Sofosbuvir for COVID-19 infection: A potential candidate
Rohit Gupta, Puneet DhamijaIndian Journal of Pharmacology 2020 52(3):232-233 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Rohit Gupta Puneet Dhamija Source Type: research

Psychiatric implications of the use of hydroxychloroquine in COVID-19 patients
Seema Rani, Sandeep Grover, Aseem Mehra, Swapnajeet SahooIndian Journal of Pharmacology 2020 52(3):229-231 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Seema Rani Sandeep Grover Aseem Mehra Swapnajeet Sahoo Source Type: research

Indian perspective of remdesivir: A promising COVID-19 drug
Devendra Singh, Himika Wasan, Apoorva Mathur, Yogendra Kumar GuptaIndian Journal of Pharmacology 2020 52(3):227-228 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Devendra Singh Himika Wasan Apoorva Mathur Yogendra Kumar Gupta Source Type: research

Target/therapies for chronic recurrent erythema nodosum leprosum
Pugazhenthan Thangaraju, Shoban Babu Varthya, Sajitha VenkatesanIndian Journal of Pharmacology 2020 52(3):222-226 A Type 2 lepra reaction or erythema nodosum leprosum is an anticipated complication in the lepromatous spectrum of leprosy cases. It is an example of an immune complex-mediated complement activated disease (Type III hypersensitivity reaction). Hence, we tried to target the inflammatory mediators and the mental stressors for the possible management strategies. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Pugazhenthan Thangaraju Shoban Babu Varthya Sajitha Venkatesan Source Type: research

Co-abuse of alprazolam augments the hepato-renal toxic effects of methylphenidate
CONCLUSION: The co-abuse of ALZ has amplified the hepato-renal toxic effects of MPH. Therefore, it is a significant concern for public safety, and their co-abuse must be restricted and discouraged. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Meenu Dutt Ravinder Naik Dharavath Tanzeer Kaur Navpreet Kaur Kanwaljit Chopra Shweta Sharma Source Type: research

Duloxetine-induced hypertensive urgency in type 2 diabetes mellitus with diabetic neuropathy
We present a case of hypertensive urgency in a diabetic patient with painful diabetic neuropathy on duloxetine treatment. The patient's blood pressure was high after taking 1-day dose of duloxetine and the patient was diagnosed with hypertensive urgency. The patient was managed with labetalol, leading to reduction in blood pressure. The patient's medication was switched to telmisartan and metoprolol, which leads to resolution of increased blood pressure. This case report is a possible case of hypertensive urgency after the initiation of duloxetine managed with antihypertensives and resolves with the discontinuation...
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Ravindra Shukla Sameer Khasbage Mahendra Kumar Garg Surjit Singh Source Type: research

A rare case of cephalexin-induced acute interstitial nephritis with hypokalemic periodic paralysis
Rajesh Kumar, Amit Kumar Singh, Kavish Sharma, Vandana TalwarIndian Journal of Pharmacology 2020 52(3):210-212 Drug-induced acute interstitial nephritis (AIN) is often encountered in clinical practice. Cephalexin is a first-generation cephalosporin with antimicrobial sensitivity ranging from Gram-positive to Gram-negative organisms. Cephalexin-induced AIN presenting with hypokalemic periodic paralysis (HPP) has been rarely reported. A 34-year-old female with recent history of oral cephalexin intake presented with acute onset paraplegia with deranged renal parameters and hypokalemia. She was treated conservatively with mec...
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Rajesh Kumar Amit Kumar Singh Kavish Sharma Vandana Talwar Source Type: research

Involvement of the toll-like receptors-2/nuclear factor-kappa B signaling pathway in atherosclerosis induced by high-fat diet and zymosan A in C57BL/6 mice
CONCLUSION: The study is first, to our current knowledge, to demonstrate the involvement of the TLR-2/NF-ƙB signaling pathway in atherosclerosis induced by HFD and Zym in C57BL/6 mice, resulting in increased degradation of LDLR protein, thereby, increasing the serum lipid levels. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Priyanka Arya Uma Bhandari Source Type: research

