a case of PHG in a 14-year-old female treated with t...
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Jagdish J Sakhiya Dhruv J Sakhiya Mehul R Patel Feral R Daruwala Source Type: research

Congenital ichthyosiform erythroderma: A rare neonatal dermatoses responding to acitretin
We report a child with diffuse peeling of skin and erythroderma presenting on the 2nd day of birth. With aseptic nursing care along with emollients and oral acitretin, the child's quality of life improved remarkably, hence highlighting the point of early and judicious use of acitretin in reducing disease morbidity. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Nibedita Patro Maitreyee Panda Pankaj Kumar Mohanty Source Type: research

Study of inhibitory potential and percent inhibition of oil of Syzygium aromaticum and leaves of Ocimum sanctum on ESBL enzyme from Escherichia coli in broilers of Jabalpur
CONCLUSION: The results depicted that the inhibition of beta-lactamase enzyme activity with S. aromaticum oil was higher than that of O. sanctum leaf juice, and combination of both the herbs showed not much difference in activity. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Arpita Shrivastav RK Sharma Neeraj Shrivastava Vidhi Gautam Sachin Kumar Jain Source Type: research

Effect of a polyherbal formulation in streptozotocin-induced diabetic nephropathy in wistar rats
CONCLUSION: Treatment with PHF showed beneficial effect on DN which may be due to the improvement of renal function parameters and hyperlipidemic and inflammatory mediators. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Kanala Somasekhar Reddy Akkiraju Sudheer Bhupalam Pradeepkumar Chappidi Suryaprakash Reddy Source Type: research

Evaluation of drug utilization in cardiovascular disease at a teaching and referral hospital in Northern Telangana
CONCLUSION: Polypharmacy and least use of generic name were observed in the study which may affect the rationality. The use of antiplatelets, statins, and angiotensin-converting enzyme-inhibitors was appropriate, but furosemide overuse is of major concern. Therefore, appropriate prescription writing improvises treatment compliance in the patients, which results in rationality. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Chandana Naliganti Chandrasekhar Valupadas Raghuram Rao Akkinepally Shivarani Eesam Source Type: research

Randomized controlled trial of topical mupirocin versus mupirocin with sucralfate combination in chronic skin ulcers
CONCLUSIONS: The wound healing effect of topical sucralfate adds to the antimicrobial effect of mupirocin toward the overall improvement of chronic skin ulcers. The effect of combined topical treatment needs comparison with other topical medications and wound healing strategies. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Subhrangsu Chatterjee Sumit Sen Avijit Hazra Amal Kanti Das Source Type: research

A systematic review and meta-analysis of the prevalence and complications of paraphenylenediamine-containing hair dye poisoning in developing countries
CONCLUSION: This meta-analysis provided clear evidence of the prevalence of hair dye poisoning among individuals with suicidal intentions and had given robust evidence for policy making to curtail emerging PPD-containing hair dye poisoning in developing countries. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Akshaya Srikanth Bhagavathula Deepak Kumar Bandari Moien Khan Abdulla Shehab Source Type: research

Nicorandil: A drug with ongoing benefits and different mechanisms in various diseased conditions
Lamiaa Ahmed AhmedIndian Journal of Pharmacology 2019 51(5):296-301 Nicorandil is a well-known antianginal agent, which has been recommended as one of the second-line treatments for chronic stable angina as justified by the European guidelines. It shows an efficacy equivalent to that of classic antianginal agents. Nicorandil has also been applied clinically in various cardiovascular diseases such as variant or unstable angina and reperfusion-induced damage following coronary angioplasty or thrombolysis. Different mechanisms have been involved in the protective effects of nicorandil in various diseases through either openi...
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Lamiaa Ahmed Ahmed Source Type: research

Emerging antimicrobial resistance and newer tools to address the resistance
Pardeep Kumar Goyal, Ankita Semwal, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2019 51(5):291-295 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Pardeep Kumar Goyal Ankita Semwal Ajay Prakash Bikash Medhi Source Type: research

Newer potential pharmacological targets for autism spectrum disorder
R Ashish Jain, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2019 51(4):284-286 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - September 13, 2019 Category: Drugs & Pharmacology Authors: R Ashish Jain Ajay Prakash Bikash Medhi Source Type: research

Quetiapine-induced leukocytoclastic vasculitis
Dushad Ram, Supriya MathurIndian Journal of Pharmacology 2019 51(4):282-283 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - September 13, 2019 Category: Drugs & Pharmacology Authors: Dushad Ram Supriya Mathur Source Type: research

