Canine Mucosal Artificial Colon: development of a new colonic in vitro model adapted to dog sizes
Appl Microbiol Biotechnol. 2024 Jan 23;108(1):166. doi: 10.1007/s00253-023-12987-2.ABSTRACTDifferences in dog breed sizes are an important determinant of variations in digestive physiology, mainly related to the large intestine. In vitro gut models are increasingly used as alternatives to animal experiments for technical, cost, societal, and regulatory reasons. Up to now, only one in vitro model of the canine colon incorporates the dynamics of different canine gut regions, yet no adaptations exist to reproduce size-related digestive parameters. To address this limitation, we developed a new model of the canine colon, the C...
Source: Applied Microbiology and Biotechnology - January 23, 2024 Category: Microbiology Authors: Charlotte Deschamps Sylvain Denis Delphine Humbert Nathalie Priymenko Sandrine Chalancon Jana De Bodt Tom Van de Wiele Ignacio Ipharraguerre Inma Alvarez-Acero Caroline Achard Emmanuelle Apper St éphanie Blanquet-Diot Source Type: research
LH supplementation in IVF: human nature, politics, and elephants in the room
ConclusionsIndividual endocrine and genetics parameters may shed meaningful light on the question of LH supplemental during ovarian stimulation. (Source: Journal of Assisted Reproduction and Genetics)
Source: Journal of Assisted Reproduction and Genetics - January 22, 2024 Category: Reproduction Medicine Source Type: research
Adopting video assignments as a tool to improve first-year pharmacy students class engagement
CONCLUSIONS: The video assignment tool was successfully used to provide immediate feedback to a large class in a pharmaceutical calculations course. The students were in favor of the video assignment compared to traditional paper assignments. This finding could encourage other instructors to assess the benefit of implementing such tools in other pharmacy courses.PMID:38244677 | DOI:10.1016/j.pharma.2024.01.003 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - January 20, 2024 Category: Drugs & Pharmacology Authors: Kawther Khalid Ahmed Ali Azeez Al-Jumaili Source Type: research
Evaluation of a self-administration of medication practice in a rehabilitation unit
CONCLUSION: The medication self-administration process set up in the rehabilitation unit did not lead to serious medication errors. Patients and caregivers reported being satisfied with this new hospital practice.PMID:38244678 | DOI:10.1016/j.pharma.2024.01.004 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - January 20, 2024 Category: Drugs & Pharmacology Authors: Marie Vanhaecke Marion Hennion-Coussemacq Benjamin Dervaux Paul Accaoui Am élie Pruvost Laurie Ferret Laura Lehmann Frederic Verryser Quentin Hiver Source Type: research
Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fc γ receptors and functional impact on immune cells in vitro
Volume 16, Issue 1, January-December 2024 . (Source: mAbs)
Source: mAbs - January 19, 2024 Category: Biomedical Science Authors: Omar S. QureshiEmma J. SuttonRosemary F. BithellShauna M. WestRona M. CutlerGillian McCluskeyGraham CraggsAsher MaroofNicholas M. BarnesDavid P. HumphreysStephen RapeckiBryan J. SmithAnthony Shocka UCB Pharma, Berkshire, UKb Celentyx Ltd, Birmingham Resea Source Type: research
Unveiling the potential anti ‐cancer activity of calycosin against multivarious cancers with molecular insights: A promising frontier in cancer research
ConclusionCalycosin exhibits excellent potential as a therapeutic drug against several cancer types and should be consumed until standard chemotherapeutics are available in pharma markets. (Source: Cancer Medicine)
Source: Cancer Medicine - January 17, 2024 Category: Cancer & Oncology Authors: Md Sohel,
Fatema Tuj Zahra Shova,
Shahporan shuvo,
Taiyara Mahjabin,
Md. Mojnu Mia,
Dibyendu Halder,
Hafizul Islam,
Md Roman Mogal,
Partha Biswas,
Hasi Rani Saha,
Bidhan Chandra Sarkar,
Abdullah Al Mamun Tags: REVIEW Source Type: research
Method Development and Syntheses Examples of Isotopically Labeled Compounds to Foster Operational Excellence in Pharma Industry
Conclusion [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Synlett)
Source: Synlett - January 17, 2024 Category: Chemistry Authors: Sib, Anna Derdau, Volker Tags: account Source Type: research
A Future European Scientific Dialogue Regulatory Framework: Connecting the Dots
This article provides an overview of these challenges and reflects on the ways in which the already available SA options could be consolidated and optimized for building an integrated, easy-to-navigate process. The key elements of the proposal are improved orientation and navigation support, a simplified process of managing parallel interactions with multiple bodies, competitive SA timelines, consistency and harmonization across stakeholders, a strengthened horizon scanning to increase network preparedness, and a mechanism for building an institutional memory. The article builds on ongoing dialogues driven by the European ...