Evaluation of diuretic efficacy and antiurolithiatic potential of ethanolic leaf extract of Annona squamosa Linn. in experimental animal models
CONCLUSION: The dose of 500 mg/kg showed a promising diuretic and antiurolithiatic activity. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Mejo C Korah Junaid Rahman R Rajeswari Haja Sherief V Lalitha S Sengottavelu T Sivakumar Source Type: research

Cytochrome P4502D6 polymorphism in eastern Indian population
CONCLUSIONS: Differences in CYP2D6 activity has treatment implications and may lead to adverse events or therapeutic failure. Phenotyping of subjects receiving CYP2D6 metabolized drugs may help clinicians personalize treatment and avert adverse drug-drug interactions. However, the frequency of the PM phenotype is low in India, and routinely phenotyping for CYP2D6 activity will not be cost-effective. We cannot recommend it at this stage. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Monalisa Dhuya Murari Mohan Pal Avijit Hazra Suparna Chatterjee Nithya Gogtay Source Type: research

Drug utilization, rationality, and cost analysis of antimicrobial medicines in a tertiary care teaching hospital of Northern India: A prospective, observational study
CONCLUSION: AMMs are being commonly prescribed without confirmation of AMM sensitivity in the hospital. A large proportion of expenditure is being incurred on expensive AMM used in a few number of patients. There is a need for developing a policy for rational use of AMM in the health facility. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: HV Bimba Vandana Roy Angelika Batta Mradul Kumar Daga Source Type: research

Effectiveness of Deferasirox in Pediatric Thalassemia Patients: Experience from a Tertiary Care Hospital of Odisha
CONCLUSIONS: Deferasirox is an effective iron chelator when started at an optimum time and with optimum dose. At least 1 year of deferasirox therapy is needed for a significant lowering of serum ferritin levels of pediatric thalassemia patients on multiple blood transfusions. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Mousumee Panigrahi Trupti Rekha Swain Rabindra Kumar Jena Ashutosh Panigrahi Nishant Debta Source Type: research

Understanding the challenges and ethical aspects of compassionate use of drugs in emergency situations
Pardeep Kumar Goyal, Roli Mathur, Bikash MedhiIndian Journal of Pharmacology 2020 52(3):163-171 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - August 4, 2020 Category: Drugs & Pharmacology Authors: Pardeep Kumar Goyal Roli Mathur Bikash Medhi Source Type: research

Update on the target structures of SARS-CoV-2: A systematic review
Manisha Prajapat, Phulen Sarma, Nishant Shekhar, Ajay Prakash, Pramod Avti, Anusuya Bhattacharyya, Hardeep Kaur, Subodh Kumar, Seema Bansal, Amit Raj Sharma, Bikash MedhiIndian Journal of Pharmacology 2020 52(2):142-149 Knowledge of structural details is very much essential from the drug-design perspective. In the systematic review, we systematically reviewed the structural basis of different target proteins of SARS-corona virus (CoV2) from a viral life cycle and from drug design perspective. We searched four literature (PubMed, EMBASE, NATURE, and Willey online library) databases and one structural database (RCSB.org) wi...
Source: Indian Journal of Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Manisha Prajapat Phulen Sarma Nishant Shekhar Ajay Prakash Pramod Avti Anusuya Bhattacharyya Hardeep Kaur Subodh Kumar Seema Bansal Amit Raj Sharma Bikash Medhi Source Type: research

Update on the target structures of SARS-nCoV-2: A systematic review
Manisha Prajapat, Phulen Sarma, Nishant Shekhar, Ajay Prakash, Pramod Avti, Anusuya Bhattacharyya, Hardeep Kaur, Subodh Kumar, Seema Bansal, Amit Raj Sharma, Bikash MedhiIndian Journal of Pharmacology 2020 52(2):142-149 Knowledge of structural details is very much essential from the drug-design perspective. In the systematic review, we systematically reviewed the structural basis of different target proteins of SARS-corona virus (CoV2) from a viral life cycle and from drug design perspective. We searched four literature (PubMed, EMBASE, NATURE, and Willey online library) databases and one structural database (RCSB.org) wi...
Source: Indian Journal of Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Manisha Prajapat Phulen Sarma Nishant Shekhar Ajay Prakash Pramod Avti Anusuya Bhattacharyya Hardeep Kaur Subodh Kumar Seema Bansal Amit Raj Sharma Bikash Medhi Source Type: research