A pediatric case report of fixed drug eruption related to carmoisine colorant present in paracetamol syrup
George Mathew Panachiyil, Tirin Babu, Juny Sebastian, Narayanappa DoddaiahIndian Journal of Pharmacology 2019 51(4):279-281 Various adverse drug reactions, including hypersensitivity skin reaction after the exposure to carmoisine colorant, have already been reported in the literature. This case report gives the details of a 5-year-old male child with a recurrent fixed drug eruption (FDE) over the neck and trunk after the use of paracetamol syrup containing carmoisine as a colorant. Patch test to the carmoisine colorant in the paracetamol syrup was positive. This case report adds an increased awareness of the probability o...
Source: Indian Journal of Pharmacology - September 13, 2019 Category: Drugs & Pharmacology Authors: George Mathew Panachiyil Tirin Babu Juny Sebastian Narayanappa Doddaiah Source Type: research

Lurasidone-induced anemia: Is there a need for hematological monitoring ?
We present two cases of schizophrenia, treated with lurasidone developing anemia after variable period of treatment and reverting after stopping lurasidone. These cases emphasize the timely monitoring of blood parameters for prevention or early detection of anemia in patients treated with lurasidone. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - September 13, 2019 Category: Drugs & Pharmacology Authors: Vivek C Kirpekar Abhijeet D Faye Sudhir H Bhave Rahul Tadke Sushil Gawande Source Type: research

Effects of clozapine and haloperidol treatment on plasma concentrations of androgen hormones and androgendependent organ changes in rats
CONCLUSION: It can be suggested that clozapine and haloperidol are effective in reducing the testosterone plasma concentration level and androgen-dependent organ sizes; therefore, clinicians should be aware of these effects when considering the use of antipsychotic drugs. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - September 13, 2019 Category: Drugs & Pharmacology Authors: Afshin Samadi Selen Yilmaz Isikhan Mohammad Hasan Khadem Ansari Mahshid Samadi Suna Sabuncuoglu Source Type: research

Jian-Pi-Yi-Fei granule suppresses airway inflammation in mice induced by cigarette smoke condensate and lipopolysaccharide
CONCLUSION: The anti-inflammatory activity of JPYF involves the suppression of pro-inflammatory cytokines, enhanced IL-10 secretion, and the restoration of HDAC2 activity. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - September 13, 2019 Category: Drugs & Pharmacology Authors: Cui-Ying Tang Si-Li Tang Kai-Feng Huang Jian Xu Hui Yu Lin Lin Source Type: research

Low-dose sodium valproate versus low-dose propranolol in prophylaxis of common migraine headache: A randomized, prospective, parallel, open-label study
CONCLUSION: Both sodium valproate and propranolol significantly reduced frequency, severity, and duration of migraine headache, but propranolol caused significantly greater reduction in the severity of headache compared to sodium valproate. Both the medications were well tolerated and did not result in discontinuation. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - September 13, 2019 Category: Drugs & Pharmacology Authors: Ganesh N Dakhale Vikas Sohanlal Sharma Manish N Thakre Mrunalini Kalikar Source Type: research

Methylenetetrahydrofolate reductase polymorphism in healthy volunteers and its correlation with homocysteine levels in patients with thrombosis
CONCLUSIONS: The prevalence of variants was more in thrombosis patients as compared to unmatched controls. Our study highlights the fact that MTHFR C677T polymorphism as compared to A1298C significantly affects Hcy levels in patients with thrombosis indicating that patients with mutant variants are at higher risk of rapid progression of their disease condition. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - September 13, 2019 Category: Drugs & Pharmacology Authors: Renuka Munshi Falguni Panchal Vrinda Kulkarni Ajay Chaurasia Source Type: research

Vaccine pharmacovigilance in India: Current context and future perspective
Bikash Ranjan MeherIndian Journal of Pharmacology 2019 51(4):243-247 Pharmacovigilance of vaccines is of paramount importance to promote the safe use of vaccines among their recipients. India launched the Adverse Events Following Immunization (AEFI) surveillance program in 1986 for monitoring suspected adverse events following immunization and since then, the AEFI surveillance guideline has been updated periodically, with the latest being in 2015. The successful AEFI surveillance program in India required the concerted effort of all stakeholders such as National AEFI Secretariat, National Technical Collaborating Centre, C...
Source: Indian Journal of Pharmacology - September 13, 2019 Category: Drugs & Pharmacology Authors: Bikash Ranjan Meher Source Type: research