Source: Clinical Therapeutics - January 16, 2024 Category: Drugs & Pharmacology Authors: Claudia Hey Alexa Hunter Mireille Muller Nadege Le Roux Simon Bennett Kasia Nowok Laura Oliveira Source Type: research
Antibacterial agents and the fight against antibiotic resistance: A real-world evidence analysis of consumption and spending by an Italian healthcare company
CONCLUSION: This real-world evidence analysis aimed to support the justified and comprehensible global concerns regarding bacterial resistance. The extensive consumption of antibiotics will inevitably lead to the development of increasingly drug-resistant bacteria for which no antibiotic may be efficacious. National programs addressing antibiotic resistance and the awareness of all healthcare personnel must be accorded the utmost priority to enhance consumption data and, consequently, safeguard future human survival.PMID:38218426 | DOI:10.1016/j.pharma.2024.01.001 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - January 13, 2024 Category: Drugs & Pharmacology Authors: Francesco Ferrara Maurizio Capuozzo Roberta Pasquinucci Roberto Langella Ugo Trama Eduardo Nava Andrea Zovi Source Type: research
Chronic kidney disease in America, Africa, and Asia: Overview of treatment cost and options
Ann Pharm Fr. 2024 Jan 11:S0003-4509(24)00002-6. doi: 10.1016/j.pharma.2024.01.002. Online ahead of print.ABSTRACTChronic kidney disease (CKD) is one of the non-infectious diseases that threaten patients' lives on a daily basis. Its prevalence is high, but under-reported by patients and those living with the disease, as it is silent and asymptomatic in the early stages. Kidney disease increases the risk of heart and vascular disease. These problems can manifest themselves slowly, over a long period of time. Early detection and treatment can often prevent chronic kidney disease from worsening. As kidney disease progresses, ...
Source: Annales Pharmaceutiques Francaises - January 13, 2024 Category: Drugs & Pharmacology Authors: Rania Mourchid Amal Yassine Mohammed Bellahcen Yahya Cherrah Samira Serragui Source Type: research
Molecules, Vol. 29, Pages 322: Hydroxylated Tetramethoxyflavone Affects Intestinal Cell Permeability and Inhibits Cytochrome P450 Enzymes
This study aims to provide insights into the chemical and biological properties of hydroxylated TMF and evaluates its effects on intestinal cell permeability and cytochrome P450 (CYP) inhibition. Liquid chromatography–mass spectrometry (LC-MS) and microsomes analyze the TMFs and hydroxylated TMFs, elucidating cell penetration and metabolic inhibition potential. 3H7-TMF shows the fastest (1-h) transport efficiency in intestinal cells. The Caco-2 cell model exhibits significant transport and absorption efficiency. Dissolved hydroxyl-TMF with hydrophilicity possibly permeates the gut. 3H7-TMF has higher transpor...
Source: Molecules - January 9, 2024 Category: Chemistry Authors: Kuo-Ching Jan Mohsen Gavahian Tags: Article Source Type: research