Potentially blinding adverse drug reaction to peribulbar lignocaine anesthesia: A rare case report
Saurabh Deshmukh, Harsha Bhattacharjee, Krati GuptaIndian Journal of Pharmacology 2020 52(2):138-141 Peribulbar lignocaine anesthesia is commonly used in ophthalmic surgeries. It rarely causes any severe allergic reaction. A 63-year-old male presented with complicated pseudophakia. He underwent successful vitrectomy under local anesthesia. He later presented with acute-onset proptosis, orbital swelling, and extraocular movement restriction. He was afebrile with normal blood workup and radiological investigations and gave a similar past history. The patient was treated successfully with intravenous medications but two mont...
Source: Indian Journal of Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Saurabh Deshmukh Harsha Bhattacharjee Krati Gupta Source Type: research

The effect of long-term valproic acid treatment in the level of total cholesterol among adult
Kurnia Kusumastuti, Santoso JaeriIndian Journal of Pharmacology 2020 52(2):134-137 Valproic acid (VA) is the antiepileptic, antimigraine and anti-mental disturbances agent. The use of VA is correlated to metabolic rearrangements including changes of lipoproteins; however, these effects still in debate. Herewith we analyze the effect of long-term VA treatment in the level of total cholesterol among adult. Sixty (30 case groups and 30 control groups) participants were asked for venous blood collection to examine the level of total cholesterol by enzymatic cholesterol oxidase phenol 4-aminoantipyrine peroxidase. The relation...
Source: Indian Journal of Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Kurnia Kusumastuti Santoso Jaeri Source Type: research

Bioactivities of 7 & #39;-ethoxy-trans-feruloyltyramine from Portulaca oleracea L. and its metabolism in rats using ultra-high-performance liquid chromatography electrospray coupled with quadrupole time-of-flight mass spectrometry
Zheming Ying, Mingyue Jiang, Lina Wang, Xixiang Ying, Guanlin YangIndian Journal of Pharmacology 2020 52(2):130-133 This research aims to study the antioxidation and anticholinesterase activities of 7'-ethoxy-trans-feruloyltyramine (ETFT), which was an alkaloid isolated from Portulaca oleracea for the first time. Furthermore, its main metabolites and metabolic pathways in rats were also explored. The antioxidation and anticholinesterase effects of ETFT were, respectively, examined using 1,1-diphenyl-2-picrylhydrazyl assay and modified Ellman's method. The results showed that ETFT exhibited both the good antioxidan...
Source: Indian Journal of Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Zheming Ying Mingyue Jiang Lina Wang Xixiang Ying Guanlin Yang Source Type: research

COVID-19 pandemic: A review based on current evidence
Vidya M Mahalmani, Dhruv Mahendru, Ankita Semwal, Sukhmeet Kaur, Harpinder Kaur, Phulen Sarma, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2020 52(2):117-129 In December 2019, severe acute respiratory syndrome-coronavirus-2, a novel coronavirus, initiated an outbreak of pneumonia from Wuhan in China, which rapidly spread worldwide. The clinical characteristics of the disease range from asymptomatic cases or mild symptoms, which include nonspecific symptoms such as fever, cough, sore throat, headache, and nasal congestion to severe cases such as pneumonia, respiratory failure demanding mechanical ventilation t...
Source: Indian Journal of Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Vidya M Mahalmani Dhruv Mahendru Ankita Semwal Sukhmeet Kaur Harpinder Kaur Phulen Sarma Ajay Prakash Bikash Medhi Source Type: research