& #8220;ADR PvPI & #8221; Android mobile app: Report adverse drug reaction at any time anywhere in India
CONCLUSION: The frequency of ADR reporting has significantly increased over the past 1 year and should be promoted further through awareness and training programs. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - September 13, 2019 Category: Drugs & Pharmacology Authors: Jai Prakash Kalpana Joshi Deepak Malik Omkar Mishra Akhilesh Sachan Bharat Kumar Shashi Bhushan Vivekanandan Kalaiselvan Gyanendra Nath Singh Source Type: research

Positive list of antibiotics and food products: Current perspective in India and across the globe
Vidya M Mahalmani, Phulen Sarma, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2019 51(4):231-235 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - September 13, 2019 Category: Drugs & Pharmacology Authors: Vidya M Mahalmani Phulen Sarma Ajay Prakash Bikash Medhi Source Type: research

Highlights of Indian Council of Medical Research National Ethical Guidelines for Biomedical and Health Research Involving Human Participants
Roli Mathur, Kalyani Thakur, Rajib Kishore HazamIndian Journal of Pharmacology 2019 51(3):214-221 Advancements in the field of biomedical and health research pose new ethical challenges warranting the need for constant updation in the existing ethics guidance. Realizing this, revision of “Ethical Guidelines for Biomedical Research on Human Participants (2006)” was initiated in the year 2015. The preparation of guidelines was a participatory process involving large number of stakeholders from various backgrounds in order to get a variety of perspectives. The initial draft went through an extensive process of co...
Source: Indian Journal of Pharmacology - July 9, 2019 Category: Drugs & Pharmacology Authors: Roli Mathur Kalyani Thakur Rajib Kishore Hazam Source Type: research

Whether introduction of competency-based medical education should be advocated in India ?
CONCLUSION: In conclusion, CBME remains the ultimate solution for the problems persisting in the conventional system of medical education. However, a systemic plan and better involvement of the stakeholders in the preparedness phase will significantly enhance the chances of the success of the program. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - July 9, 2019 Category: Drugs & Pharmacology Authors: Saurabh RamBihariLal Shrivastava Prateek Saurabh Shrivastava Source Type: research

Scrutinizing predator journals in pharmacology and calculating their predatory rate
CONCLUSION: It should be an eye-opener to the researchers, and they should deliberately select the journals to get real recognition of their work. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - July 9, 2019 Category: Drugs & Pharmacology Authors: Kopal Sharma Meenu Rani Lokendra Sharma Source Type: research

In silico evaluation of apoptogenic potential and toxicological profile of triterpenoids
CONCLUSION: Lead molecules identified through this in silico study such as friedelin, tingenone, albiziasaponin, bryonolic acid, and canophyllic acid may be utilized for further in vitro/in vivo studies as apoptotic agents targeting caspases-3 and 8. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - July 9, 2019 Category: Drugs & Pharmacology Authors: Tanvi Himanshu Desai Shrikant Vijayrao Joshi Source Type: research

Alteration in memory cognition due to activation of caveolin-1 and oxidative damage in a model of dementia of Alzheimer & #39;s type
CONCLUSION: The findings from the present investigation may conclude that the caveolin-1 from caveolae at the cell membrane induces memory deficits and oxidative stress phenotype that resemble the neurological phenotype of Alzheimer's disease. Further studies are warranted to gauge the effect of caveolin dyshomeostasis on the amyloidogenic cascade. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - July 9, 2019 Category: Drugs & Pharmacology Authors: Ankita Gupta Ashish Sharma Anil Kumar Rohit Goyal Source Type: research

Partnership in tuberculosis control through involvement of pharmacists in Delhi: An exploratory operational research study
CONCLUSION: Self-notification of TB engenders successful TB notifications from chemists. This progenitor approach to TB notification in the capital emphasizes the need to categorize pharmacists as an independent private care provider for improving TB notification across high-burden settings. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - July 9, 2019 Category: Drugs & Pharmacology Authors: Nandini Sharma Ashwani Khanna Shivani Chandra Warisha Mariam Saurav Basu Pawan Kumar Kamal K Chopra Neeti Babbar Source Type: research