Carthamus tinctorius L. Extract ameliorates cerebral ischemia-reperfusion injury in rats by regulating matrix metalloproteinases and apoptosis
Li-Li Chang, Chao Li, Zhi-Li Li, Zi-Lun Wei, Xiao-Bin Jia, Shi-Ting Pang, Yi-Qiang An, Jun-Fei Gu, Liang FengIndian Journal of Pharmacology 2020 52(2):108-116 We investigate the protective effect of Carthamus tinctorius L. (CTL, also known as Honghua in China or Safflower) on cerebral ischemia-reperfusion and explored the possible mechanisms on regulating apoptosis and matrix metalloproteinases (MMPs). High-performance liquid chromatography method with diode array detection analysis was established to analyze the components of CTL. Middle cerebral artery occlusion rats model was established to evaluate Neurological Functi...
Source: Indian Journal of Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Li-Li Chang Chao Li Zhi-Li Li Zi-Lun Wei Xiao-Bin Jia Shi-Ting Pang Yi-Qiang An Jun-Fei Gu Liang Feng Source Type: research

SB365 induces apoptosis and suppresses proliferation of glioblastoma cells
CONCLUSION: Our findings thus demonstrate that SB365 induced apoptosis and delayed the growth and migration of human glioblastoma cells. It is considered that SB365 would be a promising therapeutic option for glioblastoma. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Joo Han Lim Kyung Hee Jung Mi-Soon Kim Jee Hyeon You In-Suh Park Soon-Sun Hong Source Type: research

Network pharmacology-based study on the mechanism of Schisandra chinensis for treating Alzheimer & #39;s disease
CONCLUSIONS: These results illustrated that S. chinensis could regulate neuronal apoptosis through the calcium signaling pathway to exert anti-AD by integrating multi-component, multi-target and multi-pathway. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Cheng Kun Sun Feiyi Dong Jian Chen Feng Wu Guihua Zhu Jiangping Ji Jianwu Liu Hong Han Xiaowei Source Type: research

Comparison of the efficacy of oral fenugreek seeds hydroalcoholic extract versus placebo in nonalcoholic fatty liver disease; a randomized, triple-blind controlled pilot clinical trial
CONCLUSION: The evidence to prove the efficacy of the Fenugreek seeds' hydroalcoholic extract in NAFLD was not strong enough; hence, further experiments are still needed to assess the possible efficacy of Fenugreek on the treatment of NAFLD. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Amirhossein Babaei Seyed Alireza Taghavi Ali Mohammadi Mohammad Amin Mahdiyar Pooya Iranpour Fardad Ejtehadi Abdolali Mohagheghzadeh Source Type: research

Comparative evaluation of efficacy and tolerability of vilazodone, escitalopram, and amitriptyline in patients of major depressive disorder: A randomized, parallel, open-label clinical study
CONCLUSION: Vilazodone is more efficacious and well tolerated antidepressant compared to escitalopram and amitriptyline. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Renuka L Kadam Smita Dipak Sontakke Prashant Tiple Vijay M Motghare Chaitali S Bajait Mrunalini V Kalikar Source Type: research

Coronavirus Disease-2019 Pandemic: Hopes Ride High on Targeting Known Drugs against Unkown
Vidya M Mahalmani, Dhruv Mahendru, Phulen Sarma, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2020 52(2):75-78 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - June 3, 2020 Category: Drugs & Pharmacology Authors: Vidya M Mahalmani Dhruv Mahendru Phulen Sarma Ajay Prakash Bikash Medhi Source Type: research

Drug targets for corona virus: A systematic review
Manisha Prajapat#, Phulen Sarma#, Nishant Shekhar#, Pramod Avti, Shweta Sinha, Hardeep Kaur, Subodh Kumar, Anusuya Bhattacharyya, Harish Kumar, Seema Bansal, Bikash MedhiIndian Journal of Pharmacology 2020 52(1):56-65 The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21th century. However, the lack of specific drugs to prevent/treat an attack is a major need at this current point of time. In this regard, we conducted a systematic review to identify major druggable targets in coronavirus (CoV). We searched PubMed and RCSB database with keywords HCoV, NCoV, corona virus, SERS-CoV, MERS-CoV, 2019-nCoV, c...
Source: Indian Journal of Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Authors: Manisha Prajapat# Phulen Sarma# Nishant Shekhar# Pramod Avti Shweta Sinha Hardeep Kaur Subodh Kumar Anusuya Bhattacharyya Harish Kumar Seema Bansal Bikash Medhi Source Type: research

A rare occurrence of intrauterine death following an allergic reaction to iron sucrose
We report a case of iron sucrose causing rare reaction with generalized edema in the mother, which was followed by intrauterine death. The oxidative stress due to immune-mediated mechanisms or adjuvant used in iron sucrose could cause mild rashes to severe anaphylactic reactions. This case report warns us toward the use of parenteral iron preparations in pregnant women, as one of the safe formulations could lead to an unusual fatal outcome in the fetus. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Authors: Asha Basavareddy Source Type: research

Use of rituximab in muscle-specific tyrosine kinase antibody-positive myasthenia gravis: Preliminary observations from a tertiary care center in Northern India
CONCLUSION: Rituximab is an effective immunomodulatory therapy in MuSK antibody-positive MG patients who are not responding to the standard treatment. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Authors: Julie Sachdeva Karthik Vinay Mahesh Ritu Shree Gaurav Jain Aastha Takkar Kapila Tirulapati Padmavathi Shashikala Manoj Kumar Goyal Manish Modi Vivek Lal Source Type: research

Fasting insulin levels correlate with the frequency of hypoglycemic events in people with type 2 diabetes on treatment with sulfonylureas: A pilot study
CONCLUSION: Our results suggest that fasting insulin levels might be a predictor of the risk of hypoglycemia in people with T2D on treatment with SUs. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Authors: Konstantinos Kolokas Theocharis Koufakis Iakovos Avramidis Spyridon Gerou Maria Chatzidimitriou Kyriakos Kazakos Kalliopi Kotsa Source Type: research

Cost-effective innovation of locally assembled mannequins for undergraduate skill development in parenteral drug administration
CONCLUSION: We have observed a greater trend toward selflearning and selfefficacy and better adherence to the protocol of injection technique because of the handson training the students receive. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Authors: Susan Mani M Nisha Jolly Varghese Serah Johny Anna Mathew Source Type: research

Effect of chromium citrate on the mechanism of glucose transport and insulin resistance in Buffalo rat liver cells
CONCLUSION: The consequences illustrated that chromium citrate can affect the IR BRL cells' ameliorating glucose transport and IR. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Authors: Weijie Zhang Hui Chen Yangyang Ding Qingfang Xiang Jie Zhao Weiwei Feng Liuqing Yang Source Type: research

Comparison of midazolam and low-dose dexmedetomidine in flexible bronchoscopy: A prospective, randomized, double-blinded study
CONCLUSION: Dexmedetomidine at a dose of 0.5 μg/kg may provide clinically useful conscious sedation, comparable to midazolam. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Authors: Rahul Magazine Shivaraj Kumar Venkatachala Umesh Goneppanavar Vyshak Uddur Surendra Vasudeva Guddattu Bharti Chogtu Source Type: research

The evaluation of efficacy and safety of methotrexate and pioglitazone in psoriasis patients: A randomized, open-labeled, active-controlled clinical trial
CONCLUSIONS: Pioglitazone alone or in combination with standard treatment may be a safe alternative drug for psoriasis coexisting with MS proving beneficial for both. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Authors: Afroz Abidi Dilshad Ali Rizvi Kshitij Saxena Savita Chaudhary Ali Ahmad Source Type: research

A 12-week prospective randomized controlled comparative trial of vilazodone and sertraline in Indian patients with depression
CONCLUSIONS: Our study shows that vilazodone has similar efficacy but can be a better antidepressant due to lesser weight gain and sexual dysfunction compared to sertraline. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Authors: Manish Bathla Shazia Anjum Source Type: research

A comparative study of alpha-1a blockers (tamsulosin) versus estrogens in the treatment of lower urinary tract symptoms in perimenopausal females
CONCLUSION: Alpha-1a blockers should be used as the first-line medical management in perimenopausal females with symptoms of LUTS, as they have a clear advantage over topical estrogens. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Authors: Krishnendu Maiti Alankar Jaiswal Dilip Kumar Pal Source Type: research