Safety and efficacy of riboflavin-assisted collagen cross-linking of cornea in progressive keratoconus patients: A prospective study in North East India
CONCLUSION: Riboflavin-assisted C3R treatment showed promising efficacy in the treatment of PK patients in our population. As the collagen turnover rate of cornea is 2–3 years and the progression of PK is highly variable, we need long-term studies to evaluate the efficacy of C3R over time, requirement of repeat therapy, and safety of repeat cross-linking. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - July 9, 2019 Category: Drugs & Pharmacology Authors: Anusuya Bhattacharyya Phulen Sarma Kalyan Das Balmukund Agarwal Jnanankar Medhi Shyam Sundar Das Mohapatra Source Type: research

A prospective, randomized, placebo-controlled, double-blind comparative pilot study to evaluate the efficacy of Chlorophytum borivilianum on physical performance
CONCLUSION: CB increased physical performance when exposed to AA even after one month and in case of UA increase in performance was seen when CB was administered for two months thus validating its adaptogenic (anti-stress) potential. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - July 9, 2019 Category: Drugs & Pharmacology Authors: Raakhi K Tripathi Pradnya D Dethe Sunil K Bhojne Ashwinikumar A Raut Nirmala N Rege Source Type: research

Are plants used in the Eastern Cape province for cosmetics fully commercialized ?
Idowu Jonas Sagbo, Wilfred Otang MbengIndian Journal of Pharmacology 2019 51(3):140-149 Plants have been used for years for various cosmetic purposes. In the Eastern Cape province of South Africa, a large proportion of the population reliant (to some extent) on botanical resources for beauty and health. Despite the use of these botanical resources for various cosmetic purposes, only a few have been fully commercialized or used as ingredients in cosmetic formulation. The present study aimed to review plant species that are fully explored commercially for cosmetic products in the Eastern Cape province. A survey of cosmetic ...
Source: Indian Journal of Pharmacology - July 9, 2019 Category: Drugs & Pharmacology Authors: Idowu Jonas Sagbo Wilfred Otang Mbeng Source Type: research

Collaborative research in modern era: Need and challenges
Seema Bansal, Saniya Mahendiratta, Subodh Kumar, Phulen Sarma, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2019 51(3):137-139 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - July 9, 2019 Category: Drugs & Pharmacology Authors: Seema Bansal Saniya Mahendiratta Subodh Kumar Phulen Sarma Ajay Prakash Bikash Medhi Source Type: research

Time to take stock of Indian regulatory guidelines regarding drug use in pregnancy and lactation
Aashima Arora, Amol PatilIndian Journal of Pharmacology 2019 51(2):126-127 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - May 15, 2019 Category: Drugs & Pharmacology Authors: Aashima Arora Amol Patil Source Type: research

Levofloxacin-induced tactile hallucination and acute anxiety reaction
B Maharani, A Lourdu Jafrin, K Vyshnavi Bai, G SivagnanamIndian Journal of Pharmacology 2019 51(2):123-125 Fluoroquinolones are the commonly used antimicrobials in the treatment of urinary tract infection, bacterial diarrhea, and infections of soft tissue, bone, and joints. They may cause adverse effects ranging from gastrointestinal disturbances, headache, insomnia, and cutaneous reactions. Their rare adverse effects include phototoxicity, cardiotoxicity, arthropathy, and tendinitis. Among the fluoroquinolones, levofloxacin has more propensity to cause the central nervous system adverse effects such as headache, tremor, ...
Source: Indian Journal of Pharmacology - May 15, 2019 Category: Drugs & Pharmacology Authors: B Maharani A Lourdu Jafrin K Vyshnavi Bai G Sivagnanam Source Type: research

Phenytoin-induced bradycardia and hypotension
We report the case of a 62-year-old female with subarachnoid hemorrhage and right bundle branch block, who developed sinus bradycardia and hypotension on administration of IV phenytoin. This case report serves as a note for caution on patient selection for the administration of phenytoin and highlights the need for specific guidelines on the same. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - May 15, 2019 Category: Drugs & Pharmacology Authors: Swetha Reba Mathews Dinesh Kumar Badyal Renji Mathew Source Type: research

Efficacy of oral terbinafine versus itraconazole in treatment of dermatophytic infection of skin & #8211; A prospective, randomized comparative study
CONCLUSIONS: Itraconazole and terbinafine seem to be equally effective and safe in the treatment of tinea cruris and tinea corporis. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - May 15, 2019 Category: Drugs & Pharmacology Authors: Anuradha Bhatia Bimal Kanish Dinesh Kumar Badyal Prajakta Kate Swati Choudhary Source Type: research