Therapeutic options for the treatment of 2019-novel coronavirus: An evidence-based approach
Phulen Sarma, Manisha Prajapat, Pramod Avti, Hardeep Kaur, Subodh Kumar, Bikash MedhiIndian Journal of Pharmacology 2020 52(1):1-5 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - March 11, 2020 Category: Drugs & Pharmacology Authors: Phulen Sarma Manisha Prajapat Pramod Avti Hardeep Kaur Subodh Kumar Bikash Medhi Source Type: research

Novel therapeutic targets for amyotrophic lateral sclerosis
Gitika Batra, Manav Jain, Rahul Soloman Singh, Amit Raj Sharma, Ashutosh Singh, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2019 51(6):418-425 Amyotrophic lateral sclerosis (ALS) is an untreatable and fatal neurodegenerative disease that is identified by the loss of motor neurons in the spinal cord, brain stem, and motor cortex which theatrically reduces life expectancy. Although the primary cause of ALS remains unclear, its heterogeneity put forward for consideration of association with various factors, including endogenous and/or environmental ones, which may be involved in progressive motor neuron stress t...
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Gitika Batra Manav Jain Rahul Soloman Singh Amit Raj Sharma Ashutosh Singh Ajay Prakash Bikash Medhi Source Type: research

Fluorescence spectra of chloroquine suspension: A probable tool for quality assessment of the most common antimalarial in a user-friendly manner
Sumanpreet Kaur, Nikhil Prasad, Abhikarsh Srivastava, Monu Kumari, Sukhpreet Singh, Deepak Kumar, Rajasris Bhattacharyya, Dibyajyoti BanerjeeIndian Journal of Pharmacology 2019 51(6):416-417 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Sumanpreet Kaur Nikhil Prasad Abhikarsh Srivastava Monu Kumari Sukhpreet Singh Deepak Kumar Rajasris Bhattacharyya Dibyajyoti Banerjee Source Type: research

Is there a place for angiotensin receptor-neprilysin inhibitors in the treatment of heart failure patients after heart transplantation ?
We present a case report of a heart failure patient after heart transplantation due to end-stage ischemic cardiomyopathy with significant clinical and echocardiographic improvement 3 months after the introduction of sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor. This new class of drugs is proved to be beneficial in heart failure patients, especially with reduced ejection fraction (HFrEF), but they have not yet been used in heart failure patients after heart transplantation. We believe that the increase of left ventricular systolic function, improvement of global longitudinal strain, and reduction of pu...
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Dario Gulin Zrinka Planinic Jasna Cerkez Habek Jozica Sikic Source Type: research

Clozapine-induced seizure
We report a case in which intial titration of low dose clozapine developed seizure. A 42-year-old female who did not have any history of seizure and had normal blood parameters and normal computed tomography brain at the baseline developed seizure while on clozapine 300 mg/day. Reduction of the dose of clozapine to 250 mg/day led to the return to baseline, with having another episode of seizure on again increasing the dose of clozapine, requiring tablet haloperidol 10 mg/day as an add-on therapy for normalization of behavioral problems. Later, clozapine was maintained on 250 mg/day, with no recurrence of seizure episodes. ...
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Ankur Jyoti Borah Abhijit Kalita Satya Kumar Dutta Source Type: research

A curious finding of skin blebs: A case report
Nisha Toteja, Bharat Choudhary, Daisy Khera, Suryanarayanan BhaskarIndian Journal of Pharmacology 2019 51(6):407-409 Mannitol has been the cornerstone of osmotherapy in the treatment of raised intracranial pressure for the past several decades. We discuss here a case of subcutaneous mannitol extravasation, leading to bullous eruptions and swelling in the forearm of a postoperative patient of arteriovenous malformation. We emphasize the importance of careful selection of peripheral intravenous catheter site, especially when infusing hypertonic solutions with propensity for subcutaneous leaks and tissue damage. (Source: Ind...
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Nisha Toteja Bharat Choudhary Daisy Khera Suryanarayanan Bhaskar Source Type: research

Perception of postgraduate students in pharmacology toward animal simulation model
CONCLUSION: CSM should be integrated alongside LAE to complement, reinforce, and enhance learning from other techniques. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Sharmila V Jalgaonkar Shirish S Joshi Snehalata V Gajbhiye Kritarth Naman M. Singh Mohsin P Sayyed Source Type: research

Investigation of hub genes and their nonsynonymous single nucleotide polymorphism analysis in Plasmodium falciparum for designing therapeutic methodologies using next-generation sequencing approach
CONCLUSION: Hub genes identified in this study serve as potential targets to develop therapy to suppress the pathogenic action of P. falciprum through experimental techniques. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Sanjay Kumar Singh Sudhakara M Reddy Source Type: research

Influence of cytochrome P450 3A5 (CYP3A5) genetic polymorphism on dose-adjusted plasma levels of carbamazepine in epileptic patients in South Indian population
CONCLUSION: There is a significant influence of CYP3A5*3 genetic polymorphism (6986A>G) on dose-adjusted plasma levels of CBZ in epileptic patients in the South Indian population. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Mahalakshmi Ganesapandian Kesavan Ramasamy Surendiran Adithan Sunil K Narayan Source Type: research

Bevacizumab for eye diseases & #8211; Legal, regulatory, and ethical overview
Vinu Jose, Swetha Radhakrishna, Parag Pipalava, Inderjeet SinghIndian Journal of Pharmacology 2019 51(6):377-383 Vascular endothelial growth factor (VEGF) inhibitors, ranibizumab, aflibercept, and pegaptanib are approved treatments for certain eye diseases that occurs especially in the elderly. These drugs are mostly inaccessible due to their high cost. Bevacizumab is a VEGF inhibitor, approved for cancer treatment. Being a cheaper alternative, it is extensively used off-label as an intravitreal injection for the treatment of eye diseases. In this article, we have analyzed similarities and differences between bevacizumab ...
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Vinu Jose Swetha Radhakrishna Parag Pipalava Inderjeet Singh Source Type: research

Artificial intelligence in pharmacovigilance: Practical utility
Kotni Murali, Sukhmeet Kaur, Ajay Prakash, Bikash MedhiIndian Journal of Pharmacology 2019 51(6):373-376 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - January 16, 2020 Category: Drugs & Pharmacology Authors: Kotni Murali Sukhmeet Kaur Ajay Prakash Bikash Medhi Source Type: research

Novel targets for drug discovery in celiac disease
Rahul Soloman Singh, Ashutosh Singh, Gitika Batra, Hardeep Kaur, Bikash MedhiIndian Journal of Pharmacology 2019 51(5):359-365 Celiac disease is a lifelong, immunological disorder induced by dietary protein-gluten, in a genetically susceptible populations, resulting in different clinical manifestations, the release of antibodies, and damage to the intestinal mucosa. The only recommended therapy for the disease is to strictly follow a gluten-free diet (GFD), which is difficult to comply with. A GFD is found to be ineffective in some active Celiac disease cases. Therefore, there is an unmet need for an alternative nondietar...
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Rahul Soloman Singh Ashutosh Singh Gitika Batra Hardeep Kaur Bikash Medhi Source Type: research

Acute dystonia with metoclopramide: A common manifestation of its unscientific use in India!
Dipanjan Bhattacharjee, G Shivaprakash, Sereen Rose ThomsonIndian Journal of Pharmacology 2019 51(5):357-358 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Dipanjan Bhattacharjee G Shivaprakash Sereen Rose Thomson Source Type: research

Low-dose oxytocin - a safe strategy in postpartum hemorrhage
Pugazhenthan Thangaraju, Shoban Babu Varthya, Sajitha VenkatesanIndian Journal of Pharmacology 2019 51(5):355-356 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Pugazhenthan Thangaraju Shoban Babu Varthya Sajitha Venkatesan Source Type: research

Comment on & #8220;scrutinizing predatory journals in pharmacology and calculating their predatory rate & #8221;
Fahmi Hussein Kakamad, Shvan Hussein Mohammed, Abdulwahid Mohammed SalihIndian Journal of Pharmacology 2019 51(5):354-354 (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Authors: Fahmi Hussein Kakamad Shvan Hussein Mohammed Abdulwahid Mohammed Salih Source Type: research